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Cholesterol, on the other hand, was significantly increased two\u2010 to three\u2010fold, leading to an elevated cholesterol\/phospholipid ratio. Morpho\u2010cytochemical studies confirmed these findings because the multiple lipid droplets present in acinar cells of diabetic animals were found to be of cholesterol nature. The major alterations in phospholipid\u2010fatty acid composition were characterized by an increase of linoleate coupled to a decrease of monounsaturates and arachidonate, suggesting defective metabolism of saturates and of linoleate. This was further supported by fatty acid ratios that suggested low \u03945 and \u03949 desaturation. Daily administration of insulin for 10 days restored and overcorrected the various lipid alterations. This study suggests that there are alterations in lipid composition and metabolism in the exocrine pancreas of chronic streptozotocin\u2010induced diabetic rats. Their possible role in the mechanism regulating pancreatic function and secretion remains to be elucidated.<\/jats:p>","DOI":"10.1007\/bf02536220","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T01:50:25Z","timestamp":1164765025000},"page":"771-778","source":"Crossref","is-referenced-by-count":10,"title":["Lipid abnormalities in pancreatic tissue of streptozotocin\u2010induced diabetic rats"],"prefix":"10.1002","volume":"23","author":[{"given":"Emile","family":"Levy","sequence":"first","affiliation":[{"name":"Departments of Nutrition, Anatomy and Gastroenterology University of Montreal and Research Center, Ste\u2010Justine Hospital Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude C.","family":"Roy","sequence":"additional","affiliation":[{"name":"Departments of Nutrition, Anatomy and Gastroenterology University of Montreal and Research Center, Ste\u2010Justine Hospital Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Lepage","sequence":"additional","affiliation":[{"name":"Departments of Nutrition, Anatomy and Gastroenterology University of Montreal and Research Center, Ste\u2010Justine Hospital Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moise","family":"Bendayan","sequence":"additional","affiliation":[{"name":"Departments of Nutrition, Anatomy and Gastroenterology University of Montreal and Research Center, Ste\u2010Justine Hospital Montreal Quebec Canada"},{"name":"Department of Anatomy, Faculty of Medicine University of Montreal P.O. 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