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Paf, from 1\u00d710<jats:sup>\u22125<\/jats:sup> M to 10<jats:sup>\u22126<\/jats:sup> M, decreased B cell proliferation induced by both phorbol myristate acetate (PMA) and anti\u2010IgM antibodies (anti\u2010IgM Ab). By contrast, 1\u00d710<jats:sup>\u22127<\/jats:sup> M to 1\u00d710<jats:sup>\u22129<\/jats:sup> M paf enhanced PMA triggered, but not anti\u2010IgM triggered B cell proliferation. B cell proliferation was modulated between 24 and 72 hr of culture indicating that the effect of paf did not merely reflect a shift in proliferation kinetics. Interestingly, paf also enhanced the spontaneous proliferation of a Burkitt lymphoma\u2010derived B cell line, Raji, which suggests that paf can directly act on B cells. The modulatory effect of paf on peripheral blood B cells was independent of PMA concentration, yet the effect on Raji cells was dependent upon cell density. The data suggest that paf is a potent modulator of B cell function, and may be involved in the control of humoral immune response.<\/jats:p>","DOI":"10.1007\/bf02536532","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T20:35:06Z","timestamp":1170534906000},"page":"1204-1208","source":"Crossref","is-referenced-by-count":21,"title":["Immunoregulatory functions of paf\u2010acether. VI. Dual effect on human B cell proliferation"],"prefix":"10.1002","volume":"26","author":[{"given":"Corinne","family":"Leprince","sequence":"first","affiliation":[{"name":"Laboratoire d'Immunopathologie et d'Immunologie Virale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U131 Universite Paris\u2010Sud Clamart 92140 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Vivier","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunopharmacologie de l'Allergie et de l'Inflammation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U200 Universit\u00e9 Paris\u2010Sud 32 rue des Carnets Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Treton","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunopathologie et d'Immunologie Virale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U131 Universite Paris\u2010Sud Clamart 92140 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Galanaud","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunopathologie et d'Immunologie Virale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U131 Universite Paris\u2010Sud Clamart 92140 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Benveniste","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunopharmacologie de l'Allergie et de l'Inflammation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U200 Universit\u00e9 Paris\u2010Sud 32 rue des Carnets Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolande","family":"Richard","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunopathologie et d'Immunologie Virale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U131 Universite Paris\u2010Sud Clamart 92140 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolene","family":"Thomas","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunopharmacologie de l'Allergie et de l'Inflammation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U200 Universit\u00e9 Paris\u2010Sud 32 rue des Carnets Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,12]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1987.tb00499.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.06.040188.002413"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91259-5"},{"key":"e_1_2_2_5_1","first-page":"245","volume":"6","author":"Sharma S.","year":"1987","journal-title":"Lymphokine Research"},{"key":"e_1_2_2_6_1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.4049\/jimmunol.135.3.1674","volume":"135","author":"Monroe J.G.","year":"1985","journal-title":"J. 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