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We observed that DDP led to significant alterations in renal microcirculation when administered to Munich\u2010Wistar rats, with a concomitant decrease in single nephron glomerular filtration rate due to reduction in glomerular plasma flow and transcapillary hydraulic pressure difference. BN 52063, a platelet\u2010activating factor antagonist, caused a striking change in acute renal failure induced by DDP leading toward normalization of all parameters of renal function. The results suggest that BN 52063 could be used as a novel drug to control DDP nephrotoxicity.<\/jats:p>","DOI":"10.1007\/bf02536558","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T20:35:06Z","timestamp":1170534906000},"page":"1324-1328","source":"Crossref","is-referenced-by-count":8,"title":["Effect of platelet\u2010activating factor antagonist BN 52063 on the nephrotoxicity of cisplatin"],"prefix":"10.1002","volume":"26","author":[{"given":"Oscar F.","family":"Pav\u00e3o dos Santos","sequence":"first","affiliation":[{"name":"Nephrology Division Escola Paulista de Medicine Rua Botucatu 740 S\u00e3o Paulo, SP 04023 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian A.","family":"Boim","sequence":"additional","affiliation":[{"name":"Nephrology Division Escola Paulista de Medicine Rua Botucatu 740 S\u00e3o Paulo, SP 04023 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elivo J. 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