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Using the non\u2010steroidal, anti\u2010inflammatory agents indomethacin and aspirin, we found that cyclooxygenase products do not participate in the reaction. In contrast, vasoactive amines appear to be involved, because meclizine and methysergide reduced the edema. Dexamethasone, BW755C, LY 171883 and WEB 2170 effectively interfered with the edematogenic reaction, which suggests that lipid mediators such as leukotrienes and PAF play a role in the active anaphylactic response.<\/jats:p>","DOI":"10.1007\/bf02536574","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T20:35:06Z","timestamp":1170534906000},"page":"1396-1399","source":"Crossref","is-referenced-by-count":5,"title":["Effect of PAF\u2010acether antagonists on active anaphylactic mouse paw edema"],"prefix":"10.1002","volume":"26","author":[{"given":"Claudia Zuany","family":"Amorim","sequence":"first","affiliation":[{"name":"Unite de Pharmacologie Cellulaire Unit\u00e9 Associee Institut Pasteur\u2010INSERM U.285 Paris 75015 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria das Gra\u00e7as Muller","family":"de Oliveira Henriques","sequence":"additional","affiliation":[{"name":"Unite de Pharmacologie Cellulaire Unit\u00e9 Associee Institut Pasteur\u2010INSERM U.285 Paris 75015 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Baseches","family":"Weg","sequence":"additional","affiliation":[{"name":"Unite de Pharmacologie Cellulaire Unit\u00e9 Associee Institut Pasteur\u2010INSERM U.285 Paris 75015 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato S\u00e9rgio","family":"Bal\u00e3o Cordeiro","sequence":"additional","affiliation":[{"name":"Unite de Pharmacologie Cellulaire Unit\u00e9 Associee Institut Pasteur\u2010INSERM U.285 Paris 75015 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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