{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:21:25Z","timestamp":1791116485204,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12Part2","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 1\u2010\u03b2\u2010D\u2010arabinofuranosylcytosine (ara\u2010C) conjugates 1\u2010<jats:italic>O<\/jats:italic>\u2010alkyl (ether) and 1\u2010<jats:italic>S<\/jats:italic>\u2010alkyl (thioether) phospholipids, being analogues of ara\u2010CDP\u2010<jats:italic>sn<\/jats:italic>\u20101,2\u2010<jats:italic>O<\/jats:italic>\u2010dipalmitoylglycerol (1), showed significant antitumor activity against L1210 and P388 leukemia<jats:italic>in vivo<\/jats:italic>. The more active conjugates include the 1\u2010<jats:italic>O<\/jats:italic>\u2010alkyl analogues, ara\u2010CDP\u2010<jats:italic>rac<\/jats:italic>\u20101\u2010<jats:italic>O<\/jats:italic>\u2010hexadecyl\u20102\u2010<jats:italic>O<\/jats:italic>\u2010palmitoylglycerol (2) and ara\u2010CDP\u2010<jats:italic>rac<\/jats:italic>\u20101\u2010<jats:italic>O<\/jats:italic>\u2010octadecyl\u20102\u2010<jats:italic>O<\/jats:italic>\u2010palmitoylglycerol (3), and the corresponding 1\u2010<jats:italic>S<\/jats:italic>\u2010alkyl analogues, ara\u2010CDP\u2010<jats:italic>rac<\/jats:italic>\u20101\u2010<jats:italic>S<\/jats:italic>\u2010hexadecyl\u20102\u2010<jats:italic>O<\/jats:italic>\u2010palmitoyl\u20101\u2010thioglycerol (4) and ara\u2010CDP\u2010<jats:italic>rac<\/jats:italic>\u20101\u2010<jats:italic>S<\/jats:italic>\u2010octadecyl\u20102\u2010<jats:italic>O<\/jats:italic>\u2010palmitoyl\u20101\u2010thioglycerol (5, Cytoros). The conjugates were formulated by sonication, in which the conjugates existed as discs (size 0.01\u20130.04 \u03bc).. Among the conjugates of the three different phospholipids, the 1\u2010<jats:italic>S<\/jats:italic>\u2010alkyl analogues 4 and 5 displayed the strongest antitumor activity against L1210 leukemia in mice, followed by the 1\u2010<jats:italic>O<\/jats:italic>\u2010alkyl (2 and 3) and the 1\u2010<jats:italic>O<\/jats:italic>\u2010acyl (1) analogues. The 1\u2010<jats:italic>S<\/jats:italic>\u2010alkyl analogue 5 was considerably more effective than the 1\u2010<jats:italic>O<\/jats:italic>\u2010acyl analogue 1 against myelomonocytic WEHI\u20103B leukemia in mice. Conjugate 5 (Cytoros) showed a significant therapeutic activity in mice with colon 26 carcinoma, M5076 sarcoma, and C\u20101300 neuroblastoma. Furthermore, this agent inhibited liver metastases of M5076 sarcoma. Conjugates 3 and 5 also inhibited the metastasis of 3\u2010Lewis lung carcinoma to the lungs of mice. Cytoros (5) and its analogues, with other ether and thioether phospholipids, appear to offer increased therapeutic benefit to mice with tumors.<\/jats:p>","DOI":"10.1007\/bf02536582","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T20:35:06Z","timestamp":1170534906000},"page":"1437-1444","source":"Crossref","is-referenced-by-count":15,"title":["1\u2010\u03b2\u2010D\u2010arabinofuranosylcytosine conjugates of ether and thioether phospholipids. 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