{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:52:01Z","timestamp":1782561121088,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[1993,12,1]],"date-time":"1993-12-01T00:00:00Z","timestamp":754704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of dietary vitamin E levels on tissue \u03b1\u2010tocopherol (\u03b1\u2212T) concentrations in different parts of the nervous system are largely unknown. Therefore, we measured the \u03b1\u2212T contents of nervous and other tissues obtained from beagle dogs fed for two years a vitamin E\u2010deficient diet (\u2212E, 0.05\u00b10.02 mg vitamin E\/kg diet, n=2), a vitamin E\u2010supplemented diet (+E, 114\u00b114 mg\/kg, n=2), or a standard chow diet (E<jats:sub>n<\/jats:sub>, 74\u00b16 mg\/kg, n=3). Brain regions and spinal cords of +E dogs contained about double the \u03b1\u2212T concentrations of E<jats:sub>n<\/jats:sub> dogs, and about 10\u2010fold those of \u2212E dogs. The various brain regions of \u2212E dogs, compared with E<jats:sub>n<\/jats:sub> dogs, retained 12\u201318% of the \u03b1\u2212T concentrations, with the exception of the caudal colliculus, which retained 48%. Peripheral nerve \u03b1\u2212T concentrations in +E dogs (67 ng\/mg wet weight) were nearly 5\u2010fold higher than in E<jats:sub>n<\/jats:sub> dogs (13.4\u00b15.9 ng\/mg) and 80\u2010fold higher than in \u2212E dogs (0.8 ng\/mg). Within each dietary group, the lowest \u03b1\u2212T concentrations in the central nervous system (CNS) were in the spinal cord. Peripheral nerves were the most susceptible to vitamin E repletion or depletion: in +E dogs, nerves contained higher concentrations of \u03b1\u2212T than most brain regions; in E<jats:sub>n<\/jats:sub> dogs, they contained similar concentrations; but in \u2212E dogs, they contained less \u03b1\u2212T than most brain regions. Muscles and other tissues of \u2212E dogs retained from 1 to 10% of E<jats:sub>n<\/jats:sub> values. The studies demonstrate that the CNS conserved \u03b1\u2212T compared to peripheral nerves and nonnervous tissues in adult dogs, but contained lower absolute concentrations of \u03b1\u2212T compare with most other tissues.<\/jats:p>","DOI":"10.1007\/bf02537077","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T13:20:17Z","timestamp":1164806417000},"page":"1101-1105","source":"Crossref","is-referenced-by-count":23,"title":["\u03b1\u2010tocopherol concentrations of the nervous system and selected tissues of adult dogs fed three levels of vitamin E"],"prefix":"10.1002","volume":"28","author":[{"given":"Shreekumar R.","family":"Pillai","sequence":"first","affiliation":[{"name":"Scott\u2010Ritchey Research Center, College of Veterinary Medicine Auburn University Auburn Alabama 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maret G.","family":"Traber","sequence":"additional","affiliation":[{"name":"Department of Medicine New York University School of Medicine New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Steiss","sequence":"additional","affiliation":[{"name":"Scott\u2010Ritchey Research Center, College of Veterinary Medicine Auburn University Auburn Alabama 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert J.","family":"Kayden","sequence":"additional","affiliation":[{"name":"Department of Medicine New York University School of Medicine New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy R.","family":"Cox","sequence":"additional","affiliation":[{"name":"Scott\u2010Ritchey Research Center, College of Veterinary Medicine Auburn University Auburn Alabama 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1993,12]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"815","volume-title":"Vitamin E in Health and Disease","author":"Sokol R.J.","year":"1993"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(84)90211-X"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/121.8.1204"},{"key":"e_1_2_2_5_1","first-page":"147","volume-title":"Clinical and Nutritional Aspects of Vitamin E","author":"Vatassery G.T.","year":"1987"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(92)90014-L"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02537076"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/46.3.488"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707303170502"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02537078"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb02713.x"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198103000-00008"},{"key":"e_1_2_2_13_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2460\/javma.1970.157.01.64","volume":"157","author":"Hayes K.C.","year":"1970","journal-title":"J. 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