{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:37:46Z","timestamp":1772786266654,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Retinitis pigmentosa<\/jats:italic> (RP) is a hereditary retinal degeneration of unknown etiology, resulting in progressive night blindness, loss of peripheral vision, abnormal retinal pigmentation and reduced electroretinographic response. Docosahexaenoic acid (22\u22366\u03c93) is found in high concentration in the rod outer segment membranes of the retina. Previous reports of low 22\u22366\u03c93 in blood lipids or phospholipids in RP patients prompted us to evaluate the complete fatty acid (FA) profiles of plasma phospholipids (PL), cholesteryl esters, triglycerides (TG) and nonesterified fatty acids (NEFA) in ten patients with RP. In the PL fraction, we found significantly depressed levels of 22\u22366\u03c93, 22\u22365\u03c93, total \u03c93, 22\u22365\u03c96, 22\u22364\u03c96 and total \u03c96 polyunsaturated FA (PUFA), and elevated total saturated acids. Plasma TG showed normal levels of PUFA, normal total saturated FA and total monounsaturated FA. The NEFA fraction showed significant elevation in total saturated FA with depressed total \u03c96 PUFA. Evidence is accumulating that RP is associated with abnormal PUFA and lipid metabolism.<\/jats:p>","DOI":"10.1007\/bf02537092","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T13:37:09Z","timestamp":1164807429000},"page":"61-65","source":"Crossref","is-referenced-by-count":18,"title":["Abnormal plasma lipids of patients with<i>Retinitis pigmentosa<\/i>"],"prefix":"10.1002","volume":"29","author":[{"given":"R. T.","family":"Holman","sequence":"first","affiliation":[{"name":"The Hormel Institute University of Minnesota 801 16th Ave. NE Austin MN 55912"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Bibus","sequence":"additional","affiliation":[{"name":"The Hormel Institute University of Minnesota 801 16th Ave. NE Austin MN 55912"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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