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The results demonstrated massive concentration of total fatty acids coupled with higher levels of triglycerides, free cholesterol, cholesterol ester and phospholipids. This hyperlipidemia involved all fatty acids without distinction of carbon or bond numbers. However, the increase was more pronounced for saturated than polyunsaturated fatty acids, as was demonstrated by the ratios of both oleic acid to linoleic acid (1.91\u00b10.40 vs 0.80\u00b10.09 in controls) and of \u03c93+\u03c96 to \u03c99 fatty acid families (0.92\u00b10.11 vs 1.66\u00b10.08 in controls). The fatty acid patterns in very low (VLDL), low (LDL) and high (HDL) density lipoprotein showed substantial differences in composition, reflecting an association between an abnormal lipoprotein pattern and essential fatty acid deficiency. Furthermore, GSD\u2010I patients exhibited a significant increase in VLDL (17\u00b12 vs 47\u00b17 mg\/dl) and LDL cholesterol (124\u00b17 vs 206\u00b124 mg\/dl), coupled with a decrease in HDL cholesterol (49\u00b14 vs 28\u00b13 mg\/dl). These data documenting high LDL cholesterol and low HDL cholesterol associated with an increased concentration and proportion of saturated fatty acids suggest that GSD\u2010I patients on nocturnal intragastric feeding are at high risk for atherosclerosis and its complications.<\/jats:p>","DOI":"10.1007\/bf02537265","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T01:08:04Z","timestamp":1164762484000},"page":"381-385","source":"Crossref","is-referenced-by-count":16,"title":["Plasma and lipoprotein fatty acid composition in glycogen storage disease type I"],"prefix":"10.1002","volume":"22","author":[{"given":"Emile","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Gastroenterology Shaare Zedek Hospital Jerusalem Israel"},{"name":"Centre de Recherche, H\u00f4pital Sainte\u2010Justine, Department of Pediatrics Universit\u00e9 de Montreal 3175 Ste\u2010Catherine Road Quebec H3T 1C5 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Letarte","sequence":"additional","affiliation":[{"name":"Centre de Recherche, H\u00f4pital Sainte\u2010Justine, Department of Pediatrics Universit\u00e9 de Montreal 3175 Ste\u2010Catherine Road Quebec H3T 1C5 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Lepage","sequence":"additional","affiliation":[{"name":"Centre de Recherche, H\u00f4pital Sainte\u2010Justine, Department of Pediatrics Universit\u00e9 de Montreal 3175 Ste\u2010Catherine Road Quebec H3T 1C5 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Thibault","sequence":"additional","affiliation":[{"name":"Centre de Recherche, H\u00f4pital Sainte\u2010Justine, Department of Pediatrics Universit\u00e9 de Montreal 3175 Ste\u2010Catherine Road Quebec H3T 1C5 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude C.","family":"Roy","sequence":"additional","affiliation":[{"name":"Centre de Recherche, H\u00f4pital Sainte\u2010Justine, Department of Pediatrics Universit\u00e9 de Montreal 3175 Ste\u2010Catherine Road Quebec H3T 1C5 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"143","volume-title":"The Metabolic Basis of Inherited Disease","author":"Howell R.R.","year":"1978"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/22.5.617"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197402000-00008"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1542\/peds.29.4.553","volume":"29","author":"Howell R.R.","year":"1962","journal-title":"Pediatrics"},{"key":"e_1_2_1_6_1","first-page":"769","volume":"68","author":"Jakovcic S.","year":"1966","journal-title":"J. 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