{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:37Z","timestamp":1761006937116,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The influence of low dietary doses (0.1 and 0.8% w\/w) of a commercial fish oil preparation on peroxisomes in normal mice was studied and compared to the known strong inductive effects of high (10%) fish oil diets. Low fish oil doses were chosen to supply the mice with a concentration of docosahexaenoic acid, which was beneficial to patients with a peroxisomal disease. Peroxisomes were evaluated by cytochemical, morphometric, and enzymological techniques. The 0.1% fish oil diet had no effect on peroxisomes in liver, heart, and kidney even after prolonged treatment. The 0.8% diet did not change the peroxisomal number nor the catalase (EC 1.11.1.6) activity in the liver. Hepatic peroxisomal \u03b2\u2010oxidation, however, was increased by 50% after 14 d. This was accompanied by reduced peroxisomal size. The 0.8% diet also caused a small increase (+25%) in myocardial catalase activity. No effect was observed in kidneys. Our results indicate that in mice a low (&lt;0.8%) dietary fish oil dose has no or only a slight effect on hepatic peroxisomal \u03b2\u2010oxidation. This may be of particular interest to patients with a peroxisomal fatty acid \u03b2\u2010oxidation defect and who display a severe deficiency of docosahexaenoic acid\u2014diets supplemented with low fish oil doses will improve the docosahexaenoic acid level without adding a strong load to the disturbed fatty acid metabolism.<\/jats:p>","DOI":"10.1007\/bf02537795","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T15:06:55Z","timestamp":1164812815000},"page":"701-705","source":"Crossref","is-referenced-by-count":8,"title":["Peroxisomes in mice fed a diet supplemented with low doses of fish oil"],"prefix":"10.1002","volume":"30","author":[{"given":"C.","family":"Van den Branden","sequence":"first","affiliation":[{"name":"Menselijke Anatomie &amp; Embryologie Vrije Universiteit Brussel Laarbeeklaan 103 Brussels B\u20101090 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"De Craemer","sequence":"additional","affiliation":[{"name":"Menselijke Anatomie &amp; Embryologie Vrije Universiteit Brussel Laarbeeklaan 103 Brussels B\u20101090 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Menselijke Anatomie &amp; Embryologie Vrije Universiteit Brussel Laarbeeklaan 103 Brussels B\u20101090 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vamecq","sequence":"additional","affiliation":[{"name":"North France Center for the Study of Childhood Epilepsy Lille Cedex 59037 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,8]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.001105"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4107.62"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(93)90087-9"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1993.02160300023015"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535160"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(10)80021-6"},{"key":"e_1_2_2_8_1","first-page":"389","article-title":"Treatment with Docosahexaenoic Acid Favorably Modifies the Fatty Acid Composition of Erythrocytes in Peroxisomal Patients.","volume":"375","author":"Martinez M.","year":"1992","journal-title":"Prog. 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