{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:00Z","timestamp":1761006900314,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously shown that a continuous infusion of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) in rats results in an increase in plasma triglyceride (TG), liver protein and DNA, and at the same time a reduction in muscle protein. However, there is no information on the associated effects of TNF\u2010\u03b1 on liver and muscle lipids. The present study, therefore, determined the effect of TNF\u2010\u03b1 on the TG and phospholipid (PL) content and their fatty acid composition, in the liver and carcass of rats and correlated with the plasma levels of insulin, corticosterone, and catecholamaines. Total parenteral nutrition that met the daily nutrient requirements was continuously infused for 10 d through a central vein catheter in two groups of rats, one receiving infused TNF\u2010\u03b1 (100 \u03bcg\/kg\/d) and a control group. Hepatic TG and PL, expressed either as mg\/g dry weight or total organ content, were significantly increased in the TNF\u2010\u03b1\u2010infused group compared with controls. Livers of TNF\u2010\u03b1 infused rats contained significantly less saturated and monounsaturated fatty acids and significantly more polyunsaturated fatty acids (PUFA) of the \u03c93 and \u03c96 series than controls. The carcass, on the other hand, contained significantly more monounsaturated and significantly less polyunsaturated fatty acids of the \u03c96 series than controls. There were no changes in corticosterone level. Although plasma glucose levels were comparable between control and TNF\u2010\u03b1 infused rats, the latter had a marked increase in insulin levels, demonstrating insulin resistance. In addition TNF\u2010\u03b1 infused rats had raised norepinephrine levels. The fall in carcass and rise in liver TG and PL are consistent with the presence of insulin resistance and raised norepinephrine levels. However, the increase in PUFA content of the liver, especially the increase in 20\u22364\u03c96 levels in liver PL and TG, is likely to be the effect of TNF\u2010\u03b1 and suggests increased activity of \u03945\u2010desaturase.<\/jats:p>","DOI":"10.1007\/bf02537797","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T15:06:55Z","timestamp":1164812815000},"page":"713-718","source":"Crossref","is-referenced-by-count":14,"title":["Effect of tumor necrosis factor\u2010\u03b1 on triglyceride and phospholipid content and fatty acid composition of liver and carcass in rats"],"prefix":"10.1002","volume":"30","author":[{"given":"Nilima","family":"Raina","sequence":"first","affiliation":[{"name":"Departments of Medicine and Nutritional Sciences University of Toronto Room #6352, Medical Sciences Building Toronto Ontario M5S 1A8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Nutritional Sciences University of Toronto Room #6352, Medical Sciences Building Toronto Ontario M5S 1A8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Cunnane","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Nutritional Sciences University of Toronto Room #6352, Medical Sciences Building Toronto Ontario M5S 1A8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khursheed N.","family":"Jeejeebhoy","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Nutritional Sciences University of Toronto Room #6352, Medical Sciences Building Toronto Ontario M5S 1A8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,8]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.3.495"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-5-2336"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113991"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(89)90623-3"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(91)90027-K"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.002445"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90857-9"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113046"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-3-1016"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113733"},{"key":"e_1_2_2_12_1","first-page":"E27","article-title":"Body Composition and Metabolic Rate in Rat During a Continuous Infusion of Cachectin","volume":"260","author":"Hoshino E.","year":"1991","journal-title":"Am. 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