{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:27:25Z","timestamp":1761006445710,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Copper deficiency induces hypercholesterolemia in the rat. This hypercholesterolemia is mainly due to an increase in apo E\u2010rich high density lipoproteins (HDL<jats:sub>1<\/jats:sub>). The present study was undertaken to determine whether the HDL increase could be explained by altered low\u2010molecular weight apolipoprotein (apo) synthesis in the liver. The effect of copper deficiency on apo A\u2010I, apo A\u2010IV and apo E concentrations in plasma, as well as on respective mRNA levels and synthesis in the liver, were therefore investigated. We observed that the increased HDL<jats:sub>1<\/jats:sub> levels in the plasma of copper\u2010deficient rats were associated with a significant rise in plasma apo E concentrations; however, plasma apo A\u2010I and apo A\u2010IV concentrations remained unchanged. Liver apo synthesis and respective apo mRNA levels were not significantly altered in copper\u2010deficient animals when compared to control rats. No changes in apo E mRNA levels in various tissues from copper\u2010deficient, as compared to control rats, were noted. Based on the data obtained, it was concluded that the observed changes in plasma lipoprotein and apo concentrations are not related to changes in low\u2010molecular weight apo synthesis in the liver. The mechanisms of the impaired catabolism of HDL<jats:sub>1<\/jats:sub> should be further evaluated to possibly explain the observed increase in this fraction in copper\u2010deficient rats.<\/jats:p>","DOI":"10.1007\/bf02538918","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T14:09:11Z","timestamp":1164809351000},"page":"727-729","source":"Crossref","is-referenced-by-count":6,"title":["Apolipoprotein A\u2010I, A\u2010IV and E synthesis in the liver of copper\u2010deficient rats"],"prefix":"10.1002","volume":"29","author":[{"given":"Fatiha","family":"Nassir","sequence":"first","affiliation":[{"name":"Centre de Recherches en Nutrition Humaine, Laboratoire des Maladies M\u00e9taboliques INRA Theix St. Gen\u00e8s Champanelle 63122 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Mazur","sequence":"additional","affiliation":[{"name":"Centre de Recherches en Nutrition Humaine, Laboratoire des Maladies M\u00e9taboliques INRA Theix St. Gen\u00e8s Champanelle 63122 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyett","family":"Gueux","sequence":"additional","affiliation":[{"name":"Centre de Recherches en Nutrition Humaine, Laboratoire des Maladies M\u00e9taboliques INRA Theix St. Gen\u00e8s Champanelle 63122 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colette","family":"S\u00e9rougne","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie de la Nutrition Universit\u00e9 Paris Sud Orsay C\u00e9dex 91405 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Rayssiguier","sequence":"additional","affiliation":[{"name":"Centre de Recherches en Nutrition Humaine, Laboratoire des Maladies M\u00e9taboliques INRA Theix St. Gen\u00e8s Champanelle 63122 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,10]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"1","volume-title":"Role of Copper in Lipid Metabolism","author":"Lei K.Y.","year":"1990"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.11.070191.001405"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(91)90302-X"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.7.1563598"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/116.9.1735"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.6.1199"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81105-9"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/113.11.2178"},{"volume-title":"A Guidebook to Lipoprotein Technique. Laboratory Techniques in Biochemistry and Molecular Biology","year":"1989","author":"Mills G.L.","key":"e_1_2_2_10_1"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34804-5"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(87)90080-4"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb15842.x"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41991-1"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30653-1"},{"key":"e_1_2_2_17_1","first-page":"453","volume":"1","author":"Prohaska J.R.","year":"1990","journal-title":"J. Nutr. Biochem."},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02785240"},{"key":"e_1_2_2_19_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/jn\/123.8.1343","volume":"123","author":"Rayssiguier Y.","year":"1993","journal-title":"J. Nutr."},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.4.473"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38497-2"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02538918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:03:48Z","timestamp":1760951028000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02538918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1007\/BF02538918"],"URL":"https:\/\/doi.org\/10.1007\/bf02538918","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"type":"print","value":"0024-4201"},{"type":"electronic","value":"1558-9307"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}