{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:49:22Z","timestamp":1790567362987,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefe's Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[1996,7]]},"DOI":"10.1007\/bf02539413","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T07:17:40Z","timestamp":1165994260000},"page":"457-462","source":"Crossref","is-referenced-by-count":31,"title":["Indoleamine 2,3-dioxygenase: Antioxidant enzyme in the human eye"],"prefix":"10.1007","volume":"234","author":[{"given":"Halina Zofia","family":"Malina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Daniel","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02539413_CR1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1751-1097.1987.tb04893.x","volume":"46","author":"UP Andley","year":"1987","unstructured":"Andley UP (1987) Photodamage to the eye. Photochem Photobiol 46: 1057\u20131066","journal-title":"Photochem Photobiol"},{"key":"BF02539413_CR2","first-page":"815","volume":"28","author":"BC Barron","year":"1987","unstructured":"Barron BC, Yu N-T, Kuck JFR Jr (1987) Tryptophan Raman\/457.9-nmexcited fluorescence of intact guinea pig lenses in aging and ultraviolet light. Invest Ophthalmol Vis Sci 28: 815\u2013821","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF02539413_CR3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/BF01990503","volume":"45","author":"MJ Carlin","year":"1989","unstructured":"Carlin MJ, Ozaki Y, Byrne GI, Brown RR, Borden EC (1989) Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and indoleamine 2,3dioxygenase: role in antimicrobial and antitumor effects. Experientia 45: 535\u2013541","journal-title":"Experientia"},{"key":"BF02539413_CR4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1751-1097.1987.tb08416.x","volume":"45","author":"J Dillon","year":"1987","unstructured":"Dillon J, Chiesa R, Spector A (1987) The photochemistry of specific tryptophan residues in proteins as analysed by the fluorescent scanning of tryptic peptide maps. Photochem Photobiol 45: 147\u2013150","journal-title":"Photochem Photobiol"},{"key":"BF02539413_CR5","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.1016\/S0021-9258(19)41144-7","volume":"250","author":"F Hirata","year":"1975","unstructured":"Hirata F, Hayaishi O (1975) Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate. J Biol Chem 250: 5960\u20135966","journal-title":"J Biol Chem"},{"key":"BF02539413_CR6","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1016\/S0021-9258(17)40208-0","volume":"252","author":"F Hirata","year":"1977","unstructured":"Hirata F, Ohnishi T, Hayaishi O (1977) Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme O2-complex. J Biol Chem 252: 4637\u20134642","journal-title":"J Biol Chem"},{"key":"BF02539413_CR7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/BF02044236","volume":"231","author":"HZ Malina","year":"1993","unstructured":"Malina HZ, Martin XD (1993) Indoleamine 2,3-dioxygenase activity in the aqueous humour, iris\/ciliary body, and retina of the bovine eye. Graefe's Arch Clin Exp Ophthalmol 231: 482\u2013486","journal-title":"Graefe's Arch Clin Exp Ophthalmol"},{"key":"BF02539413_CR8","first-page":"552","volume":"6","author":"S Lerman","year":"1967","unstructured":"Lerman S, Forbes WF, Zigman S (1967) The effect of aging irradiation on the thiol content of the soluble lens proteins. Invest Ophthalmol Vis Sci 6: 552\u2013553","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF02539413_CR9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000264951","volume":"10","author":"S Lerman","year":"1978","unstructured":"Lerman S, Yamanashi BS, Palmer RA, Roark JC, Borkman R (1978) Photoacoustic, fluorescence and light transmission spectra of normal, aging and cataractous lenses. Ophthalmic Res 10: 168\u2013176","journal-title":"Ophthalmic Res"},{"key":"BF02539413_CR10","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1016\/S0021-9258(17)40209-2","volume":"252","author":"T Ohnishi","year":"1977","unstructured":"Ohnishi T, Hirata F, Hayaishi O (1977) Indoleamine 2,3-dioxygenase. Potassium superoxide as substrate. J Biol Chem 252: 4643\u20134647","journal-title":"J Biol Chem"},{"key":"BF02539413_CR11","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1073\/pnas.85.4.1242","volume":"85","author":"Y Ozaki","year":"1988","unstructured":"Ozaki Y, Edelstein MP, Duch DS (1988) Induction of indoleamine 2,3dioxygenase: a mechanism of the antitumor activity of interferon-\u03b3. Proc Natl Acad Sci USA 85: 1242\u20131246","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02539413_CR12","first-page":"1142","volume":"34","author":"SR Planck","year":"1993","unstructured":"Planck SR, Huang XN, Robertson EJ, Rosenbaum JT (1993) Cytokine mRNA levels in rat ocular tissues following systemic endotoxin treatment. Invest Ophthalmol Vis Sci [Suppl] 34: 1142","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF02539413_CR13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/205500a0","volume":"205","author":"A Pirie","year":"1965","unstructured":"Pirie A (1965) A light-catalysed reaction in the aqueous humor of the eye. Nature 205: 500\u2013501","journal-title":"Nature"},{"key":"BF02539413_CR14","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1042\/bj1281365","volume":"128","author":"A Pirie","year":"1972","unstructured":"Pirie A (1972) Fluorescence ofN-formylkynurenine and of proteins exposed to sunlight. Biochem J 128: 1365\u20131367","journal-title":"Biochem J"},{"key":"BF02539413_CR15","first-page":"5","volume-title":"Optical radiation and visual health","author":"DG Pitts","year":"1986","unstructured":"Pitts DG, Cameron LL, Jose JG, Lerman S, Moss E, Varma SD, Zigler Z, Zigman S, Zuclich J (1986) Optical radiation and cataracts. In: Waxler M, Hitchins VM (eds) Optical radiation and visual health. CRC Press, Boca Raton, Florida, pp 5\u201342"},{"key":"BF02539413_CR16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1751-1097.1987.tb04804.x","volume":"46","author":"CM Rao","year":"1987","unstructured":"Rao CM, Balasubramanian D, Chakrabarti B (1987) Monitoring isolated intact eye lenses. Photochem Photobiol 46: 511\u2013515","journal-title":"Photochem Photobiol"},{"key":"BF02539413_CR17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/230393a0","volume":"230","author":"R Heyningen Van","year":"1971","unstructured":"Van Heyningen R (1971) Fluorescent glucoside in the human lens. Nature (Lond) 230: 393\u2013394","journal-title":"Nature (Lond)"},{"key":"BF02539413_CR18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-4835(73)90203-0","volume":"17","author":"R Heyningen Van","year":"1973","unstructured":"Van Heyningen R (1973) Photo-oxidation of lens proteins by sunlight in the presence of fluorescent derivatives of kynurenine, isolated from the human lens. Exp Eye Res 17: 137\u2013147","journal-title":"Exp Eye Res"},{"key":"BF02539413_CR19","first-page":"151","volume-title":"Ciba Foundation Symposium vol. 19","author":"R Heyningen Van","year":"1973","unstructured":"Van Heyningen R (1973) The human lens \u2014 in relation to the cataract. In: Elliott K, Fitzsimons DW (eds) Ciba Foundation Symposium vol. 19. Elsevier, Amsterdam, pp 151\u2013171"},{"key":"BF02539413_CR20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1751-1097.1975.tb06723.x","volume":"22","author":"P Walrant","year":"1975","unstructured":"Walrant P, Santus R, Grossweiner LI (1975) Photosensitizing properties ofN-formylkynurenine. Photochem Photobiol 22: 63\u201365","journal-title":"Photochem Photobiol"},{"key":"BF02539413_CR21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/exer.1993.1041","volume":"56","author":"A Wood","year":"1993","unstructured":"Wood A, Truscott RJW (1993) UV filters in human lenses: tryptophan catabolism. Exp Eye Res 56: 317\u2013325","journal-title":"Exp Eye Res"},{"key":"BF02539413_CR22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/bj2300635","volume":"1230","author":"F Yamazaki","year":"1985","unstructured":"Yamazaki F, Kuroiwa T, Takikawa O, Kido R (1985) Human indolylamine 2,3-dioxygenase. Its tissue distribution and characterization of placental enzyme. Biochem 1230: 635\u2013638","journal-title":"Biochem"},{"key":"BF02539413_CR23","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1073\/pnas.75.8.3998","volume":"75","author":"R Yoshida","year":"1978","unstructured":"Yoshida R, Hayaishi O (1978) Induction of pulmonary indoleamine 2,3dioxygenase by intraperitoneal injection of bacterial lipopolisaccharide. Proc Natl Acad Sci USA 75: 3998\u20134000","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02539413_CR24","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1073\/pnas.76.8.4084","volume":"76","author":"R Yoshida","year":"1979","unstructured":"Yoshida R, Urade Y, Tokuda M, Hayaishi O (1979) Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection. Proc Natl Acad Sci USA 76: 4084\u20134086","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02539413_CR25","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1751-1097.1981.tb05505.x","volume":"33","author":"JS Zigler Jr","year":"1981","unstructured":"Zigler JS Jr, Goosey JD (1981) Photosensitized oxidation in the ocular lens: evidence for photosensitizer endogenous to the human lens. Photochem Photobiol 33: 869\u2013874","journal-title":"Photochem Photobiol"},{"key":"BF02539413_CR26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0014-4835(73)90145-0","volume":"15","author":"S Zigman","year":"1973","unstructured":"Zigman S, Griess G, Yulo T, Schultz J (1973) Ocular protein alteration by near UV light. Exp Eye Res 15: 255\u2013264","journal-title":"Exp Eye Res"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02539413.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02539413\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02539413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T22:50:50Z","timestamp":1628203850000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02539413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["BF02539413"],"URL":"https:\/\/doi.org\/10.1007\/bf02539413","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}