{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:06:58Z","timestamp":1791025618059,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1980,3,1]],"date-time":"1980-03-01T00:00:00Z","timestamp":320716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1980,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is considerable evidence that the growing tumor requires a source of unsaturated fatty acids, but the nature of this source and the mechanism of mobilizing the fatty acids from it are obscure. These experiments make use of AKR mice with implanted adipose tisue labeled with 1\u2010<jats:sup>14<\/jats:sup>C linoleic acid. With this experimental animal, it has been found that: (a) in the normal, fed mouse, fat is mobilized slowly and appears largely as respiratory CO<jats:sub>2<\/jats:sub>, following oxidation, (b) in the normal, fasted mouse, fat is mobilized rapidly and appears largely as respiratory CO<jats:sub>2<\/jats:sub>; (c) in the tumor\u2010bearing, fed mouse, fat is mobilized rapidly and appears largely in the tumor; and (d) the serum from tumor\u2010bearin mice, when injected into normal mice, produces an immediate massive fat mobilization that does not respond to feeding, whereas the serum from normal, fed mice does not. It is concluded that a mobilizing factor of unknown nature is present in the serum of tumor\u2010bearing AKR mice.<\/jats:p>","DOI":"10.1007\/bf02540964","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T19:09:24Z","timestamp":1167937764000},"page":"168-174","source":"Crossref","is-referenced-by-count":56,"title":["A lipid mobilizing factor in serum of tumor\u2010bearing mice"],"prefix":"10.1002","volume":"15","author":[{"given":"S.","family":"Kitada","sequence":"first","affiliation":[{"name":"Laboratory of Nuclear Medicine and Radiation Biology University of California 900 Veteran Avenue Los Angeles California 90024"},{"name":"Department of Biological Chemistry UCLA School of Medicine Los Angeles California 90024"},{"name":"Department of Medicine UCLA School of Medicine Los Angeles California 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. F.","family":"Hays","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine and Radiation Biology University of California 900 Veteran Avenue Los Angeles California 90024"},{"name":"Department of Biological Chemistry UCLA School of Medicine Los Angeles California 90024"},{"name":"Department of Medicine UCLA School of Medicine Los Angeles California 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Mead","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine and Radiation Biology University of California 900 Veteran Avenue Los Angeles California 90024"},{"name":"Department of Biological Chemistry UCLA School of Medicine Los Angeles California 90024"},{"name":"Department of Medicine UCLA School of Medicine Los Angeles California 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1980,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0350983"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0350996"},{"key":"e_1_2_1_4_1","first-page":"1","volume-title":"\u201cTumor Lipids: Biochemistry and Metabolism,\u201d","author":"Spector A.A.","year":"1973"},{"key":"e_1_2_1_5_1","first-page":"2218","volume":"37","author":"Baker N.","year":"1977","journal-title":"Cancer Res."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533844"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533614"},{"key":"e_1_2_1_8_1","first-page":"25","volume":"50","author":"Littman M.L.","year":"1966","journal-title":"Cancer Chemother. Rep."},{"key":"e_1_2_1_9_1","first-page":"321","volume-title":"\u201cVirus Tumorigenesis and Immunogenesis,\u201d","author":"Hays E.F.","year":"1973"},{"key":"e_1_2_1_10_1","first-page":"1685","volume":"29","author":"Vredevoe D.L.","year":"1969","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","first-page":"165","volume-title":"\u201cTransplantation of Tissues,\u201d","author":"Peer L.A.","year":"1959"},{"key":"e_1_2_1_12_1","first-page":"5118","volume":"39","author":"Ookhtens M.","year":"1979","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.27.1.13-18.1978"},{"key":"e_1_2_1_15_1","first-page":"181","volume":"1","author":"Lavik P.S.","year":"1941","journal-title":"Cancer Res."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533866"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02540964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:25:17Z","timestamp":1760876717000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02540964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,3]]}},"alternative-id":["10.1007\/BF02540964"],"URL":"https:\/\/doi.org\/10.1007\/bf02540964","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,3]]}}}