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THP\u20101 cells were incubated with 10 pM PAF in the presence or absence of 0.1 \u03bcg\/mL endotoxin for 4 hr, after which cytoplasmic RNA was extracted and subjected to Northern hybridizations. PAF, alone and in combination with endotoxin, caused an increase in mRNA levels for IL\u20101 beta. The magnitude of the effects of PAF on IL\u20101 beta mRNA levels matched closely the effects seen at the level of protein synthesis, suggesting that the effects of PAF on IL\u20101 beta release may result largely from its effects on IL\u20101 beta mRNA levels.<\/jats:p>","DOI":"10.1007\/bf02543983","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T19:33:39Z","timestamp":1167939219000},"page":"257-260","source":"Crossref","is-referenced-by-count":5,"title":["Platelet\u2010activating factor stimulates expression of IL\u20101 beta mRNA in THP\u20101 cells"],"prefix":"10.1002","volume":"26","author":[{"given":"Roger A.","family":"Barthelson","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Francisco 111H, 4150 Clement Street San Francisco California 94121\u20101598"},{"name":"the Veterans Administration Medical Center San Francisco California 94121\u20101598"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank H.","family":"Valone","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco 111H, 4150 Clement Street San Francisco California 94121\u20101598"},{"name":"the Veterans Administration Medical Center San Francisco California 94121\u20101598"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90010-7"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90437-5"},{"key":"e_1_2_2_4_1","first-page":"81","volume":"22","author":"Rola\u2010Pleszczynski M.","year":"1988","journal-title":"Prog. 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