{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:27:21Z","timestamp":1760920041819,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Streptozotocin (45 mg\/kg) was intravenously administered to 7\u2010week\u2010old Wistar rats through their tail veins. After 11 days, the rats were divided into two groups. One group was fed a lipid\u2010free diet (90%, w\/w) plus lard (8%) and safflower oil (2%) for four weeks (Diet 1 group, n=12). The other group was fed in the same way, except that safflower oil was replaced by 90% pure eicosapentaenoic acid (EPA) ethyl ester (Diet 2 group, n=13). Twenty\u2010four\u2010hour urine was collected just before the diets started and during the experiment at 7\u2010day intervals. In the second and third week, the levels of proteinuria were significantly lower in the Diet 2 group than they were in the Diet 1 group. There was no significant difference in the levels of creatinine, urea nitrogen, or lipids in plasma or in body weights between the two groups after four weeks on the diets. Because Diet 2 reduced proteinuria of diabetic rats compared to Diet 1, an EPA\u2010rich diet may retard the development of diabetic nephropathy.<\/jats:p>","DOI":"10.1007\/bf02544581","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T18:49:13Z","timestamp":1167936553000},"page":"765-768","source":"Crossref","is-referenced-by-count":3,"title":["Effect of eicosapentaenoic acid ethyl ester on proteinuria of streptozotocin\u2010induced diabetes mellitus in rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Mariko","family":"Fujikawa","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Sawazaki","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Taki","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Kaneda","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesaharu","family":"Urakaze","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohito","family":"Hamazaki","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Yano","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama\u2010shi, Toyama 930\u201001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Fujita","sequence":"additional","affiliation":[{"name":"Central Research Laboratory Nippon Suisan Kaisha Kitano\u2010cho Hachioji\u2010shi Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,9]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91505-2"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3303333"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(87)90108-X"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(86)90127-9"},{"key":"e_1_2_2_6_1","first-page":"S351","volume":"43","author":"Schimke E.","year":"1984","journal-title":"Biomed. 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