{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:03:39Z","timestamp":1786118619151,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,7]]},"DOI":"10.1007\/bf02553724","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T15:35:21Z","timestamp":1170862521000},"page":"518-522","source":"Crossref","is-referenced-by-count":49,"title":["Multiple adenocarcinomas of the colon and rectum"],"prefix":"10.1097","volume":"31","author":[{"given":"Mark B.","family":"Evers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Mullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter L.","family":"Broghamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiram C.","family":"Polk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02553724_CR1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/1097-0142(19860201)57:3<445::AID-CNCR2820570307>3.0.CO;2-D","volume":"57","author":"DZ Chu","year":"1986","unstructured":"Chu DZ, Giacco G, Martin RG, Guinee VF. The significance of synchronous carcinoma and polyps in the colon and rectum. Cancer 1986;57:445\u201350.","journal-title":"Cancer"},{"key":"BF02553724_CR2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0016-5085(58)80139-0","volume":"34","author":"CG Moertel","year":"1958","unstructured":"Moertel CG, Gargen JA, Dockerty MB. Multiple carcinomas of the large intestine: a review of the literature and a study of 261 cases. Gastroenterology 1958;34:85\u201398.","journal-title":"Gastroenterology"},{"key":"BF02553724_CR3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0002-9610(84)90161-2","volume":"147","author":"JM Langevin","year":"1984","unstructured":"Langevin JM, Nivatvongs S. The true incidence of synchronous cancer of the large bowel: a prospective study. Am J Surg 1984;147:330\u20133.","journal-title":"Am J Surg"},{"key":"BF02553724_CR4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/00000658-198204000-00020","volume":"195","author":"TK Lee","year":"1982","unstructured":"Lee TK, Barringer M, Myers RT, Sterchi JM. Multiple primary carcinomas of the colon and associated extracolonic primary malignant tumors. Ann Surg 1982;195:501\u20137.","journal-title":"Ann Surg"},{"key":"BF02553724_CR5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/bjs.1800711210","volume":"71","author":"WJ Cunliffe","year":"1984","unstructured":"Cunliffe WJ, Hasleton PS, Tweedle DE, Schofield PF. Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg 1984;71:941\u20133.","journal-title":"Br J Surg"},{"key":"BF02553724_CR6","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/1097-0142(197406)33:6<1630::AID-CNCR2820330624>3.0.CO;2-0","volume":"33","author":"GR Ekelund","year":"1974","unstructured":"Ekelund GR, Pihl B. Multiple carcinomas of the colon and rectum. Cancer 1974;33:1630\u20134.","journal-title":"Cancer"},{"key":"BF02553724_CR7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00000658-197801000-00002","volume":"187","author":"WE Enker","year":"1978","unstructured":"Enker WE, Dragacevic S. Multiple carcinomas of the large bowel: a natural experiment in etiology and pathogenesis. Ann Surg 1978;187:8\u201311.","journal-title":"Ann Surg"},{"key":"BF02553724_CR8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9610(65)80106-4","volume":"109","author":"HC Polk Jr","year":"1965","unstructured":"Polk HC Jr, Spratt JS, Butcher HR Jr. Frequency of multiple primary malignant neoplasms associated with colorectal carcinoma. Am J Surg 1965;109:71\u20135.","journal-title":"Am J Surg"},{"key":"BF02553724_CR9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/BF02564161","volume":"25","author":"JC Reilly","year":"1982","unstructured":"Reilly JC, Rusin LC, Theuerkauf FJ Jr. Colonoscopy: its role in cancer of the colon and rectum. Dis Colon Rectum 1982;25:532\u20138.","journal-title":"Dis Colon Rectum"},{"key":"BF02553724_CR10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0002-9610(86)90150-9","volume":"152","author":"CA Weber","year":"1986","unstructured":"Weber CA, Deveney KE, Pellegrini CA, Way LW. Routine colonoscopy in the management of colorectal carcinoma. Am J Surg 1986;152:87\u201392.","journal-title":"Am J Surg"},{"key":"BF02553724_CR11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02555051","volume":"29","author":"PJ Kiefer","year":"1986","unstructured":"Kiefer PJ, Thorson AG, Christensen MA. Metachronous colorectal cancer: time interval to presentation of a metachronous cancer. Dis Colon Rectum 1986;29:378\u201382.","journal-title":"Dis Colon Rectum"},{"key":"BF02553724_CR12","first-page":"367","volume":"110","author":"RV Hutter","year":"1986","unstructured":"Hutter RV, Sobin LH. A universal staging system for cancer of the colon and rectum: let there be light. Arch Pathol Lab Med 1986;110:367\u20138.","journal-title":"Arch Pathol Lab Med"},{"key":"BF02553724_CR13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1001\/archsurg.1986.01400050045006","volume":"121","author":"GM Larson","year":"1986","unstructured":"Larson GM, Bond SJ, Shallcross C, Mullins R, Polk HC Jr. Colonoscopy after curative resection of colorectal cancer. Arch Surg 1986;121:535\u201340.","journal-title":"Arch Surg"},{"key":"BF02553724_CR14","first-page":"1358","volume":"16","author":"S Warren","year":"1932","unstructured":"Warren S, Gates O. Multiple primary malignant tumors: a survey of the literature and a statistical study. Am J Cancer 1932;16: 1358\u2013414.","journal-title":"Am J Cancer"},{"key":"BF02553724_CR15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02587230","volume":"18","author":"RJ Heald","year":"1975","unstructured":"Heald RJ, Bussey HJ. Clinical experiences at St. Mark's Hospital with multiple synchronous cancers of the colon and rectum. Dis Colon Rectum 1975;18:6\u201310.","journal-title":"Dis Colon Rectum"},{"key":"BF02553724_CR16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/1097-0142(19840115)53:2<356::AID-CNCR2820530231>3.0.CO;2-G","volume":"53","author":"TJ Pagana","year":"1984","unstructured":"Pagana TJ, Ledesma EJ, Mittelman A, Nava HR. The use of colonoscopy in the study of synchronous colorectal neoplasms. Cancer 1984;53:356\u20139.","journal-title":"Cancer"},{"key":"BF02553724_CR17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0002-9610(84)90008-4","volume":"147","author":"RG Maxfield","year":"1984","unstructured":"Maxfield RG. Colonoscopy as a routine preoperative procedure for carcinoma of the colon. Am J Surg 1984;147:477\u201380.","journal-title":"Am J Surg"},{"key":"BF02553724_CR18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1001\/jama.1955.02960200009003","volume":"159","author":"RC Lillehei","year":"1955","unstructured":"Lillehei RC, Wangensteen OH. Bowel function after colectomy for cancer, polyps, and diverticulitis. JAMA 1955;159:163\u201370.","journal-title":"JAMA"},{"key":"BF02553724_CR19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1001\/archsurg.1969.01340080033004","volume":"98","author":"EM Copeland","year":"1969","unstructured":"Copeland EM, Jones RS, Miller LD. Multiple colon neoplasms. Arch Surg 1969;98:141\u20133.","journal-title":"Arch Surg"},{"key":"BF02553724_CR20","first-page":"451","volume":"67","author":"B Morson","year":"1974","unstructured":"Morson B. The polyp-cancer sequence in the large bowel. Proc R Soc Med 1974;67:451\u20137.","journal-title":"Proc R Soc Med"},{"key":"BF02553724_CR21","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/1097-0142(197210)30:4<972::AID-CNCR2820300418>3.0.CO;2-A","volume":"30","author":"M Kalus","year":"1972","unstructured":"Kalus M. Carcinoma and adenomatous polyps of the colon and rectum in biopsy and organ tissue culture. Cancer 1972;30:972\u201382.","journal-title":"Cancer"},{"key":"BF02553724_CR22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0002-9610(81)90292-0","volume":"142","author":"JP Welch","year":"1981","unstructured":"Welch JP. Multiple colorectal tumors: an appraisal of natural history and therapeutic options. Am J Surg 1981;142:274\u201380.","journal-title":"Am J Surg"},{"key":"BF02553724_CR23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0002-9610(52)90159-1","volume":"83","author":"HE Bacon","year":"1952","unstructured":"Bacon HE, Tavenner MC. Multiple primary malignant tumors involving the colon and rectum: report of ninety-four cases. Am J Surg 1952;83:55\u201363.","journal-title":"Am J Surg"},{"key":"BF02553724_CR24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/BF02586685","volume":"20","author":"PM Lynch","year":"1977","unstructured":"Lynch PM, Lynch HT, Harris RE. Hereditary proximal colon cancer. Dis Colon Rectum 1977;20:661\u20138.","journal-title":"Dis Colon Rectum"}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1007\/BF02553724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:17:54Z","timestamp":1786033074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-198831070-00004"}},"subtitle":["An analysis of incidences and current trends"],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1988]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02553724","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}