{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:09:31Z","timestamp":1760645371539},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[1991,6]]},"DOI":"10.1007\/bf02556457","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T16:42:07Z","timestamp":1170866527000},"page":"429-437","source":"Crossref","is-referenced-by-count":16,"title":["Immunohistochemical localization of a \u223c66 kD glycosylated phosphoprotein during development of the embryonic chick tibia"],"prefix":"10.1007","volume":"48","author":[{"given":"Scott P.","family":"Bruder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold I.","family":"Caplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yozoh","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis C.","family":"Gerstenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin J.","family":"Glimcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02556457_CR1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1103\/RevModPhys.31.359","volume":"31","author":"MJ Glimcher","year":"1959","unstructured":"Glimcher MJ (1959) Molecular biology of mineralized tissues with particular reference to bone. Rev Mod Physics 31:359\u2013393","journal-title":"Rev Mod Physics"},{"key":"BF02556457_CR2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00003086-196811000-00004","volume":"61","author":"MJ Glimcher","year":"1968","unstructured":"Glimcher MJ (1968) A basic architectural principle in the organization of mineralized tissues. Clin Orthop 61:16\u201336","journal-title":"Clin Orthop"},{"key":"BF02556457_CR3","first-page":"577","volume-title":"The chemistry and biology of mineralized tissues","author":"DD Lee","year":"1989","unstructured":"Lee DD, Glimcher MJ (1989) The three-dimensional spatial relationship between the collagen fibrils and the inorganic Ca\u2212P crystals of Pickerel and Herring fish bone. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, pp 577\u2013587"},{"key":"BF02556457_CR4","first-page":"25","volume-title":"Handbook of physiology 7: endocrinology","author":"MJ Glimcher","year":"1976","unstructured":"Glimcher MJ (1976) Composition, structure, and organization of bone and other mineralized tissues and the mechanism of calcification. In: Greep RO, Astowood EB (eds) Handbook of physiology 7: endocrinology, vol. VII. American Physiological Society, Washington, DC, pp 25\u2013116"},{"key":"BF02556457_CR5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1098\/rstb.1984.0041","volume":"304","author":"MJ Glimcher","year":"1984","unstructured":"Glimcher MJ (1984) Recent studies of the mineral phase in bone and its possible linkage to the organic matrix by protein-bound phosphate bonds. Phil Trans Royal Soc B 304:479\u2013508","journal-title":"Phil Trans Royal Soc B"},{"key":"BF02556457_CR6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ar.1092240205","volume":"224","author":"MJ Glimcher","year":"1989","unstructured":"Glimcher MJ (1989) Mechanism of calcification in bone: role of collagen fibrils and collagen-phosphoprotein complexes in vitro and in vivo. Anat Record 224:139\u2013153","journal-title":"Anat Record"},{"key":"BF02556457_CR7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1073\/pnas.43.10.860","volume":"43","author":"MJ Glimcher","year":"1957","unstructured":"Glimcher MJ, Hodge AJ, Schmitt FO (1957) Macromolecular aggregation states in relation to mineralization: the collagen-hydroxyapatite system as studied in vitro. Proc Natl Acad Sci USA 43:860\u2013867","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02556457_CR8","first-page":"68","volume-title":"Treatise on collagen vol 7B","author":"MJ Glimcher","year":"1968","unstructured":"Glimcher MJ, Krane SJ (1968) The organization and structure of bone, and the mechanism of calcification. In: Ramachandran GN, Gould BS (eds) Treatise on collagen vol 7B. Academic Press, New York, pp 68\u2013251"},{"key":"BF02556457_CR9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-94-009-7944-4_25","volume-title":"Biomineralization and biological metal accumulation","author":"A Veis","year":"1983","unstructured":"Veis A, Sabsay B (1983) Bone and tooth formation: insights into mineralization strategies. In: Westbrake P, deJong EW (eds) Biomineralization and biological metal accumulation. Redel Publishing Co, Dordrecht, Holland, pp 273\u2013284"},{"key":"BF02556457_CR10","first-page":"259","volume-title":"Ions in macromolecular and biological systems","author":"A Veis","year":"1978","unstructured":"Veis A (1978) The role of acidic proteins in biological mineralization. In: Everett DH, Vincent B (eds) Ions in macromolecular and biological systems. Scientechnica, Bristol, England, pp 259\u2013270"},{"key":"BF02556457_CR11","first-page":"509","volume-title":"The chemistry and biology of mineralized tissues","author":"A Endo","year":"1989","unstructured":"Endo A, Glimcher MJ (1989) The effect of complexing phosphoproteins to decalcified collagen on in vitro calcification. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, pp 509\u2013520"},{"key":"BF02556457_CR12","doi-asserted-by":"crossref","unstructured":"Glimcher MJ (1979) Phosphopeptide of enamel matrix. In: Nylen MU, Termine JD (eds) Tooth enamel. III. J Dent Res 58B:790\u2013806","DOI":"10.1177\/00220345790580023101"},{"key":"BF02556457_CR13","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1021\/bi00371a047","volume":"25","author":"A Uchiyama","year":"1986","unstructured":"Uchiyama A, Suzuki M, Lefteriou B, Glimcher MJ (1986) Isolation and chemical characterization of the phosphoproteins of chicken bone matrix: heterogeneity in molecular weight and composition. Biochemistry 25:7572\u20137583","journal-title":"Biochemistry"},{"key":"BF02556457_CR14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF02555166","volume":"43","author":"K Yamazaki","year":"1988","unstructured":"Yamazaki K, Suzuki M, Mikuni-Takagaki Y, Hiraiwa K, Lefteriou B, Glimcher MJ (1988) Preparation of monoclonal antibodies to chicken bone phosphoproteins. Calcif Tissue Int 43:41\u201343","journal-title":"Calcif Tissue Int"},{"key":"BF02556457_CR15","doi-asserted-by":"crossref","first-page":"8819","DOI":"10.1073\/pnas.83.23.8819","volume":"83","author":"A Oldberg","year":"1986","unstructured":"Oldberg A, Franzen A, Heinegard D (1986) Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc Natl Acad Sci USA 83:8819\u20138823","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02556457_CR16","doi-asserted-by":"crossref","first-page":"19430","DOI":"10.1016\/S0021-9258(19)77651-0","volume":"263","author":"A Oldberg","year":"1988","unstructured":"Oldberg A, Franzen A, Heinegard D (1988) Primary structure of a cell-binding bone sialoprotein. J Biol Chem 263:19430\u201319432","journal-title":"J Biol Chem"},{"key":"BF02556457_CR17","doi-asserted-by":"crossref","first-page":"19433","DOI":"10.1016\/S0021-9258(19)77652-2","volume":"263","author":"A Oldberg","year":"1988","unstructured":"Oldberg A, Franzen A, Heinegard D, Pierschbacher M, Ruoslahti E (1988) Identification of a bone sialoprotein receptor in osteosarcoma cells. J Biol Chem 263:19433\u201319436","journal-title":"J Biol Chem"},{"key":"BF02556457_CR18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bj2320715","volume":"232","author":"A Franzen","year":"1985","unstructured":"Franzen A, Heinegard D (1985) Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem J 232:715\u2013724","journal-title":"Biochem J"},{"key":"BF02556457_CR19","first-page":"333","volume-title":"The chemistry and biology of mineralized tissues","author":"D Heinegard","year":"1989","unstructured":"Heinegard D, Hultenby K, Oldberg A, Reihnolt F, Wendel M (1989) Macromolecules in bone matrix. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, pp 333\u2013341"},{"key":"BF02556457_CR20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","volume":"88","author":"V Hamburger","year":"1951","unstructured":"Hamburger V, Hamilton H (1951) A series of normal stages in the development of the chick embryo. J Morphol 88:49\u201392","journal-title":"J Morphol"},{"key":"BF02556457_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0022-1759(82)90035-7","volume":"55","author":"G Johnson","year":"1982","unstructured":"Johnson G, Davidson R, McNamee K, Russell G, Goodwin D, Holborrow E (1982) Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy. J Immunol Methods 55:231\u2013242","journal-title":"J Immunol Methods"},{"key":"BF02556457_CR22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1432-1033.1990.tb15276.x","volume":"187","author":"Y Gotoh","year":"1990","unstructured":"Gotoh Y, Gerstenfeld LC, Glimcher MJ (1990) Identification and characterization of the major chicken bone phosphoprotein: analysis of its synthesis by cultured embryonic chick osteoblasts. Eur J Biochem 187:49\u201358","journal-title":"Eur J Biochem"},{"key":"BF02556457_CR23","first-page":"516","volume-title":"Methods of enzymology","author":"CM Gundberg","year":"1984","unstructured":"Gundberg CM, Hauschka PV, Lian JB, Gallop PM (1984) Osteocalcin: isolation, characterization, and detection. In: Moldave K (ed) Methods of enzymology. Academic Press, New York, Vol 107: pp 516\u2013544"},{"key":"BF02556457_CR24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0022-1759(84)90001-2","volume":"72","author":"H Towbin","year":"1984","unstructured":"Towbin H, Gordon J (1984) Immunoblotting and dot immunobinding: current status and outlook. J Immunol Methods 72:313\u2013340","journal-title":"J Immunol Methods"},{"key":"BF02556457_CR25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/jmor.1050400302","volume":"40","author":"H Fell","year":"1925","unstructured":"Fell H (1925) The histogenesis of cartilage and bone in the long bones of the embryonic fowl. J Morphol Physiol 40:417\u2013459","journal-title":"J Morphol Physiol"},{"key":"BF02556457_CR26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jmor.1051620310","volume":"162","author":"P Scott-Savage","year":"1980","unstructured":"Scott-Savage P, Hall B (1980) The timing of the onset of osteogenesis in the tibia of the embryonic chick. J Morphol 162:453\u2013464","journal-title":"J Morphol"},{"key":"BF02556457_CR27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0012-1606(81)90325-0","volume":"86","author":"P Osdoby","year":"1981","unstructured":"Osdoby P, Caplan A (1981) First bone formation in the developing chick limb. Dev Biol 86:147\u2013156","journal-title":"Dev Biol"},{"key":"BF02556457_CR28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/8756-3282(86)90004-9","volume":"7","author":"D Pechak","year":"1986","unstructured":"Pechak D, Kujawa M, Caplan A (1986) Morphological and histochemical events during first bone formation in embryonic chick limbs. Bone 7:441\u2013458","journal-title":"Bone"},{"key":"BF02556457_CR29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/8756-3282(89)90133-6","volume":"10","author":"SP Bruder","year":"1989","unstructured":"Bruder SP, Caplan AI (1989) First bone formation and the dissection of an osteogenic lineage in the embryonic chick tibia is revealed by monoclonal antibodies against osteogenic cells. Bone 10:359\u2013375","journal-title":"Bone"},{"key":"BF02556457_CR30","first-page":"65","volume-title":"The chemistry and biology of mineralized tissues","author":"SP Bruder","year":"1989","unstructured":"Bruder SP, Caplan AI (1989) Cellular and molecular events during embryonic bone development. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, pp 65\u201371"},{"key":"BF02556457_CR31","first-page":"73","volume-title":"The chemistry and biology of mineralized tissues","author":"SP Bruder","year":"1989","unstructured":"Bruder SP, Caplan AI (1989) Discrete stages within the osteogenic lineage are revealed by alterations in the cell surface architecture of embryonic bone cells. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, pp 73\u201379"},{"key":"BF02556457_CR32","first-page":"5770","volume":"48","author":"DR Senger","year":"1988","unstructured":"Senger DR, Perruzzi CA, Gracey CF, Papadopoulos A, Tenen DG (1988) Secreted phosphoprotein associated with neoplastic transformation: close homology with plasma proteins cleaved during blood coagulation. Cancer Res 48:5770\u20135774","journal-title":"Cancer Res"},{"key":"BF02556457_CR33","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/0006-291X(89)90837-1","volume":"162","author":"T Kubota","year":"1988","unstructured":"Kubota T, Zhang Q, Wrana JL, Ber R, Aubin JE, Butler WT, Sodek J (1988) Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: regulation by TGF-\u03b2. Biochem Biophys Res Commun 162:1453\u20131459","journal-title":"Biochem Biophys Res Commun"},{"key":"BF02556457_CR34","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0005-2795(73)90367-X","volume":"303","author":"AR Spector","year":"1973","unstructured":"Spector AR, Glimcher MJ (1973) The identification of O-phosphoserine in the soluble anionic phosphoproteins of bone. Biochim Biophys Acta 303:360\u2013362","journal-title":"Biochim Biophys Acta"},{"key":"BF02556457_CR35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02409461","volume":"33","author":"SL Lee","year":"1981","unstructured":"Lee SL, Glimcher MJ (1981) The purification, composition, and31P spectroscopic properties of a non-collagenous phosphoprotein isolated from chicken bone matrix. Calcif Tissue Int 33:385\u2013394","journal-title":"Calcif Tissue Int"},{"key":"BF02556457_CR36","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1083\/jcb.98.3.986","volume":"98","author":"WJ Landis","year":"1984","unstructured":"Landis WJ, Sanzone, CF, Brickley-Parsons D, Glimcher MJ (1984) Radioautographic visualization and biochemical identification of O-phosphoserine and O-phosphothreonine-containing phosphoproteins in mineralizing embryonic chick bone. J Cell Biol 98:986\u2013990","journal-title":"J Cell Biol"},{"key":"BF02556457_CR37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00215443","volume":"251","author":"MP Mark","year":"1988","unstructured":"Mark MP, Prince CW, Gay S, Austin RL, Butler WT (1988) 44 kDal phosphoprotein (osteopontin) antigenicity at ectopic sites in newborn rats: kidney and nervous tissue. Cell Tissue Res 251:23\u201330","journal-title":"Cell Tissue Res"},{"key":"BF02556457_CR38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.106.2.441","volume":"106","author":"S Nomura","year":"1988","unstructured":"Nomura S, Willis AJ, Edwards DR, Heath JK, Hogan BLM (1988) Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol 106:441\u2013450","journal-title":"J Cell Biol"},{"issue":"4","key":"BF02556457_CR39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jbmr.5650020411","volume":"2","author":"MP Mark","year":"1987","unstructured":"Mark MP, Prince CW, Gay S, Austin RL, Bhown M, Finkelman RD, Butler WT (1987) A comparative immunocytochemical study on the subcellular distributions of 44 kDa bone phosphoprotein and bone \u03b3-carboxyglutamic acid (Gla)-containing protein in osteoblasts. J Bone Mine Res 2(4):337\u2013346","journal-title":"J Bone Mine Res"},{"issue":"7","key":"BF02556457_CR40","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1177\/35.7.3295029","volume":"35","author":"MP Mark","year":"1987","unstructured":"Mark MP, Prince CW, Oosawa T, Gay S, Bronckers AL, Butler WT (1987) Immunohistochemical demonstration of a 44 kDa phosphoprotein in developing rat bones. J Histochem Cytochem 35(7):707\u2013715","journal-title":"J Histochem Cytochem"},{"key":"BF02556457_CR41","first-page":"912","volume-title":"The chemistry and biology of mineralized tissues","author":"FF Reinholt","year":"1989","unstructured":"Reinholt FF, Hultenby K, Oldberg A, Heinegard D (1989) Bone and kidney localization of osteopontin. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, p 912"},{"key":"BF02556457_CR42","first-page":"351","volume-title":"The chemistry and biology of mineralized tissues","author":"MD McKee","year":"1989","unstructured":"McKee MD, Glimcher MJ, Landis WJ, Gerstenfeld LC, Gotoh Y, Nanci A (1989) Ultrastructural localization of a major phosphoprotein in embryonic chick bone. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, pp 351\u2013357"},{"key":"BF02556457_CR43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1432-0436.1988.tb00804.x","volume":"37","author":"MP Mark","year":"1988","unstructured":"Mark MP, Butler WT, Prince CW, Finkelman RD Ruch J-V (1988) Developmental expression of 44-kDa bone phosphoprotein (osteopontin) and bone \u03b3-carboxyglutamic acid (Gla)-containing protein (osteocalcin) in calcifying tissues of rat. Differentiation 37:123\u2013136","journal-title":"Differentiation"},{"key":"BF02556457_CR44","first-page":"838","volume":"56","author":"M Weinstock","year":"1973","unstructured":"Weinstock M, Leblond CP (1973) Radioautographic visualization of the deposition of a phosphoprotein at the mineralization front in the dentin of the rat incisor. J Biol Chem 56:838\u2013845","journal-title":"J Biol Chem"},{"key":"BF02556457_CR45","first-page":"S82","volume":"34","author":"JB Lian","year":"1982","unstructured":"Lian JB, Roufosse AH, Reit B, Glimcher MJ (1982) Concentrations of osteocalcin and phosphoprotein as a function of mineral content and age in cortical bone. Calcif Tissue Int 34:S82-S87","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"BF02556457_CR46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/36.2.3335773","volume":"36","author":"M Rahima","year":"1988","unstructured":"Rahima M, Tsay T-G, Andujar M, Veis A (1988) Localization of phosphoryn in rat incisor dentin using immunocytochemical techniques. J Histochem Cytochem 36(2):153\u2013157","journal-title":"J Histochem Cytochem"},{"key":"BF02556457_CR47","first-page":"545","volume-title":"The chemistry and biology of mineralized tissues","author":"LC Gerstenfeld","year":"1989","unstructured":"Gerstenfeld LC, Lian JB, Gotoh Y, Lee DD, Landis WJ, McKee MD, Nanci A, Glimcher MJ (1989) Use of cultured embryonic chicken osteoblasts as a model of cellular differentiation and bone mineralization. In: Glimcher MJ, Lian JB (eds) The chemistry and biology of mineralized tissues. Gordon and Breach, New York, pp 545\u2013553"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02556457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02556457\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02556457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T13:35:56Z","timestamp":1628429756000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02556457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["BF02556457"],"URL":"https:\/\/doi.org\/10.1007\/bf02556457","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}