{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:06:00Z","timestamp":1776229560096,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[1993,9]]},"DOI":"10.1007\/bf02584334","type":"journal-article","created":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T04:38:46Z","timestamp":1174624726000},"page":"517-530","source":"Crossref","is-referenced-by-count":22,"title":["Optimal ventilatory patterns in periodic breathing"],"prefix":"10.1007","volume":"21","author":[{"given":"Shahin D.","family":"Ghazanshahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C. K.","family":"Khoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02584334_CR1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/jphysiol.1983.sp014906","volume":"343","author":"A. Berssenbrugge","year":"1983","unstructured":"Berssenbrugge, A.; Dempsey, J.; Iber, C.; Skatrud, J.; Wilson, P. Mechanisms of hypoxia-induced periodic breathing during sleep in humans. J. Physiol. 343:507\u2013524; 1983.","journal-title":"J. Physiol."},{"key":"BF02584334_CR2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/jappl.1980.48.3.545","volume":"48","author":"P.J. Brusil","year":"1980","unstructured":"Brusil, P.J.; Waggener, T.B.; Kronauer, R.E.; Gulesian, P. Methods for identifying respiratory oscillations disclose altitude effects. J. Appl. Physiol. 48:545\u2013556; 1980.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1098\/rspb.1954.0051","volume":"143","author":"J.E. Cotes","year":"1954","unstructured":"Cotes, J.E. Ventilatory capacity at altitude and its relation to mask design. Proc. R. Soc. Lond. [Biol.] 143:32\u201339; 1954.","journal-title":"Proc. R. Soc. Lond. [Biol.]"},{"key":"BF02584334_CR4","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1152\/jappl.1989.67.6.2556","volume":"67","author":"E. D'Angelo","year":"1989","unstructured":"D'Angelo, E.; Calderini, E.; Torri, G.; Robatto, F.M.; Bono, D.; Milic-Emili, J. Respiratory mechanics in anesthetized paralyzed humans: Effects of flow, volume, and time. J. Appl. Physiol. 67:2556\u20132564; 1989.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR5","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1152\/jappl.1967.22.2.260","volume":"22","author":"F.S. Grodins","year":"1967","unstructured":"Grodins, F.S.; Buell, J.; Bart, A.J. Mathematical analysis and digital simulation of the respiratory control system. J. Appl. Physiol. 22:260\u2013267; 1967.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR6","first-page":"1419","volume-title":"The lung: Scientific foundations","author":"M.C.K. Khoo","year":"1991","unstructured":"Khoo, M.C.K. Periodic breathing. In: Crystal, R.G.; West, J.B.; Barnes, P.J.; Cherniack, N.S.; Weibel, E.R. (eds.) The lung: Scientific foundations. New York: Plenum Press; 1991: pp. 1419\u20131431."},{"key":"BF02584334_CR7","volume-title":"The noninvasive estimation of cardiopulmonary parameters","author":"M.C.K. Khoo","year":"1981","unstructured":"Khoo, M.C.K. The noninvasive estimation of cardiopulmonary parameters. Boston, MA: Harvard University; 1981. Ph.D. Dissertation."},{"key":"BF02584334_CR8","first-page":"68","volume":"21","author":"R.E. Kronauer","year":"1978","unstructured":"Kronauer, R.E.; Brusil, P.J. Periodic breathing can reduce required muscular effort. Physiologist 21:68; 1978. Abstract.","journal-title":"Physiologist"},{"key":"BF02584334_CR9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0034-5687(83)90086-5","volume":"52","author":"S. Lahiri","year":"1983","unstructured":"Lahiri, S.; Maret, K.; Sherpa, M.G. Dependence of high altitude sleep apnea on ventilatory sensitivity to hypoxia. Respir. Physiol. 52:281\u2013301; 1983.","journal-title":"Respir. Physiol."},{"key":"BF02584334_CR10","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/jappl.1966.21.4.1281","volume":"21","author":"R.L. Lange","year":"1966","unstructured":"Lange, R.L.; Horgan, J.D.; Botticelli, J.T.; Tsagaris, T.; Carlisle, R.F.; Kuida, H. Pulmonary to arterial circulatory transfer function: Importance in respiratory control. J. Appl. Physiol. 21:1281\u20131291; 1966.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1172\/JCI104336","volume":"40","author":"M. McGregor","year":"1961","unstructured":"McGregor, M.; Becklake, M. The relationship of oxygen cost of breathing to respiratory mechanical work and respiratory force. J. Clin. Invest. 40:971\u2013980; 1961.","journal-title":"J. Clin. Invest."},{"key":"BF02584334_CR12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/jappl.1960.15.3.325","volume":"15","author":"J. Mead","year":"1960","unstructured":"Mead, J. Control of respiratory frequency. J. Appl. Physiol. 15:325\u2013336; 1960.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR13","first-page":"1065","volume-title":"The lung: Scientific foundations","author":"J. Milic-Emili","year":"1991","unstructured":"Milic-Emili, J. Work of breathing. In Crystal, R.G.; West, J.B. (eds.) The lung: Scientific foundations. New York: Raven Press, 1991: pp. 1065\u20131075."},{"key":"BF02584334_CR14","volume-title":"Blood gases: Hemoglobin, base excess and maldistribution","author":"A.J. Olszowka","year":"1973","unstructured":"Olszowka, A.J.; Rahn, H.; Farhi, L.E. Blood gases: Hemoglobin, base excess and maldistribution. Philadelphia: Lea and Febiger; 1973."},{"key":"BF02584334_CR15","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1152\/jappl.1950.2.11.592","volume":"2","author":"A.B. Otis","year":"1950","unstructured":"Otis, A.B.; Fenn, W.O.; Rahn, H. Mechanics of breathing in man. J. Appl. Physiol. 2:592\u2013607; 1950.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR16","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1152\/jappl.1987.62.6.2447","volume":"62","author":"C.-S. Poon","year":"1987","unstructured":"Poon, C.-S. Ventilatory control in hypercapnia and exercise: Optimization hypothesis. J. Appl. Physiol. 62:2447\u20132459; 1987.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0013-4694(72)90106-X","volume":"32","author":"M. Reite","year":"1972","unstructured":"Reite, M.; Jackson, D.; Cahoon, R.L.; Weil, J.V. Sleep physiology at high altitude. Electroenceph. Clin. Neurophysiol. 32:701\u2013705; 1972.","journal-title":"Clin. Neurophysiol."},{"key":"BF02584334_CR18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1152\/jappl.1986.61.1.280","volume":"61","author":"J.B. West","year":"1986","unstructured":"West, J.B.; Peters, Jr., R.M.; Aksnes, G.; Maret, K.L.; Milledge, J.S.; Schoene, R.B. Nocturnal periodic breathing at altitudes of 6,300 and 8,050 m. J. Appl. Physiol. 61:280\u2013287; 1986.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1152\/jappl.1987.63.1.401","volume":"63","author":"D.P. White","year":"1987","unstructured":"White, D.P.; Gleeson, K.; Pickett, C.K.; Rannels, A.M.; Cymerman, A.; Weil, J.V. Altitude acclimatization: Influence on periodic breathing and chemoresponsiveness during sleep. J. Appl. Physiol. 63:401\u2013412; 1987.","journal-title":"J. Appl. Physiol."},{"key":"BF02584334_CR20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1152\/jappl.1971.30.5.597","volume":"30","author":"S.M. Yamashiro","year":"1972","unstructured":"Yamashiro, S.M.; Grodins, F.S. Optimal regulation of respiratory airflow. J. Appl. Physiol. 30:597\u2013602; 1972.","journal-title":"J. Appl. Physiol."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02584334.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02584334\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02584334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T17:02:28Z","timestamp":1558198948000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02584334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["BF02584334"],"URL":"https:\/\/doi.org\/10.1007\/bf02584334","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}