{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:26:57Z","timestamp":1792078017535,"version":"4.4.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Gen Intern Med"],"published-print":{"date-parts":[[1996,12]]},"DOI":"10.1007\/bf02598988","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T09:26:38Z","timestamp":1175592398000},"page":"744-749","source":"Crossref","is-referenced-by-count":165,"title":["Does treatment withl-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism?"],"prefix":"10.1007","volume":"11","author":[{"given":"Roman","family":"Jaeschke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Guyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hertzel","family":"Gerstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Carbotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02598988_CR1","first-page":"327","volume":"109","author":"RD Utiger","year":"1987","unstructured":"Utiger RD. Thyrotropin releasing hormone and thyrotropin secretion. J Lab Clin Med. 1987;109:327\u201335.","journal-title":"J Lab Clin Med"},{"key":"BF02598988_CR2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM198201073060107","volume":"306","author":"PR Larsen","year":"1982","unstructured":"Larsen PR. Thyroid-pituitary interaction. Thyroid regulation of thyrotropin secretion by thyroid hormones. N Engl J Med. 1982;306:23\u201332.","journal-title":"N Engl J Med"},{"key":"BF02598988_CR3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/bmj.1.5795.290","volume":"1","author":"DC Evered","year":"1973","unstructured":"Evered DC, Ormston BJ, Smith PA, Hall R, Bird T. Grades of hypothyroidism. BMJ. 1973;1:290\u20133.","journal-title":"BMJ"},{"key":"BF02598988_CR4","doi-asserted-by":"crossref","unstructured":"Cooper DS, Utiger RD, Larsen PR, Ross DS. Subclinical hypothyroidism. Lancet. 1986;251\u20132. Editorial.","DOI":"10.1016\/S0140-6736(86)90782-8"},{"key":"BF02598988_CR5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/jama.1987.03400020088037","volume":"258","author":"DS Cooper","year":"1987","unstructured":"Cooper DS. Subclinical hypothyroidism. JAMA. 1987;258:246\u20137. Editorial.","journal-title":"JAMA"},{"key":"BF02598988_CR6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.1977.tb01340.x","volume":"7","author":"WMG Turnbridge","year":"1977","unstructured":"Turnbridge WMG, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Wickhan survey. Clin Endocrinol (Oxf). 1977;7:481\u201393.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BF02598988_CR7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/jama.1987.03400020051029","volume":"258","author":"MJ Rosenthal","year":"1987","unstructured":"Rosenthal MJ, Hunt WC, Garry PJ, et al. Thyroid function in the elderly: microsomal antibodies as discriminant for therapy. JAMA. 1987;258:209\u201313.","journal-title":"JAMA"},{"key":"BF02598988_CR8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF03346934","volume":"9","author":"A Pacchiarotti","year":"1986","unstructured":"Pacchiarotti A, Martino E, Bartalena L, et al. Serum free thyroid hormones in subclinical hypothyroidism. J Endocrinol Invest. 1986;9:315\u20139.","journal-title":"J Endocrinol Invest"},{"key":"BF02598988_CR9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/acta.0.1140559","volume":"114","author":"C Ferrara","year":"1987","unstructured":"Ferrara C, Paracchi E, Parisio E, et al. Serum free thyroid hormones in different degrees of hypothyroidism and in euthyroid autoimmune thyroiditis. Acta Endocrinol (Copenh). 1987;114:559\u201364.","journal-title":"Acta Endocrinol (Copenh)"},{"key":"BF02598988_CR10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2265.1985.tb01068.x","volume":"22","author":"GM Bell","year":"1985","unstructured":"Bell GM, Todd WTA, Forfar JC, et al. End-organ responses to thyroxine in subclinical hypothyroidism. Clin Endocrinol (Oxf). 1985;22:83\u20139.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BF02598988_CR11","first-page":"857","volume":"57","author":"JC Forfar","year":"1985","unstructured":"Forfar JC, Wathem CG, Todd WT, et al. Left ventricular performance in subclinical hypothyroidism. QJM. 1985;57:857\u201365.","journal-title":"QJM"},{"key":"BF02598988_CR12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7326\/0003-4819-101-1-18","volume":"101","author":"DS Cooper","year":"1984","unstructured":"Cooper DS, Halpem R, Wood LC, Levin AA, Ridgway EC. L-Thyroxine therapy in subclinical hypothyroidism. A double blind, placebo controlled trial. Ann Intern Med. 1984;101:18\u201324.","journal-title":"Ann Intern Med"},{"key":"BF02598988_CR13","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1210\/jcem-53-6-1238","volume":"53","author":"EC Ridgway","year":"1981","unstructured":"Ridgway EC, Cooper DS, Walker H, Rodbard D, Haloof F. Peripheral responses to thyroid hormone before and after L-thyroxine therapy in patients with subclinical hypothyroidism. J Clin Endocrinol Metab. 1981;53:1238\u201342.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF02598988_CR14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2265.1988.tb00250.x","volume":"29","author":"E Nystrom","year":"1988","unstructured":"Nystrom E, Caidahl K, Fager G, Wikkelso C, Lundberg P-A, Lindstedt G. A double-blind cross-over 12-month study ofl-thyroxine treatment of women with \u201csubclinical\u201d hypothyroidism. Clin Endocrinol. 1988;29:63\u201376.","journal-title":"Clin Endocrinol"},{"key":"BF02598988_CR15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2165\/00003495-198631050-00005","volume":"31","author":"AJ Campbell","year":"1986","unstructured":"Campbell AJ. Thyroid disorders in the elderly. Difficulties in diagnosis and treatment. Drugs. 1986;31:455\u201361.","journal-title":"Drugs"},{"key":"BF02598988_CR16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1742-1241.1986.tb07898.x","volume":"40","author":"SK Bansal","year":"1986","unstructured":"Bansal SK, Sahi SP, Basu SK. Old JM. Hypothyroidism in elderly males\u2014an under diagnosis. Br J Clin Pract. 1986;40:17\u20138.","journal-title":"Br J Clin Pract"},{"key":"BF02598988_CR17","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.2.5971.601","volume":"2","author":"M Bahemuka","year":"1975","unstructured":"Bahemuka M, Hodkinson HM. Screening for hypothyroidism in elderly Inpatients. BMJ. 1975;2:601\u20133.","journal-title":"BMJ"},{"key":"BF02598988_CR18","first-page":"86","volume":"42","author":"JV Felicetta","year":"1987","unstructured":"Felicetta JV. Thyroid changes with aging: significance and management. Geriatrics. 1987;42:86\u20138,91\u20132.","journal-title":"Geriatrics"},{"key":"BF02598988_CR19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/0002-9343(87)90219-1","volume":"82","author":"DS Ross","year":"1987","unstructured":"Ross DS, Neer RM, Ridgway EC, Daniels GH. Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine. Am J Med. 1987;82:1167\u201370.","journal-title":"Am J Med"},{"key":"BF02598988_CR20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/archinte.1986.00360130058007","volume":"146","author":"JM Coindre","year":"1986","unstructured":"Coindre JM, David JP, Riviere L, et al. Bone loss in hypothyroidism with hormone replacement. A histomorphometric study. Arch Intern Med. 1986;146:48\u201353.","journal-title":"Arch Intern Med"},{"key":"BF02598988_CR21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0002-9343(93)90230-M","volume":"95","author":"DS Ross","year":"1993","unstructured":"Ross DS. Bone density is not reduced during the short-term administration of levo-thyroxine to postmenopausal women with subclinical hypothyroidism: a randomized, prospective study. Am J Med. 1993;95:38\u201358.","journal-title":"Am J Med"},{"key":"BF02598988_CR22","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1056\/NEJM198703263161302","volume":"316","author":"LH Fish","year":"1987","unstructured":"Fish LH, Schwartz HL, Cavanaugh J, Steffes MW, Bantle JP, Oppenheimer JH. Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans. N Engl J Med. 1987;316:764\u201370.","journal-title":"N Engl J Med"},{"key":"BF02598988_CR23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00451724","volume":"3","author":"R Jaeschke","year":"1994","unstructured":"Jaeschke R, Guyatt G, Cook D, Harper S, Gerstein HC. Spectrum of quality of life impairment in hypothyroidism. Qual Life Res. 1994;3:323\u20137.","journal-title":"Qual Life Res"},{"key":"BF02598988_CR24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0197-2456(89)90005-6","volume":"10","author":"R Jaeschke","year":"1989","unstructured":"Jaeschke R, Stager J, Guyatt G. Measurement of health status: ascertaining the minimal clinically important difference. Control Clin Trials. 1989;10:407\u201315.","journal-title":"Control Clin Trials"},{"key":"BF02598988_CR25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0895-4356(94)90036-1","volume":"47","author":"EF Juniper","year":"1994","unstructured":"Juniper EF, Guyatt GH, Willan A, Griffith LE. Determining a minimal important change in a disease-specific quality of life instrument. J Clin Epidemiol. 1994;47:81\u20137.","journal-title":"J Clin Epidemiol"},{"key":"BF02598988_CR26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00435967","volume":"5","author":"EF Juniper","year":"1996","unstructured":"Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in children with asthma. Qual Life Res. 1996;5:35\u201346.","journal-title":"Qual Life Res"},{"key":"BF02598988_CR27","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/00005650-198108000-00001","volume":"19","author":"M Bergner","year":"1981","unstructured":"Bergner M, Robbitt RA, Carter WB, Gilson BS. The Sickness Impact Profile: development and final revision of health status measure. Med Care. 1981;19:797\u2013805.","journal-title":"Med Care"},{"key":"BF02598988_CR28","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1001\/archinte.1980.00330200070023","volume":"140","author":"PH Rockey","year":"1980","unstructured":"Rockey PH, Griep RJ. Behavioral dysfunction in hyperthyroidism. Improvement with treatment. Arch Intern Med. 1980;140:1194\u20137.","journal-title":"Arch Intern Med"},{"key":"BF02598988_CR29","volume-title":"Neuropsychological Assessment","author":"MD Lezak","year":"1983","unstructured":"Lezak MD. Neuropsychological Assessment. 2nd ed. New York, NY: Oxford University Press; 1983.","edition":"2nd ed."},{"key":"BF02598988_CR30","volume-title":"Compendium of Neuropsychological Tests","author":"O Spreen","year":"1991","unstructured":"Spreen O, Strauss E. Compendium of Neuropsychological Tests. New York, NY: Oxford University Press; 1991."},{"key":"BF02598988_CR31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1532-5415.1988.tb03430.x","volume":"36","author":"DW Molloy","year":"1988","unstructured":"Molloy DW, Beerschoken DA, Borrie MJ, Crilly RG, Cape RDT. Acute effects of exercise on neuropsychological function in elderly subjects. J Am Geriatr Soc. 1988;36:29\u201333.","journal-title":"J Am Geriatr Soc"},{"key":"BF02598988_CR32","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/art.1780370907","volume":"97","author":"SD Denburg","year":"1994","unstructured":"Denburg SD, Carbotte RM, Denburg JA. Corticosteroids and neuropsychological functioning in patients with systemic lupus erythematosus. Arthritis Rheum. 1994;97:1311\u201320.","journal-title":"Arthritis Rheum"},{"key":"BF02598988_CR33","first-page":"87","volume":"40","author":"C Webber","year":"1989","unstructured":"Webber C. Some factors which influence the evaluation of dual photon measurement of lumbar spine bone mineral mass. J Can Assoc Radiol. 1989;40:87\u201391.","journal-title":"J Can Assoc Radiol"},{"key":"BF02598988_CR34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jbmr.5650020309","volume":"2","author":"SY Nottestad","year":"1987","unstructured":"Nottestad SY, Baumel JJ, Kimmel DB, Recker RR, Henney RP. The proportion of trabecular bone in human vertebrae. J Bone Miner Res. 1987;2:221\u20139.","journal-title":"J Bone Miner Res"}],"container-title":["Journal of General Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02598988.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02598988\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02598988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T08:42:01Z","timestamp":1683794521000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02598988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["BF02598988"],"URL":"https:\/\/doi.org\/10.1007\/bf02598988","relation":{},"ISSN":["0884-8734","1525-1497"],"issn-type":[{"value":"0884-8734","type":"print"},{"value":"1525-1497","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}