{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T17:26:53Z","timestamp":1751822813293},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[1981,11,1]],"date-time":"1981-11-01T00:00:00Z","timestamp":373420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Vitro"],"published-print":{"date-parts":[[1981,11]]},"DOI":"10.1007\/bf02618426","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T02:33:47Z","timestamp":1177986827000},"page":"1004-1010","source":"Crossref","is-referenced-by-count":25,"title":["Development of a toxicity test system using primary rat liver cells"],"prefix":"10.1007","volume":"17","author":[{"given":"Jeff","family":"Inmon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Stead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joellen","family":"Lewtas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02618426_CR1","volume-title":"Primary monolayer culture in gene expression and carcinogenesis in cultured liver","author":"D. M. Bissell","year":"1975","unstructured":"Bissell, D. M.; Guzelian, P. S. Microsomal functions and phenotypic change in adult rat hepatocytes. Gerschenson, L. E.; Thompson, E. B. eds. Primary monolayer culture in gene expression and carcinogenesis in cultured liver. New York: Academic Press; 1975."},{"key":"BF02618426_CR2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1083\/jcb.59.3.722","volume":"59","author":"D. M. Bissell","year":"1973","unstructured":"Bissell, D. M.; Hammaker, L.; Meyer, U. A. Parenchymal cells from adult rat liver in nonproliferating monolayer culture. J. Cell Biol. 59: 722\u2013734; 1973.","journal-title":"J. Cell Biol."},{"key":"BF02618426_CR3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF02615346","volume":"10","author":"R. J. Bonney","year":"1974","unstructured":"Bonney, R. J. Adult liver parenchymal cells in primary culture: Characteristics and cell recognition standards. In Vitro 10: 130\u2013142; 1974.","journal-title":"In Vitro"},{"key":"BF02618426_CR4","volume-title":"Gene expression and carcinogenesis in cultured liver","author":"R. J. Bonney","year":"1975","unstructured":"Bonney, R. J.; Maley, F. Some characteristics and functions of adult rat liver parenchymal cells in primary culture. Gerschenson, L. E.; Thompson, E. B. eds. Gene expression and carcinogenesis in cultured liver. New York: Academic Press; 1975."},{"key":"BF02618426_CR5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-4827(74)90196-7","volume":"89","author":"G. M. Williams","year":"1974","unstructured":"Williams, G. M.; Gunn, J. M. Long term cell culture of adult rat liver epithelial cells. Exp. Cell Res. 89: 139\u2013142; 1974.","journal-title":"Exp. Cell Res."},{"key":"BF02618426_CR6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF02796495","volume":"12","author":"B. A. Laishes","year":"1976","unstructured":"Laishes, B. A.; Williams, G. M. Conditions affecting primary cell culture of functional adult rat hepatocytes. I. The effect of insulin. In Vitro 12: 521\u2013532; 1976.","journal-title":"In Vitro"},{"key":"BF02618426_CR7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/BF02615128","volume":"13","author":"G. M. Williams","year":"1977","unstructured":"Williams, G. M.; Bermudez, E.; Scaramuzzino, D. Rat hepatocytes primary cell culture. III. Improved dissociation and attachment techniques and the enhancement of survival by culture medium. In Vitro 13: 809\u2013817; 1977.","journal-title":"In Vitro"},{"key":"BF02618426_CR8","first-page":"182","volume":"13","author":"J. L. Huisingh","year":"1977","unstructured":"Huisingh, J. L.; Inmon, J. P.; King, L. C.; Williams, K.; Waters, M. D. The use of primary rat liver parenchymal cells in evaluating cellular responses to toxic metals and carcinogenic polycyclic aromatic hydrocarbons. In Vitro 13: 182; 1977.","journal-title":"In Vitro"},{"key":"BF02618426_CR9","first-page":"180","volume":"15","author":"J. L. Huisingh","year":"1979","unstructured":"Huisingh, J. L.; Inmon, J.; King, L. C.; Waters, M. D. The development of a toxicity test system using primary liver cells. In Vitro 15: 180; 1979.","journal-title":"In Vitro"},{"key":"BF02618426_CR10","first-page":"272","volume-title":"The statistical analysis of experimental data","author":"J. Mandel","year":"1964","unstructured":"Mandel, J. The statistical analysis of experimental data. New York: J. Wiley & Sons; 1964; 272\u2013310."},{"key":"BF02618426_CR11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2307\/2528930","volume":"27","author":"D. A. Williams","year":"1971","unstructured":"Williams, D. A. A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 27: 103\u2013117; 1971.","journal-title":"Biometrics"},{"key":"BF02618426_CR12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2307\/2556164","volume":"28","author":"D. A. Williams","year":"1972","unstructured":"Williams, D. A. Comparison of several dose levels with zero dose control. Biometrics 28: 519\u2013531; 1972.","journal-title":"Biometrics"},{"key":"BF02618426_CR13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1289\/ehp.751245","volume":"12","author":"M. D. Waters","year":"1975","unstructured":"Waters, M. D.; Vaughan, T. O.; Abernethy, D. R.; Garland, H. R.; Cox, C. C.; Coffin, D. L. Toxicity of platinum (IV) salts from cells of pulmonary origins. Environ. Health Perspectives 12: 45\u201356; 1975.","journal-title":"Environ. Health Perspectives"},{"key":"BF02618426_CR14","first-page":"62","volume-title":"Statistical methods","author":"G. W. Snedecor","year":"1967","unstructured":"Snedecor, G. W.; Cochran, W. G. Statistical methods, 6th ed. Ames, Iowa: The Iowa State University Press; 1967: 62.","edition":"6th ed"},{"key":"BF02618426_CR15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-4684-3611-2_6","volume-title":"Application of short term bioassays in the fractionation and analysis of complex environmental mixtures, Vol. 15","author":"M. D. Waters","year":"1978","unstructured":"Waters, M. D.; Huisingh, J. L.; Garrett, N. E. The cellular toxicity of complex environmental mixtures. Waters, M. D.; Nesnow, S.; Huisingh, J. L.; Sandhu, S. S.; Claxton, L. eds. Application of short term bioassays in the fractionation and analysis of complex environmental mixtures, Vol. 15. New York: Plenum Press; 1978: 125\u2013167."},{"key":"BF02618426_CR16","unstructured":"U. S. Environmental Protection Agency. Health Assessment Document for Cadmium. EPA-600\/8-79-003. Research Triangle Park, NC; 1979:2-78 to 2-80."},{"key":"BF02618426_CR17","first-page":"51","volume-title":"Selenium","author":"National Research Council, Committee on Medical and Biological Effects of Environmental Pollutants","year":"1976","unstructured":"National Research Council, Committee on Medical and Biological Effects of Environmental Pollutants. Selenium. Washington, DC: National Academy of Sciences, 1976: 51\u2013133."},{"key":"BF02618426_CR18","first-page":"346","volume":"43","author":"J. L. Huisingh","year":"1977","unstructured":"Huisingh, J. L.; Campbell, J. A.; Waters, M. D. Evaluation of trace element interactions using cultured alveolar macrophages. Pulmonary macrophages and epithelial cells, ERDA Symposium Series, Vol. 43, 1977: 346\u2013357.","journal-title":"ERDA Symposium Series"},{"key":"BF02618426_CR19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/03670244.1974.9990391","volume":"3","author":"D. Huisingh","year":"1974","unstructured":"Huisingh, D.; Huisingh, J. Heavy metals in foods: factors affecting toxicity. Ecology Food Nutrition 3: 263\u2013272; 1974.","journal-title":"Ecology Food Nutrition"},{"key":"BF02618426_CR20","first-page":"1474","volume":"29","author":"C. H. Hill","year":"1970","unstructured":"Hill, C. H.; Matrone, G. Chemical parameters in the study ofin vivo andin vitro interactions of transition elements. Fed. Proc. 29: 1474\u20131481; 1970.","journal-title":"Fed. Proc."}],"container-title":["In Vitro"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02618426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02618426\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02618426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T05:02:46Z","timestamp":1558328566000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02618426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1981,11]]}},"alternative-id":["BF02618426"],"URL":"https:\/\/doi.org\/10.1007\/bf02618426","relation":{},"ISSN":["0073-5655","1475-2689"],"issn-type":[{"value":"0073-5655","type":"print"},{"value":"1475-2689","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,11]]}}}