{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:06:27Z","timestamp":1768727187638,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1986,4,1]],"date-time":"1986-04-01T00:00:00Z","timestamp":512697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Vitro Cell Dev Biol"],"published-print":{"date-parts":[[1986,4]]},"DOI":"10.1007\/bf02623307","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T18:08:05Z","timestamp":1178215685000},"page":"223-230","source":"Crossref","is-referenced-by-count":24,"title":["Vitamin adeficiency and keratin biosynthesis in cultured hamster trachea"],"prefix":"10.1007","volume":"22","author":[{"given":"Freesia L.","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis R.","family":"Roop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi M.","family":"Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02623307_CR1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF02889883","volume":"45","author":"G. A. Blobel","year":"1984","unstructured":"Blobel, G. A.; Moll, R.; Franke, W. W., et al. Cytokeratins in normal lung and lung carcinomas. I. Adenocarcinomas, squamous cell carcinomas and cultured cell lines. Virchows Arch [Cell Pathol.]. 45:407\u2013427; 1984.","journal-title":"Virchows Arch [Cell Pathol.]"},{"key":"BF02623307_CR2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0003-2697(69)90251-6","volume":"31","author":"S. Bramhall","year":"1969","unstructured":"Bramhall, S.; Noack, N.; Wu, M., et al. A simple colorimetric method for determination of protein. Anal. Biochem. 31:146\u2013148; 1969.","journal-title":"Anal. Biochem."},{"key":"BF02623307_CR3","first-page":"895","volume":"69","author":"D. P. Chopra","year":"1982","unstructured":"Chopra, D. P. Squamous metaplasia in organ cultures of vitamin A-deficient hamster trachea: cytokinetic and ultrastructural alterations. JNCI. 69:895\u2013905; 1982.","journal-title":"JNCI"},{"key":"BF02623307_CR4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0277-5379(83)90018-4","volume":"19","author":"D. P. Chopra","year":"1983","unstructured":"Chopra, D. P. Retinoid reversal of squamous metaplasia in organ cultures of tracheas derived from hamsters fed on vitamin A-deficient diet. Eur. J. Cancer Clin. Oncol. 19:847\u2013857; 1983.","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"BF02623307_CR5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/250064a0","volume":"250","author":"G. H. Clamon","year":"1974","unstructured":"Clamon, G. H.; Sporn, M. B.; Smith, J. M., et al. -and-retinyl acetate reverse metaplasias of vitamin A-deficiency in hamster trachea in organ culture. Nature 250:64\u201366; 1974.","journal-title":"Nature"},{"key":"BF02623307_CR6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(80)90150-6","volume":"22","author":"T. I. Doran","year":"1980","unstructured":"Doran, T. I.; Vidrich, A.; Sun, T.-T. Intrinsic and extrinsic regulation of the differentiation of skin, corneal and esophageal epithelial cells. Cell 22:17\u201325; 1980.","journal-title":"Cell"},{"key":"BF02623307_CR7","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1083\/jcb.98.4.1388","volume":"98","author":"R. Eichner","year":"1984","unstructured":"Eichner, R.; Bonitz, P.; Sun, T.-T. Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J. Cell Biol. 98:1388\u20131396; 1984.","journal-title":"J. Cell Biol."},{"key":"BF02623307_CR8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1432-0436.1979.tb01030.x","volume":"15","author":"W. W. Franke","year":"1979","unstructured":"Franke, W. W.; Appelhans, B.; Schmid, E., et al. Identification and characterization of epithelial cells in mammalian tissues by immunofluorescence microscopy using antibodies to prekeratin. Differentiation 15:7\u201325; 1979.","journal-title":"Differentiation"},{"key":"BF02623307_CR9","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0022-2836(81)90460-5","volume":"153","author":"W. W. Franke","year":"1981","unstructured":"Franke, W. W.; Schiller, D. L.; Moll, R., et al. Diversity of cytokeratins: differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J. Mol. Biol. 153:933\u2013959; 1981.","journal-title":"J. Mol. Biol."},{"key":"BF02623307_CR10","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.75.10.5034","volume":"75","author":"W. W. Franke","year":"1978","unstructured":"Franke, W. W.; Schmid, E.; Osborn, M., et al. Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc. Natl. Acad. Sci. USA 75:5034\u20135038; 1978.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02623307_CR11","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0092-8674(78)90273-8","volume":"15","author":"E. Fuchs","year":"1978","unstructured":"Fuchs, E.; Green, H. The expression of keratin genes in epidermis and cultured epidermal cells. Cell 15:887\u2013897; 1978.","journal-title":"Cell"},{"key":"BF02623307_CR12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(80)90094-X","volume":"19","author":"E. Fuchs","year":"1980","unstructured":"Fuchs, E.; Green, H. Changes in keratin gene expression during terminal differentiation of the keratinocytes. Cell 19:1033\u20131042; 1980.","journal-title":"Cell"},{"key":"BF02623307_CR13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0092-8674(81)90169-0","volume":"25","author":"E. Fuchs","year":"1981","unstructured":"Fuchs, E.; Green, H. Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell 25:617\u2013625; 1981.","journal-title":"Cell"},{"key":"BF02623307_CR14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0014-4827(80)90075-0","volume":"128","author":"I. K. Gipson","year":"1980","unstructured":"Gipson, I. K.; Anderson, R. A. Comparison of 10 nm filaments from three bovine tissues. Exp. Cell Res. 128:395\u2013406; 1980.","journal-title":"Exp. Cell Res."},{"key":"BF02623307_CR15","first-page":"743","volume":"48","author":"C. C. Harris","year":"1972","unstructured":"Harris, C. C.; Sporn, M. B.; Kaufman, D. G., et al. Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A-deficiency or benzo[a]pyreneferric oxide. JNCI 48:743\u2013761; 1972.","journal-title":"JNCI"},{"key":"BF02623307_CR16","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"277","author":"U. K. Laemmli","year":"1970","unstructured":"Laemmli, U. K. Cleavage of structural proteins during assembly of the head of bacteriophage T. Nature 277:680\u2013685; 1970.","journal-title":"Nature"},{"key":"BF02623307_CR17","first-page":"451","volume":"33","author":"A. C. Marchok","year":"1975","unstructured":"Marchok, A. C.; Cone, M. V.; Nettesheim, P. Induction of squamous metaplasia (vitamin A-deficiency) and hypersecretory activity in tracheal organ cultures. Lab. Invest. 33:451\u2013460; 1975.","journal-title":"Lab. Invest."},{"key":"BF02623307_CR18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02889865","volume":"45","author":"E. M. McDowell","year":"1984","unstructured":"McDowell, E. M.; Keenan, K. P.; Huang, M. Effects of vitamin A deprivation on hamster tracheal epithelium. Virchows Arch. [Cell Pathol.] 45:197\u2013219; 1984.","journal-title":"Virchows Arch. [Cell Pathol.]"},{"key":"BF02623307_CR19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1083\/jcb.88.2.312","volume":"88","author":"L. M. Milstone","year":"1981","unstructured":"Milstone, L. M.; McGuire, J. Different polypeptides from the intermediate filaments in bovine boof and esophageal epithelium and in aortic endothelium. J. Cell Biol. 88:312\u2013316; 1981.","journal-title":"J. Cell Biol."},{"key":"BF02623307_CR20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","volume":"31","author":"R. Moll","year":"1982","unstructured":"Moll, R.; Franke, W. W.; Schiller, D. L., et al. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11\u201324; 1982.","journal-title":"Cell"},{"key":"BF02623307_CR21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1432-0436.1982.tb01291.x","volume":"23","author":"R. Moll","year":"1983","unstructured":"Moll, R.; Reinhard, K.; Franke, W. W. Complex cytokerating polypeptide patterns observed in certain human carcinomas. Differentiation 23:256\u2013269; 1983.","journal-title":"Differentiation"},{"key":"BF02623307_CR22","first-page":"4176","volume":"43","author":"K. G. Nelson","year":"1982","unstructured":"Nelson, K. G.; Slaga, T. J. Keratin modifications in epidermis, papillomas, and carcinomas during two-stage carcinogenesis in the SENCAR mouse. Cancer Res. 43:4176\u20134181; 1982.","journal-title":"Cancer Res."},{"key":"BF02623307_CR23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0003-9969(84)90029-3","volume":"29","author":"T. Odajima","year":"1984","unstructured":"Odajima, T.; Aoyagi, T.; Solt, D. B. Electrophoretic study of keratin polypeptides in chemically-induced oral carcinomas in the hamster. Archs. Oral. Biol. 29:473\u2013475; 1984.","journal-title":"Archs. Oral. Biol."},{"key":"BF02623307_CR24","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1016\/S0021-9258(17)39682-5","volume":"259","author":"D. Roop","year":"1984","unstructured":"Roop, D.; Cheng, C. K.; Titterington, L., et al. Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies. J. Biol. Chem. 259:8037\u20138040; 1984.","journal-title":"J. Biol. Chem."},{"key":"BF02623307_CR25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1749-6632.1985.tb50426.x","volume":"455","author":"D. R. Roop","year":"1985","unstructured":"Roop, D. R.; Cheng, C. K.; Toftgard, R., et al. The use of cDNA clones and monospecific antibodies as probes to monitor keratin gene expression. Ann. NY Acad. Sci. 455:426\u2013435; 1985.","journal-title":"Ann. NY Acad. Sci."},{"key":"BF02623307_CR26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1073\/pnas.80.3.716","volume":"80","author":"D. R. Roop","year":"1983","unstructured":"Roop, D. R.; Hawley-Nelson, P.; Cheng, C. K., et al. Karatin gene expression in mouse epidermis and cultured epidermal cells. Proc. Natl. Acad. Sci. USA 80:716\u2013720; 1983.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02623307_CR27","unstructured":"Roop, D. R.; Toftgard, R.; Yuspa, S. H., et al. Changes in keratin gene expression during differentiation. In: Borisk, G. G.; Cleveland, D. W.; Murphy, D. D., eds. Cold Spring Harbor Symp. Quant. Biol. Molecular biology of the cytoskeleton. Cold Spring Harbor, NY: 1984:chapter 37."},{"key":"BF02623307_CR28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-4827(83)90105-2","volume":"43","author":"D. Skerrow","year":"1983","unstructured":"Skerrow, D.; Skerrow, C. J. Tonofilament differentiation in human epidermis: isolation and polypeptide chain composition of keratinocyte subpopulation. Exp. Cell Res. 43:27\u201335; 1983.","journal-title":"Exp. Cell Res."},{"key":"BF02623307_CR29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/263110a0","volume":"263","author":"M. B. Sporn","year":"1976","unstructured":"Sporn, M. B.; Dunlop, N. M.; Newton, D. L., et al. Relationships between structure and activity of retinoids. Nature 263:110\u2013113; 1976.","journal-title":"Nature"},{"key":"BF02623307_CR30","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0092-8674(81)90115-X","volume":"24","author":"J. R. Stanley","year":"1981","unstructured":"Stanley, J. R.; Hawley-Nelson, P.; Yuspa, S. H., et al. Characterization of bullous pemphigold antigen: a unique basement membrane protein of stratified squamous epithelia. Cell 24:897\u2013903; 1981.","journal-title":"Cell"},{"key":"BF02623307_CR31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0005-2795(79)90003-5","volume":"577","author":"P. M. Steinert","year":"1979","unstructured":"Steinert, P. M.; Idler, W. W.; Poirier, M. C., et al. Subunit structure of the mouse epidermal keratin filament. Biochem. Biophys. Acta. 577:11\u201321; 1979.","journal-title":"Biochem. Biophys. Acta."},{"key":"BF02623307_CR32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1073\/pnas.81.18.5709","volume":"81","author":"P. M. Steinert","year":"1984","unstructured":"Steinert, P. M.; Parry, D. A. D.; Racoosin, E. L., et al. The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: Analysis of sequence differences between type I and type II keratins. Proc. Natl. Acad. Sci. USA 81:709\u2013713; 1984.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02623307_CR33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/1523-1747.ep12540831","volume":"81","author":"T.-T. Sun","year":"1983","unstructured":"Sun, T.-T.; Eichner, R.; Nelson, W. G., et al. Keratin classes: molecular markers for different types of epithelial differentiation. J. Invest. Dermatol. 81:109\u2013115; 1983.","journal-title":"J. Invest. Dermatol."},{"key":"BF02623307_CR34","first-page":"468","volume":"14","author":"T.-T. Sun","year":"1978","unstructured":"Sun, T.-T.; Green, H. Immunofluorescent staining of keratin fibers in cultured cells. Cell 14:468\u2013476; 1978.","journal-title":"Cell"},{"key":"BF02623307_CR35","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/S0021-9258(19)62353-7","volume":"253","author":"T.-T. Sun","year":"1978","unstructured":"Sun, T.-T.; Green, H. Keratin filaments of cultured human epidermal cells: formation of intermolecular disulfide bonds during terminal differentiation. J. Biol. Chem. 253:2053\u20132060; 1978.","journal-title":"J. Biol. Chem."},{"key":"BF02623307_CR36","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1073\/pnas.76.6.2813","volume":"76","author":"T.-T. Sun","year":"1979","unstructured":"Sun, T.-T.; Shih, C.; Green, H. Keratin cytoskeletons in epithelial cells of internal organs. Proc. Natl. Acad. Sci. USA 76:2813\u20132817; 1979.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02623307_CR37","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/1523-1747.ep12510153","volume":"78","author":"L. B. Taichman","year":"1982","unstructured":"Taichman, L. B.; Prokop, C. A. Synthesis of keratin proteins during maturation of cultured human keratinocytes. J. Invest. Dermatol. 78:464\u2013467; 1982.","journal-title":"J. Invest. Dermatol."},{"key":"BF02623307_CR38","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1083\/jcb.99.6.2279","volume":"99","author":"S. C. G. Tseng","year":"1984","unstructured":"Tseng, S. C. G.; Hatchell, D.; Tierney, N., et al. Expression of specific keratin markers by rabbit corneal, conjunctival, and esophageal epithelia during vitamin A-deficiency. J. Cell Biol. 99:2279\u20132286; 1984.","journal-title":"J. Cell Biol."},{"key":"BF02623307_CR39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0092-8674(82)90234-3","volume":"30","author":"S. C. G. Tseng","year":"1982","unstructured":"Tseng, S. C. G.; Jarvinen, M. J.; Nelson, W. G., et al. Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies. Cell 30:361\u2013372; 1982.","journal-title":"Cell"},{"key":"BF02623307_CR40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/carcin\/1.5.391","volume":"1","author":"H. Winter","year":"1980","unstructured":"Winter, H.; Schweizer, J.; Goerttler, K. Keratins as markers of malignancy in mouse epidermal tumors. Carcinogenesis (Lond.) 1:391\u2013398; 1980.","journal-title":"Carcinogenesis (Lond.)"},{"key":"BF02623307_CR41","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1083\/jcb.95.2.580","volume":"95","author":"J. Woodcock-Mitchell","year":"1982","unstructured":"Woodcock-Mitchell, J.; Eichner, R.; Nelson, W. G., et al. Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J. Cell Biol. 95:580\u2013588; 1982.","journal-title":"J. Cell Biol."},{"key":"BF02623307_CR42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/B978-1-4831-9699-2.50014-9","volume-title":"The vitamins 1","author":"S. B. Wolbach","year":"1954","unstructured":"Wolbach, S. B. Effects of vitamin A-deficiency and hypervitaminosis A in animals. In: Sebrell, W. H., Jr.; Harris, R. S., eds. The vitamins 1. New York: Academic Press; 1954:106\u2013137."},{"key":"BF02623307_CR43","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1084\/jem.42.6.753","volume":"62","author":"S. B. Wolbach","year":"1925","unstructured":"Wolbach, S. B.; Howe, P. R. Tissue changes following deprivation of fat soluble A vitamin. J. Exp. Med. 62:753\u2013777; 1925.","journal-title":"J. Exp. Med."},{"key":"BF02623307_CR44","first-page":"55","volume":"24","author":"Y. Wong","year":"1971","unstructured":"Wong, Y.; Buck, R. An electron microscopic study of metaplasia of the rat tracheal epithelium in vitamin A-deficiency. Lab. Invest. 24:55\u201366; 1971.","journal-title":"Lab. Invest."}],"container-title":["In Vitro Cellular & Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02623307.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02623307\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02623307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T03:06:10Z","timestamp":1628823970000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02623307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,4]]}},"alternative-id":["BF02623307"],"URL":"https:\/\/doi.org\/10.1007\/bf02623307","relation":{},"ISSN":["0883-8364","1475-2689"],"issn-type":[{"value":"0883-8364","type":"print"},{"value":"1475-2689","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,4]]}}}