{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:30:14Z","timestamp":1773289814614,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Vitro Cell Dev Biol - Animal"],"published-print":{"date-parts":[[1991,1]]},"DOI":"10.1007\/bf02630899","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T16:52:02Z","timestamp":1179593522000},"page":"89-96","source":"Crossref","is-referenced-by-count":17,"title":["Transformed phenotype conferred to NIH\/3T3 cells by ectopic expression of heparin-binding growth factor 1\/acidic fibroblast growth factor"],"prefix":"10.1007","volume":"27","author":[{"given":"Phanpimol","family":"Bunnag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Lee","family":"Varban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ing-Ming","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02630899_CR1","first-page":"129","volume":"3","author":"S. B. Blam","year":"1988","unstructured":"Blam, S. B.; Mitchell, R.; Tischer, E., et al. Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein. Oncogene 3:129\u2013136; 1988.","journal-title":"Oncogene"},{"key":"BF02630899_CR2","first-page":"9","volume":"1","author":"T. M. Browder","year":"1989","unstructured":"Browder, T. M.; Dunbar, C. E.; Nienhuis, A. W. Private and public autocrine loops in neoplastic cells. Cancer Cells 1:9\u201317; 1989.","journal-title":"Cancer Cells"},{"key":"BF02630899_CR3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.bi.58.070189.003043","volume":"58","author":"W. H. Burgess","year":"1989","unstructured":"Burgess, W. H.; Maciag, T. The heparin-binding (fibroblast) growth factor family of proteins. Ann. Rev. Biochem. 58:575\u2013606; 1989.","journal-title":"Ann. Rev. Biochem."},{"key":"BF02630899_CR4","doi-asserted-by":"crossref","first-page":"7216","DOI":"10.1073\/pnas.83.19.7216","volume":"83","author":"W. H. Burgess","year":"1986","unstructured":"Burgess, W. H.; Mehlman, T.; Marshak, D. R., et al. Structural evidence that endothelial cell growth factor \u03b2 is the precursor of both endothelial cell growth factor \u03b1 and acidic fibroblast growth factor. Proc. Natl. Acad. Sci. USA 83:7216\u20137220; 1986.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02630899_CR5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0092-8674(84)90440-9","volume":"37","author":"C. L. Cepko","year":"1984","unstructured":"Cepko, C. L.; Roberts, B. E.; Mulligan, R. C. Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell 37:1053\u20131062; 1984.","journal-title":"Cell"},{"key":"BF02630899_CR6","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1021\/bi00591a005","volume":"18","author":"J. M. Chirgwin","year":"1979","unstructured":"Chirgwin, J. M.; Przybyla, A. E.; MacDonald, R. J., et al. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294\u20135299; 1979.","journal-title":"Biochemistry"},{"key":"BF02630899_CR7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02969485","volume":"10","author":"I.-M. Chiu","year":"1989","unstructured":"Chiu, I.-M. Growth factor genes as oncogenes. Mol. Chem. Neuropathol. 10:37\u201352; 1989.","journal-title":"Mol. Chem. Neuropathol."},{"key":"BF02630899_CR8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0092-8674(84)90307-6","volume":"37","author":"I.-M. Chiu","year":"1984","unstructured":"Chiu, I.-M.; Reddy, E. P.; Givol, D., et al. Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor. Cell 37:123\u2013129; 1984.","journal-title":"Cell"},{"key":"BF02630899_CR9","first-page":"755","volume":"5","author":"I.-M. Chiu","year":"1990","unstructured":"Chiu, I.-M.; Wang, W.-P.; Lehtoma, K. Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene 5:755\u2013762; 1990.","journal-title":"Oncogene"},{"key":"BF02630899_CR10","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1021\/bi00366a003","volume":"25","author":"J. W. Crabb","year":"1986","unstructured":"Crabb, J. W.; Armes, L. G.; Carr, S. A., et al. Complete primary structure of prostatropin, a prostate epithelial cell growth factor. Biochemistry 25:4988\u20134993; 1986.","journal-title":"Biochemistry"},{"key":"BF02630899_CR11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/307521a0","volume":"307","author":"J. Downward","year":"1984","unstructured":"Downward, J.; Yarden, Y.; Mayes, E., et al. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 307:521\u2013527; 1984.","journal-title":"Nature"},{"key":"BF02630899_CR12","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1073\/pnas.86.11.3978","volume":"86","author":"R. Z. Florkiewicz","year":"1989","unstructured":"Florkiewicz, R. Z.; Sommer, A. Human basic fibroblast growth factor gene encodes four polypeptides: Three initiate translation from non-AUG codons. Proc. Natl. Acad. Sci. USA 86:3978\u20133981; 1989.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02630899_CR13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.2432664","volume":"235","author":"J. Folkman","year":"1987","unstructured":"Folkman, J.; Klagsbrun, M. Angiogenic factors. Science 235:442\u2013447; 1987.","journal-title":"Science"},{"key":"BF02630899_CR14","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1126\/science.4071057","volume":"230","author":"G. Gimenez-Callego","year":"1985","unstructured":"Gimenez-Callego, G.; Rodkey, J.; Bennett, C., et al. Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies. Science 230:1385\u20131388; 1985.","journal-title":"Science"},{"key":"BF02630899_CR15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0076-6879(87)47102-4","volume":"147","author":"D. Gospodarowicz","year":"1987","unstructured":"Gospodarowicz, D. Isolation and characterization of acidic and basic fibroblast growth factor. Methods Enzymol. 147:106\u2013119; 1987.","journal-title":"Methods Enzymol."},{"key":"BF02630899_CR16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0006-291X(86)80158-9","volume":"141","author":"M.-C. Hung","year":"1986","unstructured":"Hung, M.-C.; Thompson, K. L.; Chiu, I.-M., et al. Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe. Biochem. Biophys. Res. Commun. 141:1109\u20131115; 1986.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF02630899_CR17","doi-asserted-by":"crossref","first-page":"16612","DOI":"10.1016\/S0021-9258(18)49300-3","volume":"262","author":"M. Jaye","year":"1987","unstructured":"Jaye, M.; Burgess, W. H.; Shaw, A. B., et al. Biological equivalence of natural bovine and recombinant human \u03b1-endothelial cell growth factors. J. Biol. Chem. 262:16612\u201316617; 1987.","journal-title":"J. Biol. Chem."},{"key":"BF02630899_CR18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1126\/science.3523756","volume":"233","author":"M. Jaye","year":"1986","unstructured":"Jaye, M.; Howk, R.; Burgess, W., et al. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosomal localization. Science 233:541\u2013545; 1986.","journal-title":"Science"},{"key":"BF02630899_CR19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/j.1460-2075.1988.tb02902.x","volume":"7","author":"M. Jaye","year":"1988","unstructured":"Jaye, M.; Lyall, R. M.; Mudd, R., et al. Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells. EMBO J. 7:963\u2013969; 1988.","journal-title":"EMBO J."},{"key":"BF02630899_CR20","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1073\/pnas.84.7.1839","volume":"84","author":"M. Klagsbrun","year":"1987","unstructured":"Klagsbrun, M.; Smith, S.; Sullivan, R., et al. Multiple forms of basic fibroblast growth factor: Amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases. Proc. Natl. Acad. Sci. USA 84:1839\u20131843; 1987.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02630899_CR21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"U. K. Laemmli","year":"1970","unstructured":"Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227:680\u2013685; 1970.","journal-title":"Nature"},{"key":"BF02630899_CR22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0092-8674(85)90182-5","volume":"43","author":"R. A. Lang","year":"1985","unstructured":"Lang, R. A.; Metcalf, D.; Gough, N. M., et al. Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity. Cell 43:531\u2013542; 1985.","journal-title":"Cell"},{"key":"BF02630899_CR23","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/j.1460-2075.1987.tb02410.x","volume":"6","author":"T. A. Libermann","year":"1987","unstructured":"Libermann, T. A.; Friesel, R.; Jaye, M., et al. An angiogenic growth factor is expressed in human glioma cells. EMBO J. 6:1627\u20131632; 1987.","journal-title":"EMBO J."},{"key":"BF02630899_CR24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0006-291X(86)80257-1","volume":"139","author":"R. R. Lobb","year":"1986","unstructured":"Lobb, R. R.; Rybak, S. M.; St. Clair, D. K., et al. Lysates of two established human tumor lines contain heparin-binding growth factors related to bovine acidic brain fibroblast growth factor. Biochem. Biophys. Res. Commun. 139:861\u2013867; 1986.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF02630899_CR25","volume-title":"Molecular Cloning: A Laboratory Manual","author":"T. Maniatis","year":"1982","unstructured":"Maniatis, T.; Fritsch, E. F.; Sambrook, J. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1982."},{"key":"BF02630899_CR26","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1083\/jcb.106.4.1385","volume":"106","author":"G. Neufeld","year":"1988","unstructured":"Neufeld, G.; Mitchell, R.; Ponte, P., et al. Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth. J. Cell. Biol. 106:1385\u20131394; 1988.","journal-title":"J. Cell. Biol."},{"key":"BF02630899_CR27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1128\/JVI.31.2.360-369.1979","volume":"31","author":"B. A. Parker","year":"1979","unstructured":"Parker, B. A.; Stark, G. R. Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA. J. Virol. 31:360\u2013369; 1979.","journal-title":"J. Virol."},{"key":"BF02630899_CR28","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1073\/pnas.86.6.1836","volume":"86","author":"H. Prats","year":"1989","unstructured":"Prats, H.; Kaghad, M.; Prats, A. C., et al. High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. Proc. Natl. Acad. Sci. USA. 86:1836\u20131840; 1989.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02630899_CR29","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1073\/pnas.79.9.2845","volume":"79","author":"S. Pulciani","year":"1982","unstructured":"Pulciani, S.; Santos, E.; Lauver, A., et al. Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc. Natl. Acad. Sci. USA 79:2845\u20132849; 1982.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02630899_CR30","first-page":"101","volume":"5","author":"N. Quarto","year":"1989","unstructured":"Quarto, N.; Talarico, D.; Sommer, A., et al. Transformation by basic fibroblast growth factor requires high levels of expression: Comparison with tranformation by hst\/K-fgf. Oncogene Res. 5:101\u2013110; 1989.","journal-title":"Oncogene Res."},{"key":"BF02630899_CR31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jcp.1041440114","volume":"144","author":"M. Renko","year":"1990","unstructured":"Renko, M.; Quarto, N.; Morimoto, T., et al. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. J. Cell. Physiol. 144:108\u2013114; 1990.","journal-title":"J. Cell. Physiol."},{"key":"BF02630899_CR32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0076-6879(87)46035-7","volume":"146","author":"A. Rizzino","year":"1987","unstructured":"Rizzino, A. Soft agar growth assays for transforming growth factors and mitogenic peptides. Methods. Enzymol. 146:341\u2013352; 1987.","journal-title":"Methods. Enzymol."},{"key":"BF02630899_CR33","first-page":"749","volume":"22","author":"A. Rizzino","year":"1986","unstructured":"Rizzino, A.; Ruff, E. Fibroblast growth factor induces the soft agar growth of two non-transformed cell lines. In Vitro 22:749\u2013755; 1986.","journal-title":"In Vitro"},{"key":"BF02630899_CR34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/331173a0","volume":"331","author":"S. Rogelj","year":"1988","unstructured":"Rogelj, S.; Weinberg, R. A.; Fanning, P., et al. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature 331:173\u2013175; 1988.","journal-title":"Nature"},{"key":"BF02630899_CR35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(86)90747-6","volume":"46","author":"A. Rosenthal","year":"1986","unstructured":"Rosenthal, A.; Lindquist, P. B.; Bringman, T. S., et al. Expression in rat fibroblasts of a human transforming growth factor-\u03b1 cDNA results in transformation. Cell 46:301\u2013309; 1986.","journal-title":"Cell"},{"key":"BF02630899_CR36","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1128\/MCB.8.2.588","volume":"8","author":"R. Sasada","year":"1988","unstructured":"Sasada, R.; Kurokawa, T.; Iwane, M., et al. Transformation of mouse BALB\/c 3T3 cells with human basic fibroblast growth factor cDNA. Mol. Cell. Biol. 8:588\u2013594; 1988.","journal-title":"Mol. Cell. Biol."},{"key":"BF02630899_CR37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0092-8674(85)80047-7","volume":"41","author":"C. Sherr","year":"1985","unstructured":"Sherr, C.; Rettenmier, C. W.; Sacca, R., et al. The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell 41:665\u2013676; 1985.","journal-title":"Cell"},{"key":"BF02630899_CR38","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","volume":"98","author":"E. M. Southern","year":"1975","unstructured":"Southern, E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503\u2013517; 1975.","journal-title":"J. Mol. Biol."},{"key":"BF02630899_CR39","first-page":"327","volume":"1","author":"P. J. Southern","year":"1982","unstructured":"Southern, P. J.; Berg, P. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1:327\u2013341; 1982.","journal-title":"J. Mol. Appl. Genet."},{"key":"BF02630899_CR40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.3492043","volume":"235","author":"D. F. Stern","year":"1987","unstructured":"Stern, D. F.; Hare, D. L.; Cecchini, M. A., et al. Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor. Science 235:321\u2013324; 1987.","journal-title":"Science"},{"key":"BF02630899_CR41","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/MCB.9.6.2387","volume":"9","author":"W.-P. Wang","year":"1989","unstructured":"Wang, W.-P.; Lehtoma, K.; Varban, M. L., et al. Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues. Mol. Cell. Biol. 9:2387\u20132395; 1989.","journal-title":"Mol. Cell. Biol."},{"key":"BF02630899_CR42","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1073\/pnas.86.8.2683","volume":"86","author":"H. L. Weiner","year":"1989","unstructured":"Weiner, H. L.; Swain, J. L. Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix. Proc. Natl. Acad. Sci. USA 86:2683\u20132687; 1989.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02630899_CR43","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1073\/pnas.84.20.7124","volume":"84","author":"J. A. Winkles","year":"1987","unstructured":"Winkles, J. A.; Friesel, R.; Burgess, W. H., et al. Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor). Proc. Natl. Acad. Sci. USA; 84:7124\u20137128; 1987.","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["In Vitro Cellular & Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02630899.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02630899\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02630899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T23:26:56Z","timestamp":1628897216000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02630899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["BF02630899"],"URL":"https:\/\/doi.org\/10.1007\/bf02630899","relation":{},"ISSN":["0883-8364","1543-706X"],"issn-type":[{"value":"0883-8364","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}