{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:05:18Z","timestamp":1759529118414},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Vitro Cell Dev Biol - Animal"],"published-print":{"date-parts":[[1994,9]]},"DOI":"10.1007\/bf02631255","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T17:37:57Z","timestamp":1179596277000},"page":"574-580","source":"Crossref","is-referenced-by-count":33,"title":["Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes"],"prefix":"10.1007","volume":"30","author":[{"given":"M. T.","family":"Donato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"G\u00f3mez-Lech\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Penco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Castell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02631255_CR1","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/0006-2952(78)90314-3","volume":"27","author":"A. J. Baars","year":"1978","unstructured":"Baars, A. J.; Jansen, N.; Breimer, D. D. The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol. Biochem. Pharmacol. 27:2487\u20132494; 1978.","journal-title":"Biochem. Pharmacol."},{"key":"BF02631255_CR2","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1073\/pnas.84.12.4073","volume":"4","author":"N. Battula","year":"1987","unstructured":"Battula, N.; Sagara, J.; Gelboin, H. V. Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P450 in mammalian cells. Proc. Natl. Acad. Sci. USA 4:4073\u20134077; 1987.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02631255_CR3","first-page":"259","volume-title":"Oncodevelopmental gene expression","author":"J. E. Becker","year":"1976","unstructured":"Becker, J. E.; DeNechaud, B.; Potter, V. R. Two new rat hepatoma cell lines for studying the unbalanced blocked ontogeny hypothesis. In: Fishman, W. J.; Sell, S., eds. Oncodevelopmental gene expression. New York: Academic Press; 1976:259\u2013270."},{"key":"BF02631255_CR4","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1016\/0006-2952(85)90355-7","volume":"34","author":"M. D. Burke","year":"1985","unstructured":"Burke, M. D.; Thompson, S.; Elcombe, C. R., et al. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450. Biochem. Pharmacol. 34:3337\u20133345; 1985.","journal-title":"Biochem. Pharmacol."},{"key":"BF02631255_CR5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0014-5793(88)81351-6","volume":"233","author":"L. Corcos","year":"1988","unstructured":"Corcos, L.; Weiss, M. C. Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells. FEBS Lett. 233:37\u201340; 1988.","journal-title":"FEBS Lett."},{"key":"BF02631255_CR6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1021\/tx00023a013","volume":"4","author":"Ch. L. Crespi","year":"1991","unstructured":"Crespi, Ch. L.; Gonzalez, F. J.; Steimel, D. T., et al. A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. Chem. Res. Toxicol. 4:566\u2013572; 1991.","journal-title":"Chem. Res. Toxicol."},{"key":"BF02631255_CR7","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0300-9084(75)80286-0","volume":"56","author":"J. Deschatrette","year":"1974","unstructured":"Deschatrette, J.; Weiss, M. C. Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochimie 56:1603\u20131911; 1974.","journal-title":"Biochimie"},{"key":"BF02631255_CR8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0304-4165(90)90086-C","volume":"1035","author":"E. Dicker","year":"1990","unstructured":"Dicker, E.; McHugh, T.; Cederbaum, A. I. Increased oxidation of p-nitrophenol and aniline by intact hepatocytes isolated from pyrazole-treated rats. Biochim. Biophys. Acta 1035:248\u2013256; 1990.","journal-title":"Biochim. Biophys. Acta"},{"key":"BF02631255_CR9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF01409106","volume":"14","author":"M. T. Donato","year":"1992","unstructured":"Donato, M. T.; Castell, J. V.; G\u00f3mez-Lech\u00f3n, M. J. A rapid and sensitive method for measuring monooxygenase activities in hepatocytes cultured in 96-well plates. J. Tissue Cult. Methods 14:153\u2013158; 1992a.","journal-title":"J. Tissue Cult. Methods"},{"key":"BF02631255_CR10","first-page":"149","volume-title":"In vitro alternatives to animal pharmaco-toxicology","author":"M. T. Donato","year":"1992","unstructured":"Donato, M. T.; G\u00f3mez-Lech\u00f3n, M. J.; Castell, J. V. Biotransformation of drugs by cultured hepatocytes. In: Castell, J. V.; G\u00f3mez-Lech\u00f3n, M. J., eds. In vitro alternatives to animal pharmaco-toxicology. Barcelona: Farmaindustria; 1992b: 149\u2013178."},{"key":"BF02631255_CR11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0887-2333(93)90051-6","volume":"7","author":"M. T. Donato","year":"1993","unstructured":"Donato, M. T.; Herrero, E.; G\u00f3mez-Lech\u00f3n, M. J., et al. Interferons decrease monooxygenase activities in human hepatocytes. Toxic. In Vitro. 7:481\u2013485; 1993.","journal-title":"Toxic. In Vitro."},{"key":"BF02631255_CR12","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/0006-2952(84)90425-8","volume":"33","author":"A. M. Edwards","year":"1984","unstructured":"Edwards, A. M.; Glistak, M. L.; Lucas, C. M., et al. 7-Ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: regulation in cultured rat hepatocytes. Biochem. Pharmacol. 33:1537\u20131546; 1984.","journal-title":"Biochem. Pharmacol."},{"key":"BF02631255_CR13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/cbf.290020415","volume":"2","author":"M. Ferro","year":"1984","unstructured":"Ferro, M.; Bassi, A. M.; Marinari, U., et al. Induction of cytochrome (s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells. Cell. Biochem. Func. 2:263\u2013268; 1984.","journal-title":"Cell. Biochem. Func."},{"key":"BF02631255_CR14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/019262338701500114","volume":"15","author":"M. Ferro","year":"1987","unstructured":"Ferro, M.; Marinari, U. M.; Bassi, A. M., et al. Biochemical properties of carcinogen-metabolizing enzymes in cultured hepatoma cells. Toxicol. Pathol. 15:97\u2013102; 1987.","journal-title":"Toxicol. Pathol."},{"key":"BF02631255_CR15","first-page":"168","volume":"120","author":"A. B. Frey","year":"1984","unstructured":"Frey, A. B.; Rosenfeld, G.; Dolan, W. I., et al. Induction of cytochrome P450 isozymes in rat hepatoma-derived cell cultures. J. Cell. Physiol. 120:168\u2013180; 1984.","journal-title":"J. Cell. Physiol."},{"key":"BF02631255_CR16","first-page":"86","volume-title":"In vitro alternatives to animal pharmaco-toxicology","author":"M. J. G\u00f3mez-Lech\u00f3n","year":"1992","unstructured":"G\u00f3mez-Lech\u00f3n, M. J.; Donato, M. T.; Ponsoda, X., et al. Experimental in vitro models to evaluate hepatotoxicity. In: Castell, J. V.; G\u00f3mez-Lech\u00f3n, M. J., eds. In vitro alternatives to animal pharmaco-toxicology. Barcelona: Farmaindustria; 1992:86\u2013107."},{"key":"BF02631255_CR17","first-page":"243","volume":"40","author":"F. J. Gonzalez","year":"1989","unstructured":"Gonzalez, F. J. The molecular biology of cytochrome P450 superfamily. Pharmacol. Rev. 40:243\u2013288; 1989.","journal-title":"Pharmacol. Rev."},{"key":"BF02631255_CR18","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"W. H. Habig","year":"1974","unstructured":"Habig, W. H.; Pabst, M. J.; Jakoby, W. B. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249:7130\u20137139; 1974.","journal-title":"J. Biol. Chem."},{"key":"BF02631255_CR19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1073\/pnas.76.1.373","volume":"76","author":"O. Hankinson","year":"1979","unstructured":"Hankinson, O. Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase. Proc. Natl. Acad. Sci. USA 76:373\u2013376; 1979.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02631255_CR20","first-page":"381","volume-title":"Methods in enzymology, vol. 206","author":"O. Hankinson","year":"1991","unstructured":"Hankinson, O. Selection for and against cells possessing cytochrome P450IA1-dependent aryl hydrocarbon hydroxylase activity. In: Waterman, M. R.; Johnson, E. F., eds. Methods in enzymology, vol. 206. San Diego, CA: Academic Press; 1991:381\u2013400."},{"key":"BF02631255_CR21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1600-0773.1983.tb01114.x","volume":"52","author":"J. A. Holme","year":"1983","unstructured":"Holme, J. A.; Soderlund, E.; Dybing, E. Drug metabolism activities of isolated rat hepatocytes in monolayer culture. Acta Pharmacol. Toxicol. 52:348\u2013356; 1983.","journal-title":"Acta Pharmacol. Toxicol."},{"key":"BF02631255_CR22","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/0006-2952(89)90192-5","volume":"38","author":"S. O. Karenlampi","year":"1989","unstructured":"Karenlampi, S. O.; Tuomi, K.; Korkalainen, M., et al. Induction of cytochrome P450IA1 in mouse hepatoma cells by several chemicals. Biochem. Pharmacol. 38:1517\u20131525; 1989.","journal-title":"Biochem. Pharmacol."},{"key":"BF02631255_CR23","first-page":"399","volume":"29","author":"D. R. Knoop","year":"1986","unstructured":"Knoop, D. R. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. Mol. Pharmacol. 29:399\u2013404; 1986.","journal-title":"Mol. Pharmacol."},{"key":"BF02631255_CR24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0005-2787(77)90342-2","volume":"475","author":"B. E. Ledford","year":"1977","unstructured":"Ledford, B. E.; Warner, R. W.; Copchran, R. A. Albumin synthesis in cultured hepatoma cells. Regulation by essential amino acids. Biochim. Biophys. Acta 475:90\u201395; 1977.","journal-title":"Biochim. Biophys. Acta"},{"key":"BF02631255_CR25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"O. H. Lowry","year":"1951","unstructured":"Lowry, O. H.; Rosebrough, N. J.; Farr, A. L., et al. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265\u2013275; 1951.","journal-title":"J. Biol. Chem."},{"key":"BF02631255_CR26","first-page":"485","volume":"68","author":"D. Magielska-Zero","year":"1987","unstructured":"Magielska-Zero, D.; Rokita, H.; Cieska, K., et al. Comparison of the acute phase response of cultured Morris hepatoma 7777 cells and rat hepatocytes. Br. J. Exp. Pathol. 68:485\u2013492; 1987.","journal-title":"Br. J. Exp. Pathol."},{"key":"BF02631255_CR27","doi-asserted-by":"crossref","first-page":"13958","DOI":"10.1016\/S0021-9258(19)45326-X","volume":"257","author":"J. Massague","year":"1982","unstructured":"Massague, J.; Blunderman, L. A.; Czech, M. P. The high affinity insulin receptor mediates growth stimulation in rat hepatoma cell. J. Biol. Chem. 257:13958\u201313963; 1982.","journal-title":"J. Biol. Chem."},{"key":"BF02631255_CR28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0887-2333(90)90020-T","volume":"4","author":"T. Miura","year":"1990","unstructured":"Miura, T.; Takahashi, Y. The induction by monochlorobenzofuran isomers of xenobiotic metabolizing systems in cell lines derived from rat and human hepatoma. Toxic. In Vitro 4:185\u2013192; 1990.","journal-title":"Toxic. In Vitro"},{"key":"BF02631255_CR29","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1016\/S0021-9258(18)94484-4","volume":"243","author":"D. W. Nebert","year":"1968","unstructured":"Nebert, D. W.; Gelboin, H. V. Substrate-inducible microsomal aryl hydrolase in mammalian cell culture. J. Biol. Chem. 243:6242\u20136249; 1968.","journal-title":"J. Biol. Chem."},{"key":"BF02631255_CR30","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1146\/annurev.bi.56.070187.004501","volume":"56","author":"D. W. Nebert","year":"1987","unstructured":"Nebert, D. W.; Gonzalez, F. J. P450 Genes: structure, evolution, and regulation. Ann. Rev. Biochem. 56:945\u2013993; 1987.","journal-title":"Ann. Rev. Biochem."},{"key":"BF02631255_CR31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0163-7258(90)90030-6","volume":"45","author":"A. B. Okey","year":"1990","unstructured":"Okey, A. B. Enzyme induction in the cytochrome P450 system. Pharmacol. & Ther. 45:241\u2013298; 1990.","journal-title":"Pharmacol. & Ther."},{"key":"BF02631255_CR32","first-page":"229","volume":"13","author":"H. C. Pitot","year":"1964","unstructured":"Pitot, H. C.; Peraino, C.; Morse, P. A., et al. Hepatomas in tissue culture compared with adapting liver in vivo. Natl. Cancer Inst. Monogr. 13:229\u2013245; 1964.","journal-title":"Natl. Cancer Inst. Monogr."},{"key":"BF02631255_CR33","first-page":"236","volume":"40","author":"U. I. Richardson","year":"1969","unstructured":"Richardson, U. I.; Tashjian, A. H.; Levine, L. Establishment of a clonal strain of hepatoma cells which secrete albumin. J. Biol. Chem. 40:236\u2013247; 1969.","journal-title":"J. Biol. Chem."},{"key":"BF02631255_CR34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0300-483X(90)90016-A","volume":"61","author":"S. F. Roesch","year":"1990","unstructured":"Roesch, S. F.; Wiebel, F. J. Differential effects of 12-O-tetradecanoylphorbol 13-acetate on cytochrome P450-dependent monooxygenase activities in rat hepatoma cells. Induction of P-450I and suppression of P450II. Toxicology 61:147\u2013159; 1990.","journal-title":"Toxicology"},{"key":"BF02631255_CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0163-7258(90)90029-2","volume":"45","author":"D. E. Ryan","year":"1990","unstructured":"Ryan, D. E.; Levin, W. Purification and characterization of hepatic microsomal cytochrome P450. Pharmacol & Ther. 45:153\u2013239; 1990.","journal-title":"Pharmacol & Ther."},{"key":"BF02631255_CR36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0003-9861(87)90291-8","volume":"255","author":"A. J. Sonderfan","year":"1987","unstructured":"Sonderfan, A. J.; Arlotto, M. P.; Dutton, D. R., et al. Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P450. Arch. Biochem. Biophys. 255:27\u201341; 1987.","journal-title":"Arch. Biochem. Biophys."},{"key":"BF02631255_CR37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1247\/csf.6.61","volume":"6","author":"K. Sorimachi","year":"1981","unstructured":"Sorimachi, K.; Niwa, A.; Yasumura, Y. Hormonal regulation of tyrosine aminotransferase and phenylalanine hydroxylase in rat hepatoma cell continuously cultured in serum-free medium. Effect of serum, dexamethasone and insulin. Cell. Struct. Func. 6:61\u201368; 1981.","journal-title":"Cell. Struct. Func."},{"key":"BF02631255_CR38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0378-4347(93)80473-H","volume":"616","author":"W. Tassaneeyakul","year":"1993","unstructured":"Tassaneeyakul, W.; Veronese, M. E.; Birkett, D. J., et al. High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomes. J. Chromatogr. 616:73\u201378; 1993.","journal-title":"J. Chromatogr."},{"key":"BF02631255_CR39","doi-asserted-by":"crossref","first-page":"10893","DOI":"10.1016\/S0021-9258(18)61048-8","volume":"262","author":"R. Taub","year":"1987","unstructured":"Taub, R.; Roy, A.; Dieter, R., et al. Insulin growth factor in rat hepatoma cells. Stimulation of protooncogene expression. J. Biol. Chem. 262:10893\u201310897; 1987.","journal-title":"J. Biol. Chem."},{"key":"BF02631255_CR40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1073\/pnas.56.1.296","volume":"56","author":"E. B. Thompson","year":"1966","unstructured":"Thompson, E. B.; Tomkins, G. M.; Curran, J. F. Induction of tirosine transaminase by steroid hormones in a newly established tissue culture cell line. Proc. Natl. Acad. Sci. USA 56:296\u2013303; 1966.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02631255_CR41","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/0006-2952(90)90409-E","volume":"40","author":"L. Ch. Xu","year":"1990","unstructured":"Xu, L. Ch.; Bresnick, E. Induction of cytochrome P450IA1 in rat hepatoma cell by polycyclic hydrocarbons and a dioxin. Biochem. Pharmacol. 40:1399\u20131403; 1990.","journal-title":"Biochem. Pharmacol."},{"key":"BF02631255_CR42","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1073\/pnas.69.12.3580","volume":"69","author":"F. J. Wiebel","year":"1972","unstructured":"Wiebel, F. J.; Gelboin, H. V.; Coon, H. G. Regulation of aryl hydrocarbon hydroxylase in intraspecific hybrids of human, mouse and hamster cells. Proc. Natl. Acad. Sci. USA 69:3580\u20133584; 1972.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02631255_CR43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0009-2797(84)90069-3","volume":"52","author":"F. J. Wiebel","year":"1984","unstructured":"Wiebel, F. J.; Kiefer, F.; Murdia, U. S. Phenobarbital induces cytochrome P450 and cytochrome P448-dependent monooxygenases in rat hepatoma cells. Chem. Biol. Interact. 52:151\u2013162; 1984a.","journal-title":"Chem. Biol. Interact."},{"key":"BF02631255_CR44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1432-1033.1984.tb08577.x","volume":"145","author":"F. J. Wiebel","year":"1984","unstructured":"Wiebel, F. J.; Park, S. S.; Kiefer, F., et al. Expression of cytochrome P450 in rat hepatoma cells: analysis by monoclonal antibodies specific for cytochromes P450 from rat liver induced by 3-methylcholanthrene or phenobarbital. Eur. J. Biochem. 145:455\u2013462; 1984b.","journal-title":"Eur. J. Biochem."},{"key":"BF02631255_CR45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0006-291X(80)91254-1","volume":"94","author":"F. J. Wiebel","year":"1980","unstructured":"Wiebel, F. J.; Wolff, T.; Lambiotte, M. Presence of cytochrome P450 and cytochrome P448-dependent monooxygenase functions in hepatoma cell lines. Biochem. Biophys. Res. Commun. 94:466\u2013472; 1980.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF02631255_CR46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-4165(92)90093-A","volume":"1156","author":"D. K. Winters","year":"1992","unstructured":"Winters, D. K.; Cederbaum, A. I. Expression of a catalitically active human cytochrome P-450IIE1 inEscherichia coli. Biochim. Biophys. Acta 1156:43\u201349; 1992.","journal-title":"Biochim. Biophys. Acta"},{"key":"BF02631255_CR47","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0006-2952(91)90726-L","volume":"42","author":"H. M. Wortelboer","year":"1991","unstructured":"Wortelboer, H. M.; de Kruif, C. A.; van Iersel, A. A. J., et al. Comparison of cytochrome P-450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities. Biochem. Pharmacol. 42:381\u2013390; 1991.","journal-title":"Biochem. Pharmacol."}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02631255.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02631255\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02631255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T23:29:12Z","timestamp":1628897352000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02631255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["BF02631255"],"URL":"https:\/\/doi.org\/10.1007\/bf02631255","relation":{},"ISSN":["1071-2690","1543-706X"],"issn-type":[{"value":"1071-2690","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}