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Alzheimer\u8217s disease does not appear to involve any specific changes in lipid composition. An hypothesis to explain the findings in Alzheimer\u8217s disease is presented.<\/jats:p>","DOI":"10.1007\/bf02635578","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T01:26:57Z","timestamp":1180056417000},"page":"412-416","source":"Crossref","is-referenced-by-count":5,"title":["Speculations on the nature of the metabolic defects in Tay\u2010Sachs, Niemann\u2010Pick, Gaucher\u8217s and Alzheimer\u8217s diseases, and metachromatic leucodystrophy"],"prefix":"10.1002","volume":"42","author":[{"given":"George","family":"Rouser","sequence":"first","affiliation":[{"name":"Department of Biochemistry City of Hope Medical Center  Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Department of Biochemistry City of Hope Medical Center  Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry City of Hope Medical Center  Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1965,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"553","volume-title":"The Metabolic Basis Of Inherited Disease","author":"Frederickson D. 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