{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:18:31Z","timestamp":1789600711443,"version":"build-2803163510"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1007\/bf02685921","type":"journal-article","created":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T15:17:56Z","timestamp":1188400676000},"page":"81-89","source":"Crossref","is-referenced-by-count":11,"title":["Fluoride-induced oxidative stress of osteoblasts and protective effects of baicalein against fluoride toxicity"],"prefix":"10.1007","volume":"116","author":[{"given":"Xiang-Qun","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02685921_CR1","first-page":"103","volume":"34","author":"Y. M. Shivarajashankara","year":"2001","unstructured":"Y. M. Shivarajashankara, A. R. Shivarajashankara, S. H. Rao, et al., Oxidative stress in children with endemic skeletal fluorosis, Fluoride 34, 103\u2013107 (2001).","journal-title":"Fluoride"},{"key":"BF02685921_CR2","first-page":"27","volume":"31","author":"P. D. Patel","year":"1998","unstructured":"P. D. Patel and N. J. Chinoy, Influence of fluoride on biological free reactions in ovary of mice and its reversal, Fluoride 31, S27 (1998).","journal-title":"Fluoride"},{"key":"BF02685921_CR3","first-page":"26","volume":"31","author":"A. Shama","year":"1998","unstructured":"A. Shama and N. J. Chinoy, Role of free radical in fluoride-induced toxicity in liver and kidney of mice and its reversal, Fluoride 31, S26 (1998).","journal-title":"Fluoride"},{"key":"BF02685921_CR4","first-page":"43","volume":"31","author":"R. Rzeuski","year":"1998","unstructured":"R. Rzeuski, D. Chlubek, and Z. Machoy, Interactions between fluoride and biological free radical reaction, Fluoride 31, 43\u201345 (1998).","journal-title":"Fluoride"},{"key":"BF02685921_CR5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/abbi.1993.1509","volume":"306","author":"H. Hamada","year":"1993","unstructured":"H. Hamada, M. Hiramatsu, R. Edamatsu, et al., Free radical scavenging action of baicalein, Arch. Biochem. Biophys. 306, 261\u2013266 (1993).","journal-title":"Arch. Biochem. Biophys."},{"key":"BF02685921_CR6","first-page":"215","volume":"39","author":"D. Gao","year":"1996","unstructured":"D. Gao, K. Sakurai, M. Katoh, et al., Inhibition of microsomal lipid peroxidation by baicalein: a possible formation of an iron-baicalein complex, Biochem. Mol. Biol. Int. 39, 215\u2013225 (1996).","journal-title":"Biochem. Mol. Biol. Int."},{"key":"BF02685921_CR7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/abio.1997.2522","volume":"257","author":"M. Yoshino","year":"1998","unstructured":"M. Yoshino and K. Murakami, Interaction of iron with polyphenolic compounds: application to antioxidant characterization, Anal. Biochem. 257, 40\u201344 (1998).","journal-title":"Anal. Biochem."},{"key":"BF02685921_CR8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-4165(84)90046-1","volume":"802","author":"J. K. Heath","year":"1984","unstructured":"J. K. Heath, S. J. Atkinson, M. C. Meikle, et al., Mouse osteoblasts synthesize collagenase in response to bone resorbing agents, Biochim. Biophys. Acta 802, 151\u2013154 (1984).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF02685921_CR9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/jcp.1041490113","volume":"149","author":"P. Rajeswari","year":"1991","unstructured":"P. Rajeswari, R. Natarajan, J. L. Nadler, et al., Glucose induces lipid peroxidation and inactivation of membrane associated ion-transport enzymes in human erythrocytes in vivo and in vitro, J. Cell. Physiol. 149, 100\u2013109 (1991).","journal-title":"J. Cell. Physiol."},{"key":"BF02685921_CR10","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.6623079","volume":"222","author":"J. R. Fareley","year":"1983","unstructured":"J. R. Fareley, J. E. Wergedal, and D. J. Baylink, Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells, Science, 222, 330\u2013332 (1983).","journal-title":"Science"},{"key":"BF02685921_CR11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/8756-3282(93)90203-M","volume":"14","author":"P. Chavassieux","year":"1993","unstructured":"P. Chavassieux, G. Boivin, C. M. Serre, et al., Fluoride increases rat osteoblast function and population after in vivo administration but not after in vitro exposure, Bone 14, 721\u2013725 (1993).","journal-title":"Bone"},{"key":"BF02685921_CR12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/kfg030","volume":"72","author":"G. B. Reddy","year":"2003","unstructured":"G. B. Reddy, A. L. Khandare, P. Y. Reddy, et al., Antioxidant defense system and lipid peroxidation in patients with skeletal fluorosis and in fluoride-intoxicated rabbits, Toxicol. Sci. 72, 363\u2013368 (2003).","journal-title":"Toxicol. Sci."},{"key":"BF02685921_CR13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0304-3940(96)12897-4","volume":"214","author":"Y. C. Ni","year":"1996","unstructured":"Y. C. Ni, B. L. Zhao, J. W. Hou, et al., Preventive effect of ginkgobiloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals, Neurosci. Lett. 214, 115\u2013118 (1996).","journal-title":"Neurosci. Lett."},{"key":"BF02685921_CR14","first-page":"397","volume":"47","author":"C. Chen","year":"1999","unstructured":"C. Chen, T. Wei, Z. Gao, et al., Different effects of the constituents of EGb761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals, Biochem. Mol. Biol. Int. 47, 397\u2013405 (1999).","journal-title":"Biochem. Mol. Biol. Int."},{"key":"BF02685921_CR15","first-page":"643","volume":"1472","author":"Z. H. Gao","year":"1999","unstructured":"Z. H. Gao, K. X. Huang, X. Yang, et al., Free radical scavenging and antioxidant activity of flavonoids extracted from the radix of Scutellaria baicalensis Georgi, Biochem. Biophys Acta 1472, 643\u2013650 (1999).","journal-title":"Acta"},{"key":"BF02685921_CR16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/phrs.2000.0761","volume":"43","author":"Z. H. Gao","year":"2001","unstructured":"Z. H. Gao, K. X. Huang, and H. B. Xu, Protective effects of flavonids in the roots of Scutellaria baicalensis georgi against hydrogen peroxide-induced oxidative stress in HSS-SY5Y cells, Pharmacol. Res. 43, 173\u2013178 (2001).","journal-title":"Pharmacol. Res."}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02685921.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02685921\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02685921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T08:11:19Z","timestamp":1558339879000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02685921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["BF02685921"],"URL":"https:\/\/doi.org\/10.1007\/bf02685921","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}