{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:43:10Z","timestamp":1767969790230,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1007\/bf02686081","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T14:17:41Z","timestamp":1187273861000},"page":"47-55","source":"Crossref","is-referenced-by-count":27,"title":["Increased Prevalence of Anti-Third Generation Cyclic Citrullinated Peptide Antibodies in Patients With Rheumatoid Arthritis and CREST Syndrome"],"prefix":"10.1007","volume":"32","author":[{"given":"R.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Shovman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gilburd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zandman-Goodard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02686081_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0049-0172(95)80004-2","volume":"24","author":"Von Muhien","year":"1995","unstructured":"Von Muhien, and Tan, E. M. (1995). Antoantibodies in the diagnosis of systemic rheumatic diseases. Semin Arthritis Rheum, 24, 323\u2013358.","journal-title":"Semin Arthritis Rheum"},{"key":"BF02686081_CR2","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1006\/bbrc.1996.1240","volume":"225","author":"T. Senshu","year":"1996","unstructured":"Senshu, T., Kan, S., Ogawa, H., Manabe, M., and Asaga, H. (1996). Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis. Biochem Biophys Res Commun\n                           225, 712\u2013719.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF02686081_CR3","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/bies.10357","volume":"25","author":"E. R. Vossenaar","year":"2003","unstructured":"Vossenaar, E. R., Zendman, A. J., van Venrooij, W. J., Pruijn, G. J., (2003), PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioassays\n                           25, 1106\u20131118.","journal-title":"Bioassays"},{"key":"BF02686081_CR4","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/art.10148","volume":"46","author":"ACR Subcommittee on RA Guidelines","year":"2002","unstructured":"ACR Subcommittee on RA Guidelines (2002), Guidelines for the management of rheumatoid arthritis. Arthritis Rheum\n                           46, 328\u2013346.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR5","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/ar93","volume":"2","author":"R. Goldbach-Mansky","year":"2000","unstructured":"Goldbach-Mansky, R., Lee, J., McCoy, A., et al. (2000), Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res\n                           2, 236\u2013243.","journal-title":"Arthritis Res"},{"key":"BF02686081_CR6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1172\/JCI1316","volume":"101","author":"G. A. Schellekens","year":"1998","unstructured":"Schellekens, G. A., de Jong, B. A., van den Hoogen, F. H., van de Putte, L. B., and van Venrooij, W. J. (1998), Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest\n                           101, 273\u2013281.","journal-title":"J Clin Invest"},{"key":"BF02686081_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","volume":"43","author":"G. A. Schellekens","year":"2000","unstructured":"Schellekens, G. A., Visser, H., de Jong, B. A., et al. (2000), The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinate peptide. Arthritis Rheum\n                           43, 155\u2013163.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR8","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/art.20018","volume":"50","author":"M. M. Nielen","year":"2004","unstructured":"Nielen, M. M., van Schaardenburg, D., Reesink, H. W., et al. (2004), Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum\n                           50, 380\u2013386.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR9","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1002\/art.11223","volume":"48","author":"S. Rantapaa-Dahlqvist","year":"2003","unstructured":"Rantapaa-Dahlqvist, S., de Jong, BA, Berglin, E., et al. (2003), Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum\n                           48, 2741\u20132749.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/03009740310003677","volume":"32","author":"K. Suzuki","year":"2003","unstructured":"Suzuki, K., Sawada, T., Murakami, A., et al. (2003), High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol\n                           32, 197\u2013204.","journal-title":"Scand J Rheumatol"},{"key":"BF02686081_CR11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10067-006-0275-5","volume":"26","author":"S. Agrawal","year":"2007","unstructured":"Agrawal, S., Misra, R., and Aggarwal, A. (2007), Autoantibodies in rheumatoid arthritis: association with severity of disease in established RA. Clin Rheumatol\n                           26, 201\u2013204.","journal-title":"Clin Rheumatol"},{"key":"BF02686081_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/17402520500233510","volume":"12","author":"O. Shovman","year":"2005","unstructured":"Shovman, O., Gilburd, B., Zandman-Goddard, G., et al. (2005), The diagnostic utility of anti-cyclic circullinated peptide antibodies, matrix metalloproteinase-3, rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein in patients with erosive and non-erosive rheumatoid arthritis. Clin Dev Immunol\n                           12, 197\u2013202.","journal-title":"Clin Dev Immunol"},{"key":"BF02686081_CR13","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1136\/ard.62.5.427","volume":"62","author":"J. Vencovsky","year":"2003","unstructured":"Vencovsky, J., Machacek, S., Sedova, L., et al. (2003), Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis. Ann Rheum Dis\n                           62, 427\u2013430.","journal-title":"Ann Rheum Dis"},{"key":"BF02686081_CR14","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1136\/ard.62.2.120","volume":"62","author":"O. Meyer","year":"2003","unstructured":"Meyer, O., Labarre, C., Dougados, M., et al. (2003), Anticitrullinated protein\/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage. Ann Rheum Dis\n                           62, 120\u2013126.","journal-title":"Ann Rheum Dis"},{"key":"BF02686081_CR15","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1136\/ard.2003.014233","volume":"63","author":"K. Forslind","year":"2004","unstructured":"Forslind, K., Ahlmen, M., Eberhardt, K., et al. (2004), Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP). Ann Rheum Dis\n                           63, 1090\u20131095.","journal-title":"Ann Rheum Dis"},{"key":"BF02686081_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/art.10117","volume":"4","author":"H. Visser","year":"2002","unstructured":"Visser, H., le Cessie, S., Vos, K., Breedveld, F. C., and Hazes, J. M. (2002), How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis Rheum, 4, 357\u2013365.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR17","first-page":"892","volume":"4","author":"H. Orbach","year":"2002","unstructured":"Orbach, H., Gilburd, B., Brickman, C., Gerli, R., and Shoenfeld, Y. (2002), Anti-cyclic peptide antibodies as a diagnostic test for rheumatoid arthritis and predictor of an erosive disease. IMAJ\n                           4, 892\u2013893.","journal-title":"IMAJ"},{"key":"BF02686081_CR18","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1002\/1529-0131(200110)44:10<2255::AID-ART388>3.0.CO;2-#","volume":"44","author":"D. Baeten","year":"2001","unstructured":"Baeten, D., Peene, I., Union, A., et al. (2001), Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. Arthritis Rheum, 44, 2255\u20132262.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/ar395","volume":"4","author":"M. A. van Boekel","year":"2002","unstructured":"van Boekel, M. A., Vossenaar, E. R., van den Hoogen, F. H., van Venrooij, W. J. (2002), Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res\n                           4, 87\u201393.","journal-title":"Arthritis Res"},{"key":"BF02686081_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.cair.2003.11.001","volume":"4","author":"E. R. Vossenaar","year":"2004","unstructured":"Vossenaar, E. R. and van Venrooij, W. J. (2004) Anti-CCP antibodies, a specific marker for (early) rheumatoid arthritis. Clin Appl Immunol Rev\n                           4, 239\u2013262.","journal-title":"Clin Appl Immunol Rev"},{"key":"BF02686081_CR21","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1136\/ard.2003.019877","volume":"63","author":"I. Vallbracht","year":"2004","unstructured":"Vallbracht, I., Rieber, J., Oppermann, M., Forger, F., Siebert, U., and Helmke, K. (2004), Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis. Ann Rheum Dis\n                           63, 1079\u20131084.","journal-title":"Ann Rheum Dis"},{"key":"BF02686081_CR22","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/rheumatology\/keg184","volume":"42","author":"S. Bas","year":"2003","unstructured":"Bas, S., Genevay, S., Meyer, O., and Gabay, C. (2003), Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis. Rheumatology (Oxford)\n                           42, 677\u2013680.","journal-title":"Rheumatology (Oxford)"},{"key":"BF02686081_CR23","first-page":"689","volume":"17","author":"C-.H. van Jaarsveld","year":"1999","unstructured":"van Jaarsveld, C-.H., ter Borg, E. J., Jacobs, J. W., et al. (1999), The prognostic value of the antiperinuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritis. Clin Exp Rheumatol. 17, 689\u2013697.","journal-title":"Clin Exp Rheumatol"},{"key":"BF02686081_CR24","first-page":"2535","volume":"30","author":"A. Saraux","year":"2003","unstructured":"Saraux, A., Berthelot, J. M., Devauchelle, V., et al. (2003), Value of antibodies to citrulline-containing peptides for diagnosing early rheumatoid arthritis. J Rheumatoln\n                           30, 2535\u20132539.","journal-title":"J Rheumatoln"},{"key":"BF02686081_CR25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1365-2249.2004.02341.x","volume":"135","author":"O. Vittecoq","year":"2004","unstructured":"Vittecoq, O., Incaurgarat, B., Jouen-Beades, F., et al. (2004), Autoantibodies recognizing citrullinated rat filaggrin in an ELISA using citrullinated and non-citrullinated recombinant proteins as antigens are highly diagnostic for rheumatoid arthritis. Clin Exp Immunol\n                           135, 173\u2013180.","journal-title":"Clin Exp Immunol"},{"key":"BF02686081_CR26","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"F. C. Arnett","year":"1988","unstructured":"Arnett, F. C., Edworthy, S. M., Bloch, D. A., et al. (1988), The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum\n                           31, 315\u2013324.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR27","first-page":"1451","volume":"30","author":"X. Zeng","year":"2003","unstructured":"Zeng, X., Ai, M., Tian, X., et al. (2003), Diagnostic value of anti-cyclic citrullinated Peptide antibody in patients with rheumatoid arthritis. J Rheumatol\n                           30, 1451\u20131455.","journal-title":"J Rheumatol"},{"key":"BF02686081_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1136\/ard.60.1.67","volume":"60","author":"R. Mediwake","year":"2001","unstructured":"Mediwake, R., Isenberg, D. A., Schellekens, G. A., and van Venrooij, W. J. (2001), Use of anti-citrullinated peptide and anti-RA33 antibodies in distinguishing erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis. Ann Rheum Dis\n                           60, 67\u201368.","journal-title":"Ann Rheum Dis"},{"key":"BF02686081_CR29","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1093\/rheumatology\/keh143","volume":"43","author":"M. Lopez-Hoyos","year":"2004","unstructured":"Lopez-Hoyos, M., Ruiz de Algegria, C., Blanco, R., et al. (2004), Clinical utility of anti-CCP antibodies in the differential diagnosis of elderly-onset rheumatoid arthritis and polymyalgia rheumatica. Rheumatology (Oxford)\n                           43, 655\u2013657.","journal-title":"Rheumatology (Oxford)"},{"key":"BF02686081_CR30","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1136\/ard.2003.019794","volume":"64","author":"J. E. Gottenberg","year":"2005","unstructured":"Gottenberg, J. E., Mignot, S., Nicaise-Rolland, P., et al. (2005), Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren\u2019s syndrome. Ann Rheum Dis\n                           64, 114\u2013147.","journal-title":"Ann Rheum Dis"},{"key":"BF02686081_CR31","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s10067-005-1104-y","volume":"24","author":"S. Kamali","year":"2005","unstructured":"Kamali, S., Polat, N. G., Kasapoglu, E., et al. (2005), Anti-CCP and antikeratin antibodies in rheumatoid arthritis, primary Sjogren\u2019s syndrome, and Wegener\u2019s granulomatosis. Clin Rheumatol\n                           24, 673\u2013676.","journal-title":"Clin Rheumatol"},{"key":"BF02686081_CR32","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1136\/ard.2005.040998","volume":"65","author":"G. M. Alenius","year":"2006","unstructured":"Alenius, G. M., Berglin, E., Rantapaa Dahlqvist, S., (2006), Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation. Ann Rheum Dis\n                           65, 398\u2013400.","journal-title":"Ann Rheum Dis"},{"key":"BF02686081_CR33","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.1002\/art.20584","volume":"50","author":"E. R. Vossenaar","year":"2004","unstructured":"Vossenaar, E. R., Smeets, T. J., Kraan, M. C., Raats, J. M., van Venrooij, W. J., and Tak, P. P. (2004), The presence of citrullinated proteins is not specific for rheumatoid synovial tissue., Arthritis Rheum\n                           50, 3485\u20133494.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR34","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/0002-9343(80)90462-3","volume":"69","author":"M. J. Fritzler","year":"1980","unstructured":"Fritzler, M. J., and Kinsella, T. D. (1980), The CREST syndrome: a distinct serologic entity with anticentromere antibodies. Am J Med\n                           69, 520\u2013526.","journal-title":"Am J Med"},{"key":"BF02686081_CR35","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/art.1780310309","volume":"31","author":"E. S. Weiner","year":"1988","unstructured":"Weiner, E. S., Earnshaw, W. C., Senecal, J. L., Bordwell, B., Johnson, P., and Rothfield, N. F. (1988), Clinical associations of anticentromere antibodies and antibodies to topoisomerase I. A study of 355 patients. Arthritis Rheum\n                           31, 378\u2013385.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR36","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/art.1780230602","volume":"23","author":"E. M. Tan","year":"1980","unstructured":"Tan, E. M., Rodnan, G. P., Garcia, J., Moroi, Y., Fritzler, M. J., and Peebles, C. (1980), Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome. Arthritis Rheum\n                           23, 617\u2013625.","journal-title":"Arthritis Rheum"},{"key":"BF02686081_CR37","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/BF00262092","volume":"14","author":"P. Caramaschi","year":"1995","unstructured":"Caramaschi, P., Biasi, D., Manzo, T., Carletto, A., Poli, F., and Bambara, L. M. (1995), Anticentromere antibody\u2014clinical associations. A study of 44 patients. Rheumatol of Int\n                           14, 253\u2013255.","journal-title":"Rheumatol of Int"},{"key":"BF02686081_CR38","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/BF02242937","volume":"13","author":"M. Zuber","year":"1994","unstructured":"Zuber, M., Gotzen, R., Filler, I. (1994), Clinical correlation of anticentromere antibodies. Clin Rheumatol\n                           13, 427\u2013432.","journal-title":"Clin Rheumatol"},{"key":"BF02686081_CR39","first-page":"1488","volume":"32","author":"S. Miyawaki","year":"2005","unstructured":"Miyawaki, S., Asanuma, H., Nishiyama, S., and Yoshinaga, Y. (2005), Clinical and serological heterogeneity in patients with anticentromere antibodies. J Rheumatol\n                           32, 1488\u20131494.","journal-title":"J Rheumatol"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02686081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF02686081\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02686081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02686081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T22:26:00Z","timestamp":1652653560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF02686081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["BF02686081"],"URL":"https:\/\/doi.org\/10.1007\/bf02686081","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}