{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:30:41Z","timestamp":1782761441527,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuro-Oncol"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1007\/bf02700027","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T05:51:50Z","timestamp":1190094710000},"page":"125-137","source":"Crossref","is-referenced-by-count":105,"title":["Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma"],"prefix":"10.1007","volume":"64","author":[{"given":"Friedrich","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Asher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bucholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Prados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai G.","family":"Rainov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Westphal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Warnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Rand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Floeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay N.","family":"Hingorani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj K.","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02700027_CR1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1056\/NEJM200101113440207","volume":"344","author":"LM DeAngelis","year":"2001","unstructured":"DeAngelis LM: Brain tumors. N Engl J Med 344: 114\u2013123, 2001","journal-title":"N Engl J Med"},{"key":"BF02700027_CR2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/neuonc\/1.1.14","volume":"1","author":"TS Surawicz","year":"1999","unstructured":"Surawicz TS et al.: Descriptive epidemiology of primary and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990\u20131994. Neuro-Oncology 1:14\u201325, 1999","journal-title":"Neuro-Oncology"},{"issue":"4","key":"BF02700027_CR3","first-page":"899","volume":"7","author":"J Guyotat","year":"2000","unstructured":"Guyotat J, Signorelli F, Frappaz D et al.: Is reoperation for recurrence of glioblastoma justified? Oncol Rep 7(4): 899\u2013904, 2000","journal-title":"Oncol Rep"},{"key":"BF02700027_CR4","first-page":"326","volume":"6","author":"AE Frankel","year":"2000","unstructured":"Frankel AE, Kreitman RJ, Sausville EA: Targeted toxins. Clin Cancer Res 6: 326\u2013334, 2000","journal-title":"Clin Cancer Res"},{"key":"BF02700027_CR5","first-page":"316","volume":"59","author":"W Jin","year":"1999","unstructured":"Jin W, Bi W, Huang ES et al.: Glioblastoma cell-specific expression of fibroblast growth factor receptor-1beta requires an intronic repressor of RNA splicing. Cancer Res 59: 316\u2013319, 1999","journal-title":"Cancer Res"},{"key":"BF02700027_CR6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/glia.440150306","volume":"15","author":"SN Kurpad","year":"1995","unstructured":"Kurpad SN, Zhao XG, Wikstrand CJ et al.: Tumor antigens in astrocytic gliomas. Glia 15: 244\u2013256, 1995","journal-title":"Glia"},{"key":"BF02700027_CR7","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/nm1297-1362","volume":"3","author":"DW Laske","year":"1997","unstructured":"Laske DW, Youle RJ, Oldfield EH: Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med 3: 1362\u20131368, 1997","journal-title":"Nat Med"},{"key":"BF02700027_CR8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ijc.2910580421","volume":"58","author":"RK Puri","year":"1994","unstructured":"Puri RK, Leland P, Kreitman RJ et al.: Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein. Int J Cancer 58: 574\u2013581, 1994","journal-title":"Int J Cancer"},{"key":"BF02700027_CR9","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/bjc.1997.147","volume":"75","author":"AM Massimo Di","year":"1997","unstructured":"Di Massimo AM, Di Loreto M, Pacilli A et al.: Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata. Br J Cancer 75: 822\u2013828, 1997","journal-title":"Br J Cancer"},{"key":"BF02700027_CR10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00666210","volume":"32","author":"CF LeMaistre","year":"1994","unstructured":"LeMaistre CF, Meneghetti C, Howes L et al.: Targeting the EGF receptor in breast cancer treatment. Breast Cancer Res Treat 32: 97\u2013103, 1994","journal-title":"Breast Cancer Res Treat"},{"key":"BF02700027_CR11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1182>3.0.CO;2-N","volume":"92","author":"SR Husain","year":"2001","unstructured":"Husain SR, Joshi BH, Puri RK: Interleukin-13 receptor as a unique target for anti-glioblastoma therapy. Int J Cancer 92: 168\u2013175, 2001","journal-title":"Int J Cancer"},{"key":"BF02700027_CR12","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1006\/cyto.2000.0773","volume":"12","author":"H Liu","year":"2000","unstructured":"Liu H, Prayson RA, Estes ML et al.:In vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex. Cytokine 12: 1656\u20131661, 2000","journal-title":"Cytokine"},{"key":"BF02700027_CR13","first-page":"1103","volume":"62","author":"SO Rahaman","year":"2002","unstructured":"Rahaman SO, Shrama P, Harbor PC et al.: Il-13Ralpha2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transudation in glioblastoma cells. Cancer Res 62: 1103\u20131109, 2002","journal-title":"Cancer Res"},{"key":"BF02700027_CR14","first-page":"1168","volume":"60","author":"BH Joshi","year":"2000","unstructured":"Joshi BH, Plautz GE, Puri RK: Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas. Cancer Res 60: 1168\u20131172, 2000","journal-title":"Cancer Res"},{"key":"BF02700027_CR15","first-page":"8058","volume":"61","author":"BH Joshi","year":"2001","unstructured":"Joshi BH, Leland P, Asher A et al.:In situ expression of Interleukin-4 receptors in human brain tumors and cytotoxicity of a recombinant interleukin-4 (IL-4) cytotoxin in primary glioblastoma cell cultures. Cancer Res 61: 8058\u20138061, 2001","journal-title":"Cancer Res"},{"key":"BF02700027_CR16","first-page":"3649","volume":"58","author":"SR Husain","year":"1998","unstructured":"Husain SR, Behari N, Kreitman RJ et al.: Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy. Cancer Res 58: 3649\u20133653, 1998","journal-title":"Cancer Res"},{"key":"BF02700027_CR17","first-page":"5631","volume":"56","author":"RK Puri","year":"1996","unstructured":"Puri RK, Hoon DS, Leland P et al.: Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. Cancer Res 56: 5631\u20135637, 1996","journal-title":"Cancer Res"},{"key":"BF02700027_CR18","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1073\/pnas.91.6.2076","volume":"91","author":"RH Bobo","year":"1994","unstructured":"Bobo RH, Laske DW, Akbasak A et al.: Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 91: 2076\u20132080, 1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02700027_CR19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3171\/jns.1994.80.3.0520","volume":"80","author":"DW Laske","year":"1994","unstructured":"Laske DW, Ilercil O, Akbasak A et al.: Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. J Neurosurg 80: 520\u2013526, 1994","journal-title":"J Neurosurg"},{"key":"BF02700027_CR20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3171\/jns.1995.82.6.1021","volume":"82","author":"DM Lieberman","year":"1995","unstructured":"Lieberman DM, Laske DW, Morrison PF et al.: Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 82: 1021\u20131029, 1995","journal-title":"J Neurosurg"},{"key":"BF02700027_CR21","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1073\/pnas.91.15.6889","volume":"91","author":"RJ Kreitman","year":"1994","unstructured":"Kreitman RJ, Puri RK, Pastan I: A circularly permuted recombinant interleukin 4 toxin with increased activity. Proc Natl Acad Sci USA 91: 6889\u20136893, 1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02700027_CR22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0140-6736(95)90755-6","volume":"345","author":"H Brem","year":"1995","unstructured":"Brem H, Piantadosi S, Burger PC et al.: Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-Brain Tumor Treatment Group. Lancet 345: 1008\u20131012, 1995","journal-title":"Lancet"},{"key":"BF02700027_CR23","first-page":"3357","volume":"55","author":"RJ Kreitman","year":"1995","unstructured":"Kreitman RJ, Puri RK, Pastan I: Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma. Cancer Res 55: 3357\u20133363, 1995","journal-title":"Cancer Res"},{"key":"BF02700027_CR24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/cimm.1996.0176","volume":"171","author":"RK Puri","year":"1996","unstructured":"Puri RK, Leland P, Obiri NI et al.: An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. Cell Immunol 171: 80\u201386, 1996","journal-title":"Cell Immunol"},{"key":"BF02700027_CR25","first-page":"2157","volume":"6","author":"RW Rand","year":"2000","unstructured":"Rand RW, Kreitman RJ, Patronas N et al.: Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma. Clin Cancer Res 6: 2157\u20132165, 2000","journal-title":"Clin Cancer Res"}],"container-title":["Journal of Neuro-oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02700027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02700027\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02700027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T23:37:13Z","timestamp":1558222633000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02700027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":25,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["BF02700027"],"URL":"https:\/\/doi.org\/10.1007\/bf02700027","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}