{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:32:27Z","timestamp":1771230747927,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[1990,12]]},"DOI":"10.1007\/bf02719705","type":"journal-article","created":{"date-parts":[[2009,5,6]],"date-time":"2009-05-06T10:34:33Z","timestamp":1241606073000},"page":"285-293","source":"Crossref","is-referenced-by-count":23,"title":["Effects of erdosteine on sputum biochemical and rheologic properties: Pharmacokinetics in chronic obstructive lung disease"],"prefix":"10.1007","volume":"168","author":[{"given":"C. F.","family":"Marchioni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Casadei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Guerzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Scuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Fregnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02719705_CR1","first-page":"235","volume":"27","author":"GL Biagi","year":"1989","unstructured":"Biagi GL, Fregnan GB, Gazzani G, Vandoni G (1989) Erdosteine protection from cigarette smoke-induced loss of\u03b11-antitrypsin activity in rat lungs. Int J Clin Pharmacol Ther Toxicol 27:235\u2013237","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"BF02719705_CR2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1042\/bj0950612","volume":"95","author":"DN Croft","year":"1965","unstructured":"Croft DN, Lubran N (1965) The estimation of deoxyribonucleic acid in the present of sialic acid: application to analysis of human gastric washings. Biochem J 95:612\u2013621","journal-title":"Biochem J"},{"key":"BF02719705_CR3","first-page":"299","volume":"42","author":"G Fumagalli","year":"1988","unstructured":"Fumagalli G, Balzarotti P, Banfi P, Dec\u00f2 P, Ferrante L, Zennaro M (1988) Erdosteine: a new molecule with mucolytic activity. Clinical and instrumental evaluation in patients with acute and exacerbated chronic bronchopneumopathies. G Ital Mal Tor 42:299\u2013308","journal-title":"G Ital Mal Tor"},{"key":"BF02719705_CR4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000195713","volume":"55","author":"G Gazzani","year":"1989","unstructured":"Gazzani G, Fregnan GB, Vandoni G (1989) In vitro protection by erdosteine against oxidative inactivation of alpha-1-antitrypsin by cigarette smoke. Respiration 55:113\u2013118","journal-title":"Respiration"},{"key":"BF02719705_CR5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1039\/an9558000268","volume":"80","author":"MN Gibbons","year":"1955","unstructured":"Gibbons MN (1955) The determination of methylpentoses. Analyst 80:268\u2013276","journal-title":"Analyst"},{"key":"BF02719705_CR6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0009-8981(81)90446-0","volume":"113","author":"F Girard","year":"1981","unstructured":"Girard F, Tourhier JM, Polu JM, Puchelle E, Beck G, Sadoul P (1981) Ultrasonic method of sputum homogenization and its application in the study of the enzymic content of sputum. Clin Chem Acta 113:105\u2013109","journal-title":"Clin Chem Acta"},{"key":"BF02719705_CR7","first-page":"76","volume":"41","author":"M Gobetti","year":"1986","unstructured":"Gobetti M, Pedrazzoli A, Bradamante S (1986) DL-S-(2-[N-3-(2-oxo-tetrahydrothienyl)acetamido])-thioglycolic acid: a novel mucolytic agent of the class of homocysteine thiolactone derivatives. Farmaco (Sci) 41:76\u201379","journal-title":"Farmaco (Sci)"},{"key":"BF02719705_CR8","first-page":"289","volume-title":"Respiratory defense mechanisms. Part I","author":"MT Lopez-Vidriero","year":"1977","unstructured":"Lopez-Vidriero MT, Das I (1977) Airways secretion: source, biochemical and rheological properties. In: Brain JD, Proctor DF, Reid L (eds) Respiratory defense mechanisms. Part I, Marcel Dekker, New York, pp 289\u2013356"},{"key":"BF02719705_CR9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/oxfordjournals.bmb.a071461","volume":"34","author":"MT Lopez-Vidriero","year":"1978","unstructured":"Lopez-Vidriero MT, Reid L (1978) Bronchial mucus in health and disease. Br Med Bull 34:63\u201374","journal-title":"Br Med Bull"},{"key":"BF02719705_CR10","first-page":"465","volume":"117","author":"MT Lopez-Vidriero","year":"1978","unstructured":"Lopez-Vidriero MT, Reid L (1978) Chemical markers of mucus and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases. Am Rev Respir Dis 117:465\u2013477","journal-title":"Am Rev Respir Dis"},{"key":"BF02719705_CR11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"O Lowry","year":"1951","unstructured":"Lowry O, Rosembroght NJ, Randall RL (1951) Protein measurement with the Folin Phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"BF02719705_CR12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","volume":"2","author":"G Mancini","year":"1965","unstructured":"Mancini G, Carbonara A, Heremans JF (1965) Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2:235\u2013254","journal-title":"Immunochemistry"},{"key":"BF02719705_CR13","first-page":"775","volume":"1","author":"Medical Research Council","year":"1965","unstructured":"Medical Research Council (1965) Definition and classification of chronic bronchitis for clinical and epidemiological purposes. Lancet 1:775\u2013779","journal-title":"Lancet"},{"key":"BF02719705_CR14","first-page":"171","volume-title":"Methods in bronchial mucology","author":"M Moretti","year":"1988","unstructured":"Moretti M (1988) Proteins, deoxyribonucleic acid and ion identification. In: Braga PC, Allegra L (eds) Methods in bronchial mucology, Raven Press, New York, pp 171\u2013188"},{"key":"BF02719705_CR15","first-page":"360","volume":"65","author":"M Moretti","year":"1984","unstructured":"Moretti M, Giannico G, Marchioni CF, Bisetti A (1984) Effect of methylprednisolone on sputum biochemical components in asthmatic bronchitis. Eur J Respir Dis 65:360\u2013365","journal-title":"Eur J Respir Dis"},{"key":"BF02719705_CR16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0003-2697(81)90498-X","volume":"114","author":"GL Newton","year":"1981","unstructured":"Newton GL, Dorion R, Fahey R (1981) Analysis of biological thiols: derivatization with monobromobimane and separation by reserve-phase high-performance liquid chromatography. Anal Biochem 114:383\u2013387","journal-title":"Anal Biochem"},{"key":"BF02719705_CR17","doi-asserted-by":"crossref","unstructured":"Olivieri D, Del Donno M, Casalini A, Fregnan GB (1990) Effect of erdosteine on mucociliary transport in patients affected by chronic bronchitis. Respiration, in press","DOI":"10.1159\/000195904"},{"key":"BF02719705_CR18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1056\/NEJM196402062700602","volume":"270","author":"DJ Prockop","year":"1964","unstructured":"Prockop DJ, Davidson WD (1964) A study of urinary and serum lysozyme in patients with renal disease. N Engl J Med 270:269\u2013274","journal-title":"N Engl J Med"},{"key":"BF02719705_CR19","first-page":"237","volume":"9","author":"E Puchelle","year":"1973","unstructured":"Puchelle E, Zahm JM, Havez R (1973) Donn\u00e9es biochimiques et rheologiques dans l\u2019expectoration. III-Relation des prot\u00e9ines et mucines bronchiques avec le propri\u00e9tes rh\u00e9ologiques. Bull Physiopathol Respir 9:237\u2013256","journal-title":"Bull Physiopathol Respir"},{"key":"BF02719705_CR20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/thx.43.8.585","volume":"43","author":"G Ricevuti","year":"1988","unstructured":"Ricevuti G, Mazzone A, Uccelli E, Gazzani G, Fregnan GB (1988) Influence of erdosteine, a mucolytic agent, on amoxycillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis. Thorax 43:585\u2013590","journal-title":"Thorax"},{"key":"BF02719705_CR21","first-page":"693","volume":"14","author":"R Scuri","year":"1988","unstructured":"Scuri R, Giannetti P, Paesano A (1988) Effect of erdosteine and its metabolites on tracheobronchial mucus production and transport. Drugs Exp Clin Res 14:693\u2013698","journal-title":"Drugs Exp Clin Res"},{"key":"BF02719705_CR22","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/jps.2600650713","volume":"65","author":"AJ Sedman","year":"1976","unstructured":"Sedman AJ, Wagner JG (1976) CSTRIP, a Fortran IV computer program for obtaining initial polyexponential parameter estimates. J Pharmacol Sci 65:1006\u20131010","journal-title":"J Pharmacol Sci"},{"key":"BF02719705_CR23","first-page":"238","volume":"27","author":"M Vagliasindi","year":"1989","unstructured":"Vagliasindi M, Fregnan GB (1989) Erdosteine protection against cigarette smoke-induced functional antiprotease deficiency in human bronchoalveolar structures. Int J Clin Pharmacol Ther Toxicol 27:238\u2013241","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"BF02719705_CR24","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/S0021-9258(18)69851-5","volume":"234","author":"L Warren","year":"1956","unstructured":"Warren L (1956) The thiobarbituric acid assay of sialic acids. J Biol Chem 234:1971\u20131975","journal-title":"J Biol Chem"},{"key":"BF02719705_CR25","first-page":"60","volume-title":"Respiratory pharmacology and therapeutics","author":"I Ziment","year":"1978","unstructured":"Ziment I (1978) Mucokinetic agents. In: Ziment I (ed) Respiratory pharmacology and therapeutics, WB Saunders, Philadelphia, pp 60\u2013104"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02719705.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02719705\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02719705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:37:49Z","timestamp":1633394269000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02719705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["BF02719705"],"URL":"https:\/\/doi.org\/10.1007\/bf02719705","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}