{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:48:36Z","timestamp":1762505316191},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[1998,8]]},"DOI":"10.1007\/bf02786513","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T17:46:43Z","timestamp":1198172803000},"page":"55-60","source":"Crossref","is-referenced-by-count":35,"title":["Partial lipodystrophy, mesangiocapillary glomerulonephritis, and complement dysregulation"],"prefix":"10.1007","volume":"18","author":[{"given":"Yair","family":"Levy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Yona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02786513_CR1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1542\/peds.33.4.593","volume":"33","author":"B Senior","year":"1964","unstructured":"Senior B, Gellis SS. The syndromes of total lipodystrophy and partial lipodystrophy. Pediatrics 1964;33:593\u2013612.","journal-title":"Pediatrics"},{"key":"BF02786513_CR2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.7326\/0003-4819-73-6-963","volume":"73","author":"RL,Vieweg WVR Piscatelli","year":"1970","unstructured":"Piscatelli RL,Vieweg WVR, Hvel RJ. Partial lipodystrophy:metabolic studies in three patients. Ann Intern Med 1970;73:963\u2013970.","journal-title":"Ann Intern Med"},{"key":"BF02786513_CR3","first-page":"605","volume":"96","author":"SS Gellis","year":"1958","unstructured":"Gellis SS, Green S, Walker D. Chronic renal disease in children with lipodystrophy. Am J Dis Child 1958;96:605\u2013611.","journal-title":"Am J Dis Child"},{"key":"BF02786513_CR4","first-page":"343","volume":"41","author":"AJ Eisinger","year":"1972","unstructured":"Eisinger AJ, Shortland JR, Moorhead PJ. Renal disease in partial lipodystrophy. Q J Med 1972;41: 343\u2013354.","journal-title":"Q J Med"},{"key":"BF02786513_CR5","first-page":"1032","volume":"76","author":"M Hamza","year":"1970","unstructured":"Hamza M, Levy M, Broyer M, et al. Deux cas de glomerulo-nephrite membrano-proliferative avec lipodystrophie partielle de type faciotronculaire. J Urol Nephrol (Paris) 1970;76:1032\u20131042.","journal-title":"J Urol Nephrol (Paris)"},{"key":"BF02786513_CR6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(73)92351-9","volume":"2","author":"DK Peters","year":"1973","unstructured":"Peters DK, Charlesworth JA, Sissons JG, Williams DG, Boulton-Jones JM. Evans DJ, et al. Mesangiocapillary nephritis, partial lipodystrophy and hypocomplementaemia. Lancet 1973;2:535\u2013538.","journal-title":"Lancet"},{"key":"BF02786513_CR7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0002-9343(77)90879-8","volume":"62","author":"WM Bennett","year":"1977","unstructured":"Bennett WM, Bardana EJ, Wuepper K, et al. Partial lypodystrophy, C3 nephritic factor and clinically inapparent mesangiocapillary glomerulonephritis. Am J Med 1977; 62:757\u2013760.","journal-title":"Am J Med"},{"key":"BF02786513_CR8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJM197303222881204","volume":"288","author":"CA Alper","year":"1973","unstructured":"Alper CA, Bloch KJ, Rosen FS. Increased susceptibility to infection in a patient with type two essential hypercatabolism of C3. N Engl J Med 1973;288:601\u2013606.","journal-title":"N Engl J Med"},{"key":"BF02786513_CR9","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1084\/jem.139.5.1249","volume":"139","author":"EH Vallota","year":"1974","unstructured":"Vallota EH, Gotza O, Spiegelberg HL, et al. A serum factor in chronic complementemic nephritis distinct from immunoglobulins and activating the alternate pathway of complement. J Exp Med 1974; 139:1249\u20131261.","journal-title":"J Exp Med"},{"key":"BF02786513_CR10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0090-1229(77)90055-1","volume":"7","author":"MM Ipp","year":"1977","unstructured":"Ipp MM, Minta JO, Gelfand EW. Disorders of the complement systems in lypodystrophy. Clin Immunobiol Immunopathol 1977; 7:281\u2013287.","journal-title":"Clin Immunobiol Immunopathol"},{"key":"BF02786513_CR11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.164.3878.436","volume":"164","author":"RE Spitzer","year":"1969","unstructured":"Spitzer RE, Vallota EH, Forristal J, Sudora E, Stitzel AE, Davis NC. Serum C\u20193 lytic system in patients with glomerulonephritis. Science 1969;164:436\u2013437.","journal-title":"Science"},{"key":"BF02786513_CR12","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1084\/jem.142.3.760","volume":"142","author":"RD Schreiber","year":"1975","unstructured":"Schreiber RD, Medicus RG, Gotze O, et al. Properdin- and nephritic factor-dependent C3 convertase: requirement of native C3 for enzyme formation and the function of bound C3b as properdin receptor. J Exp Med 1975; 142:760\u2013772.","journal-title":"J Exp Med"},{"key":"BF02786513_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.116.1.1","volume":"116","author":"MR Daha","year":"1976","unstructured":"Daha MR, Fearon DT, Austen KF. C3 nephritic factor (C3Nef): stabilization of fluid phase and cell bound alternative pathway convertase. J Immunol 1976;116:1\u20137.","journal-title":"J Immunol"},{"key":"BF02786513_CR14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0090-1229(90)90019-M","volume":"57","author":"RE Spitzer","year":"1990","unstructured":"Spitzer RE, Stitzel AE, Tsokos GC. Human anti-idiotypic antibody responses to autoantibody against the alternative pathway C3 convertase. Clin Immunol Immunopathol 1990;57:19\u201331.","journal-title":"Clin Immunol Immunopathol"},{"key":"BF02786513_CR15","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/B978-044482383-0\/50083-2","volume-title":"Autoantibodies","author":"RE Spitzer","year":"1996","unstructured":"Spitzer RE, Stitzel AE, Tsokos GC. Nephritic factor antibodies, in Peter JB, Shoenfeld Y, (eds.): Autoantibodies. Elsevier Science, Amsterdam, The Netherlands, 1996, pp. 540\u2013545."},{"key":"BF02786513_CR16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0090-1229(90)90144-F","volume":"56","author":"Y Tanuma","year":"1990","unstructured":"Tanuma Y, Ohi H, Hatano M. Two types of C3 nephritic factor:properdindependent C3NeF and properdinindependent C3NeF. Clin Immunol Immunopathol 1990;56:226\u2013238.","journal-title":"Clin Immunol Immunopathol"},{"key":"BF02786513_CR17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2249.1993.tb05917.x","volume":"91","author":"JE Finn","year":"1993","unstructured":"Finn JE, Mathieson PW. Molecular analysis of C3 allotypes in patients with nephritic factor. Clin Exp Immunol 1993;91:410\u2013414.","journal-title":"Clin Exp Immunol"},{"key":"BF02786513_CR18","first-page":"46M65","volume":"294","author":"JGP Sissons","year":"1976","unstructured":"Sissons JGP, West RJ, Fallows J, Williams DG, Boucher BJ, Amos, et al. The complement abnormalities of lipodystrophy. N Engl J Med 1976;294:46M65.","journal-title":"N Engl J Med"},{"key":"BF02786513_CR19","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.2734615","volume":"244","author":"BS Rosen","year":"1989","unstructured":"Rosen BS, Cook KS, Yaglom J, Groves DL, Volanakis D, Damm D, et al. Adipsin and complement factor D activity:an immunerelated defect in obesity. Science 1989;244:1483\u20131487.","journal-title":"Science"},{"key":"BF02786513_CR20","doi-asserted-by":"crossref","first-page":"12,736","DOI":"10.1016\/S0021-9258(18)42338-1","volume":"267","author":"LN Choy","year":"1992","unstructured":"Choy LN, Rosen BS, Spiegelman BM. Adipsin and an endogenous pathway of complement from adipose cells. J Biol Chem 1992; 267:12,736\u201312,743.","journal-title":"J Biol Chem"},{"key":"BF02786513_CR21","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1084\/jem.177.6.1827","volume":"177","author":"PW Mathieson","year":"1993","unstructured":"Mathieson PW, Wurzner R, Oliveira DBG, Lachmann PJ, Peters DK. Complement-mediated adiposcyte lysis by nephritic factor. J Exp Med 1993;177:1827\u20131831.","journal-title":"J Exp Med"},{"key":"BF02786513_CR22","first-page":"240","volume":"18","author":"FP Schena","year":"1982","unstructured":"Schena FP, Pertosa G, Stanziale P, Vox E, Pecoraro C, Andreucci VE. Biological significance of the C3 nephritic factor in membranoproliferative glomerulonephritis. Clin Nephrol 1982;18:240\u2013246.","journal-title":"Clin Nephrol"},{"key":"BF02786513_CR23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0272-6386(87)80088-4","volume":"9","author":"EC Jackson","year":"1987","unstructured":"Jackson EC, McAdams AJ, Strife CF, Forristal J, Welch TR, West CD. Differences between membranoproliferative glomerulonephritis types I and III in clinical presentation, glomerular morphology, and complement perturbation. Am J Kidney Dis 1987;9:115\u2013120.","journal-title":"Am J Kidney Dis"},{"key":"BF02786513_CR24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ki.1975.32","volume":"7","author":"R Habib","year":"1975","unstructured":"Habib R, Gubler MC, Chantal L, Maiz HB, Levy M. Dense deposit disease: a variant of membranoproliferative glomerulonephritis. Kidney Int 1975;7:204\u2013215.","journal-title":"Kidney Int"},{"key":"BF02786513_CR25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000181754","volume":"25","author":"RH McLean","year":"1980","unstructured":"McLean RH, Siegel NJ, Kashgarian M. Activation of the classic complement pathway in patients with the C3 nephritic factor. Nephron 1980;25:57\u201364.","journal-title":"Nephron"},{"key":"BF02786513_CR26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/ki.1983.89","volume":"23","author":"HK Marder","year":"1983","unstructured":"Marder HK, Coleman TH, Forristal J, Beischel L, West CD. An inherited defect in the C3 convertase C3bBb, associated with glomerulonephritis. Kidney Int 1983;23:749\u2013758.","journal-title":"Kidney Int"},{"key":"BF02786513_CR27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.175.4.939","volume":"175","author":"S Meri","year":"1992","unstructured":"Meri S, Koisteinen V, Miettinen A, Tornroth T, Seppala IJT. Activation of the alternative pathway of complement by monoclonal L light chains in membranoproliferative glomerulonephritis. J Exp Med 1992;175:939\u2013950.","journal-title":"J Exp Med"},{"key":"BF02786513_CR28","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1042\/bst0150648","volume":"15","author":"C Lopez-Larrea","year":"1987","unstructured":"Lopez-Larrea C, Dieguez MA, Enguix A, Dominguez O, Marin B, Gomez E. A familial deficiency of complement factor H. Biochem Soc Trans 1987;15:648\u2013649.","journal-title":"Biochem Soc Trans"},{"key":"BF02786513_CR29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000185849","volume":"54","author":"H Ohi","year":"1990","unstructured":"Ohi H, Tanuma Y, Hatano M. Is membranoproliferative glomerulonephritis an autoimmune disease? Nephron 1990;54:192","journal-title":"Nephron"},{"key":"BF02786513_CR30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0022-1759(90)90234-M","volume":"131","author":"H Ohi","year":"1990","unstructured":"Ohi H, Watanabe S, Fujita T, Seki M, Hatano M. Detection of C3bBbstabilizing activity (C3 nephritic factor) in the serum from patients with membranoprolifirative glomerulonephritis. J Immunol Methods 1990;131:71\u201376.","journal-title":"J Immunol Methods"},{"key":"BF02786513_CR31","first-page":"82","volume":"76","author":"Y Tanuma","year":"1989","unstructured":"Tanuma Y, Ohi H, Watanabe S, Seki M, Hatano M. C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis. Clin Exp Immunol 1989; 76:82\u201385.","journal-title":"Clin Exp Immunol"},{"key":"BF02786513_CR32","first-page":"417","volume":"40","author":"MR Daha","year":"1998","unstructured":"Daha MR, Hazevoet HM, Van Es LA, Cats A. Stabilization of the classical pathway C3 convertase C42 by a factor F-42 isolated from patients with systemic lupus erythematosus. Immunology 1998; 40:417\u201324.","journal-title":"Immunology"},{"key":"BF02786513_CR33","first-page":"656","volume":"22","author":"T Fujita","year":"1987","unstructured":"Fujita T, Sumita T, Yoshida S, Ito S, Tamura N. C4 nephritic factor in a patient with chronic glomerulonephritis. J Clin Lab Immunol 1987;22:656\u201370.","journal-title":"J Clin Lab Immunol"},{"key":"BF02786513_CR34","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1172\/JCI109787","volume":"65","author":"L Halbwachs","year":"1980","unstructured":"Halbwachs L, Leveille M, Lesarre P, Wattel S, Leibowitch I. Nephritic factor of the classical pathway of complement immunoglobulin G autoantibody directed against the classical pathway C3 convertase enzyme. J Clin Invest 1980;65:1249\u20131256.","journal-title":"J Clin Invest"},{"key":"BF02786513_CR35","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1365-2249.1994.tb06530.x","volume":"95","author":"H Ohi","year":"1994","unstructured":"Ohi H, Yasugi T. Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis. Clin Exp Immunol 1994;95:316\u2013321.","journal-title":"Clin Exp Immunol"},{"key":"BF02786513_CR36","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0272-6386(12)81068-7","volume":"24","author":"CD West","year":"1994","unstructured":"West CD. Nephritic factors predispose to chronic glomerulonephritis. Am J Kidney Dis 1994; 24:956\u2013963.","journal-title":"Am J Kidney Dis"},{"key":"BF02786513_CR37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.7326\/0003-4819-89-1-72","volume":"89","author":"WA Wilson","year":"1978","unstructured":"Wilson WA, Sissons JGP, Morgan OS. Multiple autoimmune diseases with bilateral optic atrophy and lipodystrophy. Ann Intern Med 1978;89:72\u201373.","journal-title":"Ann Intern Med"},{"key":"BF02786513_CR38","doi-asserted-by":"crossref","first-page":"474","DOI":"10.7326\/0003-4819-85-4-474","volume":"85","author":"D Alarcon-Segovia","year":"1976","unstructured":"Alarcon-Segovia D, Ramos-Niembro F. Association of partial lipodystrophy and Sjogren\u2019s syndrome. Ann Intern Med 1976;85: 474,475.","journal-title":"Ann Intern Med"},{"key":"BF02786513_CR39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0190-9622(90)70042-G","volume":"22","author":"J Font","year":"1990","unstructured":"Font J, Herrero C, Bosch X, Cervera R, Ingelmo M, Mascaro JM. Systemic lupus erythematosus in a patient with partial lipodystrophy. J Am Acad Dermatol 1990;22:337\u2013340.","journal-title":"J Am Acad Dermatol"},{"key":"BF02786513_CR40","first-page":"43","volume":"6","author":"HE Jasin","year":"1979","unstructured":"Jasin HE. Systemic lupus erythematosus, partial lipodystrophy and hypocomplementemia. J Rheumatol 1979;6:43\u201346.","journal-title":"J Rheumatol"},{"key":"BF02786513_CR41","first-page":"609","volume":"87","author":"MJ Walport","year":"1994","unstructured":"Walport MJ, Davies KA, Botto M, Naughton MA, Isenberg DA, Biasi D, et al. C3 nephritic factor and SLE:report of four cases and review of the literature. Q J Med 1994;87:609\u2013615.","journal-title":"Q J Med"},{"key":"BF02786513_CR42","first-page":"298","volume":"88","author":"CC Cronin","year":"1995","unstructured":"Cronin CC, Higgins T, Molloy M. Lupus, C3 nephritic factor and partial lypodystrophy. Q J Med 1995;88:298\u2013299.","journal-title":"Q J Med"},{"key":"BF02786513_CR43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0167-5699(91)90003-C","volume":"12","author":"BP Morgan","year":"1991","unstructured":"Morgan BP, Walport MJ. Complement deficiency and disease. Immunol Today 1991;12:301\u2013306.","journal-title":"Immunol Today"},{"key":"BF02786513_CR44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0140-6736(92)92486-Y","volume":"340","author":"VF Bacchi","year":"1992","unstructured":"Bacchi VF, Maillet F, Berlan L, Kazatchkine MD. Neutralising antibodies against C3NeF in intravenous immunoglobulin. Lancet 1992;340:63\u201364.","journal-title":"Lancet"},{"key":"BF02786513_CR45","first-page":"43","volume":"2","author":"Y Levy","year":"1996","unstructured":"Levy Y, George J, Yona E, Shoenfeld Y. Partial lypodystrophy and complement dysfunction. Turk J Immunol 1996;2: 43\u201345.","journal-title":"Turk J Immunol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02786513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02786513\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02786513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:53:53Z","timestamp":1684148033000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02786513"}},"subtitle":["An autoimmune phenomenon"],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["BF02786513"],"URL":"https:\/\/doi.org\/10.1007\/bf02786513","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}