{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:34:12Z","timestamp":1773084852790,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Chemical Neuropathology"],"published-print":{"date-parts":[[1995,12]]},"DOI":"10.1007\/bf02815143","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T07:41:43Z","timestamp":1241682103000},"page":"269-284","source":"Crossref","is-referenced-by-count":31,"title":["Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection ofS-adenosylmethionine"],"prefix":"10.1007","volume":"26","author":[{"given":"Clivel G.","family":"Charlton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Crowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02815143_CR1","first-page":"175","volume":"5","author":"E. C. Alvord","year":"1974","unstructured":"Alvord E. C., Jr., Forno L. S., Kusske J. A., Kaufman R. J., Rhodes J. S., and Goetowski C. R. (1974) The pathology of parkinsonism: comparison of degeneration in cerebral cortex and brainstem.Adv. Neurol. 5, 175\u2013193.","journal-title":"Adv. Neurol."},{"key":"BF02815143_CR2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1471-4159.1966.tb09884.x","volume":"13","author":"R. J. Baldessarini","year":"1966","unstructured":"Baldessarini R. J. and Kopin I. J. (1966)S-adenosylmethionine in brain and other tissues.J. Neurochem. 13, 769\u2013777.","journal-title":"J. Neurochem."},{"key":"BF02815143_CR3","first-page":"347","volume":"92","author":"A. Barbeau","year":"1965","unstructured":"Barbeau A., Tetreault L., Morazain L., and Oliva L. (1965) Pharmacology of 3,4-dimethoxyphenylamine.Can. Med. Assoc. J. 92, 347.","journal-title":"Can. Med. Assoc. J."},{"key":"BF02815143_CR4","first-page":"95","volume":"5","author":"A. Barbeau","year":"1968","unstructured":"Barbeau A. (1968) Dopamine and dopamine metabolites in Parkinson\u2019s disease\u2014 a review.Proc. Aust. Assoc. Neurol. 5, 95\u2013100.","journal-title":"Proc. Aust. Assoc. Neurol."},{"key":"BF02815143_CR5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(79)90447-5","volume":"179","author":"J. K. Blusztajn","year":"1979","unstructured":"Blusztajn J. K., Zeisel S. H., and Wurtman R. J. (1979) Synthesis of lecithin (phosphatidylcholine) frm phosphatidylethanolamine in bovine brain.Brain Res. 179, 319\u2013327.","journal-title":"Brain Res."},{"key":"BF02815143_CR6","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1126\/science.6867732","volume":"221","author":"J. K. Blusztajn","year":"1983","unstructured":"Blusztajn J. K. and Wurtman R. J. (1983) Choline and cholinergic neurons.Science 221, 614\u2013620.","journal-title":"Science"},{"key":"BF02815143_CR7","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.2042-7158.1978.tb13408.x","volume":"30","author":"C. G. Charlton","year":"1978","unstructured":"Charlton C. G. and Way E. L. (1978) Tremor induced byS-adenosyl-L-methionine: possible relation tol-dopa effects.J. Pharma. Pharmacol. 30, 819\u2013820.","journal-title":"J. Pharma. Pharmacol."},{"issue":"1","key":"BF02815143_CR8","first-page":"810","volume":"16","author":"C. G. Charlton","year":"1990","unstructured":"Charlton C. G. and Crowell B., Jr. (1990) Relationship between excessS-adenosylmethionine (SAM-dependent methylation) and Parkinson\u2019s disease.Neurosci. Abstr. 16(1), 810.","journal-title":"Neurosci. Abstr."},{"key":"BF02815143_CR9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0091-3057(92)90172-C","volume":"43","author":"C. G. Charlton","year":"1992","unstructured":"Charlton C. G. and Crowell B. Jr. (1992) Parkinson\u2019s disease-like effects ofS-adenosyl-l-methionine: effects ofl-dopa.Pharm. Biochem. Behav. 43, 423\u2013431.","journal-title":"Pharm. Biochem. Behav."},{"key":"BF02815143_CR10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.bi.61.070192.002035","volume":"61","author":"S. Clarke","year":"1992","unstructured":"Clarke S. (1992) Protein isoprenylation and methylation at carboxyl-terminal cysteine residues.Annu. Rev. Biochem. 61, 355\u2013386.","journal-title":"Annu. Rev. Biochem."},{"key":"BF02815143_CR11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0006-8993(92)90576-U","volume":"570","author":"M. A. Collins","year":"1992","unstructured":"Collins M. A., Neafsey E. J., Matsubara K., Cobuzzi R. J., Jr., and Rollema H. (1992) Indole-N-methylated beta-carbolinium ions as potential brain-bioactivated neurotoxins.Brain Res. 570, 154\u2013160.","journal-title":"Brain Res."},{"key":"BF02815143_CR12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1471-4159.1973.tb04225.x","volume":"21","author":"J. T. Coyle","year":"1973","unstructured":"Coyle J. T. and Henry D. (1973) Catecholamines in fetal and newborn rat brain.J. Neurochem. 21, 61\u201367.","journal-title":"J. Neurochem."},{"key":"BF02815143_CR13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0163-1047(93)90950-M","volume":"59","author":"B. Crowell","year":"1993","unstructured":"Crowell B., Jr., Benson R., Shockley D., and Charlton C. G. (1993)S-adenosyl-l-methionine decreases motor activity in rat: similarity to Parkinson\u2019s disease-like symptoms.Behav. Neural Biol. 59, 186\u2013193.","journal-title":"Behav. Neural Biol."},{"key":"BF02815143_CR14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0005-2736(79)90316-X","volume":"558","author":"O. M. Olivera Filgueiras De","year":"1979","unstructured":"De Olivera Filgueiras O. M., Van Den Basselaar A. H. H. P., and Van Den Bosch H. (1979) Localization of lysophosphatidylcholine in bovine chromaffin granules.Biochim. Biophys. Acta 558, 73\u201384.","journal-title":"Biochim. Biophys. Acta"},{"key":"BF02815143_CR15","first-page":"1159","volume":"26","author":"E. J. Diliberto","year":"1976","unstructured":"Diliberto E. J., Jr., and Axelrod J. (1976) Regional and subcellular distribution of protein carboxymethylase in brain and other tissues.J. Neurosci. 26, 1159\u20131165.","journal-title":"J. Neurosci."},{"key":"BF02815143_CR16","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1073\/pnas.73.11.4050","volume":"73","author":"E. J. Diliberto","year":"1976","unstructured":"Diliberto E. J., Jr., Viveros O. H., and Axelrod J. (1976) Subcellular distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling.Proc. Natl. Acad. Sci. USA 73, 4050\u20134054.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02815143_CR17","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/brain\/86.4.781","volume":"86","author":"M. J. Eadie","year":"1963","unstructured":"Eadie M. J. (1963) The pathology of certain medullary nuclei in parkinsonism.Brain 86, 781\u2013790.","journal-title":"Brain"},{"key":"BF02815143_CR18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/193178b0","volume":"193","author":"A. M. Ernst","year":"1962","unstructured":"Ernst A. M. (1962) Phenomena of the hypokinetic rigid type caused by O-methylation of dopamine in the para-position.Nature (Lond) 193, 178, 179.","journal-title":"Nature (Lond)"},{"key":"BF02815143_CR19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-0404.1977.tb01411.x","volume":"56","author":"C. Feuerstein","year":"1977","unstructured":"Feuerstein C., Tauche M., Serre F., Gavend M., Pellat J., and Perret J. (1977) Does O-methylation play a role in levo-dopa-induced dyskinesias?Acta Neurol. Scand. 56, 79\u201382.","journal-title":"Acta Neurol. Scand."},{"key":"BF02815143_CR20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00688674","volume":"34","author":"L. S. Forno","year":"1976","unstructured":"Forno L. S. and Norvill R. L. (1976) Ultrastructure of Lewy bodies in the stellate ganglion.Acta Neuropathol. 34, 183\u2013197.","journal-title":"Acta Neuropathol."},{"key":"BF02815143_CR21","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1016\/S0021-9258(17)34755-5","volume":"253","author":"C. Gagnon","year":"1978","unstructured":"Gagnon C., Viveros O. H., Diliberto E. J., and Axelrod J. (1978) Enzymatic methylation of carboxyl groups of chromaffin granule membrane proteins.J. Biol. Chem. 253, 3778\u20133781.","journal-title":"J. Biol. Chem."},{"key":"BF02815143_CR22","volume-title":"Review of Medical Physiology","author":"W. F. Ganong","year":"1991","unstructured":"Ganong W. F. (1991)Review of Medical Physiology. Appleton and Lange, San Francisco, CA."},{"key":"BF02815143_CR23","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1471-4159.1982.tb08702.x","volume":"38","author":"A. Gharib","year":"1982","unstructured":"Gharib A., Sarda N., Chabannes B., Cronenberger L., and Pacheco H. (1982) The regional concentrations ofS-adenosyl-l-methionine,S-adenosyl-l-homocysteine and adenosine in rat brain.J. Neurochem. 38, 810\u2013815.","journal-title":"J. Neurochem."},{"key":"BF02815143_CR24","volume-title":"The Pharmacological Basis of Therapeutics","author":"L. S. Goodman","year":"1981","unstructured":"Goodman L. S. and Gilman A. (1981)The Pharmacological Basis of Therapeutics. Macmillan, New York."},{"key":"BF02815143_CR25","first-page":"487","volume":"45","author":"R. J. Hardie","year":"1986","unstructured":"Hardie R. J., Lees A. J., and Stern G. M. (1986) Pharmacokinetics of levo-dopa and motor fluctuations.Adv. Neurol. 45, 487\u2013492.","journal-title":"Adv. Neurol."},{"key":"BF02815143_CR26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/275219a0","volume":"275","author":"F. Hirata","year":"1978","unstructured":"Hirata F. and Axelrod J. (1978) Enzymatic methylation of phosphatidylethanolamine increases erythrocyte membrane fluidity.Nature 275, 219, 220.","journal-title":"Nature"},{"key":"BF02815143_CR27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/jnnp.23.4.283","volume":"6","author":"D. H. Jager","year":"1960","unstructured":"Jager D. H. and Bethlem J. (1960) The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans.J. Neurol. Neurosurg. Psychiatr. 6, 283\u2013290.","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"BF02815143_CR28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archneur.1969.00480180071006","volume":"21","author":"W. A. Jager den","year":"1969","unstructured":"Jager W. A. den (1969) Sphingomyelin in Lewy inclusion bodies in Parkinson\u2019s disease.Arch. Neurol. (Chicago) 21, 615\u2013619.","journal-title":"Arch. Neurol. (Chicago)"},{"key":"BF02815143_CR29","first-page":"37","volume-title":"Parkinson\u2019s Disease and Movement Disorders","author":"P. J. Jenner","year":"1988","unstructured":"Jenner P. J. and Marsden C. D. (1988) MPTP-induced parkinsonism as an experimental model of Parkinson\u2019s disease. In:Parkinson\u2019s Disease and Movement Disorders (Jankovic J. and Tolosa E., eds.), pp. 37\u201348, Urban & Schwarzenberg, Baltimore-Munich."},{"key":"BF02815143_CR30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0047-6374(88)90128-5","volume":"46","author":"J. Knoll","year":"1988","unstructured":"Knoll J. (1988) The striatal dopamine dependency of life span in male rats, longivity study with (\u2212) deprenyl.Mech. Aging Dev. 46, 237\u2013262.","journal-title":"Mech. Aging Dev."},{"key":"BF02815143_CR31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ana.410030207","volume":"3","author":"J. W. Langston","year":"1978","unstructured":"Langston J. W. and Forno L. S. (1978) The hypothalamus in Parkinson disease.Ann. Neurol. 3, 129\u2013133.","journal-title":"Ann. Neurol."},{"key":"BF02815143_CR32","first-page":"288","volume":"115","author":"J. Maksem","year":"1984","unstructured":"Maksem J., Jacobson N., and Neiderhiser D. H. (1984) Lysophosphatidylcholine-induced gastric injury and ulceration in the guinea pig.Am. J. Pathol. 115, 288\u2013295.","journal-title":"Am. J. Pathol."},{"key":"BF02815143_CR33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/243411a0","volume":"243","author":"L. I. Mays","year":"1973","unstructured":"Mays L. I., Borek E., and Finch C. E. (1973) Glycine N-methyltransferase is a regulatory enzyme which increases in aging animals.Nature 243, 411\u2013413.","journal-title":"Nature"},{"key":"BF02815143_CR34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1212\/WNL.27.5.481","volume":"45","author":"M. A. Mena","year":"1977","unstructured":"Mena M. A., Murados V., Brazen E., Reiriz J., and De Yebenes J. G. (1977) Pharmacokinetics ofl-dopa in patients with Parkinson\u2019s disease.Adv. Neurol. 45, 481\u2013486.","journal-title":"Adv. Neurol."},{"key":"BF02815143_CR35","first-page":"389","volume":"47","author":"M. D. Muenter","year":"1972","unstructured":"Muenter M. D., Sharpless N. S., and Tyce G. M. (1972) Plasma 3-O-methyldopa inl-dopa therapy of Parkinson\u2019s disease.Mayo Clin. Proc. 47, 389\u2013395.","journal-title":"Mayo Clin. Proc."},{"key":"BF02815143_CR36","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF00696560","volume":"34","author":"E. Ohama","year":"1976","unstructured":"Ohama E. and Ikuta F. (1976) Parkinson\u2019s disease: distribution of Lewy bodies and monoamine neuron system.Acta Neuropathol. (Berl) 34, 311\u2013319.","journal-title":"Acta Neuropathol. (Berl)"},{"key":"BF02815143_CR37","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.8438158","volume":"259","author":"M. R. Phillips","year":"1993","unstructured":"Phillips M. R., Pillinger M. H., Strand R., Volker C., Rosenfeld M. G., Weissman G., and Stock J. B. (1993) Carboxymethylation of Ras-related proteins during signal transduction in neurophils.Science 259, 977\u2013980.","journal-title":"Science"},{"key":"BF02815143_CR38","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/jnnp.39.11.1092","volume":"39","author":"A. H. Rajput","year":"1970","unstructured":"Rajput A. H. and Rozdisky B. (1970) Dysautonomia in parkinsonism: a clinico-pathological study.J. Neurol. Neurosurg. Psychiatr. 39, 1092\u20131100.","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"BF02815143_CR39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0306-3623(88)90055-9","volume":"19","author":"W. Schultz","year":"1988","unstructured":"Schultz W. (1988) MPTP-induced parkinsonism in monkeys: mechanisms of action, selectivity and pathophysiology.Gen. Pharmacol. 19, 153\u2013161.","journal-title":"Gen. Pharmacol."},{"key":"BF02815143_CR40","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0022-510X(68)90034-8","volume":"6","author":"G. Selby","year":"1968","unstructured":"Selby G. (1968) Cerebral atrophy in parkinsonismJ. Neurol. Sci. 6, 517\u2013559.","journal-title":"J. Neurol. Sci."},{"key":"BF02815143_CR41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0047-6374(88)90044-9","volume":"43","author":"O. Z. Sellinger","year":"1988","unstructured":"Sellinger O. Z., Kramer C. M., Conger A., and Duboff G. S. (1988) The carboxylmethylation of cerebral membrane-bound proteins increases with age.Mech. Aging Dev. 43, 161\u2013173.","journal-title":"Mech. Aging Dev."},{"key":"BF02815143_CR42","first-page":"24","volume-title":"Third Symposium on Parkinson\u2019s Disease","author":"D. F. Sharman","year":"1976","unstructured":"Sharman D. F. (1976) The effect of drugs on dopamine in the striatum. In:Third Symposium on Parkinson\u2019s Disease (Gillingham F. J. and Donaldson I. M. L., eds.), pp. 24\u201332, E and L Livingston, London."},{"key":"BF02815143_CR43","first-page":"163","volume-title":"International Symposium on Mucus in Health and Disease","author":"B. L. Slomiany","year":"1981","unstructured":"Slomiany B. L., Jerzy-Glass G. B., Kojima K., Banas-Gruszka Z., and Slomiany A. (1981) Effect of lysolecithin on the constitutents of gastric mucus. In:International Symposium on Mucus in Health and Disease (Chantler N., Elder J. B., and Elstein M., eds.), pp. 163\u2013174, Plenum, New York."},{"key":"BF02815143_CR44","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/geronj\/32.4.392","volume":"32","author":"G. Stramentinoli","year":"1977","unstructured":"Stramentinoli G., Gualano M., Catto E., and Algeri S. (1977) Tissue levels ofS-adenosylmethionine in aging rats.J. Gerontol. 32, 392\u2013394.","journal-title":"J. Gerontol."},{"key":"BF02815143_CR45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1042\/bst0080062","volume":"8","author":"H. R. Taufek","year":"1984","unstructured":"Taufek H. R. and Bone A. H. (1984) Influence of exogenousl-3,4-hydroxyphenylalanine (l-dopa) on methionine andS-adenosylmethionine concentrations in the brain and other tissues.Biochem. Soc. Trans. 8, 62\u201363.","journal-title":"Biochem. Soc. Trans."},{"key":"BF02815143_CR46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1471-4159.1977.tb07744.x","volume":"28","author":"L. Tuomisto","year":"1977","unstructured":"Tuomisto L. (1977) Ontogenesis and regional distribution of histamine and histamine-N-methyltransferase in the guinea pig brain.J. Neurochem. 28, 271\u2013276.","journal-title":"J. Neurochem."},{"key":"BF02815143_CR47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/archneur.1970.00480210017002","volume":"22","author":"J. J. Vanderhaegen","year":"1970","unstructured":"Vanderhaegen J. J., Poirier O., and Steronon J. E. (1970) Pathological findings in idiopathic orthostatic hypotension.Arch. Neurol. 22, 207\u2013214.","journal-title":"Arch. Neurol."},{"key":"BF02815143_CR48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1471-4159.1970.tb02228.x","volume":"17","author":"J. J. Volpe","year":"1970","unstructured":"Volpe J. J. and Laster L. (1970) Trans-sulphuration in primate brain: regional distribution of methionine-activating enzyme in the brain of the Rhesus monkey at various stages of development.J. Neurochem. 17, 413\u2013424.","journal-title":"J. Neurochem."},{"key":"BF02815143_CR49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-4157(79)90004-2","volume":"559","author":"H. U. Weltzien","year":"1979","unstructured":"Weltzien H. U. (1979) Cytolytic and membrane perturbing properties of lysophosphatidylcholine.Biochim. Biophys. Acta 559, 259\u2013287.","journal-title":"Biochim. Biophys. Acta"},{"key":"BF02815143_CR50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.169.3943.395","volume":"169","author":"R. J. Wurtman","year":"1970","unstructured":"Wurtman R. J., Rose C. M., Matthysse S., Stephenson J., and Baldessarini R. J. (1970)l-dihydroxyphenylalanine: effect onS-adenosylmethionine in brain.Science 169, 395\u2013397.","journal-title":"Science"},{"key":"BF02815143_CR51","volume-title":"Parkinson\u2019s Disease: Present Status and Research Trends","author":"M. D. Yahr","year":"1968","unstructured":"Yahr M. D. and Bering E. A. (1968)Parkinson\u2019s Disease: Present Status and Research Trends. Columbia University Press, New York."}],"container-title":["Molecular and Chemical Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02815143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02815143\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02815143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T01:31:54Z","timestamp":1633397514000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02815143"}},"subtitle":["A possible role of hypermethylation in parkinsonism"],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["BF02815143"],"URL":"https:\/\/doi.org\/10.1007\/bf02815143","relation":{},"ISSN":["1044-7393"],"issn-type":[{"value":"1044-7393","type":"print"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}