{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:29:20Z","timestamp":1777454960104,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Pancreatol"],"published-print":{"date-parts":[[1997,4]]},"DOI":"10.1007\/bf02822387","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T09:08:46Z","timestamp":1628586526000},"page":"157-164","source":"Crossref","is-referenced-by-count":28,"title":["Dissociated secretion of islet amyloid polypeptide and insulin in serum-free culture media conditioned by human pancreatic adenocarcinoma cell lines"],"prefix":"10.1007","volume":"21","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rgen","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avni","family":"Abdiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gasslander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Westermark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Permert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02822387_CR1","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/BF01072886","volume":"23","author":"SS Schwartz","year":"1978","unstructured":"Schwartz SS, Zeidler A, Moossa AR, Kuku SF, Rubenstein AH. A prospective study of glucose tolerance, insulin, C-peptide, and glucagon responses in patients with pancreatic carcinoma.Dig Dis 1978; 23: 1107\u20131114.","journal-title":"Dig Dis"},{"key":"BF02822387_CR2","first-page":"101","volume":"159","author":"J Permert","year":"1993","unstructured":"Permert J, Ihse I, Jorfeldt L, von Schenck H, Arnqvist HJ, Larsson J. Pancreatic cancer is associated with impaired glucose metabolism.Eur J Surg 1993; 159: 101\u2013107.","journal-title":"Eur J Surg"},{"key":"BF02822387_CR3","first-page":"1020","volume":"86","author":"H Kaji","year":"1991","unstructured":"Kaji H, Inoue K, Miyashita T, Uchida K, Takahashi K, Tobe T. Relationship between glucose tolerance and quantitative changes of islet cells in chronic obstructive pancreatitis due to pancreatoduodenal cancer.Am J Gastroenterol 1991; 86: 1020\u20131026.","journal-title":"Am J Gastroenterol"},{"key":"BF02822387_CR4","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/1097-0142(19910115)67:2<486::AID-CNCR2820670228>3.0.CO;2-1","volume":"67","author":"E Cersosimo","year":"1991","unstructured":"Cersosimo E, Pisters PWT, Pesola G, McDermott K, Bajorunas D, Brennan MF. Insulin secretion and action in patients with pancreatic cancer.Cancer 1991; 67: 486\u2013493.","journal-title":"Cancer"},{"key":"BF02822387_CR5","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1002\/1097-0142(19890901)64:5<1107::AID-CNCR2820640523>3.0.CO;2-Y","volume":"64","author":"O Ishikawa","year":"1989","unstructured":"Ishikawa O, Ohhigashi H, Wada A, et al. Morphologic characteristics of pancreatic carcinoma with diabetes mellitus.Cancer 1989; 64: 1107\u20131112.","journal-title":"Cancer"},{"key":"BF02822387_CR6","first-page":"673","volume":"44","author":"II Kessler","year":"1970","unstructured":"Kessler II. Cancer mortality among diabetics.J Natl Cancer Inst 1970; 44: 673\u2013686.","journal-title":"J Natl Cancer Inst"},{"key":"BF02822387_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1056\/NEJM199407143310203","volume":"331","author":"L Gullo","year":"1994","unstructured":"Gullo L, Pezzilli R, Morselli-Labate AM. Diabetes and the risk of pancreatic cancer.N Engl J Med 1994; 331: 81\u201384.","journal-title":"N Engl J Med"},{"key":"BF02822387_CR8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1464-5491.1985.tb00612.x","volume":"2","author":"JN Fox","year":"1985","unstructured":"Fox JN, Frier BM, Armitage M, Ashby JP. Abnormal insulin secretion in carcinoma of the pancreas: response to glucagon stimulation.Diabet Med 1985; 2: 113\u2013116.","journal-title":"Diabet Med"},{"key":"BF02822387_CR9","first-page":"2577","volume":"13","author":"P Fogar","year":"1993","unstructured":"Fogar P, Basso D, Panozzo MP, et al. C-peptide pattern in patients with pancreatic cancer.Anticancer Res 1993; 13: 2577\u20132580.","journal-title":"Anticancer Res"},{"key":"BF02822387_CR10","first-page":"2827","volume":"14","author":"P Fogar","year":"1994","unstructured":"Fogar P, Pasquali C, Basso D, et al. Diabetes mellitus in pancreatic cancer follow-up.Anticancer Res 1994; 14: 2827\u20132830.","journal-title":"Anticancer Res"},{"key":"BF02822387_CR11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1136\/pgmj.45.529.726","volume":"45","author":"MT McKiddie","year":"1969","unstructured":"McKiddie MT, McBain GC, Buchanan KD, Bell G. The insulin response to glucose in patients with pancreatic disease.Prostgrad Med J 1969; 45: 726\u2013728.","journal-title":"Prostgrad Med J"},{"key":"BF02822387_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1056\/NEJM199402033300503","volume":"330","author":"J Permert","year":"1994","unstructured":"Permert J, Larsson J, Westermark GT, Herrington MK, Christmanson L, Pour PM, Westermark P, Adrian TE. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes.N Engl J Med 1994; 330: 313\u2013318.","journal-title":"N Engl J Med"},{"key":"BF02822387_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0168-8227(89)90008-9","volume":"7","author":"P Westermark","year":"1989","unstructured":"Westermark P, Engstr\u00f6m U, Westermark GT, Johnson KH, Permert J, Betsholtz C. Islet amyloid polypeptide (IAPP) and pro-IAPP immunoreactivity in human islets of Langerhans.Diabetes Res Clin Pract 1989; 7: 219\u2013226.","journal-title":"Diabetes Res Clin Pract"},{"key":"BF02822387_CR14","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0167-0115(93)90362-C","volume":"45","author":"M Stridsberg","year":"1993","unstructured":"Stridsberg M, Sandler S, Wilander E. Cosecretion of islet amyloid polypeptide (IAPP) and insulin from isolated rat pancreatic islets following stimulation or inhibition of \u03b2-cell function.Regul Pept 1993; 45: 363\u2013370.","journal-title":"Regul Pept"},{"key":"BF02822387_CR15","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0014-5793(90)80210-A","volume":"262","author":"HC Fehmann","year":"1990","unstructured":"Fehmann HC, Weber V, G\u00f6ke R, G\u00f6ke B, Arnold R. Cosecretion of amylin and insulin from isolated rat pancreas.FEBS Lett 1990; 262: 279\u2013281.","journal-title":"FEBS Lett"},{"key":"BF02822387_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0168-8227(92)90061-U","volume":"15","author":"T Kobayashi","year":"1992","unstructured":"Kobayashi T, Ito Y, and Nakanish K, et al. Relationship between islet amyloid polypeptide (IAPP) deposition and insulin response and \u03b2-cell volume in diabetes mellitus.Diabetes Res Clin Pract 1992; 15: 15\u201316.","journal-title":"Diabetes Res Clin Pract"},{"key":"BF02822387_CR17","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/0006-291X(89)92529-1","volume":"160","author":"H Ohsawa","year":"1989","unstructured":"Ohsawa H, Kanatsuka A, Yamaguchi T, Makino H, Yoshida S. Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets.Biochem Biophys Res Commun 1989; 160: 961\u2013967.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF02822387_CR18","doi-asserted-by":"publisher","first-page":"330","DOI":"10.2337\/diabetes.42.2.330","volume":"42","author":"Z Wang","year":"1993","unstructured":"Wang Z, Bennet WM, Ghatei MA, Byfield PGH, Smith DM, Bloom SR. Influence of islet amyloid polypeptide and the 8\u201337 fragment of islet amyloid polypeptide on insulin release from perifused rat islets.Diabetes 1993; 42: 330\u2013335.","journal-title":"Diabetes"},{"key":"BF02822387_CR19","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/335632a0","volume":"335","author":"B Leighton","year":"1988","unstructured":"Leighton B, Cooper GJS. Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.Nature 1988; 335: 632\u2013635.","journal-title":"Nature"},{"key":"BF02822387_CR20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/BF00405079","volume":"34","author":"SJ Koopmans","year":"1991","unstructured":"Koopmans SJ, von Mansfeld ADM, Jansz HS, et al. Amylin-induced in vivo insulin resistance in conscious rats: The liver is more sensitive to amylin than peripheral tissues.Diabetologia 1991; 34: 218\u2013224.","journal-title":"Diabetologia"},{"key":"BF02822387_CR21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/carcin\/10.5.861","volume":"10","author":"H Egami","year":"1989","unstructured":"Egami H, Takiyama Y, Cano M, Houser WH, Pour PM. Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens.Carcinogenesis 1989; 10: 861\u2013869.","journal-title":"Carcinogenesis"},{"key":"BF02822387_CR22","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/ijc.2910150505","volume":"15","author":"M Lieber","year":"1975","unstructured":"Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G. Establishment of continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.Int J Cancer 1975; 15: 741\u2013747.","journal-title":"Int J Cancer"},{"key":"BF02822387_CR23","first-page":"601","volume":"42","author":"RS Metzgar","year":"1982","unstructured":"Metzgar RS, Gaillard MT, Levine SJ, Tuck FL, Bossen EH, Borowitz MJ. Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies.Cancer Res 1982; 42: 601\u2013608.","journal-title":"Cancer Res"},{"key":"BF02822387_CR24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","volume":"16","author":"PE Lacy","year":"1967","unstructured":"Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas.Diabetes 1967; 16: 35\u201339.","journal-title":"Diabetes"},{"key":"BF02822387_CR25","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1210\/endo-122-5-2134","volume":"122","author":"JC Henquin","year":"1988","unstructured":"Henquin JC, Garcia MC, Bozen M, Hermans MP, Nenquin M. Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx.Endocrinology 1988; 122: 2134\u20132142.","journal-title":"Endocrinology"},{"key":"BF02822387_CR26","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/0014-5793(84)81398-8","volume":"170","author":"P Rorsman","year":"1984","unstructured":"Rorsman P, Abrahamsson H, Gylfe E, Hellman B. Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic \u03b2-cells.FEBS Lett 1984; 170: 196\u2013200.","journal-title":"FEBS Lett"},{"key":"BF02822387_CR27","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2337\/diab.21.4.224","volume":"21","author":"E Cerasi","year":"1972","unstructured":"Cerasi E, Luft R, Efendic S. Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects.Diabetes 1972; 21: 224\u2013234.","journal-title":"Diabetes"},{"key":"BF02822387_CR28","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/bjs.1800800841","volume":"80","author":"J Permert","year":"1993","unstructured":"Permert J, Ihse I, Jorfeldt L, von Schenck H, Arnquist HJ, Larsson J. Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer.Br J Surg 1993; 80: 1047\u20131050.","journal-title":"Br J Surg"},{"key":"BF02822387_CR29","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1172\/JCI114528","volume":"85","author":"A Ogawa","year":"1990","unstructured":"Ogawa A, Harris V, McCorkle SK, Unger RH, Luskey KL. Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment.J Clin Invest 1990; 85: 973\u2013976.","journal-title":"J Clin Invest"},{"key":"BF02822387_CR30","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2337\/diabetes.41.6.723","volume":"41","author":"K Inoue","year":"1992","unstructured":"Inoue K, Hisatomi A, Umeda F, Nawata H. Relative hypersecretion of amylin to insulin from rat pancreas after neonatal STZ treatment.Diabetes 1992; 41: 723\u2013727.","journal-title":"Diabetes"},{"key":"BF02822387_CR31","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.2337\/diabetes.42.10.1514","volume":"42","author":"A Novial","year":"1993","unstructured":"Novial A, Sarri Y, Casamitjana R, Rivera F, Gomis R. Regulation of islet amyloid polypeptide in human pancreatic islets.Diabetes 1993; 42: 1514\u20131519.","journal-title":"Diabetes"},{"key":"BF02822387_CR32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/ajcp\/100.3.223","volume":"100","author":"MP Pour","year":"1993","unstructured":"Pour MP, Permert J, Mogaki M, Fujii H, Kazakoff K. Endocrine aspects of exocrine cancer of the pancreas.Am J Clin Pathol 1993; 100: 223\u2013230.","journal-title":"Am J Clin Pathol"},{"key":"BF02822387_CR33","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.2337\/diabetes.40.12.1701","volume":"40","author":"TD O'Brien","year":"1991","unstructured":"O'Brien TD, Westermark P, Johnson KH. Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats.Diabetes 1991; 40: 1701\u20131706","journal-title":"Diabetes"},{"key":"BF02822387_CR34","first-page":"522","volume":"66","author":"KH Johnson","year":"1992","unstructured":"Johnson KH, O'Brein TD, Betsholtz C, Westermark P. Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus.Lab Invest 1992; 66: 522\u2013535.","journal-title":"Lab Invest"},{"key":"BF02822387_CR35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/BF02576207","volume":"193","author":"B Ahren","year":"1993","unstructured":"Ahren B, Andren-Sandberg \u00c5. Glucose tolerance and insulin secretion in experimental pancreatic cancer in the Syrian hamster.Res Exp Med 1993; 193: 21\u201326.","journal-title":"Res Exp Med"},{"key":"BF02822387_CR36","first-page":"A285","volume":"102","author":"J Permert","year":"1992","unstructured":"Permert J, Kazakoff K, Herrington MK, Adrian TE, Pour PM. Insulin and IAPP changes in the hamster pancreatic cancer model.Gastroenterology 1992; 102: A285.","journal-title":"Gastroenterology"},{"key":"BF02822387_CR37","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/S0140-6736(69)91709-7","volume":"1","author":"RDG Milner","year":"1969","unstructured":"Milner RDG. Stimulation of insulin secretion in vitro by essential amino acids.Lancet 1969; 1: 1075\u20131076.","journal-title":"Lancet"},{"key":"BF02822387_CR38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1051\/rnd:19940207","volume":"34","author":"JM Lopes","year":"1994","unstructured":"Lopes JM, Larbier M. Influence of amino-acid concentration in the culture medium on the rate of amino-acid incorporation into protein and amino-acid oxidation of cultured chicken hepatocytes.Reprod Nutr Dev 1994; 34: 157\u2013164.","journal-title":"Reprod Nutr Dev"}],"container-title":["International journal of pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02822387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF02822387\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02822387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T10:41:13Z","timestamp":1657190473000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF02822387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["BF02822387"],"URL":"https:\/\/doi.org\/10.1007\/bf02822387","relation":{},"ISSN":["0169-4197","2363-5134"],"issn-type":[{"value":"0169-4197","type":"print"},{"value":"2363-5134","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}