{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:25:53Z","timestamp":1784204753164,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1987,12,1]],"date-time":"1987-12-01T00:00:00Z","timestamp":565315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Archiv B Cell Pathol"],"published-print":{"date-parts":[[1987,12]]},"DOI":"10.1007\/bf02899196","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T03:17:23Z","timestamp":1214450243000},"page":"52-58","source":"Crossref","is-referenced-by-count":70,"title":["Level ofOpisthorchis infestation and carcinogen dose-dependence of cholangiocarcinoma induction in Syrian golden hamsters"],"prefix":"10.1007","volume":"54","author":[{"given":"Witaya","family":"Thamavit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungtiva","family":"Kongkanuntn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"Tiwawech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm Anthony","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02899196_CR1","first-page":"87","volume-title":"Primary liver tumors","author":"P Bannasch","year":"1978","unstructured":"Bannasch P (1978) Cellular and subcellular pathology of liver carcinogenesis. In: Remmer H, Bolt HM, Bannasch P, Popper H (eds) Primary liver tumors. University Park Press, Baltimore, p 87"},{"key":"BF02899196_CR2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00506497","volume":"87","author":"P Bannasch","year":"1976","unstructured":"Bannasch P, Massner B (1976) Histogenese und Cytogenese von Cholangiofibromen und Cholangiocarcinomen bei Ni-trosomorpholinvergifteten Ratten. Z Krebsforsch 87: 239\u2013255","journal-title":"Z Krebsforsch"},{"key":"BF02899196_CR3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF02889287","volume":"24","author":"P Bannasch","year":"1977","unstructured":"Bannasch P, Massner B (1977) Die Feinstruktur des Nitrosomorpholin-induzierten Cholangiofibroms der Ratte. Virchows Arch [Cell Pathol] 24:295\u2013315","journal-title":"Virchows Arch [Cell Pathol]"},{"key":"BF02899196_CR4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00303564","volume":"76","author":"P Bannasch","year":"1971","unstructured":"Bannasch P, Reiss W (1971) Histogenese und Cytogenese cholangiocellularer Tumoren bei Nitrosomorpholin-vergifteten Ratten. Zugleich ein Beitrag zur Morphogenese der Cystenleber. Z Krebsforsch 76:193\u2013215","journal-title":"Z Krebsforsch"},{"key":"BF02899196_CR5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/1097-0142(197302)31:2<468::AID-CNCR2820310226>3.0.CO;2-J","volume":"31","author":"J Belamaric","year":"1973","unstructured":"Belamaric J (1973) Intrahepatic bile duct carcinoma and C. sinensis infection in Hong Kong. Cancer 31:468\u2013473","journal-title":"Cancer"},{"key":"BF02899196_CR6","first-page":"241","volume":"89","author":"F Bergman","year":"1981","unstructured":"Bergman F, Wahlin T (1981) Tumour induction in Syrian hamsters fed a combination of aminopyrine and nitrite. Acta Pathol Microbiol Scand Sec. A 89:241\u2013245","journal-title":"Acta Pathol Microbiol Scand Sec. A"},{"key":"BF02899196_CR7","first-page":"267","volume":"45","author":"N Bhamarapravati","year":"1966","unstructured":"Bhamarapravati N, Viranuvatti V (1966) Liver diseases in Thailand. An analysis of liver biopsies. Am J Gastroenterol 45:267\u2013275","journal-title":"Am J Gastroenterol"},{"key":"BF02899196_CR8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4269\/ajtmh.1978.27.787","volume":"27","author":"N Bhamarapravati","year":"1978","unstructured":"Bhamarapravati N, Thamavit W, Vajrasthira S (1978) Liver changes in hamsters infected with a liver fluke of man, Opisthorchis viverrini. Am J Trop Med Hyg 27:787\u2013794","journal-title":"Am J Trop Med Hyg"},{"key":"BF02899196_CR9","first-page":"135","volume":"19","author":"S Boonpucknavig","year":"1986","unstructured":"Boonpucknavig S, Kurathong S, Thamavit W (1986) Detection of antibodies in sera from patients with Opisthorchiasis. J Clin Lab Immunol 19:135\u2013137","journal-title":"J Clin Lab Immunol"},{"key":"BF02899196_CR10","first-page":"185","volume":"93","author":"PH Chan","year":"1969","unstructured":"Chan PH, Teoh TB (1969) The pathology of Clonorchis sinensis infestation of the pancreas. J Pathol Bacteriol 93:185\u2013189","journal-title":"J Pathol Bacteriol"},{"key":"BF02899196_CR11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/path.1711080109","volume":"108","author":"ST Chou","year":"1972","unstructured":"Chou ST, Gibson JB (1972) A comparative histochemical study of rat livers in alpha-napthyl-iso-thiocyanate (ANIT) and DL-ethionine intoxication. J Pathol 108:73\u201383","journal-title":"J Pathol"},{"key":"BF02899196_CR12","first-page":"2096","volume":"41","author":"A Columbano","year":"1981","unstructured":"Columbano A, Rajalakshmi S, Sarma DS (1981) Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures. Cancer Res 41:2096\u20132102","journal-title":"Cancer Res"},{"key":"BF02899196_CR13","first-page":"899","volume":"47","author":"VM Craddock","year":"1971","unstructured":"Craddock VM (1971) Liver carcinomas induced in rats by single administration of dimethylnitrosamine after partial hepatectomy. J Natl Cancer Inst 47:899\u2013907","journal-title":"J Natl Cancer Inst"},{"key":"BF02899196_CR14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/path.1711040305","volume":"104","author":"AH Cruickshank","year":"1971","unstructured":"Cruickshank AH, Sparshott SM (1971) Malignancy in natural and experimental cysts: experiments with aflatoxin in rats and the malignant transformation of cysts in human livers. J Pathol 104:185\u2013190","journal-title":"J Pathol"},{"key":"BF02899196_CR15","first-page":"57","volume":"66","author":"KR Falchuk","year":"1976","unstructured":"Falchuk KR, Lesser PB, Galdabini JJ, Isselbacher KJ (1976) Cholangiocarcinoma as related to chronic intrahepatic cholangitis and hepatolithiasis. Am J Gastroenterol 66:57\u201361","journal-title":"Am J Gastroenterol"},{"key":"BF02899196_CR16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/bjc.1982.313","volume":"46","author":"DJ Flavell","year":"1982","unstructured":"Flavell DJ, Lucas SB (1982) Potentiation by the human liver fluke Opisthorchis viverrini of the carcinogenic action of N-nitrosodimethylamine upon the biliary epithelium of the hamster. Br J Cancer 46:985\u2013989","journal-title":"Br J Cancer"},{"key":"BF02899196_CR17","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/carcin\/4.7.927","volume":"4","author":"DJ Flavell","year":"1983","unstructured":"Flavell DJ, Lucas SB (1983) Promotion of N-nitrosodimethylamine-initiated bile duct carcinogenesis in the hamster by the human liver fluke, Opisthorchis viverrini. Carcinogenesis 4:927\u2013930","journal-title":"Carcinogenesis"},{"key":"BF02899196_CR18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0009-2797(79)90048-6","volume":"25","author":"BGJ Floot","year":"1979","unstructured":"Floot BGJ, Philippus EJ, Hart AAM, Den Engelse L (1979) Persistence and accumulation of (potential) single-strand breaks in liver DNA of rats treated with diethylnitrosamine or dimethylnitrosamine: correlation with hepatocarcinogenicity. Chem-Biol Interact 25:229\u2013242","journal-title":"Chem-Biol Interact"},{"key":"BF02899196_CR19","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/bjc.1982.278","volume":"46","author":"KG Giambarresi","year":"1982","unstructured":"Giambarresi KG, Katyal SL, Lombardi B (1982) Promotion of liver cancer in the rat by a choline devoid diet: role of liver necrosis and regeneration. Br J Cancer 46:825\u2013829","journal-title":"Br J Cancer"},{"key":"BF02899196_CR20","first-page":"1099","volume":"39","author":"KM Herrold","year":"1967","unstructured":"Herrold KM (1967) Histogenesis of malignant liver tumors induced by dimethylnitrosamine. An experimental study in Syrian hamsters. J Natl Cancer Inst 39:1099\u20131111","journal-title":"J Natl Cancer Inst"},{"key":"BF02899196_CR21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/path.1700720130","volume":"72","author":"PC Hou","year":"1956","unstructured":"Hou PC (1956) The relationship between primary liver cancer and infestation with Clonorchis sinensis. J Pathol Bact 72:239\u2013246","journal-title":"J Pathol Bact"},{"key":"BF02899196_CR22","first-page":"239","volume":"87","author":"PC Hou","year":"1984","unstructured":"Hou PC (1984) Primary carcinoma of bile duct of the liver of the cat (Felis catus) infested with Clonorchis sinensis. J Pathol Bact 87:239\u2013244","journal-title":"J Pathol Bact"},{"key":"BF02899196_CR23","first-page":"356","volume":"89","author":"PC Hou","year":"1965","unstructured":"Hou PC (1965) Hepatic clonorchiasis and carcinoma of the bile duct in a dog. J Pathol Bact 89:356\u2013367","journal-title":"J Pathol Bact"},{"key":"BF02899196_CR24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","volume":"29","author":"SM Hsu","year":"1981","unstructured":"Hsu SM, Raine L, Farger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody PAP procedures. J Histochem Cytochem 29:577\u2013580","journal-title":"J Histochem Cytochem"},{"key":"BF02899196_CR25","first-page":"247","volume":"15","author":"Y II Kim","year":"1974","unstructured":"Kim Y II, Yang DH, Chang KR (1974) Clonorchis sinensis infestation and cholangiocarcinoma of the liver in Korea: epidemiological and pathological reappraisal of 495 consecutive primary carcinomas of the liver in Seoul and Pusan areas. Seoul J Med 15:247\u2013253","journal-title":"Seoul J Med"},{"key":"BF02899196_CR26","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/1097-0142(19841115)54:10<2277::AID-CNCR2820541037>3.0.CO;2-W","volume":"54","author":"S Kozuka","year":"1984","unstructured":"Kozuka S, Kurashina M, Tsubone M, Hachisuka K, Yasui A (1984) Significance of intestinal metaplasia for the evolution of cancer in the biliary tract. Cancer 54:2277\u20132285","journal-title":"Cancer"},{"key":"BF02899196_CR27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0016-5085(85)90755-3","volume":"89","author":"S Kurathong","year":"1985","unstructured":"Kurathong S, Lerdvirasirikul P, Wougpaitoon V, Pramoolsinsap C, Kanjanapitak A, Varawithaya W, Phupradit P, Bunyaratvej S, Upatham S, Brockelman WY (1985) Opisthorchis viverrini infection and cholangiocarcinoma: a prospective, case-control study. Gastroenterol 89:151\u2013156","journal-title":"Gastroenterol"},{"key":"BF02899196_CR28","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/carcin\/3.6.707","volume":"3","author":"AEM McClean","year":"1982","unstructured":"McClean AEM, Smith M, Driver HE (1982) Liver tumors after single dose dimethylnitrosamine, low and high protein diet, and phenobarbitone. Carcinogenesis 3:707\u2013709","journal-title":"Carcinogenesis"},{"key":"BF02899196_CR29","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/0016-5085(84)90540-7","volume":"87","author":"WM Melia","year":"1984","unstructured":"Melia WM, Johnson PJ, Neuberger J, Zaman S, Portmann BC, Williams R (1984) Hepatocellular carcinoma in primary biliary cirrhosis: detection by a-fetoprotein estimation. Gastroenterol 87:660\u2013663","journal-title":"Gastroenterol"},{"key":"BF02899196_CR30","first-page":"175","volume":"57","author":"P Migasena","year":"1974","unstructured":"Migasena P, Changbumrung S (1974) The role of nitrosamines in the causation of primary carcinoma. J Med Assoc Thailand 57:175\u2013178","journal-title":"J Med Assoc Thailand"},{"key":"BF02899196_CR31","first-page":"500","volume":"63","author":"P Migasena","year":"1980","unstructured":"Migasena P, Reaunsuwan W, Changbumrung S (1980) Nitrates and nitrites in local Thai preserved protein foods. J Med Assoc Thailand 63:500\u2013505","journal-title":"J Med Assoc Thailand"},{"key":"BF02899196_CR32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02899013","volume":"51","author":"MA Moore","year":"1986","unstructured":"Moore MA, Fukushima S, Ichihara A, Sato K, Ito N (1986) Intestinal metaplasia and altered enzyme expression in propylnitrosamine-induced Syrian hamster cholangiocellular and gallbladder lesions. Virch Archiv B Cell Pathol 51:29\u201338","journal-title":"Virch Archiv B Cell Pathol"},{"key":"BF02899196_CR33","first-page":"272","volume":"68","author":"MR Moore","year":"1982","unstructured":"Moore MR, Pitot HC, Miller EC, Miller JA (1982) Cholangiocellular carcinomas induced in Syrian golden hamsters administered aflatoxin Bl in large doses. J Natl Cancer Inst 68:272\u2013278","journal-title":"J Natl Cancer Inst"},{"key":"BF02899196_CR34","first-page":"620","volume":"3","author":"RW Mowry","year":"1957","unstructured":"Mowry RW, Morard JC (1957) The distribution of acid mucopolysaccharides in normal kidneys, as shown by the Alcianblue Feulgen (AB-F) and Alcian-blue-periodic acid-Schiff (AB-PAS) stains. Am J Pathol 3:620\u2013621","journal-title":"Am J Pathol"},{"key":"BF02899196_CR35","first-page":"191","volume":"605","author":"HC Pitot","year":"1980","unstructured":"Pitot HC, Scirica AE (1980) The stages of initiation and promotion in hepatocarcinogenesis. Biochim Biophys Acta 605:191\u2013215","journal-title":"Biochim Biophys Acta"},{"key":"BF02899196_CR36","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/bjc.1978.88","volume":"37","author":"AW Pound","year":"1978","unstructured":"Pound AW, McGuire LJ (1978a) Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats. Br J Cancer 37:585\u2013594","journal-title":"Br J Cancer"},{"key":"BF02899196_CR37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/bjc.1978.89","volume":"37","author":"AW Pound","year":"1978","unstructured":"Pound AW, McGuire LJ (1978b) Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice. Br J Cancer 37:595\u2013602","journal-title":"Br J Cancer"},{"key":"BF02899196_CR38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/jnci\/54.1.141","volume":"54","author":"P Pour","year":"1974","unstructured":"Pour P, Kruger FW, Althoff J, Cardesa A, Mohr U (1974) Effect of beta-oxidised nitrosamines on Syrian hamsters. III. 2,2\u2032-Dihydroxy-di-n-propymitrosamine. J Natl Cancer Inst 54:141\u2013145","journal-title":"J Natl Cancer Inst"},{"key":"BF02899196_CR39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0304-3835(78)80007-X","volume":"5","author":"MS Rao","year":"1978","unstructured":"Rao MS, Pour P (1978) Development of biliary and hepatic neoplasms in Guinea pigs treated with nitrosobis(2-oxopro-pyl)amine. Cancer Lett 5:31\u201334","journal-title":"Cancer Lett"},{"key":"BF02899196_CR40","first-page":"189","volume":"87","author":"KP Reddy","year":"1977","unstructured":"Reddy KP, Buschmann RJ, Chomet B (1977) Cholangiocarcinomas induced by feeding 3\u2032-methyl-4-dimethylaminoazobenzene to rats: histopathology and ultrastructure. Am J Pathol 87:189\u2013204","journal-title":"Am J Pathol"},{"key":"BF02899196_CR41","first-page":"901","volume":"38","author":"MD Reuber","year":"1967","unstructured":"Reuber MD (1967) Poorly differentiated cholangiocarcinomas occurring \u201cspontaneously\u201d in C3H and C3H\u00d7Y hybrid mice. J Natl Cancer Inst 38:901\u2013907","journal-title":"J Natl Cancer Inst"},{"key":"BF02899196_CR42","first-page":"239","volume":"59","author":"MD Reuber","year":"1968","unstructured":"Reuber MD (1968) Histogenesis of cholangiofibrosis and welldifferentiated cholangiocarcinoma in Syrian hamsters given 2-acetamidofluorene or 2-diacetamidofluorene. Gann 59: 239\u2013246","journal-title":"Gann"},{"key":"BF02899196_CR43","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1073\/pnas.82.12.3964","volume":"82","author":"K Satoh","year":"1985","unstructured":"Satoh K, Kitahara A, Soma Y, Hatayama I, Sato K (1985) Purification, induction and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical carcinogenesis. Proc Natl Acad Sci USA 82:3964\u20133968","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02899196_CR44","first-page":"567","volume":"17","author":"S Sirisinha","year":"1986","unstructured":"Sirisinha S, Wongratanacheewin S (1986) Immunization of hamsters against Opisthorchis viverrini infection. Southeast Asian J Trop Med Pub Hlth 17:567\u2013573","journal-title":"Southeast Asian J Trop Med Pub Hlth"},{"key":"BF02899196_CR45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S0031182000057231","volume":"86","author":"S Sirisinha","year":"1983","unstructured":"Sirisinha S, Tuti S, Tawatsin A, Vichasri S, Upatham ES, Bunnag D (1983) Attempts to induce protective immunity in hamsters against infection by a liver fluke of man (Opisthorchis viverrini). Parasitology 86:127\u2013136","journal-title":"Parasitology"},{"key":"BF02899196_CR46","first-page":"215","volume":"9","author":"D Sonakul","year":"1978","unstructured":"Sonakul D, Koompirochana C, Chinda K, Stitnimakarn T (1978) Hepatic carcinoma with opisthorchiasis. Southeast Asian J Trop Med Pub Hlth 9:215\u2013219","journal-title":"Southeast Asian J Trop Med Pub Hlth"},{"key":"BF02899196_CR47","first-page":"234","volume":"16","author":"P Srivatanakul","year":"1985","unstructured":"Srivatanakul P, Viyanant V, Kurathong S, Tiwawech D (1985) Enzyme-linked immunosorbent assay for detection of Opisthorchis viverrini infection. Southeast Asian J Trop Med Pub Hlth 16:234\u2013239","journal-title":"Southeast Asian J Trop Med Pub Hlth"},{"key":"BF02899196_CR48","first-page":"249","volume":"65","author":"K Terao","year":"1974","unstructured":"Terao K, Nakano M (1974) Cholangiofibrosis induced by short-term feeding of 3\u2032-methyl-4-dimethylaminoazobenzene to rats: an electron microscope observation. Gann 65:249\u2013260","journal-title":"Gann"},{"key":"BF02899196_CR49","first-page":"4634","volume":"38","author":"W Thamavit","year":"1978","unstructured":"Thamavit W, Bhamarapravati N, Sahaphong S, Vajrasthira S, Angsubhakorn S (1978) Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverriniinfected Syrian golden hamsters. Cancer Res 38:4634\u20134639","journal-title":"Cancer Res"},{"key":"BF02899196_CR50","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.4269\/ajtmh.1982.31.1156","volume":"31","author":"ES Upatham","year":"1982","unstructured":"Upatham ES, Viyanant V, Kurathong S, Brockelman WY, Menaruchi A, Soawakontha S, Intarakhao S, Vajrasthira S, Warren KS (1982) Morbidity in relation to intensity of infection inOpisthorchis viverrini: study of a community in Khon Kaen, Thailand. Am J Trop Med Hyp 31:1156\u20131163","journal-title":"Thailand. Am J Trop Med Hyp"},{"key":"BF02899196_CR51","first-page":"451","volume":"62","author":"ES Upatham","year":"1984","unstructured":"Upatham ES, Viyanant V, Kurathong S, Rojborwonwitaya J, Brockelman WY, Ardsurgnoen S, Lee P, Vajrasthira S (1984) Relations between prevalence, intensity of infection, and clinical symptoms and signs inOpisthorchis viverrini infection in a rural community in northeast Thailand. Bull WHO 62:451\u2013461","journal-title":"Bull WHO"}],"container-title":["Virchows Archiv B Cell Pathology Including Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02899196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02899196\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02899196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T16:59:12Z","timestamp":1631465952000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02899196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,12]]}},"alternative-id":["BF02899196"],"URL":"https:\/\/doi.org\/10.1007\/bf02899196","relation":{},"ISSN":["0042-6431"],"issn-type":[{"value":"0042-6431","type":"print"}],"subject":[],"published":{"date-parts":[[1987,12]]}}}