{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:31:28Z","timestamp":1768001488992,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Pharm Res"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1007\/bf02974078","type":"journal-article","created":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T04:41:59Z","timestamp":1225341719000},"page":"768-776","source":"Crossref","is-referenced-by-count":42,"title":["Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob\/ob mice"],"prefix":"10.1007","volume":"29","author":[{"given":"Sang Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Gil","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Keel","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hyun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02974078_CR1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","volume":"346","author":"P. Angulo","year":"2002","unstructured":"Angulo, P. Nonalcoholic fatty liver disease.New Engl. J. Med., 346, 1221\u20131231 (2002).","journal-title":"New Engl. J. Med."},{"key":"BF02974078_CR2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P. Chomczynski","year":"1987","unstructured":"Chomczynski, P. and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.Anal. Biochem. 162, 156\u2013159 (1987).","journal-title":"Anal. Biochem."},{"key":"BF02974078_CR3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.1071527","volume":"297","author":"P. Cohen","year":"2002","unstructured":"Cohen, P., Miyazaki, M., Socci, N. D., Hagge-Greenberg, A., Liedtke, W., Soukas, A. A., Sharma, R., Hudgins, L. C., Ntambi, J. M., and Friedman, J. M., Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.Science, 297, 240\u2013243 (2002).","journal-title":"Science"},{"key":"BF02974078_CR4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1172\/JCI200113914","volume":"108","author":"P. Cohen","year":"2001","unstructured":"Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S. C., Feinstein, P., Mombaerts, P., and Friedman, J. M., Selective deletion of leptin receptor in neurons leads to obesity.J. Clin. Invest., 108, 1113\u20131121 (2001).","journal-title":"J. Clin. Invest."},{"key":"BF02974078_CR5","first-page":"4059","volume":"81","author":"K. Cusi","year":"1996","unstructured":"Cusi, K., Consol, A., and DeFronzo, R. A., Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.J. Clin. Endocr. and Metab. 81, 4059\u20134067 (1996).","journal-title":"J. Clin. Endocr. and Metab."},{"key":"BF02974078_CR6","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0006-2952(01)00764-X","volume":"62","author":"G. F. Davies","year":"2001","unstructured":"Davies, G. F., Khandelwal, R. L., Wu, L., Juurlink, B. H., and Roesler, W. J., Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism.Biochem Pharmacol., 62, 1071\u20131079 (2001).","journal-title":"Biochem Pharmacol."},{"key":"BF02974078_CR7","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","volume":"115","author":"K. L. Donnelly","year":"2005","unstructured":"Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., and Parks, E. J., Sources of fatty acids stored in liver and secreted via lipoproteins in patients with NAFLD.J. Clin. Invest., 115, 1343\u20131351 (2005).","journal-title":"J. Clin. Invest."},{"key":"BF02974078_CR8","first-page":"2093","volume":"98","author":"P. Hookman","year":"2002","unstructured":"Hookman, P. and Barkin, J. S., Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach.Am. J. Gastroenterol., 98, 2093\u20132097 (2002).","journal-title":"Am. J. Gastroenterol."},{"key":"BF02974078_CR9","doi-asserted-by":"crossref","first-page":"49066","DOI":"10.1074\/jbc.M107250200","volume":"276","author":"C. P. Liang","year":"2001","unstructured":"Liang, C. P. and Tall, A. R., Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob\/ob mouse liver.J. Biol. Chem., 276, 49066\u201349076 (2001).","journal-title":"J. Biol. Chem."},{"key":"BF02974078_CR10","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/79697","volume":"6","author":"H. Z. Lin","year":"2000","unstructured":"Lin, H. Z., Yang, S. Q., Kujhada, F., Ronnet, G., and Diehl, A. M., Metformin reverses nonalcoholic fatty liver disease in obese leptin-deficient mice.Nat. Med., 6, 998\u20131003 (2000).","journal-title":"Nat. Med."},{"key":"BF02974078_CR11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1462-8902.2004.00356.x","volume":"6","author":"M. Manco","year":"2004","unstructured":"Manco, M., Calvani, M., and Mingrone, G., Effects of dietary fatty acids on insulin sensitivity and secretion.Diabetes. Obes. Metab., 6, 402\u2013413 (2004).","journal-title":"Diabetes. Obes. Metab."},{"key":"BF02974078_CR12","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(01)06042-1","volume":"358","author":"G. Marchesini","year":"2001","unstructured":"Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Zoli, M., and Melchionda, N., Metformin in non-alcoholic steatohepatitis.Lancet., 358, 893\u2013894 (2001).","journal-title":"Lancet."},{"key":"BF02974078_CR13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"D. R. Matthews","year":"1985","unstructured":"Matthews, D. R., Hosker, J. P., Rudenky, A. S., Naylor, B. A., Treacher, D. F., and Turner, R. C., Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentration in man.Diabetologia, 28, 412\u2013419 (1985).","journal-title":"Diabetologia"},{"key":"BF02974078_CR14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1530\/eje.0.1360137","volume":"136","author":"G. Mithieux","year":"1997","unstructured":"Mithieux, G., New knowledge regarding glucose-6-phosphatase gene and protein and their roles in the regulation of glucose metabolism.Eur. J. Endocr., 136, 137\u2013145 (1997).","journal-title":"Eur. J. Endocr."},{"key":"BF02974078_CR15","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1053\/jhep.2003.50420","volume":"38","author":"B. A. Neuschwander-Tetri","year":"2003","unstructured":"Neuschwander-Tetri, B. A., Brunt, E. M., Wehmeier, K. R., Oliver, D., and Bacon, B. R., Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone.Hepatology, 38, 1008\u20131017 (2003).","journal-title":"Hepatology"},{"key":"BF02974078_CR16","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1248\/cpb.38.2871","volume":"38","author":"S. Nishioka","year":"1990","unstructured":"Nishioka, S., Kinoshita, H., Takeda, H., and Okano, G., Phenolic compounds from the stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats.Chem. Pharm Bull., 38, 1763\u20131765 (1990).","journal-title":"Chem. Pharm Bull."},{"key":"BF02974078_CR17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/ajcn\/77.1.43","volume":"77","author":"J. M. Schwarz","year":"2003","unstructured":"Schwarz, J. M., Linfoot, P., Date, D. and Aghajanian, K., Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high fat, low carbohydrate and low fat, high catbohydrate isoenergetic diets.Am. J. Clin. Nutr., 77, 43\u201350 (2003).","journal-title":"Am. J. Clin. Nutr."},{"key":"BF02974078_CR18","doi-asserted-by":"crossref","first-page":"30028","DOI":"10.1074\/jbc.274.42.30028","volume":"274","author":"I. Shimomura","year":"1999","unstructured":"Shimomura, I., Bashmakov, Y., and Horton, J. D., Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus.J. Biol. Chem. 274, 30028\u201330032 (1999).","journal-title":"J. Biol. Chem."},{"key":"BF02974078_CR19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jcp.22.2.158","volume":"22","author":"P. Trinder","year":"1969","unstructured":"Trinder, P., Determination of blood glucose using an oxidaseperoxidase system with a non-carcinogenic chromogen.J. Clin. Pathol., 22, 158\u2013161 (1969).","journal-title":"J. Clin. Pathol."},{"key":"BF02974078_CR20","doi-asserted-by":"crossref","first-page":"946","DOI":"10.7326\/0003-4819-141-12-200412210-00011","volume":"141","author":"K. G. Tolman","year":"2004","unstructured":"Tolman, K. G., Fonseca, V., Tan, M. H., and Dalpiaz, A., Narative review: hepatobiliary disease in type 2 diabetes mellitus.Annu. Intern. Med., 141, 946\u2013956 (2004).","journal-title":"Annu. Intern. Med."}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02974078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02974078\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02974078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T23:40:02Z","timestamp":1558568402000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02974078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["BF02974078"],"URL":"https:\/\/doi.org\/10.1007\/bf02974078","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}