{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:44:29Z","timestamp":1774061069144,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Pharm Res"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1007\/bf02977787","type":"journal-article","created":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T09:51:17Z","timestamp":1225360277000},"page":"114-123","source":"Crossref","is-referenced-by-count":34,"title":["Formulation of parenteral microemulsion containing itraconazole"],"prefix":"10.1007","volume":"30","author":[{"given":"Yun-Seok","family":"Rhee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Woong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Young","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Sub","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Cheol","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Seok","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"Suppl 1","key":"BF02977787_CR1","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1093\/clinids\/14.Supplement_1.S43","volume":"14","author":"E. Anaissie","year":"1992","unstructured":"Anaissie, E., Opportunistic mycoses in the immunocompromised host: experience at a cancer center and review.Clin. Infect. Dis., 14(Suppl 1), S43\u201353 (1992).","journal-title":"Clin. Infect. Dis."},{"key":"BF02977787_CR2","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1093\/clinids\/14.Supplement_1.S161","volume":"14","author":"G. P. Bodey","year":"1992","unstructured":"Bodey, G. P., Azole antifungal agents.Clin. Infect. Dis., 14 (SuppM), S161\u2013169 (1992).","journal-title":"Clin. Infect. Dis."},{"key":"BF02977787_CR3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/jac\/28.4.555","volume":"28","author":"C. R. Bradford","year":"1991","unstructured":"Bradford, C. R., Prentice, A. G., Warnock, D.W., and Copplestone, J. A., Comparison of the multiple dose pharma-cokinetics of two formulations of itraconazole during remission induction for acute myeloblastic leukaemia.J. Antimicrob. Chemother., 28, 555\u2013560(1991).","journal-title":"J. Antimicrob. Chemother."},{"key":"BF02977787_CR4","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1093\/clinids\/9.Supplement_1.S146","volume":"9","author":"G Cauwenbergh","year":"1987","unstructured":"Cauwenbergh, G, De Doncker, P., Stoops, K., De Dier, A. M., Goyvaerts, H., and Schuermans, V., Itraconazole in the treatment of human mycoses: review of three years of clinical experience.Rev. Infect. Dis., 9(Suppl 1), S146\u2013152 (1987).","journal-title":"Rev. Infect. Dis."},{"key":"BF02977787_CR5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM199401273300407","volume":"330","author":"J. A. Como","year":"1994","unstructured":"Como, J. A. and Dismukes, W. E., Oral azole drugs as systemic antifungal therapy.N. Engl. J. Med., 330, 263\u2013272 (1994).","journal-title":"N. Engl. J. Med."},{"key":"BF02977787_CR6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1439-0507.1988.tb03653.x","volume":"31","author":"K. Beule De","year":"1988","unstructured":"De Beule, K., De Doncker, P., Cauwenbergh, G., Koster, M., Legendre, R., Blatchford, N., Daunas, J., and Chwetzoff, E., The treatment of aspergillosis and aspergilloma with itraconazole, clinical results of an open international study (1982-1987).Mycoses, 31, 476\u2013485 (1988).","journal-title":"Mycoses"},{"key":"BF02977787_CR7","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/clinids\/12.6.1147","volume":"12","author":"D. W. Denning","year":"1990","unstructured":"Denning, D. W. and Stevens, D. A., Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases.Rev. Infect. Dis., 12,1147\u20131201 (1990).","journal-title":"Rev. Infect. Dis."},{"key":"BF02977787_CR8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0190-9622(90)70263-H","volume":"23","author":"B. Dupont","year":"1990","unstructured":"Dupont, B., Itraconazole therapy in aspergillosis: study in 49 patients.J. Am. Acad. Dermatol., 23, 607\u2013614 (1990).","journal-title":"J. Am. Acad. Dermatol."},{"key":"BF02977787_CR9","first-page":"261","volume":"2","author":"A. G. Floyd","year":"1996","unstructured":"Floyd, A. G. and Jain, S., Injectable emulsions and suspensions. Pharmaceutical dosage forms: disperse system. Marcel Dekker, Vol. 2, pp. 261\u2013318 (1996).","journal-title":"Pharmaceutical dosage forms: disperse system. Marcel Dekker"},{"key":"BF02977787_CR10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1461-5347(99)00141-8","volume":"2","author":"A. G. Floyd","year":"1999","unstructured":"Floyd, A. G., Top ten considerations in the development of parenteral emulsions.Pham. Sci. Technolo. Today, 2, 134\u2013143(1999).","journal-title":"Pham. Sci. Technolo. Today"},{"key":"BF02977787_CR11","first-page":"164","volume":"41","author":"R. C Fu","year":"1987","unstructured":"Fu, R. C, Lidgate, D. M., Whatley, J. L., and Mccullough, T., The biocompatibility of parenteral vehicles-in vitro\/in vivo screening comparison and the effect of excipients on hemolysis.J. Parenter. Sci. Technol., 41,164\u2013168 (1987).","journal-title":"J. Parenter. Sci. Technol."},{"key":"BF02977787_CR12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-5173(90)90225-S","volume":"62","author":"M. R. Gasco","year":"1990","unstructured":"Gasco, M. R., Patarino, F., and Lattanzi, F., Long-acting delivery systems for peptides: reduced plasma testosterone levels in male rats after a single injection.Int. J. Pharm., 62, 119\u2013123 (1990).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2165\/00003495-198937030-00003","volume":"37","author":"S. M. Grant","year":"1989","unstructured":"Grant, S. M. and Clissold, S. P., Itraconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses.Drugs, 37,310\u2013344(1989).","journal-title":"Drugs"},{"key":"BF02977787_CR14","first-page":"63","volume":"34","author":"F. R. Hallett","year":"1989","unstructured":"Hallett, F. R., Craig, T, Marsh, J., and Nickel, B., Particle size analysis: number distributions by dynamic light scattering.Can. J. Spectrosc, 34, 63\u201370 (1989).","journal-title":"Can. J. Spectrosc"},{"key":"BF02977787_CR15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1439-0507.1989.tb02296.x","volume":"32","author":"J. Heykants","year":"1989","unstructured":"Heykants, J., Van Peer, A., Van de Velde, V., Van Rooy, P., Meuldermans, W., Lavrijsen, K., Woestenborghs, R., and Cauwenbergh, G., The clinical pharmacokinetics of itraconazole: an overview.Mycoses, 32, 67\u201387 (1989).","journal-title":"Mycoses"},{"key":"BF02977787_CR16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijpharm.2004.02.025","volume":"276","author":"S. R. Hwang","year":"2004","unstructured":"Hwang, S. R., Lim, S. J., Park, J. S., and Kim, C. K., Phospholipid-based microemulsion formulation of all-trans-retinoic acid for parenteral administration.Int. J. Pharm., 276,175\u2013183 (2004).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0939-6411(97)00170-7","volume":"46","author":"M. Jumaa","year":"1998","unstructured":"Jumaa, M., Kleinebudde, P., and Muller, B. W., Mixture experiments with the oil phase of parenteral emulsions.Eur. J. Pharm. Biopharm., 46,161\u2013167 (1998).","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"BF02977787_CR18","first-page":"37","volume":"29","author":"K. K. Kim","year":"1999","unstructured":"Kim, K. K., Rhee, Y S., Bae, J. H., Chi, S. C., and Park, E. S., Improvement of dissolution rate of poorly water soluble drug using self-microemulsifying drug delivery system.J. Kor. Pharm. Sci., 29, 37\u201345 (1999).","journal-title":"J. Kor. Pharm. Sci."},{"key":"BF02977787_CR19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpharm.2004.07.019","volume":"284","author":"J. E. Kipp","year":"2004","unstructured":"Kipp, J. E., The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs.Int. J. Pharm., 284,109\u2013122 (2004).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-5173(97)00082-3","volume":"152","author":"J. F. Krzyzaniak","year":"1997","unstructured":"Krzyzaniak, J. F., Raymond, D. M., and Yalkowsky, S. H., Lysis of human red blood cells 2: effect of contact time on cosolvent induced hemolysis.Int. J. Pharm., 152,193\u2013200 (1997).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0378-5173(98)00393-7","volume":"179","author":"K. Miyake","year":"1999","unstructured":"Miyake, K., Irie, T., Arima, H, Hirayama, F., Uekama, K., Hirano, M., and Okamaoto, Y., Characterization of itraconazole\/2-hydroxypropyl-beta-cyclodextrin inclusion complex in aqueous propylene glycol solution.Int. J. Pharm., 179,237\u2013245 (1999).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR22","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/jps.10412","volume":"92","author":"M. A. Moreno","year":"2003","unstructured":"Moreno, M. A., Ballesteros, M.P., and Frutos, P., Lecithin-based oil-in-water microemulsions for parenteral use: pseudoternary phase diagrams, characterization and toxicity studies.J. Pharm. Sci., 92,1428\u20131437 (2003).","journal-title":"J. Pharm. Sci."},{"key":"BF02977787_CR23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0378-5173(99)00029-0","volume":"181","author":"K. M. Park","year":"1999","unstructured":"Park, K. M. and Kim, C. K., Preparation and evaluation of flurbi- profen-loaded microemulsion for parenteral delivery.Int. J. Pharm., 181,173\u2013179(1999)","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-5173(99)00080-0","volume":"183","author":"K. M. Park","year":"1999","unstructured":"Park, K. M., Lee, M. K., Hwang, K. J., and Kim, C. K., Phospho-lipid-based microemulsions of flurbiprofen by the spontaneous emulsification process.Int. J. Pharm., 183, 145\u2013154 (1999).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-5173(99)00436-6","volume":"196","author":"A. Racomska","year":"2000","unstructured":"Racomska, A. and Dobrucki, R., The use of some ingredients for microemulsion preparation containing retinol and its esters.Int. J. Pharm., 196, 131\u2013134 (2000).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR26","first-page":"64","volume":"39","author":"K. W. Reed","year":"1985","unstructured":"Reed, K. W. and Yalkowsky, S. H., Lysis of human red blood cells in the presence of various cosolvents.J. Parenter. Sci. Techno\/., 39, 64\u201369(1985).","journal-title":"J. Parenter. Sci. Techno\/."},{"key":"BF02977787_CR27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0378-5173(94)00316-W","volume":"116","author":"H. S. Ruth","year":"1995","unstructured":"Ruth, H. S., Attwood, D., Ktistis, G, and Taylor, C. J., Phase studies and particle size analysis of oil-in-water phospholipid microemulsions.Int. J. Pharm., 116, 253\u2013261 (1995).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR28","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/BF02977908","volume":"28","author":"H. K. Ryoo","year":"2005","unstructured":"Ryoo, H. K., Park, C. W., Chi, S. C., and Park, E. S., Development of propofol-loaded microemulsion systems for parenteral delivery.Arch. Pharm. Res., 28, 1400\u20131404 (2005).","journal-title":"Arch. Pharm. Res."},{"key":"BF02977787_CR29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0378-5173(01)00986-3","volume":"235","author":"A. K. Singla","year":"2002","unstructured":"Singla, A. K., Garg, A., and Agarwal, D., Paclitaxel and its formulations.Int. J. Pharm., 235,179\u2013192 (2002).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR30","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1093\/clinids\/9.Supplement_1.S94","volume":"9","author":"G. Tricot","year":"1987","unstructured":"Tricot, G., Joosten, E., Boogaerts, M.A., Vande Pitte, J., and Cauwenbergh, G., Ketoconazole vs. itraconazole for antifungal prophylaxis in patients with severe granulocytopenia: preliminary results of two nonrandomized studies.Rev. Infect. Dis., 9(Suppl 1), S94\u201399 (1987).","journal-title":"Rev. Infect. Dis."},{"key":"BF02977787_CR31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-5173(96)04688-1","volume":"143","author":"M. Trotta","year":"1996","unstructured":"Trotta, M., Cavalli, R., Ugazio, E., and Gasco, M. R., Phase behaviour of microemulsion systems containing lecithin and lysolecithin as surfactants,Int. J. Pharm., 143,67\u201373 (1996).","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR32","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1093\/clinids\/9.Supplement_1.S15","volume":"9","author":"J. Cutsem Van","year":"1987","unstructured":"Van Cutsem, J., Van Gerven, F., and Janssen, P. A., Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models.Rev. Infect. Dis., 9(Suppl 1), S15\u201332 (1987).","journal-title":"Rev. Infect. Dis."},{"key":"BF02977787_CR33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1081-1206(10)62949-3","volume":"80","author":"G. W. Volcheck","year":"1998","unstructured":"Volcheck, G. W. and nVan Dellen, R. G, Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.Ann. Allergy Asthma Immunol., 80, 159\u2013163(1998).","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"BF02977787_CR34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0378-5173(99)00406-8","volume":"198","author":"W. Warisnoicharoen","year":"2000","unstructured":"Warisnoicharoen, W., Lansley, A. B., and Lawrence, M. J., Nonionic oil-in-water microemulsions: the effect of oil type on phase behaviour.Int. J. Pharm., 198, 7\u201327 (2000).ba]","journal-title":"Int. J. Pharm."},{"key":"BF02977787_CR35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/jac\/24.3.275","volume":"24","author":"D. W. Warnock","year":"1989","unstructured":"Warnock, D. W., Itraconazole and fluconazole: new drugs for deep fungal infection.J. Antimicrob. Chemother, 24, 275\u2013277(1989).","journal-title":"J. Antimicrob. Chemother"},{"key":"BF02977787_CR36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/32.1.5","volume":"32","author":"Working party of the British Society for Antimicrobial Chemotherapy","year":"1993","unstructured":"Working party of the British Society for Antimicrobial Chemotherapy, Chemoprophylaxis for candidosis and aspergillosis in neutropenia and transplantation: a review and recommendations.J. Antimicrob. Chemother, 32, 5\u201321 (1993).","journal-title":"J. Antimicrob. Chemother"},{"key":"BF02977787_CR37","doi-asserted-by":"crossref","unstructured":"Yi, Y., Yoon, H.J., Kim, B. O., Shim, M., Kim, S. O., Hwang, S. J., and Seo, M. H., A mixed polymeric micellar formulation of itraconazole: Characteristics, toxicity and pharmacokinetics.J. Control. Release, doi:10.1016\/j.jconrel.2006.10.001 (2006).","DOI":"10.1016\/j.jconrel.2006.10.001"},{"key":"BF02977787_CR38","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1248\/cpb.48.798","volume":"48","author":"S. D. Yoo","year":"2000","unstructured":"Yoo, S. D., Kang, E. H., Jun, H., Shin, B. S., Lee, K. C., and Lee, K. H., Absorption, First- pass metabolism, and disposition of itraconazole in rats.Chem. Pharm. Bull., 48, 798\u2013801 (2000).","journal-title":"Chem. Pharm. Bull."},{"key":"BF02977787_CR39","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1248\/cpb.53.1246","volume":"53","author":"X. Zhao","year":"2005","unstructured":"Zhao, X., Chen, D., Gao, P., Ding, P., and Li, K., Synthesis of ibuprofen eugenol ester and its microemulsion formulation for parenteral delivery.Chem. Pharm. Bull., 53, 1246\u20131250 (2005).","journal-title":"Chem. Pharm. Bull."}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02977787.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02977787\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02977787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T21:35:48Z","timestamp":1558474548000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02977787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["BF02977787"],"URL":"https:\/\/doi.org\/10.1007\/bf02977787","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}