{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:53:26Z","timestamp":1791140006486,"version":"4.1.0"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1007\/bf02981934","type":"journal-article","created":{"date-parts":[[2008,11,3]],"date-time":"2008-11-03T14:56:01Z","timestamp":1225724161000},"page":"170-176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Pathogenesis of Chronic Myeloproliferative Diseases"],"prefix":"10.1007","volume":"73","author":[{"given":"Ayalew","family":"Tefferi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,2,1]]},"reference":[{"key":"BF02981934_CR1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.4065\/73.12.1177","volume":"73","author":"A Tefferi","year":"1998","unstructured":"Tefferi A. The Philadelphia chromosome negative chronic myeloproliferative disorders: a practical overview.Mayo Clin Proc. 1998;73:1177\u20131184.","journal-title":"Mayo Clin Proc."},{"key":"BF02981934_CR2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0145-2126(96)00028-8","volume":"20","author":"R Neuwirtova","year":"1996","unstructured":"Neuwirtova R, Mocikova K, Musilova J, et al. Mixed myelodysplastic and myeloproliferative syndromes.Leuk Res. 1996;20:717\u2013726.","journal-title":"Leuk Res."},{"key":"BF02981934_CR3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0002-9343(00)00449-6","volume":"109","author":"A Tefferi","year":"2000","unstructured":"Tefferi A, Solberg LA Jr, Silverstein MN. A clinical update in polycythemia vera and essential thrombocythemia.Am J Med. 2000;109:141\u2013149.","journal-title":"Am J Med."},{"key":"BF02981934_CR4","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1056\/NEJM200004273421706","volume":"342","author":"A Tefferi","year":"2000","unstructured":"Tefferi A. Myelofibrosis with myeloid metaplasia.N Engl J Med. 2000;342:1255\u20131265.","journal-title":"N Engl J Med."},{"key":"BF02981934_CR5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0065-230X(08)60796-4","volume":"49","author":"WH Raskind","year":"1987","unstructured":"Raskind WH, Fialkow PJ. The use of cell markers in the study of human hematopoietic neoplasia.Adv Cancer Res. 1987;49:127\u2013167.","journal-title":"Adv Cancer Res."},{"key":"BF02981934_CR6","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1182\/blood.V75.9.1770.1770","volume":"75","author":"A Tefferi","year":"1990","unstructured":"Tefferi A, Thibodeau SN, Solberg LA Jr. Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphisms.Blood. 1990;75:1770\u20131773.","journal-title":"Blood"},{"key":"BF02981934_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0925-5710(96)00498-7","volume":"64","author":"H Heimpel","year":"1996","unstructured":"Heimpel H. The present state of pathophysiology and therapeutic trials in polycythemia vera.Int J Hematol. 1996;64:153\u2013165.","journal-title":"Int J Hematol."},{"key":"BF02981934_CR8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1182\/blood.V93.2.417","volume":"93","author":"CN Harrison","year":"1999","unstructured":"Harrison CN, Gale RE, Machin SJ, Linch DC. A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at a lower risk of thrombotic complications.Blood. 1999;93:417\u2013424.","journal-title":"Blood"},{"key":"BF02981934_CR9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/ajcp\/112.1.93","volume":"112","author":"G Mitterbauer","year":"1999","unstructured":"Mitterbauer G, Winkler K, Gisslinger H, Geissler K, Lechner K, Mannhalter C. Clonality analysis using X-chromosome inactivation at the human androgen receptor gene (Humara): evaluation of large cohorts of patients with chronic myeloproliferative diseases, secondary neutrophilia, and reactive thrombocytosis.Am J Clin Pathol. 1999;112:93\u2013100.","journal-title":"Am J Clin Pathol."},{"key":"BF02981934_CR10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM198708203170802","volume":"317","author":"PJ Fialkow","year":"1987","unstructured":"Fialkow PJ, Singer JW, Raskind WH, et al. Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia.N Engl J Med. 1987;317:468\u2013473.","journal-title":"N Engl J Med."},{"key":"BF02981934_CR11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1046\/j.1365-2141.1997.1933010.x","volume":"97","author":"KM Champion","year":"1997","unstructured":"Champion KM, Gilbert JG, Asimakopoulos FA, Hinshelwood S, Green AR. Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromes.Br J Haematol. 1997;97:920\u2013926.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1182\/blood.V51.2.189.189","volume":"51","author":"RJ Jacobson","year":"1978","unstructured":"Jacobson RJ, Salo A, Fialkow PJ. Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis.Blood. 1978;51:189\u2013194.","journal-title":"Blood"},{"key":"BF02981934_CR13","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1182\/blood.V78.7.1814.1814","volume":"78","author":"H Kreipe","year":"1991","unstructured":"Kreipe H, Jaquet K, Felgner J, Radzun HJ, Parwaresch MR. Clonal granulocytes and bone marrow cells in the cellular phase of agnogenic myeloid metaplasia.Blood. 1991;78:1814\u20131817.","journal-title":"Blood"},{"key":"BF02981934_CR14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-2141.1994.tb04723.x","volume":"86","author":"N Tsukamoto","year":"1994","unstructured":"Tsukamoto N, Morita K, Maehara T, et al. Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: demonstration of heterogeneity in lineage involvement.Br J Haematol. 1994;86:253\u2013258.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR15","first-page":"1022","volume":"52","author":"H Sugiyama","year":"1989","unstructured":"Sugiyama H, Ichiba S, Okuno Y, et al. Cytogenetic evidence for a clonal disorder involving CFU-GEMM, BFU-E and CFU-C in patients with myeloproliferative disorders.Nippon Ketsueki Gakkai Zasshi. 1989;52:1022\u20131032.","journal-title":"Nippon Ketsueki Gakkai Zasshi."},{"key":"BF02981934_CR16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1600-0609.1983.tb00649.x","volume":"31","author":"T Ruutu","year":"1983","unstructured":"Ruutu T, Partanen S, Knuutila S. Clonal karyotype abnormalities in erythroid and granulocyte-monocyte precursors in polycythaemia vera and myelofibrosis.Scand J Haematol. 1983;31:253\u2013256.","journal-title":"Scand J Haematol."},{"key":"BF02981934_CR17","first-page":"658","volume":"2","author":"M Buschle","year":"1988","unstructured":"Buschle M, Janssen JW, Drexler H, Lyons J, Anger B, Bartram CR. Evidence for pluripotent stem cell origin of idiopathic myelofibrosis: clonal analysis of a case characterized by a N-ras gene mutation.Leukemia. 1988;2:658\u2013660.","journal-title":"Leukemia"},{"key":"BF02981934_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02890110","volume":"48","author":"G Biagini","year":"1985","unstructured":"Biagini G, Severi B, Govoni E, et al. Stromal cells in primary myelofibrosis: ultrastructural observations.Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;48:1\u20138.","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol."},{"key":"BF02981934_CR19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1600-0609.1985.tb02787.x","volume":"34","author":"T Hotta","year":"1985","unstructured":"Hotta T, Utsumi M, Katoh T, Maeda H, Yamao H, Yamada H. Granulocytic and stromal progenitors in the bone marrow of patients with primary myelofibrosis.Scand J Haematol. 1985;34:251\u2013255.","journal-title":"Scand J Haematol."},{"key":"BF02981934_CR20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF01607136","volume":"421","author":"J Thiele","year":"1992","unstructured":"Thiele J, Braeckel C, Wagner S, et al. Macrophages in normal human bone marrow and in chronic myeloproliferative disorders: an immunohistochemical and morphometric study by a new monoclonal antibody (PG-M1) on trephine biopsies.Virchows Arch A Pathol Anat Histopathol. 1992;421:33\u201339.","journal-title":"Virchows Arch A Pathol Anat Histopathol."},{"key":"BF02981934_CR21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2141.1979.tb05843.x","volume":"41","author":"D Charron","year":"1979","unstructured":"Charron D, Robert L, Couty MC, Binet JL. Biochemical and histological analysis of bone marrow collagen in myelofibrosis.Br J Haematol. 1979;41:151\u2013161.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR22","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/jcp.41.12.1269","volume":"41","author":"JT Reilly","year":"1988","unstructured":"Reilly JT, Nash JR. Vitronectin (serum spreading factor): its localisation in normal and fibrotic tissue.J Clin Pathol. 1988;41:1269\u20131272.","journal-title":"J Clin Pathol."},{"key":"BF02981934_CR23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2257.1995.tb00314.x","volume":"17","author":"JT Reilly","year":"1995","unstructured":"Reilly JT, Brindley L, Kay M, et al. Bone marrow and serum connective tissue polypeptides in idiopathic myelofibrosis.Clin Lab Haematol. 1995;17:35\u201339.","journal-title":"Clin Lab Haematol."},{"key":"BF02981934_CR24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1365-2141.1986.tb07535.x","volume":"63","author":"M Apaja-Sarkkinen","year":"1986","unstructured":"Apaja-Sarkkinen M, Autio-Harmainen H, Alavaikko M, Risteli J, Risteli L. Immunohistochemical study of basement membrane proteins and type III procollagen in myelofibrosis.Br J Haematol. 1986;63:571\u2013580.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/jcp.46.3.218","volume":"46","author":"Y Soini","year":"1993","unstructured":"Soini Y, Kamel D, Apaja-Sarkkinen M, Virtanen I, Lehto VP. Tenascin immunoreactivity in normal and pathological bone marrow.J Clin Pathol. 1993;46:218\u2013221.","journal-title":"J Clin Pathol."},{"key":"BF02981934_CR26","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1182\/blood.V96.10.3374","volume":"96","author":"RA Mesa","year":"2000","unstructured":"Mesa RA, Hanson CA, Rajkumar SV, Schroeder G, Tefferi A. Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia.Blood. 2000;96:3374\u20133380.","journal-title":"Blood"},{"key":"BF02981934_CR27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2141.1992.tb08905.x","volume":"80","author":"J Thiele","year":"1992","unstructured":"Thiele J, Rompcik V, Wagner S, Fischer R. Vascular architecture and collagen type IV in primary myelofibrosis and polycythaemia vera: an immunomorphometric study on trephine biopsies of the bone marrow.Br J Haematol. 1992;80:227\u2013234.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1365-2141.1985.tb07465.x","volume":"60","author":"JT Reilly","year":"1985","unstructured":"Reilly JT, Nash JR, Mackie MJ, McVerry BA. Endothelial cell proliferation in myelofibrosis.Br J Haematol. 1985;60:625\u2013630.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2257.1991.tb00297.x","volume":"13","author":"TP Baglin","year":"1991","unstructured":"Baglin TP, Crocker J, Timmins A, Chandler S, Boughton BJ. Bone marrow hypervascularity in patients with myelofibrosis identified by infra-red thermography.Clin Lab Haematol. 1991;13:341\u2013348.","journal-title":"Clin Lab Haematol."},{"key":"BF02981934_CR30","first-page":"9","volume-title":"Dahlem Workshop on Myelofibrosis-Osteosclerosis Syndrome","author":"R Burkhardt","year":"1975","unstructured":"Burkhardt R, Bartl R, Beil E, et al. Myelofibrosis-osteosclerosis syndrome: review of literature and histomorphology. In: Burkhardt R, ed.Dahlem Workshop on Myelofibrosis-Osteosclerosis Syndrome. Braunschweig, Vieweg:Pergamon Press; 1975;16:9\u201356."},{"key":"BF02981934_CR31","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/ajcp\/103.5.574","volume":"103","author":"JB Johnston","year":"1995","unstructured":"Johnston JB, Dalal BI, Israels SJ, et al. Deposition of transforming growth factor-beta in the marrow in myelofibrosis, and the intracellular localization and secretion of TGF-beta by leukemic cells.Am J Clin Pathol. 1995;103:574\u2013582.","journal-title":"Am J Clin Pathol."},{"key":"BF02981934_CR32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-2141.1997.292671.x","volume":"97","author":"MC Martyre","year":"1997","unstructured":"Martyre MC, Le Bousse-Kerdiles MC, Romquin N, et al. Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis.Br J Haematol. 1997;97:441\u2013448.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ajh.2830350302","volume":"35","author":"O Katoh","year":"1990","unstructured":"Katoh O, Kimura A, Itoh T, Kuramoto A. Platelet derived growth factor messenger RNA is increased in bone marrow megakaryocytes in patients with myeloproliferative disorders.Am J Hematol. 1990;35:145\u2013150.","journal-title":"Am J Hematol."},{"key":"BF02981934_CR34","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/excr.1999.4528","volume":"250","author":"JA Andrades","year":"1999","unstructured":"Andrades JA, Han B, Becerra J, Sorgente N, Hall FL, Nimni ME. A recombinant human TGF-beta1 fusion protein with collagenbinding domain promotes migration, growth, and differentiation of bone marrow mesenchymal cells.Exp Cell Res. 1999;250:485\u2013498.","journal-title":"Exp Cell Res."},{"key":"BF02981934_CR35","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1172\/JCI117738","volume":"95","author":"MW Long","year":"1995","unstructured":"Long MW, Robinson JA, Ashcraft EA, Mann KG. Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors.J Clin Invest. 1995;95:881\u2013887.","journal-title":"J Clin Invest."},{"key":"BF02981934_CR36","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1365-2141.1992.tb08898.x","volume":"80","author":"JC Wang","year":"1992","unstructured":"Wang JC, Lang HD, Lichter S, Weinstein M, Benn P. Cytogenetic studies of bone marrow fibroblasts cultured from patients with myelofibrosis and myeloid metaplasia.Br J Haematol. 1992;80:184\u2013188.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2141.1987.tb01332.x","volume":"66","author":"BR Greenberg","year":"1987","unstructured":"Greenberg BR, Woo L, Veomett IC, Payne CM, Ahmann FR. Cytogenetics of bone marrow fibroblastic cells in idiopathic chronic myelofibrosis.Br J Haematol. 1987;66:487\u2013490.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR38","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1182\/blood.V59.5.1046.1046","volume":"59","author":"H Castro-Malaspina","year":"1982","unstructured":"Castro-Malaspina H, Gay RE, Jhanwar SC, et al. Characteristics of bone marrow fibroblast colony-forming cells (CFU-F) and their progeny in patients with myeloproliferative disorders.Blood. 1982;59:1046\u20131054.","journal-title":"Blood"},{"key":"BF02981934_CR39","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1182\/blood.V57.4.781.781","volume":"57","author":"H Castro-Malaspina","year":"1981","unstructured":"Castro-Malaspina H, Rabellino EM, Yen A, Nachman RL, Moore MA. Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts.Blood. 1981;57:781\u2013787.","journal-title":"Blood"},{"key":"BF02981934_CR40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2141.1994.tb04970.x","volume":"88","author":"MC Martyre","year":"1994","unstructured":"Martyre MC, Romquin N, Le Bousse-Kerdiles MC, et al. Transforming growth factor-beta and megakaryocytes in the pathogenesis of idiopathic myelofibrosis.Br J Haematol. 1994;88:9\u201316.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR41","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1182\/blood.V75.7.1540.1540","volume":"75","author":"T Terui","year":"1990","unstructured":"Terui T, Niitsu Y, Mahara K, et al. The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis.Blood. 1990;75:1540\u20131548.","journal-title":"Blood"},{"key":"BF02981934_CR42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2141.1997.3293146.x","volume":"99","author":"T Murate","year":"1997","unstructured":"Murate T, Yamashita K, Isogai C, et al. The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis.Br J Haematol. 1997;99:181\u2013189.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR43","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.4049\/jimmunol.153.6.2819","volume":"153","author":"P Rameshwar","year":"1994","unstructured":"Rameshwar P, Denny TN, Stein D, Gascon P. Monocyte adhesion in patients with bone marrow fibrosis is required for the production of fibrogenic cytokines: potential role for interleukin-1 and TGF-beta.J Immunol. 1994;153:2819\u20132830.","journal-title":"J Immunol."},{"key":"BF02981934_CR44","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2141.1989.tb04310.x","volume":"72","author":"A Kimura","year":"1989","unstructured":"Kimura A, Katoh O, Hyodo H, Kuramoto A. Transforming growth factor-beta regulates growth as well as collagen and fibronectin synthesis of human marrow fibroblasts.Br J Haematol. 1989;72:486\u2013491.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR45","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1046\/j.1365-2141.1996.d01-1739.x","volume":"93","author":"A Dalley","year":"1996","unstructured":"Dalley A, Smith JM, Reilly JT, Neil SM. Investigation of calmodulin and basic fibroblast growth factor (bFGF) in idiopathic myelofibrosis: evidence for a role of extracellular calmodulin in fibroblast proliferation.Br J Haematol. 1996;93:856\u2013862.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR46","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1073\/pnas.94.2.663","volume":"94","author":"R Mohle","year":"1997","unstructured":"Mohle R, Green D, Moore MA, Nachman RL, Rafii S. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets.Proc Natl Acad Sci U S A. 1997;94:663\u2013668.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"BF02981934_CR47","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1182\/blood.V83.8.2126.2126","volume":"83","author":"H Avraham","year":"1994","unstructured":"Avraham H, Banu N, Scadden DT, Abraham J, Groopman JE. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor.Blood. 1994;83:2126\u20132132.","journal-title":"Blood"},{"key":"BF02981934_CR48","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1182\/blood.V82.2.430.430","volume":"82","author":"E Bruno","year":"1993","unstructured":"Bruno E, Cooper RJ, Wilson EL, Gabrilove JL, Hoffman R. Basic fibroblast growth factor promotes the proliferation of human megakaryocyte progenitor cells.Blood. 1993;82:430\u2013435.","journal-title":"Blood"},{"key":"BF02981934_CR49","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1182\/blood.V94.3.984.415k31_984_993","volume":"94","author":"V Jouan","year":"1999","unstructured":"Jouan V, Canron X, Alemany M, et al. Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action.Blood. 1999;94:984\u2013993.","journal-title":"Blood"},{"key":"BF02981934_CR50","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1182\/blood.V85.4.989.bloodjournal854989","volume":"85","author":"LS Rusten","year":"1995","unstructured":"Rusten LS, Jacobsen SE. Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors.Blood. 1995;85:989\u2013996.","journal-title":"Blood"},{"key":"BF02981934_CR51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/stem.5530050103","volume":"5","author":"K Akahane","year":"1987","unstructured":"Akahane K, Hosoi T, Urabe A, Kawakami M, Takaku F. Effects of recombinant human tumor necrosis factor (rhTNF) on normal human and mouse hemopoietic progenitor cells.Int J Cell Cloning. 1987;5:16\u201326.","journal-title":"Int J Cell Cloning"},{"key":"BF02981934_CR52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1699-0463.1999.tb01521.x","volume":"107","author":"Z Werb","year":"1999","unstructured":"Werb Z, Vu TH, Rinkenberger JL, Coussens LM. Matrix-degrading proteases and angiogenesis during development and tumor formation.APMIS. 1999;107:11\u201318.","journal-title":"APMIS"},{"key":"BF02981934_CR53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/(SICI)1097-4652(199809)176:3<445::AID-JCP1>3.0.CO;2-O","volume":"176","author":"B Schmitz","year":"1998","unstructured":"Schmitz B, Thiele J, Otto F, et al. Evidence for integrin receptor involvement in megakaryocyte-fibroblast interaction: a possible pathomechanism for the evolution of myelofibrosis.J Cell Physiol. 1998;176:445\u2013455.","journal-title":"J Cell Physiol."},{"key":"BF02981934_CR54","first-page":"337","volume":"72","author":"S-Y Yoon","year":"2000","unstructured":"Yoon S-Y, Li C-Y, Lloyd RV, Tefferi A. Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders.Int J Hematol. 2000;72:337\u2013342.","journal-title":"Int J Hematol."},{"key":"BF02981934_CR55","first-page":"52","volume":"86","author":"SY Yoon","year":"2001","unstructured":"Yoon SY, Tefferi A, Li CY. Bone marrow stromal cell distribution of basic fibroblast growth factor in chronic myeloid disorders.Haematologica. 2001;86:52\u201357.","journal-title":"Haematologica"},{"key":"BF02981934_CR56","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ajh.2830270409","volume":"27","author":"O Katoh","year":"1988","unstructured":"Katoh O, Kimura A, Kuramoto A. Platelet-derived growth factor is decreased in patients with myeloproliferative disorders.Am J Hematol. 1988;27:276\u2013280.","journal-title":"Am J Hematol."},{"key":"BF02981934_CR57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2141.1991.tb07952.x","volume":"77","author":"MC Martyre","year":"1991","unstructured":"Martyre MC, Magdelenat H, Bryckaert MC, Laine-Bidron C, Calvo F. Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-beta in patients with myelofibrosis with myeloid metaplasia.Br J Haematol. 1991;77:80\u201386.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000205544","volume":"81","author":"A Caenazzo","year":"1989","unstructured":"Caenazzo A, Pietrogrande F, Polato G, et al. Changes in the mitogenic activity of platelet-derived growth factor(s) in patients with myeloproliferative disease.Acta Haematol. 1989;81:131\u2013135.","journal-title":"Acta Haematol."},{"key":"BF02981934_CR59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2141.1993.tb04624.x","volume":"83","author":"G Zauli","year":"1993","unstructured":"Zauli G, Visani G, Catani L, Vianelli N, Gugliotta L, Capitani S. Reduced responsiveness of bone marrow megakaryocyte progenitors to platelet-derived transforming growth factor beta 1, produced in normal amount, in patients with essential thrombocythaemia.Br J Haematol. 1993;83:14\u201320.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR60","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1182\/blood.V90.11.4369","volume":"90","author":"JL Villeval","year":"1997","unstructured":"Villeval JL, Cohen-Solal K, Tulliez M, et al. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice.Blood. 1997;90:4369\u20134383.","journal-title":"Blood"},{"key":"BF02981934_CR61","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1182\/blood.V88.2.402.bloodjournal882402","volume":"88","author":"XQ Yan","year":"1996","unstructured":"Yan XQ, Lacey D, Hill D, et al. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation.Blood. 1996;88:402\u2013409.","journal-title":"Blood"},{"key":"BF02981934_CR62","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1046\/j.1365-2141.1997.4843288.x","volume":"99","author":"M Yanagida","year":"1997","unstructured":"Yanagida M, Ide Y, Imai A, et al. The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats.Br J Haematol. 1997;99:739\u2013745.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1182\/blood.V93.1.125","volume":"93","author":"AL Taksin","year":"1999","unstructured":"Taksin AL, Couedic JPL, Dusanter-Fourt I, et al. Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L.Blood. 1999;93:125\u2013139.","journal-title":"Blood"},{"key":"BF02981934_CR64","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1056\/NEJM199802263380903","volume":"338","author":"AR Moliterno","year":"1998","unstructured":"Moliterno AR, Hankins WD, Spivak JL. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera.N Engl J Med. 1998;338:572\u2013580.","journal-title":"N Engl J Med."},{"key":"BF02981934_CR65","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1182\/blood.V90.10.4031","volume":"90","author":"Y Horikawa","year":"1997","unstructured":"Horikawa Y, Matsumura I, Hashimoto K, et al. Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia.Blood. 1997;90:4031\u20134038.","journal-title":"Blood"},{"key":"BF02981934_CR66","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1365-2141.1998.01054.x","volume":"103","author":"H Tamura","year":"1998","unstructured":"Tamura H, Ogata K, Luo S, et al. Plasma thrombopoietin (TPO) levels and expression of TPO receptor on platelets in patients with myelodysplastic syndromes.Br J Haematol. 1998;103:778\u2013784.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR67","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1182\/blood.V96.2.771","volume":"96","author":"A Tefferi","year":"2000","unstructured":"Tefferi A, Yoon S-Y, Li C-Y. Immunohistochemical staining for megakaryocyt.c-mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis.Blood. 2000;96:771\u2013772.","journal-title":"Blood"},{"key":"BF02981934_CR68","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood.V91.3.923","volume":"91","author":"JE Cardier","year":"1998","unstructured":"Cardier JE, Dempsey J. Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: evidence of thrombopoietin as a growth factor for liver endothelial cells.Blood. 1998;91:923\u2013929.","journal-title":"Blood"},{"key":"BF02981934_CR69","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.RES.84.7.785","volume":"84","author":"MF Brizzi","year":"1999","unstructured":"Brizzi MF, Battaglia E, Montrucchio G, et al. Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism.Circ Res. 1999;84:785\u2013796.","journal-title":"Circ Res."},{"key":"BF02981934_CR70","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1038\/sj.leu.2400846","volume":"11","author":"JC Wang","year":"1997","unstructured":"Wang JC, Chen C, Lou LH, Mora M. Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia.Leukemia. 1997;11:1827\u20131832.","journal-title":"Leukemia"},{"key":"BF02981934_CR71","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1182\/blood.V89.8.2782","volume":"89","author":"PJ Fielder","year":"1997","unstructured":"Fielder PJ, Hass P, Nagel M, et al. Human platelets as a model for the binding and degradation of thrombopoietin.Blood. 1997;89:2782\u20132788.","journal-title":"Blood"},{"key":"BF02981934_CR72","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1182\/blood.V94.6.1961","volume":"94","author":"S Sakamaki","year":"1999","unstructured":"Sakamaki S, Hirayama Y, Matsunaga T, et al. Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity.Blood. 1999;94:1961\u20131970.","journal-title":"Blood"},{"key":"BF02981934_CR73","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJM197610212951702","volume":"295","author":"JW Adamson","year":"1976","unstructured":"Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L. Polycythemia vera: stem-cell and probable clonal origin of the disease.N Engl J Med. 1976;295:913\u2013916.","journal-title":"N Engl J Med."},{"issue":"suppl 1","key":"BF02981934_CR74","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/stem.5530110613","volume":"11","author":"JT Prchal","year":"1993","unstructured":"Prchal JT, Guan YL. A novel clonality assay based on transcriptional analysis of the active X chromosome.Stem Cells. 1993;11(suppl 1):62\u201365.","journal-title":"Stem Cells."},{"key":"BF02981934_CR75","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/sj.leu.2400934","volume":"12","author":"WH Raskind","year":"1998","unstructured":"Raskind WH, Steinmann L, Najfeld V. Clonal development of myeloproliferative disorders: clues to hematopoietic differentiation and multistep pathogenesis of cancer.Leukemia. 1998;12:108\u2013116.","journal-title":"Leukemia"},{"key":"BF02981934_CR76","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1172\/JCI111840","volume":"75","author":"WH Raskind","year":"1985","unstructured":"Raskind WH, Jacobson R, Murphy S, Adamson JW, Fialkow PJ. Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia.J Clin Invest. 1985;75:1388\u20131390.","journal-title":"J Clin Invest."},{"key":"BF02981934_CR77","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0950-3536(98)80040-1","volume":"11","author":"R Kralovics","year":"1998","unstructured":"Kralovics R, Prchal JT. Haematopoietic progenitors and signal transduction in polycythaemia vera and primary thrombocythaemia.Baillieres Clin Haematol. 1998;11:803\u2013818.","journal-title":"Baillieres Clin Haematol."},{"key":"BF02981934_CR78","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2141.1984.tb08502.x","volume":"57","author":"JS Powell","year":"1984","unstructured":"Powell JS, Fialkow PJ, Adamson JW. Human mixed cell colonies: unicellular or multicellular origin\u2014analysis by G-6-PD.Br J Haematol. 1984;57:89\u201395.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR79","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1073\/pnas.88.15.6848","volume":"88","author":"DG Gilliland","year":"1991","unstructured":"Gilliland DG, Blanchard KL, Levy J, Perrin S, Bunn HF. Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction.Proc Natl Acad Sci U S A. 1991;88:6848\u20136852.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"BF02981934_CR80","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1182\/blood.V88.7.2690.bloodjournal8872690","volume":"88","author":"FA Asimakopoulos","year":"1996","unstructured":"Asimakopoulos FA, Gilbert JGR, Aldred MA, Pearson TC, Green AR. Interstitial deletion constitutes the major mechanism for loss of heterozygosity on chromosome 20q in polycythemia vera.Blood. 1996;88:2690\u20132698.","journal-title":"Blood"},{"key":"BF02981934_CR81","first-page":"1382","volume":"290","author":"JF Prchal","year":"1974","unstructured":"Prchal JF, Axelrad AA. Bone-marrow responses in polycythemia vera [letter].N Engl J Med. 1974;290:1382.","journal-title":"N Engl J Med."},{"key":"BF02981934_CR82","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1172\/JCI108706","volume":"59","author":"ED Zanjani","year":"1977","unstructured":"Zanjani ED, Lutton JD, Hoffman R, Wasserman LR. Erythroid colony formation by polycythemia vera bone marrow in vitro: dependence on erythropoietin.J Clin Invest. 1977;59:841\u2013848.","journal-title":"J Clin Invest."},{"key":"BF02981934_CR83","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1182\/blood.V84.6.1982.1982","volume":"84","author":"MJ Fisher","year":"1994","unstructured":"Fisher MJ, Prchal JF, Prchal JT, D\u2019Andrea AD. Anti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera.Blood. 1994;84:1982\u20131991.","journal-title":"Blood"},{"key":"BF02981934_CR84","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1365-2141.1994.tb05119.x","volume":"88","author":"G Hess","year":"1994","unstructured":"Hess G, Rose P, Gamm H, Papadileris S, Huber C, Seliger B. Molecular analysis of the erythropoietin receptor system in patients with polycythaemia vera.Br J Haematol. 1994;88:794\u2013802.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR85","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/sj.onc.1200942","volume":"14","author":"FA Asimakopoulos","year":"1997","unstructured":"Asimakopoulos FA, Hinshelwood S, Gilbert JG, et al. The gene encoding hematopoietic cell phosphatase (SHP-1) is structurally and transcriptionally intact in polycythemia vera.Oncogene. 1997;14:1215\u20131222.","journal-title":"Oncogene"},{"key":"BF02981934_CR86","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1182\/blood.V59.2.447.447","volume":"59","author":"N Casadevall","year":"1982","unstructured":"Casadevall N, Vainchenker W, Lacombe C, et al. Erythroid progenitors in polycythemia vera: demonstration of their hypersensitivity to erythropoietin using serum free cultures.Blood. 1982;59:447\u2013451.","journal-title":"Blood"},{"key":"BF02981934_CR87","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1182\/blood.V83.1.99.99","volume":"83","author":"PN Correa","year":"1994","unstructured":"Correa PN, Eskinazi D, Axelrad AA. Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium.Blood. 1994;83:99\u2013112.","journal-title":"Blood"},{"key":"BF02981934_CR88","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJM199802263380902","volume":"338","author":"M Silva","year":"1998","unstructured":"Silva M, Richard C, Benito A, Sanz C, Olalla I, Fernandez-Luna JL. Expression of Bcl-x in erythroid precursors from patients with polycythemia vera.N Engl J Med. 1998;338:564\u2013571.","journal-title":"N Engl J Med."},{"key":"BF02981934_CR89","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1182\/blood.V86.3.877.877","volume":"86","author":"AM Mirza","year":"1995","unstructured":"Mirza AM, Correa PN, Axelrad AA. Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor beta subunit in circulating mononuclear cells of patients with polycythemia vera.Blood. 1995;86:877\u2013882.","journal-title":"Blood"},{"key":"BF02981934_CR90","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0268-960X(97)90021-7","volume":"11","author":"S Hinshelwood","year":"1997","unstructured":"Hinshelwood S, Bench AJ, Green AR. Pathogenesis of polycythaemia vera.Blood Rev. 1997;11:224\u2013232.","journal-title":"Blood Rev."},{"key":"BF02981934_CR91","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1182\/blood.V89.6.1862","volume":"89","author":"AM Mirza","year":"1997","unstructured":"Mirza AM, Ezzat S, Axelrad AA. Insulin-like growth factor binding protein-1 is elevated in patients with polycythemia vera and stimulates erythroid burst formation in vitro.Blood. 1997;89:1862\u20131869.","journal-title":"Blood"},{"key":"BF02981934_CR92","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1182\/blood.V90.2.651","volume":"90","author":"X Sui","year":"1997","unstructured":"Sui X, Krantz SB, Zhao Z. Identification of increased protein tyrosine phosphatase activity in polycythemia vera erythroid progenitor cells.Blood. 1997;90:651\u2013657.","journal-title":"Blood"},{"key":"BF02981934_CR93","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1182\/blood.V89.10.3574","volume":"89","author":"CH Dai","year":"1997","unstructured":"Dai CH, Krantz SB, Sawyer ST. Polycythemia vera, V: enhanced proliferation and phosphorylation due to vanadate are diminished in polycythemia vera erythroid progenitor cells: a possible defect of phosphatase activity in polycythemia vera.Blood. 1997;89:3574\u20133581.","journal-title":"Blood"},{"key":"BF02981934_CR94","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1182\/blood.V94.8.2555.420k14_2555_2561","volume":"94","author":"AR Moliterno","year":"1999","unstructured":"Moliterno AR, Spivak JL. Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera.Blood. 1999;94:2555\u20132561.","journal-title":"Blood"},{"key":"BF02981934_CR95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0609.2000.9e003.x","volume":"64","author":"S-Y Yoon","year":"2000","unstructured":"Yoon S-Y, Li C-Y, Tefferi A. Megakaryocyte c-Mpl expression in chronic myeloproliferative disorders and the myelodysplastic syndrome: immunoperoxidase staining patterns and clinical correlates.Eur J Haematol. 2000;64:1\u20135.","journal-title":"Eur J Haematol."},{"key":"BF02981934_CR96","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1182\/blood.V58.5.916.916","volume":"58","author":"PJ Fialkow","year":"1981","unstructured":"Fialkow PJ, Faguet GB, Jacobson RJ, Vaidya K, Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell.Blood. 1981;58:916\u2013919.","journal-title":"Blood"},{"key":"BF02981934_CR97","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1182\/blood.V89.1.128","volume":"89","author":"N el-Kassar","year":"1997","unstructured":"el-Kassar N, Hetet G, Briere J, Grandchamp B. Clonality analysis of hematopoiesis in essential thrombocythemia: advantages of studying T lymphocytes and platelets.Blood. 1997;89:128\u2013134.","journal-title":"Blood"},{"key":"BF02981934_CR98","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1182\/blood.V75.8.1633.1633","volume":"75","author":"JW Janssen","year":"1990","unstructured":"Janssen JW, Anger BR, Drexler HG, Bartram CR, Heimpel H. Essential thrombocythemia in two sisters originating from different stem cell levels.Blood. 1990;75:1633\u20131636.","journal-title":"Blood"},{"key":"BF02981934_CR99","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1046\/j.1365-2141.1997.2573078.x","volume":"98","author":"RE Gale","year":"1997","unstructured":"Gale RE, Fielding AK, Harrison CN, Linch DC. Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age.Br J Haematol. 1997;98:512\u2013519.","journal-title":"Br J Haematol."},{"issue":"suppl 1","key":"BF02981934_CR100","first-page":"700a","volume":"94","author":"P Chiusolo","year":"1999","unstructured":"Chiusolo P, Sica S, Ortu La Barbera E, et al. Patients with essential thrombocythemia and clonal hemopoiesis detected by X-inactivation pattern are at high risk for thrombotic complication [abstract].Blood. 1999;94(suppl 1):700a.","journal-title":"Blood"},{"key":"BF02981934_CR101","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1046\/j.1365-2141.1998.00747.x","volume":"101","author":"M Hou","year":"1998","unstructured":"Hou M, Andersson PO, Stockelberg D, Mellqvist UH, Ridell B, Wadenvik H. Plasma thrombopoietin levels in thrombocytopenic states: implication for a regulatory role of bone marrow megakaryocytes.Br J Haematol. 1998;101:420\u2013424.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR102","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0002-9343(98)00090-4","volume":"104","author":"JC Wang","year":"1998","unstructured":"Wang JC, Chen C, Novetsky AD, Lichter SM, Ahmed F, Friedberg NM. Blood thrombopoietin levels in clonal thrombocytosis and reactive thrombocytosis.Am J Med. 1998;104:451\u2013455.","journal-title":"Am J Med."},{"key":"BF02981934_CR103","first-page":"312","volume":"84","author":"I Espanol","year":"1999","unstructured":"Espanol I, Hernandez A, Cortes M, Mateo J, Pujol-Moix N. Patients with thrombocytosis have normal or slightly elevated thrombopoietin levels.Haematologica. 1999;84:312\u2013316.","journal-title":"Haematologica"},{"key":"BF02981934_CR104","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V87.2.567.bloodjournal872567","volume":"87","author":"R Stoffel","year":"1996","unstructured":"Stoffel R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets.Blood. 1996;87:567\u2013573.","journal-title":"Blood"},{"key":"BF02981934_CR105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng0198-49","volume":"18","author":"A Wiestner","year":"1998","unstructured":"Wiestner A, Schlemper RJ, Van der Maas AP, Skoda RC. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.Nat Genet. 1998;18:49\u201352.","journal-title":"Nat Genet."},{"key":"BF02981934_CR106","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/sj.leu.2400845","volume":"11","author":"JJ Kiladjian","year":"1997","unstructured":"Kiladjian JJ, Elkassar N, Hetet G, Briere J, Grandchamp B, Gardin C. Study of the thrombopoietin receptor in essential thrombocythemia.Leukemia. 1997;11:1821\u20131826.","journal-title":"Leukemia"},{"key":"BF02981934_CR107","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1365-2141.1999.01667.x","volume":"107","author":"CN Harrison","year":"1999","unstructured":"Harrison CN, Gale RE, Pezella F, Mire-Sluis A, MacHin SJ, Linch DC. Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value.Br J Haematol. 1999;107:139\u2013147.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR108","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2141.1993.tb08271.x","volume":"83","author":"E Juvonen","year":"1993","unstructured":"Juvonen E, Ikkala E, Oksanen K, Ruutu T. Megakaryocyte and erythroid colony formation in essential thrombocythaemia and reactive thrombocytosis: diagnostic value and correlation to complications.Br J Haematol. 1993;83:192\u2013197.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR109","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2141.1994.tb08300.x","volume":"87","author":"Y Li","year":"1994","unstructured":"Li Y, Hetet G, Maurer AM, Chait Y, Dhermy D, Briere J. Spontaneous megakaryocyte colony formation in myeloproliferative disorders is not neutralizable by antibodies against IL3, IL6 and GM-CSF.Br J Haematol. 1994;87:471\u2013476.","journal-title":"Br J Haematol."},{"key":"BF02981934_CR110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2141.1993.tb04688.x","volume":"83","author":"S Kobayashi","year":"1993","unstructured":"Kobayashi S, Teramura M, Hoshino S, Motoji T, Oshimi K, Mizoguchi H. Circulating megakaryocyte progenitors in myelopro- liferative disorders are hypersensitive to interleukin-3.Br J Haematol. 1993;83:539\u2013544.","journal-title":"Br J Haematol."},{"issue":"suppl 1","key":"BF02981934_CR111","first-page":"488a","volume":"92","author":"AA Axelrad","year":"1998","unstructured":"Axelrad AA, Eskinazi D, Amato D. Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia [abstract].Blood. 1998;92(suppl 1):488a.","journal-title":"Blood"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02981934\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02981934.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02981934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02981934.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:26:18Z","timestamp":1684617978000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02981934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":111,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["BF02981934"],"URL":"https:\/\/doi.org\/10.1007\/bf02981934","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}