{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:27:42Z","timestamp":1762100862302},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1007\/bf02981959","type":"journal-article","created":{"date-parts":[[2008,11,3]],"date-time":"2008-11-03T15:00:00Z","timestamp":1225724400000},"page":"339-345","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased Frequency of Monoclonal Gammopathy of Undetermined Significance in Patients With Nonimmune Chronic Idiopathic Neutropenia Syndrome"],"prefix":"10.1007","volume":"73","author":[{"given":"Helen A.","family":"Papadaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris G.","family":"Eliopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charis","family":"Ponticoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Eliopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"BF02981959_CR1","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1056\/NEJM196811072791902","volume":"279","author":"RA Kyle","year":"1968","unstructured":"Kyle RA, Linman JW. Chronic idiopathic neutropenia.N Engl J Med. 1968;279:1015\u20131019.","journal-title":"N Engl J Med."},{"key":"BF02981959_CR2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/00005792-197903000-00002","volume":"58","author":"D Dale","year":"1979","unstructured":"Dale D, Guerry D, Wewerka J, Bull J, Chusid M. Chronic neutropenia.Medicine (Baltimore). 1979;58:128\u2013144.","journal-title":"Medicine (Baltimore)"},{"key":"BF02981959_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s002770050518","volume":"78","author":"HA Papadaki","year":"1999","unstructured":"Papadaki HA, Xylouri I, Coulocheri S, Kalmanti M, Kafatos A, Eliopoulos GD. Prevalence of chronic idiopathic neutropenia of adults among an apparently healthy population living on the island of Crete.Ann Hematol. 1999;78:293\u2013297.","journal-title":"Ann Hematol"},{"key":"BF02981959_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1053\/lc.1999.v133.a94931","volume":"133","author":"TB Haddy","year":"1999","unstructured":"Haddy TB, Rana SR, Castro O. Benign ethnic neutropenia: what is a healthy absolute neutrophil count?J Lab Clin Med. 1999;133:15\u201322.","journal-title":"J Lab Clin Med."},{"key":"BF02981959_CR5","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1600-0609.1998.tb01714.x","volume":"61","author":"HA Papadaki","year":"1998","unstructured":"Papadaki HA, Eliopoulos GD. Enhanced neutrophil extravasation may be a contributing factor in the determination of neutropenia in patients with chronic idiopathic neutropenia of adults.Eur J Haematol. 1998;61:272\u2013277.","journal-title":"Eur J Haematol"},{"key":"BF02981959_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/1096-8652(200012)65:4<271::AID-AJH1>3.0.CO;2-R","volume":"65","author":"HA Papadaki","year":"2000","unstructured":"Papadaki HA, Coulocheri S, Eliopoulos GD. Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines.Am J Hematol. 2000;65:271\u2013277.","journal-title":"Am J Hematol"},{"key":"BF02981959_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s002770050433","volume":"77","author":"HA Papadaki","year":"1998","unstructured":"Papadaki HA, Eliopoulos GD. Selective loss of peripheral blood CD45RO+ T-lymphocytes correlates with increased levels of serum cytokines and endothelial cell-derived cell adhesion molecules in patients with chronic idiopathic neutropenia of adults.Ann Hematol. 1998;77:153\u2013159.","journal-title":"Ann Hematol"},{"key":"BF02981959_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1600-0609.1999.tb01763.x","volume":"63","author":"HA Papadaki","year":"1999","unstructured":"Papadaki HA, Giouremou K, Eliopoulos GD. Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-\u03b21 by bone marrow stromal cells.Eur J Haematol. 1999;63:154\u2013162.","journal-title":"Eur J Haematol"},{"key":"BF02981959_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1034\/j.1600-0609.2000.065004237.x","volume":"65","author":"HA Papadaki","year":"2000","unstructured":"Papadaki HA, Palmblad J, Kapsimali V, Anagnou NP, Eliopoulos GD. Increased serum IgA and decreased IgG3 strongly correlate with increased levels of serum TGF-\u03b21 in patients with nonimmune chronic idiopathic neutropenia of adults.Eur J Haematol. 2000;65:237\u2013244.","journal-title":"Eur J Haematol"},{"key":"BF02981959_CR10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s002770000207","volume":"79","author":"HA Papadaki","year":"2000","unstructured":"Papadaki HA, Chatzivassili A, Stefanaki K, Koumaki V, Kanavaros P, Eliopoulos GD. Morphologically defined myeloid cell compartments, lymphocyte subpopulations and histological findings of bone marrow in patients with nonimmune chronic idiopathic neutropenia of adults.Ann Hematol. 2000;79:563\u2013570.","journal-title":"Ann Hematol"},{"key":"BF02981959_CR11","first-page":"32","volume":"1","author":"HA Papadaki","year":"1998","unstructured":"Papadaki HA, Katrinakis G, Eliopoulos AG, Coulocheri SA, Alexandrakis M, Eliopoulos GD. Low numbers of peripheral blood natural killer cells in patients with chronic idiopathic neutropenia of adults is probably due to enhanced extravasation into the tissues.Haematologica. 1998;1:32\u201339.","journal-title":"Haematologica"},{"key":"BF02981959_CR12","volume-title":"Essential Haematology","author":"AV Hoffbrand","year":"1993","unstructured":"Hoffbrand AV, Pettit JE.Essential Haematology. 3rd ed. Oxford, England: Blackwell Scientific Publications; 1993.","edition":"3rd ed."},{"key":"BF02981959_CR13","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.4049\/jimmunol.152.3.1442","volume":"152","author":"KB Islam","year":"1994","unstructured":"Islam KB, Baskin B, Nilsson L, Hammarstrom L, Sideras P, Smith CI. Molecular analysis of IgA deficiency: evidence for impaired switching to IgA.J Immunol. 1994;152:1442\u20131452.","journal-title":"J Immunol"},{"key":"BF02981959_CR14","first-page":"2202","volume-title":"Wintrobe\u2019s Clinical Hematology","author":"J Foerster","year":"1993","unstructured":"Foerster J. Plasma cell dyscrasias. In: Lee GR, et al, eds.Wintrobe\u2019s Clinical Hematology. Vol. 2. Philadelphia, PA: Lee & Febiger; 1993:2202\u20132218."},{"key":"BF02981959_CR15","first-page":"176","volume":"26","author":"RA Kyle","year":"1989","unstructured":"Kyle RA, Lust JA. Monoclonal gammopathies of undetermined significance.Semin Hematol. 1989;26:176\u2013200.","journal-title":"Semin Hematol"},{"key":"BF02981959_CR16","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/j.0954-6820.1963.tb17460.x","volume":"173","author":"J Hallen","year":"1963","unstructured":"Hallen J. Frequency of \u2018abnormal\u2019 serum globulins (M-components) in the aged.Acta Med Scand. 1963;173:737\u2013744.","journal-title":"Acta Med Scand."},{"key":"BF02981959_CR17","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1423-0410.1972.tb03468.x","volume":"23","author":"JM Fine","year":"1972","unstructured":"Fine JM, Lambin P, Leroux P. Frequency of monoclonal gammopathies (\u2018M-components\u2019) in 13400 sera from blood donors.Vox Sang. 1972;23:336\u2013343.","journal-title":"Vox Sang"},{"key":"BF02981959_CR18","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1046\/j.1537-2995.1979.19379204218.x","volume":"19","author":"JM Fine","year":"1979","unstructured":"Fine JM, Lambin P, Derycke C, Muller JY, Marneux M. Systematic survey of monoclonal gammopathies in the sera from blood donors.Transfusion. 1979;19:332\u2013335.","journal-title":"Transfusion"},{"issue":"3A","key":"BF02981959_CR19","first-page":"75","volume":"23","author":"HJ Cohen","year":"1988","unstructured":"Cohen HJ. Monoclonal gammopathies and aging [abstract].Hosp Pract. 1988;23(3A):75.","journal-title":"Hosp Pract."},{"key":"BF02981959_CR20","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/bjc.1971.53","volume":"25","author":"O Norgaard","year":"1971","unstructured":"Norgaard O. Three cases of multiple myeloma in which the preclinical asymptomatic phases persisted for 15 to 24 years.Br J Cancer. 1971;25:417\u2013422.","journal-title":"Br J Cancer"},{"key":"BF02981959_CR21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.V91.1.3","volume":"91","author":"M Hallek","year":"1998","unstructured":"Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma: increasing evidence for a multistep transformation process.Blood. 1998;91:3\u201321.","journal-title":"Blood"},{"key":"BF02981959_CR22","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0140-6736(65)90344-2","volume":"2","author":"U Axelsson","year":"1965","unstructured":"Axelsson U, Hallen J. Familial occurrence of pathological serum proteins of different gammaglobulin groups.Lancet. 1965;2:369\u2013370.","journal-title":"Lancet"},{"key":"BF02981959_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0090-1229(79)90147-8","volume":"14","author":"J Radl","year":"1979","unstructured":"Radl J. Idiopathic paraproteinemia: a consequence of an agerelated deficiency in the T immune system.Clin Immunol Immunopathol. 1979;14:251\u2013255.","journal-title":"Clin Immunol Immunopathol"},{"key":"BF02981959_CR24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0009-8981(95)06104-L","volume":"239","author":"M Pradella","year":"1995","unstructured":"Pradella M, Nemetz L, Bovo C, et al. Quantitative cytochemistry of human leukocyte elastase compared with plasma elastase and acute phase proteins in inflammatory diseases.Clin Chim Acta. 1995;239:91\u2013101.","journal-title":"Clin Chim Acta."}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02981959\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02981959.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02981959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02981959.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:26:18Z","timestamp":1684617978000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02981959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["BF02981959"],"URL":"https:\/\/doi.org\/10.1007\/bf02981959","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}