{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:07:22Z","timestamp":1769072842933,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":5434,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1007\/s12603-009-0018-9","type":"journal-article","created":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T17:23:36Z","timestamp":1258046616000},"page":"121-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Total serum homocysteine levels do not identify cognitive dysfunction in multimorbid elderly patients"],"prefix":"10.1016","volume":"13","author":[{"given":"S.","family":"Hengstermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Laemmler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hanemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schweter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Steinhagen-Thiessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. -J.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6Suppl","key":"10.1007\/s12603-009-0018-9_bib1","doi-asserted-by":"crossref","first-page":"1237S","DOI":"10.1093\/ajcn\/55.6.1237S","article-title":"Nutritional factors in physical and cognitive functions of elderly people","volume":"55","author":"Rosenberg","year":"1992","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"10.1007\/s12603-009-0018-9_bib2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"issue":"7","key":"10.1007\/s12603-009-0018-9_bib3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jama.1992.03490070059042","article-title":"A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians","volume":"268","author":"Stampfer","year":"1992","journal-title":"JAMA"},{"issue":"8987","key":"10.1007\/s12603-009-0018-9_bib4","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0140-6736(95)92407-8","article-title":"Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men","volume":"346","author":"Perry","year":"1995","journal-title":"Lancet."},{"issue":"2","key":"10.1007\/s12603-009-0018-9_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/ajcn\/67.2.188","article-title":"Determinants of plasma homocysteine","volume":"67","author":"Blom","year":"1998","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1007\/s12603-009-0018-9_bib6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/ajcn\/73.3.613","article-title":"Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort","volume":"73","author":"Jacques","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1007\/s12603-009-0018-9_bib7","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/MCO.0b013e3282f0cfe3","article-title":"Homocysteine as a biomarker for cognitive dysfunction in the elderly","volume":"10","author":"Schulz","year":"2007","journal-title":"Curr Opin Nutr Metab Care"},{"issue":"9","key":"10.1007\/s12603-009-0018-9_bib8","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1532-5415.1994.tb06583.x","article-title":"Serum vitamin B12 levels and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study","volume":"42","author":"Crystal","year":"1994","journal-title":"J Am Geriatr Soc"},{"issue":"11","key":"10.1007\/s12603-009-0018-9_bib9","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1532-5415.1996.tb01407.x","article-title":"The significance of subnormal serum vitamin B12 concentration in older people: a case control study","volume":"44","author":"Metz","year":"1996","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"10.1007\/s12603-009-0018-9_bib10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcn\/63.3.306","article-title":"Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study","volume":"63","author":"Riggs","year":"1996","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1007\/s12603-009-0018-9_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/ajcn\/65.1.20","article-title":"Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment","volume":"65","author":"La Rue","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1007\/s12603-009-0018-9_bib12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1037\/0882-7974.11.3.487","article-title":"Effects of serum vitamin B12 and folate status on episodic memory performance in very old age: a population-based study","volume":"11","author":"Wahlin","year":"1996","journal-title":"Psychol Aging"},{"issue":"2","key":"10.1007\/s12603-009-0018-9_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2362.1992.tb01940.x","article-title":"Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status","volume":"22","author":"Andersson","year":"1992","journal-title":"Eur J Clin Invest"},{"issue":"22","key":"10.1007\/s12603-009-0018-9_bib14","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1001\/jama.1993.03510220049033","article-title":"Vitamin status and intake as primary determinants of homocysteinemia in an elderly population","volume":"270","author":"Selhub","year":"1993","journal-title":"JAMA"},{"issue":"2","key":"10.1007\/s12603-009-0018-9_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/ajcn\/73.2.232","article-title":"Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore","volume":"73","author":"Saw","year":"2001","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"10.1007\/s12603-009-0018-9_bib16","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1503\/cmaj.1031586","article-title":"Homocysteine and cognitive function in elderly people","volume":"171","author":"Garcia","year":"2004","journal-title":"CMAJ"},{"key":"10.1007\/s12603-009-0018-9_bib17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1749-6632.2000.tb06392.x","article-title":"Plasma total homocysteine and cognitive performance in a volunteer elderly population","volume":"903","author":"Budge","year":"2000","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.1007\/s12603-009-0018-9_bib18","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ajcn\/75.5.908","article-title":"Homocysteine, B vitamin status, and cognitive function in the elderly","volume":"75","author":"Duthie","year":"2002","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1007\/s12603-009-0018-9_bib19","first-page":"153","article-title":"Homocysteine: a marker for cognitive performance? A longitudinal follow-up study","volume":"7","author":"Teunissen","year":"2003","journal-title":"J Nutr Health Aging"},{"issue":"3","key":"10.1007\/s12603-009-0018-9_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.aje.a010000","article-title":"Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study","volume":"150","author":"Kalmijn","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1007\/s12603-009-0018-9_bib21","first-page":"218","article-title":"Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects","volume":"4","author":"Ravaglia","year":"2000","journal-title":"J Nutr Health Aging"},{"key":"10.1007\/s12603-009-0018-9_bib22","series-title":"Diagnosis and treatment of senile dementia","first-page":"164","article-title":"SKT: The SKT: a short cognitive performance test as an instrument for the assessment of clinical efficacy of cognition enhancers","author":"Erzigkeit","year":"1989"},{"issue":"3","key":"10.1007\/s12603-009-0018-9_bib23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1007\/s12603-009-0018-9_bib24","doi-asserted-by":"crossref","first-page":"M197","DOI":"10.1093\/geronj\/47.6.M197","article-title":"Equations for predicting stature in white and black elderly individuals","volume":"47","author":"Chumlea","year":"1992","journal-title":"J Gerontol."},{"key":"10.1007\/s12603-009-0018-9_bib25","first-page":"15","article-title":"Mini Nutritional Assessment: A practical assessment tool for grading the nutritional state of elderly patients","volume":"2","author":"Guigoz","year":"1994","journal-title":"Facts and Research in Gerontology"},{"issue":"12","key":"10.1007\/s12603-009-0018-9_bib26","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1073\/pnas.4.12.370","article-title":"A biometric study of human basal metabolism","volume":"4","author":"Harris","year":"1918","journal-title":"Proc Natl Acad Sci. USA"},{"key":"10.1007\/s12603-009-0018-9_bib27","first-page":"61","article-title":"Functional evaluation: The Bathel Index","volume":"14","author":"Mahoney","year":"1965","journal-title":"Md State Med J."},{"issue":"3","key":"10.1007\/s12603-009-0018-9_bib28","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/ajcn\/69.3.482","article-title":"Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey","volume":"69","author":"Jacques","year":"1999","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"10.1007\/s12603-009-0018-9_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1024\/0300-9831.74.2.129","article-title":"Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors","volume":"74","author":"Strassburg","year":"2004","journal-title":"Int J Vitam Nutr Res"},{"issue":"10","key":"10.1007\/s12603-009-0018-9_bib30","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.clinbiochem.2004.06.012","article-title":"Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population","volume":"37","author":"Huerta","year":"2004","journal-title":"Clin Biochem"},{"issue":"4","key":"10.1007\/s12603-009-0018-9_bib31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ajcn\/78.4.765","article-title":"B vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women","volume":"78","author":"Wolters","year":"2003","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"10.1007\/s12603-009-0018-9_bib32","first-page":"181","article-title":"Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. 1988","volume":"11","author":"Lindenbaum","year":"1995","journal-title":"Nutrition"},{"issue":"5","key":"10.1007\/s12603-009-0018-9_bib33","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/ajcn\/73.5.927","article-title":"Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey","volume":"73","author":"Morris","year":"2001","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"10.1007\/s12603-009-0018-9_bib34","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1007\/s12603-009-0018-9_bib35","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0024-3205(00)00722-0","article-title":"Changes in the intracellular homocysteine and glutathione content associated with aging","volume":"67","author":"Hernanz","year":"2000","journal-title":"Life Sci"},{"issue":"10","key":"10.1007\/s12603-009-0018-9_bib36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1532-5415.1984.tb04170.x","article-title":"Folate and vitamin B12 status in a healthy elderly population","volume":"32","author":"Garry","year":"1984","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"10.1007\/s12603-009-0018-9_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/ajcn\/60.1.2","article-title":"Prevalence of cobalamin deficiency in the Framingham elderly population","volume":"60","author":"Lindenbaum","year":"1994","journal-title":"Am J Clin Nutr"},{"issue":"14","key":"10.1007\/s12603-009-0018-9_bib38","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1096\/fasebj.7.14.7901104","article-title":"Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency","volume":"7","author":"Allen","year":"1993","journal-title":"FASEB J"},{"key":"10.1007\/s12603-009-0018-9_bib39","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/meta.2001.28079","article-title":"Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects","volume":"50","author":"Ventura","year":"2001","journal-title":"Metabolism"},{"issue":"1","key":"10.1007\/s12603-009-0018-9_bib40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"issue":"11","key":"10.1007\/s12603-009-0018-9_bib41","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1093\/jn\/133.11.3416","article-title":"Framingham Offspring Study Cohort. Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort","volume":"133","author":"Russo","year":"2003","journal-title":"J Nutr"},{"issue":"4","key":"10.1007\/s12603-009-0018-9_bib42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1046\/j.1365-2141.1997.00124.x","article-title":"Diagnosis of cobalamin deficiency: the old and the new","volume":"97","author":"Chanarin","year":"1997","journal-title":"Br J Haematol"},{"issue":"2","key":"10.1007\/s12603-009-0018-9_bib43","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1172\/JCI113343","article-title":"Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry","volume":"81","author":"Stabler","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1007\/s12603-009-0018-9_bib44","doi-asserted-by":"crossref","unstructured":"Kim JM, Stewart R, Kim SW, Yang SJ, Shin HY, Shin, IS, Yoon JS. Changes in folate, vitamin B12, and homocysteine associated with incident dementia. J Neurol Neurosurg Psychiatry. 2008; Feb 5 (in print).","DOI":"10.1136\/jnnp.2007.131482"},{"issue":"9557","key":"10.1007\/s12603-009-0018-9_bib45","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0140-6736(07)60109-3","article-title":"Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial","volume":"369","author":"Durga","year":"2007","journal-title":"Lancet"},{"key":"10.1007\/s12603-009-0018-9_bib46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/00365510600615972","article-title":"Homocysteine measurements in geriatric patients","volume":"66","author":"Raeder","year":"2006","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1007\/s12603-009-0018-9_bib47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/ajcn\/65.1.20","article-title":"Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment","volume":"65","author":"La Rue","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"19","key":"10.1007\/s12603-009-0018-9_bib48","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N Engl J Med"}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-009-0018-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12603-009-0018-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723023023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723023023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-009-0018-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:04:49Z","timestamp":1761138289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770723023023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":48,"aliases":["10.1007\/bf02982675"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S1279770723023023"],"URL":"https:\/\/doi.org\/10.1007\/s12603-009-0018-9","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total serum homocysteine levels do not identify cognitive dysfunction in multimorbid elderly patients","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-009-0018-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}