{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T09:04:05Z","timestamp":1718701445613},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1007\/bf02988835","type":"journal-article","created":{"date-parts":[[2008,11,15]],"date-time":"2008-11-15T12:34:43Z","timestamp":1226752483000},"page":"1-7","source":"Crossref","is-referenced-by-count":22,"title":["Idiotype-specific T cells in multiple myeloma:Targets for an immunotherapeutic intervention?"],"prefix":"10.1007","volume":"13","author":[{"given":"Qing","family":"Yi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00d6sterborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02988835_CR1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0065-230X(08)60018-4","volume":"41","author":"H. Mellstedt","year":"1984","unstructured":"Mellstedt, H., Holm, G. and Bj\u00f6rkholm, M. (1984) Multiple myeloma, Waldenstr\u00f6m\u2019s macroglobulinemia, and benign monoclonal gammopathy: characteristics of the B cell clone, immunoregulatory cell populations and clinical implications.Adv. Cancer Res. 41, 257\u201389.","journal-title":"Adv. Cancer Res."},{"key":"BF02988835_CR2","first-page":"1","volume":"9","author":"E.E. Osgood","year":"1960","unstructured":"Osgood, E.E. (1960) The survival time of patients with plasmacytic myeloma.Cancer Chemther. Rep. 9, 1\u201310.","journal-title":"Cancer Chemther. Rep."},{"key":"BF02988835_CR3","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1001\/jama.1969.03160090040009","volume":"208","author":"R. Alexanian","year":"1969","unstructured":"Alexanian, R., Haut, A., Khan, A.U.et al. (1969) Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens.JAMA 208, 1680\u201385.","journal-title":"JAMA"},{"key":"BF02988835_CR4","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1182\/blood.V85.11.3077.bloodjournal85113077","volume":"85","author":"J.-L. Harousseau","year":"1995","unstructured":"Harousseau, J.-L., Attal, M., Divine, M.et al. (1995) Auto-logous stem cell transplantation after first remission induction treatment in multiple myeloma: a report of the French registry on autologous transplantation in multiple myeloma.Blood 85, 3077\u201385.","journal-title":"Blood"},{"key":"BF02988835_CR5","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM199110313251802","volume":"325","author":"G. Gahrton","year":"1991","unstructured":"Gahrton, G., Tura, S., Ljungman, P.et al. (1991) Allogeneic bone marrow transplantation in multiple myeloma.N. Engl. J. Med. 325, 1267\u201373.","journal-title":"N. Engl. J. Med."},{"key":"BF02988835_CR6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-4608(85)90096-2","volume":"17","author":"M.R. MacKenzie","year":"1985","unstructured":"MacKenzie, M.R. and Lewis, J.P. (1985) Cytogenetic evidence that the malignant event in multiple myeloma occurs in a precursor lymphocyte.Cancer Genet. Cytogenet. 17, 13\u201320.","journal-title":"Cancer Genet. Cytogenet."},{"key":"BF02988835_CR7","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1182\/blood.V70.5.1550.1550","volume":"70","author":"J. Berenson","year":"1987","unstructured":"Berenson, J., Wong, R., Kim, K.et al. (1987) Evidence of peripheral blood B lymphocyte but not T lymphocyte involvement in multiple myeloma.Blood 70, 1550\u20133.","journal-title":"Blood"},{"key":"BF02988835_CR8","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1182\/blood.V80.7.1818.1818","volume":"80","author":"D. Billadeau","year":"1992","unstructured":"Billadeau, D., Quam, L., Thomas, W.et al. (1992) Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients.Blood 80, 1818\u201324.","journal-title":"Blood"},{"key":"BF02988835_CR9","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1182\/blood.V78.10.2642.2642","volume":"78","author":"A. \u00d6sterborg","year":"1991","unstructured":"\u00d6sterborg, A., Steinitz, M., Lewin, N.et al. (1991) Establishment of idiotype bearing B-lymphocyte clones from a patient with monoclonal gammopathy.Blood 78, 2642\u20139.","journal-title":"Blood"},{"key":"BF02988835_CR10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1084\/jem.170.2.613","volume":"170","author":"L. Bergui","year":"1989","unstructured":"Bergui, L., Schena, M., Gaidano, G.et al. (1989) Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma.J. Exp. Med. 170, 613\u20138.","journal-title":"J. Exp. Med."},{"key":"BF02988835_CR11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1365-2141.1994.tb06732.x","volume":"87","author":"M Takishita","year":"1994","unstructured":"Takishita, M, Kosaka, M., Goto, T.et al. (1994) Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies.Br. J. Haematol. 87, 735\u201342.","journal-title":"Br. J. Haematol."},{"key":"BF02988835_CR12","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.178.3.1023","volume":"178","author":"D. Billadeau","year":"1993","unstructured":"Billadeau, D., Ahmann, G., Greipp, P.et al. (1993) The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell.J. Exp. Med. 178, 1023\u201331.","journal-title":"J. Exp. Med."},{"key":"BF02988835_CR13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2141.1994.tb04872.x","volume":"87","author":"M.H. Bakkus","year":"1994","unstructured":"Bakkus, M.H., van Riet, I., Camp, B.V.et al. (1994) Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.Br. J. Haemtol. 87, 68\u201374.","journal-title":"Br. J. Haemtol."},{"key":"BF02988835_CR14","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.4049\/jimmunol.155.5.2487","volume":"155","author":"R.A. Vescio","year":"1995","unstructured":"Vescio, R.A., Cao, J., Hong, C.H.et al. (1995) Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but not intraclonal diversity.J. Immunol. 155, 2487\u201397.","journal-title":"J. Immunol."},{"key":"BF02988835_CR15","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","volume":"61","author":"E.R. Fearon","year":"1990","unstructured":"Fearon, E.R. and Vogelstein, B. (1990) A genetic mode for colorectal tumorigenesis.Cell 61, 759\u201367.","journal-title":"Cell"},{"key":"BF02988835_CR16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.0954-6820.1977.tb16853.x","volume":"202","author":"H. Mellstedt","year":"1977","unstructured":"Mellstedt, H., Killander, D. and Pettersson, D. (1977) Bone marrow kinetic studies on three patients with myeloma-tosis: indications for malignant proliferation within both the plasma cell and lymphoid cell compartments.Acta Med. Scand. 202, 413\u20137.","journal-title":"Acta Med. Scand."},{"key":"BF02988835_CR17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ajh.2830330206","volume":"33","author":"C.S. Chan","year":"1990","unstructured":"Chan, C.S., Wormsley, S.B., Pierce, L.E.et al. (1990) B-cell surface phenotypes of proliferating myeloma cells: target antigen for immunotherapy.Am. J. Hematol. 33, 101\u20139.","journal-title":"Am. J. Hematol."},{"key":"BF02988835_CR18","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1182\/blood.V83.3.724.724","volume":"83","author":"L.M. Pilarski","year":"1994","unstructured":"Pilarski, L.M. and Belch, A.R. (1994) Circulating monoclonal B cells expressing P glycoprotein may be a reservoir of multidrug-resistant disease in multiple myeloma.Blood 83, 724\u201336.","journal-title":"Blood"},{"key":"BF02988835_CR19","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1182\/blood.V85.6.1596.bloodjournal8561596","volume":"85","author":"P. Corradini","year":"1995","unstructured":"Corradini, P., Voena, C., Astolfi, M.et al. (1995) High-dose sequential chemoradiotherapy in multiple myeloma:residual tumor cells are detectable in bone marrow and peripheral blood cell harvests and after autografting.Blood 85, 1596\u20131602.","journal-title":"Blood"},{"key":"BF02988835_CR20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1600-0609.1987.tb01158.x","volume":"38","author":"A. \u00d6sterborg","year":"1987","unstructured":"\u00d6sterborg, A., Nilsson, B., Bj\u00f6rkholm, M.et al. (1987) Blood clonal B cell excess at diagnosis in multiple myeloma. Relation to prognosis.Eur. J. Haematol. 38, 173\u20138.","journal-title":"Eur. J. Haematol."},{"key":"BF02988835_CR21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-2141.1996.294826.x","volume":"92","author":"E. Isaksson","year":"1996","unstructured":"Isaksson, E., Bj\u00f6rkholm, M., Holm, G.et al. (1996) Blood clonal B-cell excess in patients with monoclonal gammopathy of undetermined significance (MGUS): association with malignant transformation.Br. J. Haematol. 92, 71\u20136.","journal-title":"Br. J. Haematol."},{"key":"BF02988835_CR22","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1073\/pnas.69.6.1540","volume":"69","author":"R.G. Lynch","year":"1972","unstructured":"Lynch, R.G., Graff, R.J., Sirisinha, S.et al. (1972) Myeloma proteins as tumor-specific transplantation antigens.Proc. Natl. Acad. Sci. USA 69, 1540\u20134.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02988835_CR23","first-page":"126","volume":"48","author":"F.K. Stevenson","year":"1990","unstructured":"Stevenson, F.K., George, A.J.T. and Glennie, M.J. (1990) Anti-idiotypic therapy of leukemias and lymphomas.Chem. Immunol. 48, 126\u201366.","journal-title":"Chem. Immunol."},{"key":"BF02988835_CR24","first-page":"373","volume":"125C","author":"N.K. Jerne","year":"1974","unstructured":"Jerne, N.K. (1974) Towards a network theory of the immune system.Ann. Immunol (Inst. Pasteur),125C, 373\u201389.","journal-title":"Ann. Immunol (Inst. Pasteur)"},{"key":"BF02988835_CR25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0065-2776(08)60239-4","volume":"40","author":"R.G. Lynch","year":"1987","unstructured":"Lynch, R.G. (1987) Immunoglobulin-specific suppressor T cells.Adv. Immunol 40, 135\u201351.","journal-title":"Adv. Immunol"},{"key":"BF02988835_CR26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4049\/jimmunol.126.1.113","volume":"126","author":"J. Mahony","year":"1981","unstructured":"Mahony, J., Bose, A., Cowdrey, D.et al. (1981) A monoclonal antiidiotypic antibody to MOPC 315 IgA inhibits the growth of MOPC 315 myeloma cellsin vitro. J. Immunol 126, 113\u20137.","journal-title":"in vitro. J. Immunol"},{"key":"BF02988835_CR27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0092-8674(94)90336-0","volume":"76","author":"R.N. Germain","year":"1994","unstructured":"Germain, R.N. (1994) MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.Cell 76, 287\u201399.","journal-title":"Cell"},{"key":"BF02988835_CR28","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/eji.1830161110","volume":"16","author":"B. Bogen","year":"1986","unstructured":"Bogen, B., Malissen, B. and Haas, W. (1986) Idiotype-specific T cell clones that recognize syngeneic immunoglo-bulin fragments in the context of class II molecules.Eur. J. Immunol 16, 1373\u20138.","journal-title":"Eur. J. Immunol"},{"key":"BF02988835_CR29","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.4049\/jimmunol.120.5.1620","volume":"120","author":"M.J. Daley","year":"1978","unstructured":"Daley, M.J., Gebel, H.M. and Lynch, R.G. (1978) Idiotype-specific transplantation resistance to MOPC-315: abrogation by post-immunization thymectomy.J. Immunol 120, 1620\u20134.","journal-title":"J. Immunol"},{"key":"BF02988835_CR30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4049\/jimmunol.124.1.424","volume":"124","author":"P.M. Flood","year":"1980","unstructured":"Flood, P.M., Philipps, C, Taupier, M.A.et al. (1980) Regulation of myeloma growthin vitro by idiotype-specific T lymphocytes.J. Immunol 124, 424\u201330.","journal-title":"J. Immunol"},{"key":"BF02988835_CR31","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/jnci\/87.17.1289","volume":"87","author":"R.L. Hornung","year":"1995","unstructured":"Hornung, R.L., Longo, D.L., Bowersox, O.C.et al. (1995) Tumor antigen-specific immunization of bone marrow transplantation donors as adoptive therapy against established rumor.J. Natl Cancer Inst. 87, 1289\u201396.","journal-title":"J. Natl Cancer Inst."},{"key":"BF02988835_CR32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-0609.1985.tb02251.x","volume":"34","author":"L. Bergman","year":"1985","unstructured":"Bergman, L., Mitrou, P.S., Kelker, W.et al. (1985) T-cell subsets in malignant lymphomas and monoclonal gammopathies.Scand. J. Haematol 34, 170\u20136.","journal-title":"Scand. J. Haematol"},{"key":"BF02988835_CR33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0609.1982.tb00563.x","volume":"29","author":"H. Mellstedt","year":"1982","unstructured":"Mellstedt, H., Holm, G., Pettersson, D.et al. (1982) T cells in monoclonal gammopathies.Scand. J. Haematol 29, 57\u201364.","journal-title":"Scand. J. Haematol"},{"key":"BF02988835_CR34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ajh.2830200308","volume":"20","author":"J.F. San Miguel","year":"1985","unstructured":"San Miguel, J.F., Caballero, M.D. and Gonzalez, M. (1985) T-cell subpopulations in patients with monoclonal gammopathies: essential monoclonal gammopathy, multiple myeloma, and Waidenstrom macroglobulinemia.Am. J. Hematol. 20, 267\u201373.","journal-title":"Am. J. Hematol."},{"key":"BF02988835_CR35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2141.1989.tb04258.x","volume":"71","author":"R. Shapira","year":"1989","unstructured":"Shapira, R., Froom, P., Kinarty, A.et al. (1989) Increase in the suppressor-inducer T cell subset in multiple myeloma and monoclonal gammopathy of undetermined significance.Br. J. Haematol. 71, 223\u20135.","journal-title":"Br. J. Haematol."},{"key":"BF02988835_CR36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00916554","volume":"8","author":"H.M. Serra","year":"1988","unstructured":"Serra, H.M., Mant, M.J., Ruether, B.A.et al. (1988) Selective loss of CD4+ CD45R+ T cells in peripheral blood of multiple myeloma patients.J. Clin. Immunol 8, 259\u201365.","journal-title":"J. Clin. Immunol"},{"key":"BF02988835_CR37","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1182\/blood.V54.1.226.226","volume":"54","author":"T. Paglieroni","year":"1979","unstructured":"Paglieroni, T. and MacKenzie, M.R. (1979)In vitro cytotoxic response to human myeloma plasma cells by peripheral blood leukocytes from patients with multiple myeloma and benign monoclonal gammopathy.Blood 54, 226\u201337.","journal-title":"Blood"},{"key":"BF02988835_CR38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1172\/JCI110028","volume":"67","author":"R.G. Hoover","year":"1981","unstructured":"Hoover, R.G., Hickman, S., Gebel, H.M.et al. (1981) Expansion of Fc receptor-bearing T lymphocytes in patients with immunoglobulin G and immunoglobulin A myeloma.J. Clin. Invest. 67, 308\u201311.","journal-title":"J. Clin. Invest."},{"key":"BF02988835_CR39","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1182\/blood.V82.6.1787.1787","volume":"82","author":"M. Massaia","year":"1993","unstructured":"Massaia, M., Attisano, C, Peola, S.et al. (1993) Rapid generation of antiplasma cell activity in the bone marrow of myeloma patients by CD3-activated T cells.Blood 82, 1787\u201397.","journal-title":"Blood"},{"key":"BF02988835_CR40","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1182\/blood.V85.12.3679.bloodjournal85123679","volume":"85","author":"M. Massaia","year":"1995","unstructured":"Massaia, M., Borrione, P., Attisano, C.et al. (1995) Dysre- gulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients.Blood 85, 3679\u201387.","journal-title":"Blood"},{"key":"BF02988835_CR41","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1182\/blood.V77.8.1776.1776","volume":"77","author":"C.K Janson","year":"1991","unstructured":"Janson, C.K, Grunewald, J., \u00d6sterborg, A.et al. (1991) Predominant T cell receptor V gene usage in patients with abnormal clones of B cells.Blood 77, 1776\u201380.","journal-title":"Blood"},{"issue":"1","key":"BF02988835_CR42","first-page":"177","volume":"84","author":"P.A.H. Moss","year":"1994","unstructured":"Moss, P.A.H., Gillespie, G., Frodsham, P.et al. (1994) Clonal populations of CD4 and CD8 T cells in patients with paraproteinaemia and myeloma.Blood 84 (suppl. 1), 177a (abstr.).","journal-title":"Blood"},{"key":"BF02988835_CR43","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.4049\/jimmunol.153.9.4281","volume":"153","author":"F. Farace","year":"1994","unstructured":"Farace, F., Orlanducci, F., Dietrich, P-Y.et al. (1994) T cell repertoire in patients with B chronic lymphocytic leukemia.J. Immunol. 153, 4281\u201390.","journal-title":"J. Immunol."},{"key":"BF02988835_CR44","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/0167-5699(95)80082-4","volume":"16","author":"M.L. Sensi","year":"1995","unstructured":"Sensi, M.L. and Parmiani, G. (1995) Analyses of TCR usage in human tumors: a new tool for assessing tumor specific immune responses.Immunol. Today 16, 588\u201395.","journal-title":"Immunol. Today"},{"key":"BF02988835_CR45","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.4049\/jimmunol.131.3.1049","volume":"131","author":"T.T. Hecht","year":"1983","unstructured":"Hecht, T.T., Longo, D.L. and Matis, L.A. (1983) The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones.J. Immunol 131, 1049\u201355.","journal-title":"J. Immunol"},{"key":"BF02988835_CR46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0022-1759(88)90079-8","volume":"110","author":"C.C. Czerkinsky","year":"1988","unstructured":"Czerkinsky, C.C., Andersson, G., Ekre, H.P.et al. (1988) Reverse ELISPOT assay for clonal analysis of cytokine production. I. Enumeration of gamma-interferon-secreting cells.J. Immunol Meth. 110, 29\u201336.","journal-title":"J. Immunol Meth."},{"key":"BF02988835_CR47","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-3083.1993.tb03236.x","volume":"38","author":"Q. Yi","year":"1993","unstructured":"Yi, Q., Bergenbrant, S., \u00d6sterborg, A.et al. (1993) T-cell stimulation induced by idiotypes on monoclonal immuno-globulins in patients with monoclonal gammopathies.Scand. J. Immunol 38, 529\u201334.","journal-title":"Scand. J. Immunol"},{"key":"BF02988835_CR48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF01742306","volume":"34","author":"A. \u00d6sterborg","year":"1991","unstructured":"\u00d6sterborg, A., Masucci, M., Bergenbrant, S.et al. (1991) Generation of T cell clones binding F(ab\u2032)2 fragments of the idiotypic immunoglobulin in patients with monoclonal gammopathy.Cancer Immunol Immunother. 34, 157\u201362.","journal-title":"Cancer Immunol Immunother."},{"key":"BF02988835_CR49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1749-6632.1991.tb33449.x","volume":"636","author":"G. Holm","year":"1991","unstructured":"Holm, G., Bergenbrant, S., Lefvert, A.K., Yi, Q.et al. (1991) Anti-idiotypic immunity as a potential regulator in myeloma and related diseases.Ann. NY Acad. Sci. 636, 178\u201383.","journal-title":"Ann. NY Acad. Sci."},{"key":"BF02988835_CR50","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2141.1995.tb08902.x","volume":"89","author":"A. \u00d6sterborg","year":"1995","unstructured":"\u00d6sterborg, A., Yi, Q., Bergenbrant, S.et al. (1995) Idiotype- specific T cells in multiple myeloma stage I: an evaluation by four different functional tests.Br.. Haematol 89, 110\u20136.","journal-title":"Br.. Haematol"},{"key":"BF02988835_CR51","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-5699(91)90120-I","volume":"12","author":"S. Romagnani","year":"1991","unstructured":"Romagnani, S. (1991) Human TH1 and TH2 subsets: doubt no more.Immunol Today 12, 256\u20137.","journal-title":"Immunol Today"},{"key":"BF02988835_CR52","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1182\/blood.V86.8.3043.3043","volume":"86","author":"Q. Yi","year":"1995","unstructured":"Yi, Q., \u00d6sterborg, A., Bergenbrant, S.et al. (1995) Idiotype- reactive T-cell subsets and tumor load in monoclonal gammopathies.Blood 86, 3043\u20139.","journal-title":"Blood"},{"key":"BF02988835_CR53","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-3083.1991.tb02537.x","volume":"33","author":"G.F. Lauritzsen","year":"1991","unstructured":"Lauritzsen, G.F. and Bogen, B. (1991) Idiotype-specific, major histocompatibility complex restricted T cells are of both Thl and Th2 type.Scand. J. Immunol 33, 647\u201356.","journal-title":"Scand. J. Immunol"},{"key":"BF02988835_CR54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-3083.1993.tb01668.x","volume":"37","author":"G.F. Lauritzsen","year":"1993","unstructured":"Lauritzsen, G.F., Weiss, S. and Bogen, B. (1993) Anti-tumor activity of idiotype-specific, MHC-restricted Thl and Th2 clonesin vitro andin vivo.Scand. J. Immunol 37, 77\u201385.","journal-title":"Scand. J. Immunol"},{"key":"BF02988835_CR55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/367425a0","volume":"367","author":"E. A. Clark","year":"1994","unstructured":"Clark, E. A. and Ledbetter, J. A. (1994) How B and T cells talk to each other.Nature 367, 425\u20138.","journal-title":"Nature"},{"key":"BF02988835_CR56","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1073\/pnas.92.3.649","volume":"92","author":"D.M. Hilbert","year":"1995","unstructured":"Hilbert, D.M., Shen, M-Y., Rapp, U.R.et al. (1995) T cells induce terminal differentiation of transformed B cells to mature plasma cell tumors.Proc. Natl. Acad. Sci. USA 92, 649\u201353.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02988835_CR57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ajh.2830400111","volume":"40","author":"T. Paglieroni","year":"1992","unstructured":"Paglieroni, T., Caggiano, V. and MacKenzie, M. (1992) Abnormalities in immune regulation precede the development of multiple myeloma.Am. J. Hematol. 40, 51\u20135.","journal-title":"Am. J. Hematol."},{"key":"BF02988835_CR58","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1182\/blood.V72.3.1064.bloodjournal7231064","volume":"72","author":"U. Dianzani","year":"1988","unstructured":"Dianzani, U., Pileri, A., Boccadoro, M.et al. (1988) Activated idiotype-reactive cells in suppressor\/cytotoxic sub-populations of monoclonal gammopathies: correlation with diagnosis and disease status.Blood 72, 1064\u20138.","journal-title":"Blood"},{"key":"BF02988835_CR59","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1084\/jem.154.2.411","volume":"154","author":"K. Bottomly","year":"1981","unstructured":"Bottomly, K. and Mosier, D.E. (1981) Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted.J. Exp. Med. 154, 411\u201321.","journal-title":"J. Exp. Med."},{"key":"BF02988835_CR60","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.4049\/jimmunol.140.7.2401","volume":"140","author":"C.C. Parra","year":"1988","unstructured":"Parra, C.C., Lima, M.S., Gazzinelli, G.et al. (1988) Immune responses during human Schistosomiasis Mansoni. XV. Anti-idiotypic T cells can recognize and respond to anti-SEA idiotypes directly.J. Immunol. 140, 2401\u20135.","journal-title":"J. Immunol."},{"key":"BF02988835_CR61","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/eji.1830170522","volume":"17","author":"H. Yamamoto","year":"1987","unstructured":"Yamamoto, H., Araki, K., Bitoh, S.et al. (1987) Cytotoxic T lymphocyte clone recognizing self idiotype: its regulatory role in antibody production.Eur. J. Immunol. 17, 719\u201322.","journal-title":"Eur. J. Immunol."},{"key":"BF02988835_CR62","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1046\/j.1365-2249.1996.27735.x","volume":"104","author":"Q. Yi","year":"1996","unstructured":"Yi, Q., Holm, G. and Lefvert, A.K. (1996) Idiotype-induced T cell stimulation requires antigen presentation in association with HLA-DR molecules.Clin. Exp. Immunol. 104, 359\u2013650.","journal-title":"Clin. Exp. Immunol."},{"key":"BF02988835_CR63","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.4049\/jimmunol.141.6.2168","volume":"141","author":"A.J.T. George","year":"1988","unstructured":"George, A.J.T., Folkard, S.G., Hamblin, T.et al. (1988) Idiotypic vaccination as a treatment for a B cell lymphoma.J. Immunol 141, 2168\u201374.","journal-title":"J. Immunol"},{"key":"BF02988835_CR64","first-page":"323","volume":"15","author":"L.W. Kwak","year":"1991","unstructured":"Kwak, L.W., Campbell, M. and Levy, R. (1991) Idiotype vaccination post-bone marrow transplantation for B-cell lymphoma: initial studies in a murine model.Cancer Detec. Prev. 15, 323\u20135.","journal-title":"Cancer Detec. Prev."},{"key":"BF02988835_CR65","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJM199210223271705","volume":"327","author":"L.W. Kwak","year":"1992","unstructured":"Kwak, L.W., Campbell, M., Czerwinski, D.K.et al. (1992) Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors.N. Engl. J. Med. 327, 1209\u201315.","journal-title":"N. Engl. J. Med."},{"key":"BF02988835_CR66","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1056\/NEJM198506273122601","volume":"312","author":"M. Raffeld","year":"1985","unstructured":"Raffeld, M., Necker, L., Longo, D.L.et al. (1985) Spontaneous alteration of idiotype in a monoclonal B-cell lymphoma: Escape from detection by anti-idiotype.N. Engl J. Med. 312, 1653\u20138.","journal-title":"N. Engl J. Med."},{"key":"BF02988835_CR67","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1182\/blood.V80.6.1502.1502","volume":"80","author":"D.G. Maloney","year":"1992","unstructured":"Maloney, D.G., Brown, S., Czerwinski, D.K.et al. (1992) Monoclonal anti-idiotype antibody therapy of B-cell lymphoma: the addition of a short course of chemotherapy does not interfere with the antitumor effect nor prevent the emergence of idiotype-negative variant cells.Blood 80, 1502\u201310.","journal-title":"Blood"},{"key":"BF02988835_CR68","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1182\/blood.V80.9.2326.2326","volume":"80","author":"M.H.C. Bakkus","year":"1992","unstructured":"Bakkus, M.H.C., Heirman,C, van Riet, I.et al. (1992) Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation.Blood 80, 2326\u201335.","journal-title":"Blood"},{"key":"BF02988835_CR69","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1046\/j.1365-2141.1996.419959.x","volume":"92","author":"S. Bergenbrant","year":"1996","unstructured":"Bergenbrant, S., Yi, Q., \u00d6sterborg, A.et al. (1996) Modulation of anti-idiotypic immune response by immunization with the autologous M-component protein in multiple myeloma patients.Br. J. Haematol. 92, 840\u20136.","journal-title":"Br. J. Haematol."},{"key":"BF02988835_CR70","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(95)90757-2","volume":"345","author":"L.W. Kwak","year":"1995","unstructured":"Kwak, L.W., Taub, D.D., Duffey, P.L.et al. (1995) Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor.Lancet 345, 1016\u201320.","journal-title":"Lancet"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02988835.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02988835\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02988835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T03:08:06Z","timestamp":1684638486000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02988835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["BF02988835"],"URL":"https:\/\/doi.org\/10.1007\/bf02988835","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}