{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:14:20Z","timestamp":1789964060883,"version":"4.0.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[1990,11,1]],"date-time":"1990-11-01T00:00:00Z","timestamp":657417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Anaesth"],"published-print":{"date-parts":[[1990,11]]},"DOI":"10.1007\/bf03006641","type":"journal-article","created":{"date-parts":[[2009,5,2]],"date-time":"2009-05-02T02:04:43Z","timestamp":1241229883000},"page":"933-942","source":"Crossref","is-referenced-by-count":62,"title":["The chemoreflex control of breathing and its measurement"],"prefix":"10.1007","volume":"37","author":[{"given":"James","family":"Duffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF03006641_CR1","first-page":"475","volume-title":"Handbook of Physiology, Section 3, The Respiratory System, Volume II, Control of Breathing, Part 2","author":"DJC Cunningham","year":"1986","unstructured":"Cunningham DJC, Robbins PA, Wolff CB. Integration of respiratory responses to changes in alveolar partial pressures of CO2 and O2 and in arterial pH.In: Cherniack NS, Widdicombe JG (Eds.). Handbook of Physiology, Section 3, The Respiratory System, Volume II, Control of Breathing, Part 2. Bethesda: Am Physiol Soc 1986; 475\u2013528."},{"key":"BF03006641_CR2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1152\/jappl.1987.62.2.389","volume":"62","author":"BN Eugene","year":"1987","unstructured":"Eugene BN, Cherniack NS. Central chemoreceptors. J Appl Physiol 1987; 62: 389\u2013402.","journal-title":"J Appl Physiol"},{"key":"BF03006641_CR3","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1139\/y83-207","volume":"61","author":"PA Stewart","year":"1983","unstructured":"Stewart PA. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983; 61: 1444\u201361.","journal-title":"Can J Physiol Pharmacol"},{"key":"BF03006641_CR4","first-page":"347","volume-title":"Regulation of Breathing, Part I","author":"SW Bledsoe","year":"1981","unstructured":"Bledsoe SW, Hornbein TF. Central chemosensors and the regulation of their chemical environment.In: Hornbein TF (Ed.). Regulation of Breathing, Part I. New York: Marcel Dekker 1981; 347\u2013428."},{"key":"BF03006641_CR5","first-page":"516","volume-title":"Applied Respiratory Physiology","author":"JF Nunn","year":"1967","unstructured":"Nunn JF. Appendix F. The exponential function.In: Nunn JF(Ed.). Applied Respiratory Physiology. Cambridge: Butterworths 1967; 516\u201327."},{"key":"BF03006641_CR6","first-page":"163","volume-title":"Handbook of Physiology, Section 3, The Respiratory System, Volume II, Control of Breathing, Part 1","author":"TV Santiago","year":"1986","unstructured":"Santiago TV, Edelman NH. Brain blood flow and control of breathing.In: Cherniack NS, Widdicombe JG (Eds.). Handbook of Physiology, Section 3, The Respiratory System, Volume II, Control of Breathing, Part 1. Bethesda: Am Physiol Soc 1986; 163\u201379."},{"key":"BF03006641_CR7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1113\/jphysiol.1989.sp017578","volume":"411","author":"A Berkenbosch","year":"1989","unstructured":"Berkenbosch A, Bovill JG, Dahan A, De Goede J, Olevier ICW. The ventilatory CO2 sensitivities from Read\u2019s rebreathing method and the steady-state method are not equal in man. J Physiol 1989; 411: 367\u201377.","journal-title":"J Physiol"},{"key":"BF03006641_CR8","first-page":"350","volume-title":"Applied Respiratory Physiology","author":"JF Nunn","year":"1967","unstructured":"Nunn JF. Respiratory aspects of anaesthesia.In: Nunn JF (Ed.). Applied Respiratory Physiology. Cambridge: Butterworths 1967; 350\u201378."},{"key":"BF03006641_CR9","first-page":"909","volume":"118","author":"EA Phillipson","year":"1978","unstructured":"Phillipson EA. Control of breathing during sleep. Am Rev RespDis 1978; 118:909\u201339.","journal-title":"Am Rev RespDis"},{"key":"BF03006641_CR10","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1152\/jappl.1981.51.6.1398","volume":"51","author":"EA Phillipson","year":"1981","unstructured":"Phillipson EA, Bowes G, Townsend ER, Duffin J, Cooper JD. Carotid chemoreceptors in ventilatory responses to changes in venous CO2 load. J Appl Physiol 1981; 51: 1398\u2013403.","journal-title":"J Appl Physiol"},{"key":"BF03006641_CR11","first-page":"247","volume-title":"Handbook of Physiology, Section 3, The Respiratory System, Volume II, Control of Breathing, Part 2","author":"SJ Fidone","year":"1986","unstructured":"Fidone SJ, Gonzales C. Initiation and control of chemoreceptor activity in the carotid body.In: Cherniack NS, Widdicombe JG (Eds.). Handbook of Physiology, Section 3, The Respiratory System, Volume II, Control of Breathing, Part 2. Bethesda: Am Physiol Soc 1986; 247\u2013312."},{"key":"BF03006641_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1987.sp016440","volume":"384","author":"DJC Cunningham","year":"1987","unstructured":"Cunningham DJC. Studies on arterial chemoreceptors in man. J Physiol 1987; 384: 1\u201326.","journal-title":"J Physiol"},{"key":"BF03006641_CR13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-5793(89)80623-4","volume":"249","author":"MA Delpiano","year":"1989","unstructured":"Delpiano MA, Hescheler J. Evidence for a PO2-sensitive K+ channel in the type-l cell of the rabbit carotid body. FEBBS Lett 1989; 249: 195\u20138.","journal-title":"FEBBS Lett"},{"key":"BF03006641_CR14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/bja\/48.10.975","volume":"48","author":"J Duffin","year":"1976","unstructured":"Duffin J, Triscott A, Whitwam JG. The effect of halothane and thiopentone on ventilatory responses mediated by the peripheral chemoreceptors in man. Br J Anaesth 1976; 48:975\u201381.","journal-title":"Br J Anaesth"},{"key":"BF03006641_CR15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF03004877","volume":"25","author":"J Duffin","year":"1978","unstructured":"Duffin J, Jacobson ER, Orsini EC. The effect of ethanol on the ventilatory responses mediated by the peripheral chemoreceptors in man. Can Anaesth Soc J 1978; 25: 181\u20139.","journal-title":"Can Anaesth Soc J"},{"key":"BF03006641_CR16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/imj.1967.16.1.20","volume":"16","author":"DJC Read","year":"1967","unstructured":"Read DJC. A clinical method for assessing the ventilatory response to carbon dioxide. Australasian Annals of Medicine 1967; 16:20\u201332.","journal-title":"Australasian Annals of Medicine"},{"key":"BF03006641_CR17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1113\/jphysiol.1988.sp017365","volume":"406","author":"J Duffin","year":"1988","unstructured":"Duffin J, McAvoy GV. The peripheral-chemoreceptor threshold to carbon dioxide in man. J. Physiol 1988; 406: 15\u201326.","journal-title":"J. Physiol"}],"container-title":["Canadian Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03006641.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03006641\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03006641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T22:34:17Z","timestamp":1558478057000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03006641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["BF03006641"],"URL":"https:\/\/doi.org\/10.1007\/bf03006641","relation":{},"ISSN":["0832-610X","1496-8975"],"issn-type":[{"value":"0832-610X","type":"print"},{"value":"1496-8975","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}