{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:26:47Z","timestamp":1788960407121,"version":"build-2803163510"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1007\/bf03026317","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T07:09:34Z","timestamp":1231830574000},"page":"11-15","source":"Crossref","is-referenced-by-count":94,"title":["Roles for NF-\u03baB and c-Fos in osteoclasts"],"prefix":"10.1007","volume":"23","author":[{"given":"Brendan F.","family":"Boyce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhito","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianping","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF03026317_CR1","first-page":"1","volume-title":"The Physiological Basis of Metabolic Bone Disease","author":"H Rasmussen","year":"1974","unstructured":"Rasmussen H, Bordier P (1974) The Physiological Basis of Metabolic Bone Disease. William & Wilkins, Baltimore, USA, pp 1\u2013314"},{"key":"BF03026317_CR2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/258325a0","volume":"258","author":"AJ Kahn","year":"1975","unstructured":"Kahn AJ, Simmons DJ (1975) Investigation of cell lineage in bone using a chimaera of chick and quial embryonic tissue. Nature (Lond) 258: 325\u2013327","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR3","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.1105786","volume":"190","author":"DG Walker","year":"1975","unstructured":"Walker DG (1975) Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science 190: 784\u2013785","journal-title":"Science"},{"key":"BF03026317_CR4","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1172\/JCI108106","volume":"56","author":"LG Raisz","year":"1975","unstructured":"Raisz LG, Luben RA, Mundy GR, Dietrich JW, Horton JE, Trummel CL (1975) Effect of osteoclast activating factor from human leukocytes on bone metabolism. J Clin Invest 56: 408\u2013413","journal-title":"J Clin Invest"},{"key":"BF03026317_CR5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(91)90499-O","volume":"64","author":"P Soriano","year":"1991","unstructured":"Soriano P, Montgomery C, Geske R, Bradley A (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693\u2013702","journal-title":"Cell"},{"key":"BF03026317_CR6","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1172\/JCI116032","volume":"90","author":"BF Boyce","year":"1992","unstructured":"Boyce BF, Yoneda T, Lowe C, Soriano P, Mundy GR (1992) Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest 90: 1622\u20131627","journal-title":"J Clin Invest"},{"key":"BF03026317_CR7","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","volume":"11","author":"G Franzoso","year":"1997","unstructured":"Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U (1997) Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 11: 3482\u20133496","journal-title":"Genes Dev"},{"key":"BF03026317_CR8","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nm1197-1285","volume":"3","author":"V Iotsova","year":"1997","unstructured":"Iotsova V, Caamano J, Loy J, Lewin A, Bravo R (1997) Osteopetrosis in mice lacking NF-\u03baB1 and NF-KB2. Nat Med 3: 1285\u20131289","journal-title":"Nat Med"},{"key":"BF03026317_CR9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","volume":"89","author":"WS Simonet","year":"1997","unstructured":"Simonet WS, Lacey DL, Dunstan CR, et al (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89: 309\u2013319","journal-title":"Cell"},{"key":"BF03026317_CR10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan HL, et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93: 165\u2013176","journal-title":"Cell"},{"key":"BF03026317_CR11","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.97.4.1566","volume":"97","author":"J Li","year":"2000","unstructured":"Li J, Sarosi I, Yan XQ, et al (2000) RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A 97: 1566\u20131571","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BF03026317_CR12","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","volume":"13","author":"WC Dougall","year":"1999","unstructured":"Dougall WC, Glaccum M, Charrier K, Brasel KR, Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Schuh JP (1999) RANK is essential for osteoclast and lymph node development. Genes Dev 13: 2412\u20132424","journal-title":"Genes Dev"},{"key":"BF03026317_CR13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","volume":"397","author":"YY Kong","year":"1999","unstructured":"Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (Lond) 397: 315\u2013323","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","volume":"402","author":"YY Kong","year":"1999","unstructured":"Kong YY, Feige U, Sarosi I, et al (1999) Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (Lond) 402: 304\u2013309","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH672>3.0.CO;2-W","volume":"192","author":"I Itonaga","year":"2000","unstructured":"Itonaga I, Fujikawa Y, Sabokbar A, Murray DW, Athanasou NA (2000) Rheumatoid arthritis synovial macrophage-osteoclast differentiation is osteoprotegerin ligand-dependent. J Pathol 192: 97\u2013104","journal-title":"J Pathol"},{"key":"BF03026317_CR16","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1210\/endo.140.9.7131","volume":"140","author":"LC Hofbauer","year":"1999","unstructured":"Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Spelsberg TC, Riggs BL (1999) Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 140: 4367\u20134370","journal-title":"Endocrinology"},{"key":"BF03026317_CR17","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1006\/bbrc.1998.9394","volume":"250","author":"LC Hofbauer","year":"1998","unstructured":"Hofbauer LC, Dunstan CR, Spelsberg TC, Riggs BL, Khosla S (1998) Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines. Biochem Biophys Res Commun 250: 776\u2013781","journal-title":"Biochem Biophys Res Commun"},{"key":"BF03026317_CR18","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1359\/jbmr.2003.18.6.1088","volume":"18","author":"GJ Atkins","year":"2003","unstructured":"Atkins GJ, Kostakis P, Pan B, Farrugia A, Gronthos S, Evdokiou A, Harrison K, Findlay DM, Zannettino AC (2003) RANKL expression is related to the differentiation state of human osteoblasts. J Bone Miner Res 18: 1088\u20131098","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature (Lond) 423: 337\u2013342","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR20","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","volume":"18","author":"MS Hayden","year":"2004","unstructured":"Hayden MS, Ghosh S (2004) Signaling to NF-kappa B. Genes Dev 18: 2195\u20132224","journal-title":"Genes Dev"},{"key":"BF03026317_CR21","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1359\/jbmr.2002.17.7.1200","volume":"17","author":"L Xing","year":"2002","unstructured":"Xing L, Bushnell TP, Carlson L, Tai Z, Tondravi M, Siebenlist U, Young F, Boyce BF (2002) NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis. J Bone Miner Res 17: 1200\u20131210","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.cb.10.110194.002201","volume":"10","author":"U Siebelist","year":"1994","unstructured":"Siebelist U, Franzoso G, Brown K (1994) Structure, regulation and function of NF-\u03baB. Annu Rev Cell Biol 10: 405\u2013455","journal-title":"Annu Rev Cell Biol"},{"key":"BF03026317_CR23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/JCI11891","volume":"107","author":"A Baldwin","year":"2001","unstructured":"Baldwin A (2001) The transcription factor NF-\u03baB and human disease. J Clin Invest 107: 3\u20136","journal-title":"J Clin Invest"},{"key":"BF03026317_CR24","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1084\/jem.20030116","volume":"198","author":"DV Novack","year":"2003","unstructured":"Novack DV, Yin L, Hagen-Stapleton A, Schreiber RD, Goeddel DV, Ross FP, Teitelbaum SL (2003) The IkappaB function of NF- kappaB2 p100 controls stimulated osteoclastogenesis. J Exp Med 198: 771\u2013781","journal-title":"J Exp Med"},{"key":"BF03026317_CR25","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1038\/ncb0502-e131","volume":"4","author":"E Shaulian","year":"2002","unstructured":"Shaulian E, Karin M (2002) AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-E136","journal-title":"Nat Cell Biol"},{"key":"BF03026317_CR26","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/360741a0","volume":"360","author":"Z-Q Wang","year":"1992","unstructured":"Wang Z-Q, OVitt C, Grigoriadis AE, Mohle-Steinlein U, Ruther U, Wagner EF (1992) Bone and haematopoietic defects in mice lacking c-Fos. Nature (Lond) 360: 741\u2013745","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR27","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","volume":"109","author":"GR Crabtree","year":"2002","unstructured":"Crabtree GR, Olson EN (2002) NFAT signaling: choreographing the social lives of cells. Cell 109(suppl): S67-S79","journal-title":"Cell"},{"key":"BF03026317_CR28","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","volume":"15","author":"A Rao","year":"1997","unstructured":"Rao A, Luo C, Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15: 707\u2013747","journal-title":"Annu Rev Immunol"},{"key":"BF03026317_CR29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","volume":"3","author":"H Takayanagi","year":"2002","unstructured":"Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T (2002) Induction and activation of the transcription factor NFATcl (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3: 889\u2013901","journal-title":"Dev Cell"},{"key":"BF03026317_CR30","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature02444","volume":"428","author":"T Koga","year":"2004","unstructured":"Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T (2004) Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature (Lond) 428: 758\u2013763","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR31","doi-asserted-by":"crossref","first-page":"41147","DOI":"10.1074\/jbc.M205063200","volume":"277","author":"N Ishida","year":"2002","unstructured":"Ishida N, Hayashi K, Hoshijima M, Ogawa T, Koga S, Miyatake Y, Kumegawa M, Kimura T, Takeya T (2002) Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. J Biol Chem 277: 41147\u201341156","journal-title":"J Biol Chem"},{"key":"BF03026317_CR32","doi-asserted-by":"crossref","first-page":"13984","DOI":"10.1074\/jbc.M213067200","volume":"279","author":"H Hirotani","year":"2004","unstructured":"Hirotani H, Tuohy NA, Woo JT, Stern PH, Clipstone NA (2004) The calcineurin\/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells. J Biol Chem 279: 13984\u201313992","journal-title":"J Biol Chem"},{"key":"BF03026317_CR33","doi-asserted-by":"crossref","first-page":"26475","DOI":"10.1074\/jbc.M313973200","volume":"279","author":"K Matsuo","year":"2004","unstructured":"Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, Wagner EF (2004) Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem 279: 26475\u201326480","journal-title":"J Biol Chem"},{"key":"BF03026317_CR34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bone.2004.02.009","volume":"35","author":"K Igarashi","year":"2004","unstructured":"Igarashi K, Hirotani H, Woo JT, Stern PH (2004) Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone 35: 47\u201356","journal-title":"Bone"},{"key":"BF03026317_CR35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI200419657","volume":"114","author":"F Ikeda","year":"2004","unstructured":"Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy SV, Hata K, Yamashita K, Hiraga T, Watanabe T, Kukita T, Yoshioka K, Rao A, Yoneda T (2004) Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 114: 475\u2013484","journal-title":"J Clin Invest"},{"key":"BF03026317_CR36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(02)00762-6","volume":"109","author":"GG McGill","year":"2002","unstructured":"McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109: 707\u2013718","journal-title":"Cell"},{"key":"BF03026317_CR37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S8756-3282(01)00416-1","volume":"28","author":"V Rajapurohitam","year":"2001","unstructured":"Rajapurohitam V, Chalhoub N, Benachenhou N, Neff L, Baron R, Vacher J (2001) The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation\/function. Bone 28: 513\u2013523","journal-title":"Bone"},{"key":"BF03026317_CR38","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bone.2003.11.010","volume":"34","author":"GA Partington","year":"2004","unstructured":"Partington GA, Fuller K, Chambers TJ, Pondel M (2004) Mitf- PU.l interactions with the tartrate-resistant acid phosphatase gene promoter during osteoclast differentiation. Bone 34: 237\u2013245","journal-title":"Bone"},{"key":"BF03026317_CR39","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1359\/jbmr.1999.14.10.1654","volume":"14","author":"M Gowen","year":"1999","unstructured":"Gowen M, Lazner F, Dodds R, Kapadia R, Feild J, Tavaria M, Bertoncello I, Drake F, Zavarselk S, Tellis I, Hertzog P, Debouck C, Kola I (1999) Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization. J Bone Miner Res 14: 1654\u20131663","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1530\/eje.0.1400376","volume":"140","author":"LC Hofbauer","year":"1999","unstructured":"Hofbauer LC, Heufelder AE (1999) Osteopetrosis in cathepsin K-deficient mice. Eur J Endocrinol 140: 376\u2013377","journal-title":"Eur J Endocrinol"},{"key":"BF03026317_CR41","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.122.10.3151","volume":"122","author":"AR Hayman","year":"1996","unstructured":"Hayman AR, Jones SJ, Boyde A, Foster D, Colledge WH, Carlton MB, Evans MJ, Cox TM (1996) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. Development (Camb) 122: 3151\u20133162","journal-title":"Development (Camb)"},{"key":"BF03026317_CR42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nm842","volume":"9","author":"N Chalhoub","year":"2003","unstructured":"Chalhoub N, Benachenhou N, Rajapurohitam V, Pata M, Ferron M, Frattini A, Villa A, Vacher J (2003) Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. Nat Med 9: 399\u2013406","journal-title":"Nat Med"},{"key":"BF03026317_CR43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nm0403-395","volume":"9","author":"BF Boyce","year":"2003","unstructured":"Boyce BF (2003) Bad bones, grey hair, one mutation. Nat Med 9: 395\u2013396","journal-title":"Nat Med"},{"key":"BF03026317_CR44","first-page":"1041","volume":"4","author":"B Wong","year":"1999","unstructured":"Wong B, Besser D, Kim N, Arron J, Vologodskaia M, Hanafusa H, Choi Y (1999) TRANCE, a TNF family member, activates Akt\/ PKB through a signaling complex involving TRAF6 and c-Src. Cell 4: 1041\u20131049","journal-title":"Cell"},{"key":"BF03026317_CR45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.840301","volume":"15","author":"L Xing","year":"2001","unstructured":"Xing L, Venegas AM, Chen A, Garrett-Beal L, Boyce BF, Varmus HE, Schwartzberg PL (2001) Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes Dev 15: 241\u2013253","journal-title":"Genes Dev"},{"key":"BF03026317_CR46","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bone.2003.06.004","volume":"34","author":"I Recchia","year":"2004","unstructured":"Recchia I, Rucci N, Funari A, Migliaccio S, Taranta A, Longo M, Kneissel M, Susa M, Fabbro D, Teti A (2004) Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1\/2 pathway. Bone 34: 65\u201379","journal-title":"Bone"},{"key":"BF03026317_CR47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.148.2.333","volume":"148","author":"T Miyazaki","year":"2000","unstructured":"Miyazaki T, Katagiri H, Kanegae Y, Takayanagi H, Sawada Y, Yamamoto A, Pando MP, Asano T, Verma IM, Oda H, Nakamura K, Tanaka S (2000) Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol 148: 333\u2013342","journal-title":"J Cell Biol"},{"key":"BF03026317_CR48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/jcb.10503","volume":"89","author":"A Gingery","year":"2003","unstructured":"Gingery A, Bradley E, Shaw A, Oursler MJ (2003) Phosphatidylinositol 3-kinase coordinately activates the MEK\/ ERK and AKT\/NFkappaB pathways to maintain osteoclast survival. J Cell Biochem 89: 165\u2013179","journal-title":"J Cell Biochem"},{"key":"BF03026317_CR49","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/416744a","volume":"416","author":"H Takayanagi","year":"2002","unstructured":"Takayanagi H, Kim S, Matsuo K, Suzuki H, Suzuki T, Sato K, Yokochi T, Oda H, Nakamura K, Ida N, Wagner EF, Taniguchi T (2002) RANKL maintains bone homeostasis through c-Fosdependent induction of interferon-beta [see comment]. Nature (Lond) 416: 744\u2013749","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR50","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"GS Firestein","year":"2003","unstructured":"Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature (Lond) 423: 356\u2013361","journal-title":"Nature (Lond)"},{"key":"BF03026317_CR51","first-page":"S171","volume":"19","author":"Z Yao","year":"2004","unstructured":"Yao Z, Li P, Zhang Q, Schwarz EM, Ma L, Keng P, Boyce BF, Xing LP (2004) TNF increases bone marrow osteoclast precursor numbers by stimulating their proliferation and differentiation through up-regulation of c-Fms expression. J Bone Miner Res 19: S171","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR52","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/art.11419","volume":"50","author":"P Li","year":"2004","unstructured":"Li P, Schwarz EM, O\u2019Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L (2004) Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11b high osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum 50: 265\u2013276","journal-title":"Arthritis Rheum"},{"key":"BF03026317_CR53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1359\/JBMR.0301233","volume":"19","author":"P Li","year":"2004","unstructured":"Li P, Schwarz EM, O\u2019Keefe RJ, Ma L, Boyce BF, Xing L (2004) RANK signaling is not required for TNFa-mediated increase in CD11bhi osteoclast precursors, but is essential for mature osteoclast formation in TNFa-mediated inflammatory arthritis. J Bone Miner Res 19: 207\u2013213","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR54","first-page":"S131","volume":"17","author":"T Yamashita","year":"2002","unstructured":"Yamashita T, Xing L, Li P, Schwarz EM, Dougall WC, Boyce BF (2002) c-Fos over-expression induces osteoclastogenesis independent of RANK signaling. J Bone Miner Res 17: S131","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR55","first-page":"S17","volume":"18","author":"T Yamashita","year":"2003","unstructured":"Yamashita T, Xing L, Matsuo K, Wagner EF, Boyce BF (2003) Treatment of c-Fos over-expressing osteoclast precursors with cytokines induces osteoclastformation and abrogates bisphosphonate-induced osteoclast apoptosis. J Bone Miner Res 18: S17","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR56","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm1096-1132","volume":"2","author":"DE Hughes","year":"1996","unstructured":"Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF (1996) Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-13. Nat Med 2: 1132\u20131136","journal-title":"Nat Med"},{"key":"BF03026317_CR57","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jcb.10490","volume":"89","author":"RM Locklin","year":"2003","unstructured":"Locklin RM, Khosla S, Turner RT, Riggs BL (2003) Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone. J Cell Biochem 89: 180\u2013190","journal-title":"J Cell Biochem"},{"key":"BF03026317_CR58","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa031975","volume":"349","author":"DM Black","year":"2003","unstructured":"Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ (2003) The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349: 1207\u20131215","journal-title":"N Engl J Med"},{"key":"BF03026317_CR59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1010010912302","volume":"2","author":"SV Reddy","year":"2001","unstructured":"Reddy SV, Kurihara N, Menaa C, Roodman GD (2001) Paget\u2019s disease of bone: a disease of the osteoclast. Rev Endocr Metab Disord 2: 195\u2013201","journal-title":"Rev Endocr Metab Disord"},{"key":"BF03026317_CR60","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1359\/jbmr.2003.18.10.1748","volume":"18","author":"TL Johnson-Pais","year":"2003","unstructured":"Johnson-Pais TL, Wisdom JH, Weldon KS, Cody JD, Hansen MF, Singer FR, Leach RJ (2003) Three novel mutations in SQSTM1 identified in familial Paget\u2019s disease of bone. J Bone Miner Res 18: 1748\u20131753","journal-title":"J Bone Miner Res"},{"key":"BF03026317_CR61","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1093\/hmg\/11.22.2735","volume":"11","author":"LJ Hocking","year":"2002","unstructured":"Hocking LJ, Lucas GJ, Daroszewska A, Mangion J, Olavesen M, Cundy T, Nicholson GC, Ward L, Bennett ST, Wuyts W, Van Hul W, Ralston SH (2002) Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget\u2019s disease. Hum Mol Genet 11: 2735\u20132739","journal-title":"Hum Mol Genet"},{"key":"BF03026317_CR62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/71667","volume":"24","author":"AE Hughes","year":"2000","unstructured":"Hughes AE, Ralston SH, Marken J, Bell C, MacPherson H, Wallace RG, van Hul W, Whyte MP, Nakatsuka K, Hovy L, Anderson DM (2000) Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet 24: 45\u201348","journal-title":"Nat Genet"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03026317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03026317\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03026317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T20:35:10Z","timestamp":1632947710000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03026317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":62,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["BF03026317"],"URL":"https:\/\/doi.org\/10.1007\/bf03026317","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}