{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:01:13Z","timestamp":1790924473099,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Anesth\/J Can Anesth"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1007\/bf03028318","type":"journal-article","created":{"date-parts":[[2009,5,3]],"date-time":"2009-05-03T20:41:50Z","timestamp":1241383310000},"page":"502-509","source":"Crossref","is-referenced-by-count":66,"title":["Multiple organ dysfunction syndrome: a narrative review"],"prefix":"10.1007","volume":"48","author":[{"given":"David","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvin","family":"Mayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF03028318_CR1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00000658-197308000-00001","volume":"178","author":"NL Tilney","year":"1973","unstructured":"Tilney NL, Bailey GL, Morgan AP. Sequential system failure after rupture of abdominal aortic aneurysms: an unsolved problem in postoperative care. Ann Surg 1973; 178: 117\u201322.","journal-title":"Ann Surg"},{"key":"BF03028318_CR2","first-page":"310","volume":"81","author":"HC Polk","year":"1977","unstructured":"Polk HC Jr, Shields CL. Remote organ failure: a valid sign of occult intra-abdominal infection. Surgery 1977; 81: 310\u20133.","journal-title":"Surgery"},{"key":"BF03028318_CR3","first-page":"323","volume":"144","author":"B Eiseman","year":"1977","unstructured":"Eiseman B, Beart R, Norton L. Multiple organ failure. Surgery Gynecology & Obstetrics 1977; 144: 323\u20136.","journal-title":"Surgery Gynecology & Obstetrics"},{"key":"BF03028318_CR4","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/BF03012222","volume":"45","author":"I Mayers","year":"1998","unstructured":"Mayers I, Johnson D. The nonspecific inflammatory response to injury. Can J Anaesth 1998; 45: 871\u20139.","journal-title":"Can J Anaesth"},{"key":"BF03028318_CR5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","volume":"20","author":"Members of the American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference Committee","year":"1992","unstructured":"Members of the American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Consensus Conference: definitions of sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864\u201374.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00003246-200002000-00042","volume":"28","author":"EDE Papathanassoglou","year":"2000","unstructured":"Papathanassoglou EDE, Moynihan JA, Ackerman MH. Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in the critically ill patients? A review and theoretical framework. Crit Care Med 2000; 28: 537\u201349.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0749-0704(05)70114-7","volume":"16","author":"J-L Vincent","year":"2000","unstructured":"Vincent J-L, Fereira F, Moreno R Scoring systems for assessing organ dysfunction and survival. Crit Care Clin 2000; 16: 353\u201366.","journal-title":"Crit Care Clin"},{"key":"BF03028318_CR8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1378\/chest.104.1.230","volume":"104","author":"PC Hebert","year":"1993","unstructured":"Hebert PC, Drummond AJ, Singer J, Bernard GR, Russell JA A simple multiple system organ failure scoring system predicts mortality of patients who have sepsis syndrome. Chest 1993; 104: 230\u20135.","journal-title":"Chest"},{"key":"BF03028318_CR9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"J-L Vincent","year":"1996","unstructured":"Vincent J-L, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22: 707\u201310.","journal-title":"Intensive Care Med"},{"key":"BF03028318_CR10","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1097\/00003246-199510000-00007","volume":"23","author":"JC Marshall","year":"1995","unstructured":"Marshall JC, Cook DJ Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995; 23: 1638\u201352.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR11","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jama.1996.03540100046027","volume":"276","author":"JR Gall Le","year":"1996","unstructured":"Le Gall JR, Klar J, Lemeshow S, et al. The logistic organ dysfunction system. A new way to assess organ dysfunction in the intensive care unit. JAMA 1996; 276: 802\u201310.","journal-title":"JAMA"},{"key":"BF03028318_CR12","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1378\/chest.115.6.1490","volume":"115","author":"MH Kollef","year":"1999","unstructured":"Kollef MH. Improving outcomes in the ICU setting: are we effectively using all of the information that is potentially available to us? Chest 1999; 115: 1490\u20132.","journal-title":"Chest"},{"key":"BF03028318_CR13","first-page":"21","volume":"114","author":"DD Tran","year":"1993","unstructured":"Tran DD, Cuesta MA, van Leeuwen PA, Nauta JJ Wesdorp RI. Risk factors for multiple organ system failure and death in critically injured patients. Surgery 1993; 114: 21\u201330.","journal-title":"Surgery"},{"key":"BF03028318_CR14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00003246-199005000-00002","volume":"18","author":"DD Tran","year":"1990","unstructured":"Tran DD, Groeneveld J, van der Meulen J, Nauta JJ, Strack van Schijndel RJ, Thijs LG. Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Crit Care Med 1990; 18: 474\u20139.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0749-0704(05)70113-5","volume":"16","author":"RA Balk","year":"2000","unstructured":"Balk RA Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock. Crit Care Clin 2000; 16: 337\u201352.","journal-title":"Crit Care Clin"},{"key":"BF03028318_CR16","first-page":"276","volume":"23","author":"SL Barriere","year":"1995","unstructured":"Barriere SL, Lowry SF. An overview of mortality risk prediction in sepsis. Crit Care Med 1995; 23: 276\u2013393.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR17","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/00003246-199904000-00005","volume":"27","author":"JC Marshall","year":"1999","unstructured":"Marshall JC. Charting the course of critical illness: prognostication and outcome description in the intensive care unit. Crit Care Med 1999; 27: 676\u20138.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF03012937","volume":"46","author":"CJ Wright","year":"1999","unstructured":"Wright CJ. Withdrawal of treatment in the intensive care unit (Editorial). Can J Anesth 1999; 46: 405\u20138.","journal-title":"Can J Anesth"},{"key":"BF03028318_CR19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/archsurg.1980.01380020006003","volume":"115","author":"DE Fry","year":"1980","unstructured":"Fry DE, Pearlstein L, Fulton RL, Polk HC Jr. Multiple system organ failure. The role of uncontrolled infection. Arch Surg 1980; 115: 136\u201340.","journal-title":"Arch Surg"},{"key":"BF03028318_CR20","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1136\/bmj.318.7198.1606","volume":"318","author":"TW Evans","year":"1999","unstructured":"Evans TW, Smithies M. ABC of organ dysfunction: organ dysfunction. Br Med J 1999; 318: 1606\u20139.","journal-title":"Br Med J"},{"key":"BF03028318_CR21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1258\/0007142991902213","volume":"55","author":"BJ Rowlands","year":"1999","unstructured":"Rowlands BJ, Soong CV, Gardiner KR. The gastrointestinal tract as a barrier in sepsis. Br Med Bull 1999; 55: 196\u2013211.","journal-title":"Br Med Bull"},{"key":"BF03028318_CR22","first-page":"611","volume":"4","author":"DE Taylor","year":"1998","unstructured":"Taylor DE. Revving the motor of multiple organ dysfunction syndrome. Gut dysfunction in ARDS and multiorgan failure. Respir Care Clin N Am 1998; 4: 611\u201331.","journal-title":"Respir Care Clin N Am"},{"key":"BF03028318_CR23","first-page":"239","volume":"216","author":"S Bahrami","year":"1996","unstructured":"Bahrami S, Redl H, Yao YM, Schlag G. Involvement of bacteria\/endotoxin translocation in the development of multiple organ failure. Curr Top Microbiol Immunol 1996; 216: 239\u201358.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BF03028318_CR24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0140-6736(92)90002-K","volume":"339","author":"G Gutierrez","year":"1992","unstructured":"Gutierrez G, Palizas F, Doglio P, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992; 339: 195\u20139.","journal-title":"Lancet"},{"key":"BF03028318_CR25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0749-0704(05)70263-3","volume":"12","author":"SD Brown","year":"1996","unstructured":"Brown SD, Gutierrez G Does gastric tonometry work? Yes. Crit Care Clin 1996; 12: 569\u201385.","journal-title":"Crit Care Clin"},{"key":"BF03028318_CR26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0749-0704(05)70264-5","volume":"12","author":"E Benjamin","year":"1996","unstructured":"Benjamin E, Oropello JM. Does gastric tonometry work? No. Crit Care Clin 1996; 12: 587\u2013601.","journal-title":"Crit Care Clin"},{"key":"BF03028318_CR27","doi-asserted-by":"crossref","unstructured":"Liberati A, D\u2019Arnim R, Pifferi S, et al. Antibiotics for preventing respiratory tract infections in adults receiving intensive care. Cochrane Database of Systematic Reviews. 2000: volume 3.","DOI":"10.1002\/14651858.CD000022"},{"key":"BF03028318_CR28","first-page":"810","volume":"134","author":"WC Shoemaker","year":"1972","unstructured":"Shoemaker WC. Cardiorespiratory patterns of surviving and nonsurviving postoperative surgical patients. Surgery Gynecology & Obstetrics 1972; 134: 810\u20134.","journal-title":"Surgery Gynecology & Obstetrics"},{"key":"BF03028318_CR29","first-page":"145","volume":"1","author":"WC Shoemaker","year":"1993","unstructured":"Shoemaker WC, Appel PL, Kram HB, Bishop M, Abraham E. Hemodynamic and oxygen transport monitoring to titrate therapy in septic shock. New Horizons 1993; 1: 145\u201359.","journal-title":"New Horizons"},{"key":"BF03028318_CR30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1258\/0007142991902330","volume":"55","author":"O Boyd","year":"1999","unstructured":"Boyd O, Hayes M. The oxygen trail: the goal. Br Med Bull 1999; 55: 125\u201339.","journal-title":"Br Med Bull"},{"key":"BF03028318_CR31","first-page":"233","volume":"5","author":"GM Matuschak","year":"1997","unstructured":"Matuschak GM. Supranormal oxygen delivery in critical illness. New Horizons 1997; 5: 233\u20138.","journal-title":"New Horizons"},{"key":"BF03028318_CR32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1164\/ajrccm.150.2.8049809","volume":"150","author":"PT Phang","year":"1994","unstructured":"Phang PT, Cunningham KF, Ronco JJ, Wiggs BR, Russel JA. Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in ARDS. Am J Respir Crit Care Med 1994; 150: 318\u201323.","journal-title":"Am J Respir Crit Care Med"},{"key":"BF03028318_CR33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1258\/0007142991902295","volume":"55","author":"JM Gutteridge","year":"1999","unstructured":"Gutteridge JM, Mitchell J. Redox imbalance in the critically ill. Br Med Bull 1999; 55: 49\u201375.","journal-title":"Br Med Bull"},{"key":"BF03028318_CR34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1748-1716.1992.tb09359.x","volume":"145","author":"S Moncada","year":"1992","unstructured":"Moncada S. The 1991 Ulf von Euler Lecture. The Larginine: nitric oxide pathway. Acta Physiol Scand 1992; 145: 201\u201327.","journal-title":"Acta Physiol Scand"},{"key":"BF03028318_CR35","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1073\/pnas.87.24.10043","volume":"87","author":"MW Radomski","year":"1990","unstructured":"Radomski MW, Palmer RM, Moncada S. Glucocorticoids inhibit the expression of an inducible, but not constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 1990; 87: 10043\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF03028318_CR36","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1073\/pnas.91.14.6702","volume":"91","author":"MA Moro","year":"1994","unstructured":"Moro MA, Darley-Usmar VM, Goodwin DA, et al. Paradoxical fate and biological action of peroxynitrite on human platelets. Proc Natl Acad Sci USA 1994; 91: 6702\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF03028318_CR37","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/bjs.1800820705","volume":"82","author":"AA Vlessis","year":"1995","unstructured":"Vlessis AA, Goldman RK, Trunkey DD. New concepts in the pathophysiology of oxygen metabolism during sepsis Br J Surg 1995; 82: 870\u20136.","journal-title":"Br J Surg"},{"key":"BF03028318_CR38","doi-asserted-by":"crossref","first-page":"680","DOI":"10.7326\/0003-4819-125-8-199610150-00009","volume":"125","author":"RC Bone","year":"1996","unstructured":"Bone RC. Immunoligic dissonance: a continuing evolution our understanding of the Systemic Inflammatory Response Syndrome (SIRS) and the Multiple Organ Dysfunction Syndrome (MODS). Ann Intern Med 1996; 125: 680\u20137.","journal-title":"Ann Intern Med"},{"key":"BF03028318_CR39","doi-asserted-by":"crossref","first-page":"622","DOI":"10.7326\/0003-4819-133-8-200010170-00015","volume":"133","author":"DP Kotier","year":"2000","unstructured":"Kotier DP. Cachexia. Ann Intern Med 2000; 133: 622\u201334.","journal-title":"Ann Intern Med"},{"key":"BF03028318_CR40","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1152\/jappl.1990.69.1.214","volume":"69","author":"J Markos","year":"1990","unstructured":"Markos J Hooper RO, Kavanagh-Gray D, Wiggs BR, Hogg JC. Effect of raised alveolar pressure on leukocyte retention in the lung. J Appl Physiol 1990; 69: 214\u201321.","journal-title":"J Appl Physiol"},{"key":"BF03028318_CR41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1258\/0007142991902277","volume":"55","author":"G Bellingan","year":"1999","unstructured":"Bellingan G. Inflammatory cell activation in sepsis. Br Med Bull 1999; 55: 12\u201329.","journal-title":"Br Med Bull"},{"key":"BF03028318_CR42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00003246-199601000-00026","volume":"24","author":"RC Bone","year":"1996","unstructured":"Bone RC. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do not know about cytokine regulation. Crit Care Med 1996; 24: 163\u201372.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR43","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1164\/ajrccm\/139.4.1017","volume":"139","author":"LA Mizer","year":"1989","unstructured":"Mizer LA, Weisbrode SE, Dorinsky PM. Neutrophils accumulation and structural changes in nonpulmonary organs after acute lung injury induced by phorbol myrisate acetate. Am Rev Respir Dis 1989; 139: 1017\u201326.","journal-title":"Am Rev Respir Dis"},{"key":"BF03028318_CR44","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1182\/blood.V87.12.5051.bloodjournal87125051","volume":"87","author":"K Johnson","year":"1996","unstructured":"Johnson K, Aarden L, Choi Y, De Groot E, Creasey A The pro inflammatory cytokine response to coagulation and endotoxin in whole blood. Blood 1996; 87: 5051\u201360.","journal-title":"Blood"},{"key":"BF03028318_CR45","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1378\/chest.96.4.885","volume":"96","author":"PM Dorinsky","year":"1989","unstructured":"Dorinsky PM, Gadek JE. Mechanisms of multiple nonpulmonary organ failure in ARDS. Chest 1989; 96: 885\u201392.","journal-title":"Chest"},{"key":"BF03028318_CR46","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1378\/chest.103.2.565","volume":"103","author":"MR Pinsky","year":"1993","unstructured":"Pinsky MR, Vincent JL, Deviere J, Alegre M, Kahn RJ, Dupont E. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 1993; 103: 565\u201375.","journal-title":"Chest"},{"key":"BF03028318_CR47","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/jama.1995.03530040066043","volume":"274","author":"TM Perl","year":"1995","unstructured":"Perl TM, Dvorak L, Hwang T, Wenzel RP. Long-term survival and function after suspected gram-negative sepsis. JAMA 1995; 274: 338\u201345.","journal-title":"JAMA"},{"key":"BF03028318_CR48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0022-4804(92)90025-U","volume":"53","author":"I Engelberts","year":"1992","unstructured":"Engelberts I, Samyo SK, Leeuwenberg JF, van der Linen CJ, Buurman WA. A role for ELAM-1 in the pathogenesis of MOF during septic shock. J Surg Res 1992; 53: 136\u201344.","journal-title":"J Surg Res"},{"key":"BF03028318_CR49","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1055\/s-0037-1614339","volume":"82","author":"SE Humphries","year":"1999","unstructured":"Humphries SE, Luong LA, Montgomery HE, Day LN, Mohamed-Ali V, Yudkin JS. Gene-environment interaction in the determination of levels of plasma fibrinogen. Thromb Haemost 1999; 82: 818\u201325.","journal-title":"Thromb Haemost"},{"key":"BF03028318_CR50","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00003246-199603000-00004","volume":"24","author":"F Stuber","year":"1996","unstructured":"Stuber F, Peterson M, Bokelman F, Schade U. A genomic polymorphism within tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis. Crit Care Med 1996; 24: 381\u20134.","journal-title":"Crit Care Med"},{"key":"BF03028318_CR51","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s001340050400","volume":"23","author":"M Liu","year":"1997","unstructured":"Liu M, Slutsky AS. Anti-inflammatory therapies: application of molecular biology techniques in intensive care medicine. Intensive Care Med 1997; 23: 718\u201331.","journal-title":"Intensive Care Med"},{"key":"BF03028318_CR52","doi-asserted-by":"crossref","first-page":"771","DOI":"10.7326\/0003-4819-120-9-199405010-00009","volume":"120","author":"C Natanson","year":"1994","unstructured":"Natanson C, Hoffman WD, Suffredini AF, Eichacker PQ, Danner RL. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann Intern Med 1994; 120: 771\u201383.","journal-title":"Ann Intern Med"},{"key":"BF03028318_CR53","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1378\/chest.92.6.1032","volume":"92","author":"RC Bone","year":"1987","unstructured":"Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA. Early methylprednisolone treatment for septic syndrome and the adult respiratory distress syndrome. Chest 1987; 92: 1032\u20136.","journal-title":"Chest"},{"key":"BF03028318_CR54","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1056\/NEJM199703273361303","volume":"336","author":"GR Bernard","year":"1997","unstructured":"Bernard GR, Wheeler AP, Russell JA, et al. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 1997; 336: 912\u20138.","journal-title":"N Engl J Med"},{"key":"BF03028318_CR55","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1056\/NEJM199606273342603","volume":"334","author":"CJ Fisher","year":"1996","unstructured":"Fisher CJ Jr, Agosti JM, Opal SM, et al. Treatment of septic shock with tumor necrosis factor receptor: fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996; 334: 1697\u2013702.","journal-title":"N Engl J Med"},{"key":"BF03028318_CR56","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/emj.13.3.154","volume":"13","author":"BA Foex","year":"1996","unstructured":"Foex BA, Shelly MP. The cytokine response to critical illness. J Accid Emerg Med 1996; 13: 154\u201362.","journal-title":"J Accid Emerg Med"},{"key":"BF03028318_CR57","unstructured":"Alejandria MM, Lansang MA Mantaring JBV. Intravenous immunoglobulin for treating sepsis and septic shock. Cochrane Database of Systematic Reviews. 2000: volume 3."},{"key":"BF03028318_CR58","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1378\/chest.117.3.841","volume":"117","author":"T Stefanec","year":"2000","unstructured":"Stefanec T. Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease? Chest 2000; 117: 841\u201354.","journal-title":"Chest"},{"key":"BF03028318_CR59","first-page":"151","volume":"4","author":"K Waxman","year":"1996","unstructured":"Waxman K. What mediates tissue injury after shock? New Horizons 1996; 4: 151\u20132.","journal-title":"New Horizons"}],"container-title":["Canadian Journal of Anesthesia\/Journal canadien d'anesth\u00e9sie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03028318.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03028318\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03028318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T22:01:07Z","timestamp":1589752867000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03028318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["BF03028318"],"URL":"https:\/\/doi.org\/10.1007\/bf03028318","relation":{},"ISSN":["0832-610X","1496-8975"],"issn-type":[{"value":"0832-610X","type":"print"},{"value":"1496-8975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}