{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:23:14Z","timestamp":1785709394757,"version":"3.56.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[1994,1]]},"DOI":"10.1007\/bf03035706","type":"journal-article","created":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T12:26:00Z","timestamp":1239107160000},"page":"15-23","source":"Crossref","is-referenced-by-count":25,"title":["Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors"],"prefix":"10.1007","volume":"68","author":[{"given":"Lynn M.","family":"Fowler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Lock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF03035706_CR1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/10408448809037470","volume":"18","author":"MW Anders","year":"1988","unstructured":"Anders MW, Lash LH, Dekant W, Elfarra AA, Dohn DR (1988) Biosynthesis and biotransformation of glutathioneS-conjugates to toxic metabolites. CRC Crit Rev Toxicol 18: 311\u2013341","journal-title":"CRC Crit Rev Toxicol"},{"key":"BF03035706_CR2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0009-2797(79)90129-7","volume":"27","author":"IC Calder","year":"1979","unstructured":"Calder IC, Yong AC, Woods RA, Crowe CA, Ham KN, Tange JD (1979) The nephrotoxicity of 4-aminophenol. II. The effect of metabolic inhibitors and inducers, Chem Biol Interact 27: 245\u2013254","journal-title":"Chem Biol Interact"},{"key":"BF03035706_CR3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0009-2797(79)90128-5","volume":"27","author":"CA Crowe","year":"1979","unstructured":"Crowe CA, Yong AC, Calder IC, Ham KN, Tange JD (1979) The nephrotoxicity of 4-aminophenol. I. The effect on microsomal cytochromes, glutathione and covalent binding in kidney and liver. Chem Biol Interact 27: 235\u2013243","journal-title":"Chem Biol Interact"},{"key":"BF03035706_CR4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1159\/000458694","volume":"24","author":"NP Curthoys","year":"1979","unstructured":"Curthoys NP, Hughey RP (1979) Characterization and physiological function of rat renal \u03b3-glutamyl transpeptidase. Enzyme 24: 383\u2013403","journal-title":"Enzyme"},{"key":"BF03035706_CR5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0041-008X(88)80006-1","volume":"95","author":"ME Davis","year":"1988","unstructured":"Davis ME (1988) Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats. Toxicol Appl Pharmacol 95: 44\u201352","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR6","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/ki.1983.221","volume":"24","author":"JM Davis","year":"1983","unstructured":"Davis JM, Emslie KR, Sweet RS, Walker LL, Naughton RJ, Skinner SL, Tange JD (1983) Early functional and morphological changes in renal tubular necrosis due to 4-aminophenol. Kidney Int 24: 740\u2013747","journal-title":"Kidney Int"},{"key":"BF03035706_CR7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/03602538908994144","volume":"20","author":"W Dekant","year":"1989","unstructured":"Dekant W, Vamvakas S, Anders MW (1989) Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate \u00df-lyase. Drug Metab Rev 20: 43\u201383","journal-title":"Drug Metab Rev"},{"key":"BF03035706_CR8","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0026-895X(25)14616-6","volume":"21","author":"MW Duffel","year":"1982","unstructured":"Duffel MW, Jakoby WB (1982). CysteineS-conjugate.N-Acetyltransferase from rat kidney microsomes. Mol Pharmacol 21: 444\u2013448","journal-title":"Mol Pharmacol"},{"key":"BF03035706_CR9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/00498259009046851","volume":"20","author":"KG Eckert","year":"1990","unstructured":"Eckert KG, Eyer P, Sonnenbichler J, Zetl I (1990) Activation and detoxification of aminophenols. II. Synthesis and structural elucidation of various thiol addition products of 1,4-benzoquinoneimine andN-acetyl-1,4-benzoquinoneimine. Xenobiotica 20: 333\u2013350","journal-title":"Xenobiotica"},{"key":"BF03035706_CR10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-2952(86)90527-7","volume":"35","author":"AA Elfarra","year":"1986","unstructured":"Elfarra AA, Jacobson I, Anders MW (1986) Mechanism ofS-1,2-dichlorovinyl) glutathione-induced nephrotoxicity. Biochem Pharmacol 35: 283\u2013288","journal-title":"Biochem Pharmacol"},{"key":"BF03035706_CR11","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3109\/00498259109039518","volume":"21","author":"R Eyanagi","year":"1991","unstructured":"Eyanagi R, Hisarari Y, Shigematsu H (1991) Studies of paracetamol\/phenacetin toxicity: isolation and characterization ofp-aminophenol-glutathione conjugate. Xenobiotica 21: 793\u2013803","journal-title":"Xenobiotica"},{"key":"BF03035706_CR12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/096032719101000615","volume":"10","author":"LM Fowler","year":"1991","unstructured":"Fowler LM, Moore RB, Foster JR, Lock EA (1991) Nephrotoxicity of 4-aminophenol glutathione conjugate. Hum Exp Toxicol 10: 451\u2013459","journal-title":"Hum Exp Toxicol"},{"key":"BF03035706_CR13","unstructured":"Fowler LM (1992) Studies on the mechanisms of nephrotoxicity of 4-aminophenol. PhD thesis, Council for National Academic Awards"},{"key":"BF03035706_CR14","doi-asserted-by":"crossref","unstructured":"Fowler LM, Foster JR, Lock EA (1993) The effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat. Arch Toxicol (in press)","DOI":"10.1007\/BF01974068"},{"key":"BF03035706_CR15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00316430","volume":"63","author":"KPR Gartland","year":"1989","unstructured":"Gartland KPR, Bonner FW, Timbrell JA, Nicholson JK (1989) Biochemical characterisation of 4-aminophenol-induced nephrotoxic lesions in the F344 rat. Arch Toxicol 63: 97\u2013106","journal-title":"Arch Toxicol"},{"key":"BF03035706_CR16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF01973371","volume":"64","author":"KPR Gartland","year":"1990","unstructured":"Gartland KPR, Eason CT, Bonner FW, Nicholson JK (1990) Effects of biliary cannulation and butathione sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat. Arch Toxicol 64: 14\u201325","journal-title":"Arch Toxicol"},{"key":"BF03035706_CR17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/bmj.1.5637.162","volume":"1","author":"CR Green","year":"1969","unstructured":"Green CR, Ham KN, Tange JD (1969) Kidney lesions induced in rats by 4-aminophenol. BMJ 1: 162\u2013164","journal-title":"BMJ"},{"key":"BF03035706_CR18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1432-1033.1976.tb10588.x","volume":"66","author":"D Job","year":"1976","unstructured":"Job D, Dunford HB (1976) Substituent effect on the oxidation of phenols and aromatic amines by horseradish peroxidase compound I. Eur J Biochem 66: 607\u2013614","journal-title":"Eur J Biochem"},{"key":"BF03035706_CR19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0026-895X(25)14283-1","volume":"23","author":"PD Josephy","year":"1982","unstructured":"Josephy PD, Eling TE, Mason RP (1982) Oxidation of 4-aminophenol catalysed by horseradish peroxidase and prostaglandin synthase. Mol Pharmacol 23: 461\u2013466","journal-title":"Mol Pharmacol"},{"key":"BF03035706_CR20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF00353854","volume":"34","author":"M Kiese","year":"1975","unstructured":"Kiese M, Szincz L, Tinel N, Weger N (1975) Ferrihaemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethyl-aminophenol. Arch Toxicol 34: 337\u2013340","journal-title":"Arch Toxicol"},{"key":"BF03035706_CR21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0041-008X(92)90372-Y","volume":"115","author":"C Klos","year":"1992","unstructured":"Klos C, Koob M, Kramer C, Dekant W (1992)p-Aminophenol-nephrotoxicity. Biosynthesis of toxic glutathione conjugates. Toxicol Appl Pharmacol 115: 98\u2013106","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10408448809040816","volume":"19","author":"EA Lock","year":"1988","unstructured":"Lock EA (1988) Studies on the mechanism of nephrotoxicity and nephrocarcinogenicity of halogenated alkenes. CRC Crit Rev Toxicol 19: 23\u201342","journal-title":"CRC Crit Rev Toxicol"},{"key":"BF03035706_CR23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/096032719301200507","volume":"12","author":"EA Lock","year":"1993","unstructured":"Lock EA, Cross T, Schnellmann R (1993) Studies on the mechanism of 4-aminophenol-induced toxicity to renal proximal tubules. Hum Exp Toxicol 12: 383\u2013388","journal-title":"Hum Exp Toxicol"},{"key":"BF03035706_CR24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0041-008X(85)90117-6","volume":"81","author":"EA Lock","year":"1985","unstructured":"Lock EA, Ishmael J (1985) Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates. Toxicol Appl Pharmacol 81: 32\u201342","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randell RJ (1951) Protein measurements with the folin-phenol reagent. J Biol Chem 193: 265\u2013275","journal-title":"J Biol Chem"},{"key":"BF03035706_CR26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0076-6879(81)77032-0","volume":"77","author":"A Meister","year":"1981","unstructured":"Meister A, Tate SS, Griffith OW (1981) \u03b3-Glutamyltranspeptidase. Methods Enzymol 77: 237\u2013242","journal-title":"Methods Enzymol"},{"key":"BF03035706_CR27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0041-008X(91)90288-P","volume":"110","author":"JJWM Mertens","year":"1991","unstructured":"Mertens JJWM, Temmink HHM, Bladeren PJ, Jones TW, Lo HH, Lau SS, Monks TJ (1991) Inhibition of \u03b3-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones. Toxicol Appl Pharmacol 110: 45\u201360","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0041-008X(90)90328-R","volume":"103","author":"TJ Monks","year":"1990","unstructured":"Monks TJ, Lau SS (1990) Glutathione \u03b3-glutamyl transpeptidase, and the mercapturic acid pathway as modulators of 2-bromohy-droquinone oxidation. Toxicol Appl Pharmacol 103: 557\u2013563","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR29","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0090-9556(25)08249-2","volume":"13","author":"TJ Monks","year":"1995","unstructured":"Monks TJ, Lau SS, Highet RJ, Gillette JR (1995) Glutathione conjugates of 2-bromohydroquinone are nephrotoxic. Drug Metab Dispos 13: 553\u2013559","journal-title":"Drug Metab Dispos"},{"key":"BF03035706_CR30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0026-895X(25)09782-2","volume":"34","author":"TJ Monks","year":"1988","unstructured":"Monks TJ, Highet RJ, Lau SS (1988a) 2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity. Physiological biochemical and electrochemical determinants. Mol Pharmacol 34: 492\u2013500","journal-title":"Mol Pharmacol"},{"key":"BF03035706_CR31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0026-895X(25)08645-6","volume":"34","author":"TJ Monks","year":"1988","unstructured":"Monks TJ, Highet RJ, Chu PS, Lau SS (1988b). Synthesis and nephrotoxicity of 6-bromo-2,5-dihydroxy-thiophenol. Mol Pharmacol 34: 15\u201322","journal-title":"Mol Pharmacol"},{"key":"BF03035706_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0041-008X(90)90100-9","volume":"106","author":"TJ Monks","year":"1990","unstructured":"Monks TJ, Anders MW, Dekant W, Stevens JL, Lau SS, Van Bladeren PJ (1990) Contemporary issues in toxicology. Glutathione conjugate mediated toxicities. Toxicol Appl Pharmacol 106: 1\u201319","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0041-008X(91)90031-9","volume":"111","author":"TJ Monks","year":"1991","unstructured":"Monks TJ, Jones TW, Hill BA, Lau SS (1991) Nephrotoxicity of 2-bromo-(cysteinyl) hydroquinone and 2-brom-(N-acetyl-L-cysteinyl) hydroquinone thioethers. Toxicol Appl Pharmacol 111: 279\u2013298","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0041-008X(84)90061-9","volume":"73","author":"JA Nash","year":"1984","unstructured":"Nash JA, King LJ, Lock EA, Green T (1984) The metabolism and disposition of hexachloro-1,3-butadience in the rat and its relevance to nephrotoxicity. Toxicol Appl Pharmacol 73: 124\u2013137","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0041-008X(83)90312-5","volume":"69","author":"JF Newton","year":"1983","unstructured":"Newton JF, Yoshimoto M, Bernstein J, Rush GF, Hook JB (1983) Acetaminophen nephrotoxicity in the rat. II. Strain differences in nephrotoxicity and metabolism of 4-aminophenol, a metabolite of acetaminophen. Toxicol Appl Pharmacol 69: 308\u2013318","journal-title":"Toxicol Appl Pharmacol"},{"key":"BF03035706_CR36","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/clinchem\/19.11.1265","volume":"19","author":"MA Pesce","year":"1973","unstructured":"Pesce MA, Strande CS (1973) A new micromethod for determination of protein in cerebrospinal fluid and urine. Clin Chem 19: 1265\u20131267","journal-title":"Clin Chem"},{"key":"BF03035706_CR37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0022-3565(25)22973-1","volume":"256","author":"FAM Redegeld","year":"1991","unstructured":"Redegeld FAM, Hofman GA, Van de Loo PGF, Koster AS, Noordhoek J (1991) Nephrotoxicity of the glutathione conjugate menadione (2-methyl-1,4-napthoquinone) in the isolated perfused rat kidney. Role of metabolism by \u03b3-glutamyltranspeptidase and probenecid-sensitive transport. J Pharmacol Exp Ther 256: 665\u2013669","journal-title":"J Pharmacol Exp Ther"},{"key":"BF03035706_CR38","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0026-895X(25)14351-4","volume":"23","author":"JL Stevens","year":"1983","unstructured":"Stevens JL, Jakoby WB (1983) Cysteine conjugate \u00df-lyase. Mol Pharmacol 23: 761\u2013765","journal-title":"Mol Pharmacol"},{"key":"BF03035706_CR39","doi-asserted-by":"crossref","first-page":"15.529","DOI":"10.1016\/S0021-9258(18)66746-8","volume":"261","author":"JL Stevens","year":"1986","unstructured":"Stevens JL, Robbins JD, Byrd RA (1986) A purified cysteine conjugate \u03b2-lyase from rat kidney cortex cytosol: requirement of an \u03b1-keto acid or an amino acid oxidase and identity with soluble glutamine transaminase K. J Biol Chem 261: 15.529\u201315.537","journal-title":"J Biol Chem"},{"key":"BF03035706_CR40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/clinchem\/15.2.124","volume":"15","author":"G Szasz","year":"1969","unstructured":"Szasz G (1969) A kinetic photometric method for serum \u03b2-glutamyl-transpeptidase. Clin Chem 15: 124\u2013136","journal-title":"Clin Chem"},{"key":"BF03035706_CR41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/B978-0-12-380002-2.50011-7","volume-title":"Enzymatic basis of detoxication","author":"SS Tate","year":"1980","unstructured":"Tate SS (1980) Enzymes of mercapturic acid formation. In: Jakoby WB (ed) Enzymatic basis of detoxication, Vol. 2. Academic Press, New York, pp 95\u2013120"},{"key":"BF03035706_CR42","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0076-6879(85)13053-3","volume":"113","author":"SS Tate","year":"1985","unstructured":"Tate SS, Meister A (1985) \u03b3-Glutamyltranspeptidase from kidney. Methods Enzymol 113: 400\u2013419","journal-title":"Methods Enzymol"},{"key":"BF03035706_CR43","first-page":"295","volume":"9","author":"PJ Bladeren Van","year":"1988","unstructured":"Van Bladeren PJ (1988) Formation of toxic metabolites from drugs and other xenobiotics by glutathione conjugation. TIPS 9: 295\u2013298","journal-title":"TIPS"},{"key":"BF03035706_CR44","first-page":"743","volume-title":"Phar The macological basis of therapeutics","author":"IM Weiner","year":"1990","unstructured":"Weiner IM (1990) Inhibitors of tubular transport of organic compounds. In: Gilman AG, Rall TW, Nies AS, Taylor P, eds, Phar The macological basis of therapeutics, 8th edn. Pergamon, New York, pp 743\u2013748","edition":"8th edn"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03035706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03035706\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03035706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T21:53:34Z","timestamp":1739051614000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03035706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["BF03035706"],"URL":"https:\/\/doi.org\/10.1007\/bf03035706","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}