{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:40:12Z","timestamp":1756384812963},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1007\/bf03161210","type":"journal-article","created":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T08:19:56Z","timestamp":1251447596000},"page":"258-260","source":"Crossref","is-referenced-by-count":9,"title":["Lamotrigine-associated reversible severe hepatitis: A case report"],"prefix":"10.1007","volume":"4","author":[{"given":"Adeline Ngo","family":"Su-Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winnie W.","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent R.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"6","key":"BF03161210_CR1","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1172\/JCI113798","volume":"82","author":"NH Shear","year":"1988","unstructured":"Shear NH, Spielberg SP. Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.J Clin Invest 1988; 82(6): 1826\u20131832.","journal-title":"J Clin Invest"},{"issue":"3","key":"BF03161210_CR2","first-page":"357","volume":"137","author":"JR Sullivan","year":"2001","unstructured":"Sullivan JR, Shear NH. The drug hypersensitivity syndrome: what is the pathogenesis?Arch Dermatol 2001; 137(3): 357\u2013364.","journal-title":"Arch Dermatol"},{"issue":"10","key":"BF03161210_CR3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1528-1167.2005.00269.x","volume":"46","author":"O Mecarelli","year":"2005","unstructured":"Mecarelli O, Pulitano P, Mingoia M, Ferretti G, Rossi M, Berloco PB, et al. Acute hepatitis associated with lamotrigine and managed with the molecular adsorbents recirculating system (Mars).Epilepsia 2005; 46(10): 1687\u20131689.","journal-title":"Epilepsia"},{"issue":"9","key":"BF03161210_CR4","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1023\/A:1019627618972","volume":"47","author":"K Overstreet","year":"2002","unstructured":"Overstreet K, Costanza C, Behling C, Hassanin T, Masliah E. Fatal progressive hepatic necrosis associated with lamotrigine treatment: a case report and literature review.Dig Dis Sci 2002; 47(9): 1921\u20131925.","journal-title":"Dig Dis Sci"},{"issue":"1","key":"BF03161210_CR5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0887-8994(99)00106-X","volume":"22","author":"M Fayad","year":"2000","unstructured":"Fayad M, Choueiri R, Mikati M. Potential hepatotoxicity of lamotrigine.Pediatr Neurol 2000; 22(1): 49\u201352.","journal-title":"Pediatr Neurol"},{"issue":"3","key":"BF03161210_CR6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0887-8994(97)00196-3","volume":"18","author":"R Arnon","year":"1998","unstructured":"Arnon R, DeVivo D, Defelice AR, Kazlow PG. Acute hepatic failure in a child treated with lamotrigine.Pediatr Neurol 1998; 18(3): 251\u2013252.","journal-title":"Pediatr Neurol"},{"issue":"7000","key":"BF03161210_CR7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/bmj.311.7000.292b","volume":"29","author":"AJ Makin","year":"1995","unstructured":"Makin AJ, Fitt S, Williams R, Duncan JS. Fulminant hepatic failure induced by lamotrigine.BMJ 1995 29;311(7000): 292.","journal-title":"BMJ"},{"issue":"8920","key":"BF03161210_CR8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0140-6736(94)91818-X","volume":"13","author":"JE Schaub","year":"1994","unstructured":"Schaub JE, Williamson PJ, Barnes EW, Trewby PN. Multisystem adverse reaction to lamotrigine.Lancet 1994; 13;344(8920): 481.","journal-title":"Lancet"},{"key":"BF03161210_CR9","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/0140-6736(92)91207-O","volume":"339","author":"MJ Brodie","year":"1992","unstructured":"Brodie MJ. Lamotrigine.Lancet 1992; 339: 1397\u20131400.","journal-title":"Lancet"},{"key":"BF03161210_CR10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4088\/JCP.v60n0203","volume":"60","author":"JR Calabrese","year":"1999","unstructured":"Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression Lamictal 602 Study Group.J Clin Psychiatry 1999; 60: 79\u201388.","journal-title":"J Clin Psychiatry"},{"key":"BF03161210_CR11","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4088\/JCP.v64n0906","volume":"64","author":"JR Calabrese","year":"2003","unstructured":"Calabrese JR, Bowden CL, Sachs G, Yatham LN, Behnke K, Mehtonen OP. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder.J Clin Psychiatry 2003; 64: 1013\u20131024.","journal-title":"J Clin Psychiatry"},{"issue":"11","key":"BF03161210_CR12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4088\/JCP.v63n1110","volume":"63","author":"JR Calabrese","year":"2002","unstructured":"Calabrese JR, Sullivan JR, Bowden CL, Suppes T, Goldberg JF, Sachs GS, et al. Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management.J Clin Psychiatry 2002; 63(11): 101\u2013129.","journal-title":"J Clin Psychiatry"},{"issue":"7","key":"BF03161210_CR13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1999.tb00807.x","volume":"40","author":"AH Guberman","year":"1999","unstructured":"Guberman AH, Besag FM, Brodie MJ, Dooley JM, Duchowny MS, Pellock JM, et al. Lamotrigine-associated rash: risk\/benefit considerations in adults and children.Epilepsia 1999; 40(7): 985\u2013991.","journal-title":"Epilepsia"},{"issue":"8","key":"BF03161210_CR14","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1528-1157.1999.tb00831.x","volume":"40","author":"E Faught","year":"1999","unstructured":"Faught E, Morris G, Jacobson M, French J, Harden C, Montouris G, et al. Adding lamotrigine to valproate: incidence of rash and other adverse effects: Postmarketing Antiepileptic Drug Survey (PADS) Group.Epilepsia 1999; 40(8): 1135\u20131140.","journal-title":"Epilepsia"},{"issue":"4","key":"BF03161210_CR15","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1212\/WNL.51.4.1172","volume":"51","author":"RG Schlienger","year":"1998","unstructured":"Schlienger RG, Knowles SR, Shear NH. Lamotrigine-associated anticonvulsant hypersensitivity syndrome.Neurology 1998; 51(4): 1172\u20131175.","journal-title":"Neurology"},{"key":"BF03161210_CR16","first-page":"148","volume-title":"Poisoning and Drug Overdose","author":"TE Kearney","year":"2007","unstructured":"Kearney TE: Carbamazepine and oxcarbazepine. In: Olson KR, ed. Poisoning and Drug Overdose, 5th ed. International: McGraw-Hill Lange 2007: 148\u2013150.","edition":"5th ed."},{"issue":"9","key":"BF03161210_CR17","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.arcped.2004.05.018","volume":"11","author":"E Bosdure","year":"2004","unstructured":"Bosdure E, Cano A, Roquelaure B, Reynaud R, Boyer M, Viard L, et al. Oxcarbazepine and DRESS syndrome: a paediatric cause of acute liver failure.Arch Pediatr 2004; 11(9): 1073\u20131077.","journal-title":"Arch Pediatr"},{"issue":"2","key":"BF03161210_CR18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00007691-199904000-00007","volume":"21","author":"TW May","year":"1999","unstructured":"May TW, Rambeck B, Jurgens U. Influence of oxcarbazepine and methsuximide on lamotrigine concentrations in epileptic patients with and without valproic acid comedication: results of a retrospective study.Ther Drug Monit 1999; 21(2): 175\u2013181.","journal-title":"Ther Drug Monit"},{"issue":"10","key":"BF03161210_CR19","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00228-003-0686-z","volume":"59","author":"N Guenault","year":"2003","unstructured":"Guenault N, Odou P, Robert H. Increase in dihydroxycarbamazepine serum levels in patients co-medicated with oxcarbazepine and lamotrigine.Eur J Clin Pharmacol 2003; 59(10): 781\u2013782.","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"BF03161210_CR20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1034\/j.1398-9995.2000.00467.x","volume":"55","author":"N Schaub","year":"2000","unstructured":"Schaub N, Bircher AJ. Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.Allergy 2000; 55(2): 191\u2013193.","journal-title":"Allergy"},{"issue":"4","key":"BF03161210_CR21","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.pnpbp.2005.11.033","volume":"30","author":"CC Chang","year":"2006","unstructured":"Chang CC, Shiah IS, Yeh CB, Wang TS, Chang HA. Lamotrigine-associated anticonvulsant hypersensitivity syndrome in bipolar disorder.Prog Neuropsychopharmacol Biol Psychiatry 2006; 30(4): 741\u2013744.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03161210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03161210\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03161210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T22:36:29Z","timestamp":1558478189000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03161210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["BF03161210"],"URL":"https:\/\/doi.org\/10.1007\/bf03161210","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"value":"1556-9039","type":"print"},{"value":"1937-6995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}