{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:50:22Z","timestamp":1791903022834,"version":"4.3.4"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Hematol"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1007\/bf03165102","type":"journal-article","created":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T07:15:00Z","timestamp":1254294900000},"page":"123-131","source":"Crossref","is-referenced-by-count":22,"title":["Idiopathic thrombocytopenic purpura: Pathophysiology and management"],"prefix":"10.1007","volume":"76","author":[{"given":"Yeon S.","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence L","family":"Horstman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF03165102_CR1","first-page":"1","volume":"38","author":"WJ Harrington","year":"1951","unstructured":"Harrington WJ, Minnich V, Hollingsworth JW, et al. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura.J Lab Clin Med. 1951;38:1\u201310.","journal-title":"J Lab Clin Med"},{"key":"BF03165102_CR2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-38-3-433","volume":"38","author":"WJ Harrington","year":"1953","unstructured":"Harrington WJ, Sprague CC, Minnich V, et al. Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura.Ann Int Med. 1953;38:433\u2013469.","journal-title":"Ann Int Med"},{"key":"BF03165102_CR3","first-page":"166","volume":"1","author":"WJ Harrington","year":"1956","unstructured":"Harrington WJ, Minnich V, Arimura G. The autoimmune thrombocytopenias.Progress Hematol. 1956;1:166\u2013192.","journal-title":"Progress Hematol"},{"key":"BF03165102_CR4","first-page":"374","volume":"78","author":"NR Shulman","year":"1965","unstructured":"Shulman NR, Weinrach RS, Libre EP, et al. The role of reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura.Trans Assoc Am Physicans. 1965; 78:374\u2013390.","journal-title":"Trans Assoc Am Physicans"},{"key":"BF03165102_CR5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1365-2141.1996.d01-1702.x","volume":"93","author":"S Kosugi","year":"1996","unstructured":"Kosugi S, Kurata Y, Tomiyama Y. Circulating thrombopoietin level in chronic immune thrombocytopenic purpura.Br J Haematol. 1996; 93:704\u2013706.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2141.1969.tb00379.x","volume":"16","author":"RH Aster","year":"1969","unstructured":"Aster RH, Keene WR. Sites of platelet destruction in idiopathic thrombocytopenic purpura.Br J Haematol. 1969;16:61\u201373.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1365-2141.1986.tb05552.x","volume":"63","author":"T Tsubakio","year":"1986","unstructured":"Tsubakio T, Tani P, Curd JG, et al. Complement activation in vivo by antiplatelet antibodies in chronic immune thrombocytopenic purpura.Brit J Haematol. 1986;63:293\u2013300.","journal-title":"Brit J Haematol"},{"key":"BF03165102_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00320233","volume":"58","author":"V Kiefel","year":"1989","unstructured":"Kiefel V, Salama A, Mueller-Eckhardt C. In vitro fixation of C3d and C5b-9 on platelets by human platelet reactive antibodies.Blut. 1989;58:33\u201337.","journal-title":"Blut"},{"issue":"4","key":"BF03165102_CR9","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1056\/NEJM198701223160406","volume":"316","author":"HA Lehman","year":"1987","unstructured":"Lehman HA, Lehman LO, Rustagi PK, et al. Complement mediated autoimmune thrombocytopenia.N Engl J Med. 1987; 316(4):194\u2013198.","journal-title":"N Engl J Med"},{"key":"BF03165102_CR10","first-page":"515","volume":"123","author":"LL Horstman","year":"1994","unstructured":"Horstman LL, Jy W, Schultz DR, et al. Complement mediated fragmentation and lysis of opsonized platelets: Gender differences in sensitivity.J Lab Clin Med. 1994;123:515\u2013525.","journal-title":"J Lab Clin Med"},{"key":"BF03165102_CR11","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1126\/science.1062722","volume":"293","author":"P Wentworth","year":"2001","unstructured":"Wentworth P, Jones LH, Wentworth AD, et al. Antibody catalysis of the oxidation of water.Science. 2001;293:1806\u20131811.","journal-title":"Science"},{"key":"BF03165102_CR12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0092-8674(01)00477-9","volume":"106","author":"M Nardi","year":"2001","unstructured":"Nardi M, Tomlinson S, Greco MA, et al. Complement- independent, peroxide-induced antibody lyhsis of platelets in HIV-1-related immune thrombocytopenia.Cell. 2001;106:551\u2013561.","journal-title":"Cell"},{"key":"BF03165102_CR13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.7326\/0003-4819-120-10-199405150-00005","volume":"120","author":"M Olenich","year":"1994","unstructured":"Olenich M, Schattner E. Postpartum thrombotic thrombocytopenic purpura (TTP) complicating pregnancy-associated immune thrombocytopenic purpura.Ann Int Med. 1994;120:845\u2013847.","journal-title":"Ann Int Med"},{"key":"BF03165102_CR14","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/00007611-198412000-00034","volume":"77","author":"RS Stein","year":"1984","unstructured":"Stein RS, Flexner JM. Idiopathic thrombocytopenic purpura during remission of thrombotic thrombocytopenic purpura.Southern Med J. 1984;77:1599\u20131601.","journal-title":"Southern Med J"},{"key":"BF03165102_CR15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000204876","volume":"85","author":"M Krupsky","year":"1991","unstructured":"Krupsky M, Sarel R, Hurwitz N, et al. Late appearance of thrombotic thrombocytopenic purpura after autoimmune hemolytic anemia and in the course of chronic autoimmune thrombocytopenic purpura: two case reports.Acta Haematol. 1991; 85:139\u2013142.","journal-title":"Acta Haematol"},{"key":"BF03165102_CR16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ajh.2830380414","volume":"38","author":"JP Routy","year":"1991","unstructured":"Routy JP, Beaulieu R, Monte M, et al. Immunologic thrombocytopenia followed by thrombotic thrombocytopenic purpura in two HIV1 patients.Am J Hematol. 1991;38:328\u2013328.","journal-title":"Am J Hematol"},{"key":"BF03165102_CR17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJM197709082971001","volume":"297","author":"D Zucker-Franklin","year":"1977","unstructured":"Zucker-Franklin D, Karpatkin S. Red cell and platelet fragmentation in idiopathic thrombocytopenic purpura.N Engl J Med. 1977;297:517\u2013523.","journal-title":"N Engl J Med"},{"key":"BF03165102_CR18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1056\/NEJM197203232861202","volume":"286","author":"R Clancy","year":"1972","unstructured":"Clancy R, Jenkins E, Firkin B. Qualitative platelet abnormalities in idiopathic thrombocytopenic purpura.N Engl J Med. 1972;286:622\u2013626.","journal-title":"N Engl J Med"},{"key":"BF03165102_CR19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0609.1991.tb00529.x","volume":"46","author":"M Yanabu","year":"1991","unstructured":"Yanabu M, Suzuki M, Soga T, et al. Influence of antiplatelet autoantibodies on platelet function in immune thrombocytopenic purpura.Eur J Haematol. 1991;46:101\u2013106.","journal-title":"Eur J Haematol"},{"key":"BF03165102_CR20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-0038-1656350","volume":"68","author":"CL Balduini","year":"1992","unstructured":"Balduini CL, Bertolino G, Noris P, et al. Defect of platelet aggregation and adhesion induced by autoantibodies against platelet glycoprotein IIIa.Thromb Haemost. 1992;68:208.","journal-title":"Thromb Haemost"},{"key":"BF03165102_CR21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ajh.2830410118","volume":"41","author":"D Varon","year":"1992","unstructured":"Varon D, Gitel SN, Varon N. Immune Bernard-Soulier-like syndrome associated with anti-glycoprotein-IX antibody.Am J Hematol. 1992;41:67.","journal-title":"Am J Hematol"},{"key":"BF03165102_CR22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1365-2141.1990.tb02592.x","volume":"74","author":"SL Pfueller","year":"1990","unstructured":"Pfueller SL, David R, Firkin BG, et al. Platelet aggregating IgG antibody to platelet surface glycoproteins associated with thrombosis and thrombocytopenia.Br J Haematol. 1990;74: 336\u2013341.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1163\/15685590051130137","volume":"30","author":"AM Chen","year":"2000","unstructured":"Chen AM, Cycowitz Z, Mittelman M, et al. The incidence of pseudothrombocytopenia in automatic blood analyzers.Haematologia (Budap). 2000;30:117\u2013121.","journal-title":"Haematologia (Budap)"},{"key":"BF03165102_CR24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1423-0410.1995.tb02542.x","volume":"68","author":"F Silvestri","year":"1995","unstructured":"Silvestri F, Virgolini L, Savignano C, et al. Incidence and diagnosis of EDTA-dependant pseudothrombocytopenia in a consecutive outpatient population referred for isolated thrombovytopenia.Vox Sang. 1995;68:35\u201339.","journal-title":"Vox Sang"},{"key":"BF03165102_CR25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1055\/s-0038-1642729","volume":"73","author":"H Schrezenmeier","year":"1995","unstructured":"Schrezenmeier H, Muller H, Gunsilius E, et al. Anticoagulant-induced pseudothrombocytopenia and pseudoleucocytosis.Thromb Haemost. 1995;73:506\u2013513.","journal-title":"Thromb Haemost"},{"key":"BF03165102_CR26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0049-3848(96)00129-6","volume":"83","author":"J Golanski","year":"1996","unstructured":"Golanski J, Pietrucha T, Baj Z, et al. Molecular insights into the anticoagulant-induced spontaneous activation of platelets in whole blood-various anticoagulants are not equal.Thromb Res. 1996;83:199\u2013216.","journal-title":"Thromb Res."},{"key":"BF03165102_CR27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1515\/CCLM.1999.155","volume":"37","author":"AJ Lombarts","year":"1999","unstructured":"Lombarts AJ, Zijlstra JJ, Peters RH, et al. Accurate platelet counting in an insidious case of pseudothrombocytopenia.Clin Chem Lab Med. 1999;37:11\u201312.","journal-title":"Clin Chem Lab Med"},{"key":"BF03165102_CR28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1365-2141.1997.4773280.x","volume":"99","author":"S Sakurai","year":"1997","unstructured":"Sakurai S, Shiojima I, Tanigawa T, et al. Aminoglycosides prevent and dissociate the aggregation of platelets in patients with EDTA-dependent pseudothrombocytopenia.Br J Haematol. 1997; 99:817\u2013823.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/ajcp\/110.2.178","volume":"110","author":"F Fiorin","year":"1998","unstructured":"Fiorin F, Steffan A, Pradella P, et al. IgG platelet antibodies in EDTA-dependent pseudothrombocytopenia bind to platelet membrane glycoprotein IIb.Am J Clin Pathol. 1998;110:178\u2013183.","journal-title":"Am J Clin Pathol"},{"key":"BF03165102_CR30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2141.1986.tb02962.x","volume":"62","author":"HH vanVliet","year":"1986","unstructured":"vanVliet HH, Kappers-Klunne MC, Abels J. Pseudothrombocytopenia: a cold autoantibody against platelet glycoprotein GP IIb.Br J Haematol. 1986;62:501\u2013511.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ajcp\/103.1.103","volume":"103","author":"N Bizzaro","year":"1995","unstructured":"Bizzaro N, Brandalise M. EDTA-dependent pseudothrombocytopenia: association with antiplatelet and antiphospholipid antibodies.Am J Clin Pathol. 1995;103:103\u2013107.","journal-title":"Am J Clin Pathol"},{"key":"BF03165102_CR32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1365-2141.1994.tb08333.x","volume":"87","author":"CG Christopoulos","year":"1994","unstructured":"Christopoulos CG, Machin SJ. A new type of pseudothrombocytopenia: EDTA-mediated agglutination of platelets bearing fab fragments of chimaeric antibody.Br J Haematol. 1994; 87:650\u2013652.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2141.1971.tb03433.x","volume":"21","author":"E Amorosi","year":"1971","unstructured":"Amorosi E, Garg SK, Karpatkin S. Heterogeneity of human platelets. IV. Identification of a young platelet population with selenomethionine.Br J Haematol. 1971;21:227.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJM197101072840103","volume":"284","author":"SK Garg","year":"1971","unstructured":"Garg SK, Amorosi EL, Karpatkin S. Use of the megathrombocyte as an index of megakaryocyte number.N Engl J Med. 1971;284:11.","journal-title":"N Engl J Med"},{"key":"BF03165102_CR35","first-page":"334","volume":"119","author":"W Jy","year":"1992","unstructured":"Jy W, Horstman LL, Arce M, et al. Clinical significance of platelet microparticles in autoimmune thrombocytopenias.J Lab Clin Med. 1992;119:334\u2013345.","journal-title":"J Lab Clin Med"},{"key":"BF03165102_CR36","first-page":"83","volume-title":"Proceedings: First International Congress on Vascular Dementia","author":"YS Ahn","year":"1999","unstructured":"Ahn YS, Cui Y, Horstman LL, et al. Chronic platelet activation and progressive vascular dementia in patients with immune thrombocytopenic purpura (ITP). In: Korczyn AD, editor. Proceedings: First International Congress on Vascular Dementia. Geneva, Switzerland: Monduzzi Editore; 1999. p.83\u201386."},{"key":"BF03165102_CR37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1040-8428(98)00044-4","volume":"30","author":"LL Horstman","year":"1999","unstructured":"Horstman LL, Ahn YS. Platelet microparticles: A wide-angle perspective.Crit Rev Oncol\/Hematol. 1999;30:111\u2013142.","journal-title":"Crit Rev Oncol\/Hematol"},{"key":"BF03165102_CR38","unstructured":"Ahn YS, Jy W, Jimenez JJ, et al. Vascular dementia among patients with ITP (immune thrombocytopenic purpura) and risk factors.Blood. 2000;96(11,Prt1; Presented at 42nd ASH Meeting):250a."},{"key":"BF03165102_CR39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-0037-1615177","volume":"80","author":"S Miyamoto","year":"1998","unstructured":"Miyamoto S, Marcinkiewicz C, EdmundsJr LH, et al. Measurement of platelet microparticles during cardiopulmonary bypass by means of captured ELISA for GP IIb\/IIIa.Thromb Haemost. 1998;80:225\u2013230.","journal-title":"Thromb Haemost"},{"key":"BF03165102_CR40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/107602969700300107","volume":"3","author":"MD Ozner","year":"1997","unstructured":"Ozner MD, Ahn YS, Horstman LL, et al. Chronic platelet activation and acute coronary syndromes in 13 middle-aged patients.Clin Appl Thromb Hemost. 1997;3:46\u201353.","journal-title":"Clin Appl Thromb Hemost"},{"key":"BF03165102_CR41","unstructured":"Ahn YS, Horstman LL, Jy W, et al. Thrombotic complications in patients with ITP [abstract].Thromb Haemost. 2001;July Suppl (Presented at XVIII Congress of ISTH):"},{"key":"BF03165102_CR42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01891778","volume":"7","author":"YS Ahn","year":"1984","unstructured":"Ahn YS, Harrington WJ, Mylvaganam R. Immunosuppressant therapy of idiopathic thrombocytopenic purpura ITP.Spring Semin Immunopathol. 1984;7:35\u201342.","journal-title":"Spring Semin Immunopathol."},{"key":"BF03165102_CR43","first-page":"1556","volume":"92","author":"JN George","year":"1996","unstructured":"George JN, Woolf SH, Raskob GE, et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology [see comments].Blood. 1996;92:1556\u20131564.","journal-title":"Blood"},{"key":"BF03165102_CR44","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMra010501","volume":"346","author":"DB Cines","year":"2002","unstructured":"Cines DB, Blanchette VS, Chir B. Immune Thrombocytopenic purpura.N Engl J Med. 2002;346:995\u20131008.","journal-title":"N Engl J Med"},{"key":"BF03165102_CR45","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood.V97.3.812","volume":"97","author":"G Emilia","year":"2001","unstructured":"Emilia G, Longo G, Luppi M. Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura.Blood. 2001;97:812\u2013814.","journal-title":"Blood"},{"key":"BF03165102_CR46","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1046\/j.1365-2141.2001.03194.x","volume":"115","author":"I Jarque","year":"2001","unstructured":"Jarque I, Andreu R, Llopis I, et al. Absence of platelet response after eradication of helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura.Br J Haematol. 2001;115:1002\u20131003.","journal-title":"Br J Haematol"},{"key":"BF03165102_CR47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0140-6736(77)90132-5","volume":"2","author":"CD Robinette","year":"1977","unstructured":"Robinette CD, FraumeniJr JF. Splenectomy and subsequent mortality in veterans of the 1936\u20131945 war.Lancet (Jul 16). 1977;2:127\u2013129.","journal-title":"Lancet (Jul 16)"},{"key":"BF03165102_CR48","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJM198306093082306","volume":"308","author":"YS Ahn","year":"1983","unstructured":"Ahn YS, Harrington WJ, Simon SR, et al. Danazol for the treatment of idiopathic thrombocytopenic purpura.N Engl J Med. 1983;308:1396\u20131399.","journal-title":"N Engl J Med"},{"key":"BF03165102_CR49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-107-2-177","volume":"107","author":"YS Ahn","year":"1987","unstructured":"Ahn YS, Mylvaganam R, Garcia RO, et al. Low-dose danazol for ITP.Ann Int Med. 1987;107:177\u2013181.","journal-title":"Ann Int Med"},{"key":"BF03165102_CR50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.7326\/0003-4819-111-9-723","volume":"111","author":"YS Ahn","year":"1989","unstructured":"Ahn YS, Rocha R, Mylvaganam R, et al. Long-term danazol therapy in autoimmune thrombocytopenia: unmaintained remission and age-dependent response in women.Annals Int Med. 1989;111:723\u2013728.","journal-title":"Annals Int Med"},{"key":"BF03165102_CR51","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000205048","volume":"84","author":"YS Ahn","year":"1990","unstructured":"Ahn YS. Danazol for hematologic disorders.Acta Hematol. 1990;84:122\u2013129.","journal-title":"Acta Hematol"},{"key":"BF03165102_CR52","first-page":"531","volume":"121","author":"SA Ansar","year":"1983","unstructured":"Ansar SA, Penhale W, Talal N. Sex hormones, immune responses and auto- immune diseases. Mechanisms of sex hormone action.Am J Path. 1983;121:531.","journal-title":"Am J Path"},{"key":"BF03165102_CR53","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1056\/NEJM197408222910802","volume":"291","author":"YS Ahn","year":"1974","unstructured":"Ahn YS, Harrington WJ, Seelman RC, et al. Vincristine therapy of idiopathic and secondary thrombocytopenias.N Engl J Med. 1974;291:376\u2013380.","journal-title":"N Engl J Med."},{"key":"BF03165102_CR54","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1056\/NEJM197805182982001","volume":"298","author":"YS Ahn","year":"1978","unstructured":"Ahn YS, Byrnes JJ, Harrington WJ, et al. The treatment of idiopathic thrombocytopenia with vincristine-loaded platelets.N Engl J Med. 1978;298:1101.","journal-title":"N Engl J Med."},{"key":"BF03165102_CR55","doi-asserted-by":"crossref","first-page":"192","DOI":"10.7326\/0003-4819-100-2-192","volume":"100","author":"YS Ahn","year":"1984","unstructured":"Ahn YS, Harrington WJ, Mylvaganam R, et al. Slow infusion of vinca alkaloid in the treatment of ITP.Ann Int Med. 1984;100:192\u2013196.","journal-title":"Ann Int Med"},{"key":"BF03165102_CR56","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0076-6879(87)49069-1","volume":"149","author":"YS Ahn","year":"1987","unstructured":"Ahn YS, Mylvaganam R, Harrington WJ. Use of platelets as drug carriers for the treatment of hematologic diseases.Meth Enzymol. 1987;149:312\u2013326.","journal-title":"Meth Enzymol"},{"key":"BF03165102_CR57","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood.V98.4.952","volume":"98","author":"R Stasi","year":"2001","unstructured":"Stasi R, Pagano A, Stipa E, et al. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura.Blood. 2001;98: 952\u2013957.","journal-title":"Blood"},{"key":"BF03165102_CR58","doi-asserted-by":"crossref","first-page":"625","DOI":"10.7326\/0003-4819-96-5-625","volume":"96","author":"AE Madanes","year":"1982","unstructured":"Madanes AE, Farber M. Danazol.Ann Int Med. 1982;96:625\u2013630.","journal-title":"Ann Int Med."},{"key":"BF03165102_CR59","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2141.1985.tb04070.x","volume":"61","author":"BA McVerry","year":"1985","unstructured":"McVerry BA, Auger M, Bellingham AJ. The use of danazol in the management of chronic immune thrombocytopenic purpura.Br J Haematol. 1985;61:145\u2013148.","journal-title":"Br J Haematol."},{"key":"BF03165102_CR60","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000206184","volume":"74","author":"D Almagro","year":"1985","unstructured":"Almagro D. Danazol in idiopathic thrombocytopenic purpura [letter].Acta Haematol. 1985;74:120.","journal-title":"Acta Haematol"},{"key":"BF03165102_CR61","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000206176","volume":"74","author":"M Buelli","year":"1985","unstructured":"Buelli M, Corelazzo S, Viero P, et al. Danazol for the treatment of idiopathic thrombocytopenic purpura.Acta Haematol. 1985; 74:97\u201398.","journal-title":"Acta Haematol"},{"key":"BF03165102_CR62","first-page":"418","volume":"21","author":"J Heyd","year":"1985","unstructured":"Heyd J, Hershko C. Use of danazol in the management of chronic idiopathic thrombocytopenic purpura.Isr J Med Sci. 1985;21:418\u2013420.","journal-title":"Isr J Med Sci."},{"key":"BF03165102_CR63","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/08880019009033391","volume":"7","author":"RK Marwahn","year":"1990","unstructured":"Marwahn RK, Singh RP, EtAl. Danazol therapy in immune thrombocytopenic purpura.Pediatr Hematol Oncol. 1990;7:193\u2013198.","journal-title":"Pediatr Hematol Oncol."},{"key":"BF03165102_CR64","first-page":"1317","volume":"142","author":"ME Weinblatt","year":"1988","unstructured":"Weinblatt ME, Kochen J, Ortega J. Danazol for children with immune thrombocytopenic purpura.Am J Dis Child. 1988; 142:1317\u20131319.","journal-title":"Am J Dis Child."},{"key":"BF03165102_CR65","doi-asserted-by":"crossref","first-page":"703","DOI":"10.7326\/0003-4819-108-5-703","volume":"108","author":"SG West","year":"1988","unstructured":"West SG, Johnson SC. Danazol for treatment of refractory autoimmune thrombocytopenia in systemic lupus erythematosus.Ann Int Med. 1988;108:703\u2013706.","journal-title":"Ann Int Med."},{"key":"BF03165102_CR66","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1445-5994.1987.tb01276.x","volume":"17","author":"A Manoharan","year":"1987","unstructured":"Manoharan A. Danazol therapy in patients with immune cytopenias.Aust NZ J Med. 1987;17:613\u2013614.","journal-title":"Aust NZ J Med."},{"key":"BF03165102_CR67","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000205948","volume":"77","author":"MG Mazzucconi","year":"1987","unstructured":"Mazzucconi MG, Francesconi M, Falcione E, et al. Danazol therapy in refractory chronic immune thrombocytopenic purpura.Acta Hematol. 1987;77:45\u201347.","journal-title":"Acta Hematol"},{"key":"BF03165102_CR68","first-page":"768","volume":"114","author":"S Kotlarek-Haus","year":"1987","unstructured":"Kotlarek-Haus S, Podolak-Dawidziak M. Danazol in chronic idiopathic thrombocytopenic purpura resistent to corticosteroids.Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114:768\u2013776.","journal-title":"Folia Haematol Int Mag Klin Morphol Blutforsch"},{"key":"BF03165102_CR69","first-page":"143","volume":"32","author":"P Fenaux","year":"1990","unstructured":"Fenaux P, Quiquandon I, Huart J, et al. The role of danazol in the treatment of refractory idiopathic thrombocytopenic purpura. A report of 22 cases.Nouv Rev Fr Hematol. 1990; 32:143\u2013146.","journal-title":"Nouv Rev Fr Hematol."},{"key":"BF03165102_CR70","first-page":"55","volume":"73","author":"G Nalli","year":"1988","unstructured":"Nalli G, EtAl. Danazol therapy for idiopathic thrombocytopenic purpura (ITP).Haematologica. 1988;73:55\u201357.","journal-title":"Haematologica"},{"key":"BF03165102_CR71","first-page":"275","volume":"28","author":"R Ambriz","year":"1986","unstructured":"Ambriz R, Puzzuto J, Morales M, et al. Therapeutic effect of danazol on metrorrhagia in patients with idiopathic thrombocytopenic purpura (ITP).Nouv Rev Fr Hematol. 1986;28: 275\u2013279.","journal-title":"Nouv Rev Fr Hematol."},{"key":"BF03165102_CR72","first-page":"295","volume":"16","author":"R Ambriz-Fernandez","year":"1985","unstructured":"Ambriz-Fernandez R, GChavez-Sanchez, Pizzuto-Chavez J, et al. Danazol In refractory autoimmune thrombocytopenic purpura (ATP) a new therapeutic sequence.Arch Invest Med. 1985;16:295.","journal-title":"Arch Invest Med."},{"key":"BF03165102_CR73","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJM198702263160903","volume":"316","author":"AD Schreiber","year":"1987","unstructured":"Schreiber AD, Chien P, Tomaski A, et al. Effect of danazol in immune thrombocytopenic purpura.N Engl J Med. 1987; 316:503\u2013508.","journal-title":"N Engl J Med."},{"key":"BF03165102_CR74","first-page":"293","volume":"55","author":"H Kondo","year":"1992","unstructured":"Kondo H, Iseki T, Goto S, et al. Danazol therapy in idiopathic thrombocytopenic purpura: the efficacy of low-medium dose therapy.Int J Hematol. 1992;55:293\u2013300.","journal-title":"Int J Hematol"},{"key":"BF03165102_CR75","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/rheumatology\/36.10.1095","volume":"36","author":"R Blanco","year":"1997","unstructured":"Blanco R, EtAl. Successful therapy with danazol in refractory autoimmune thrombocytopenia associated with rheumatic diseases.Br J Rheumatol. 1997;36:1095\u20131099.","journal-title":"Br J Rheumatol"},{"key":"BF03165102_CR76","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/00043426-199123000-00014","volume":"13","author":"FT Saulsbury","year":"1991","unstructured":"Saulsbury FT, Bringelsen KA. Danazol therapy for chronic immune-mediated thrombocytopenic purpura in a patient with common variable immunodeficiency.Am J Pediatr Hematol Oncol. 1991;13:326\u2013329.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"BF03165102_CR77","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0925-5710(95)00357-X","volume":"61","author":"VP Choudhry","year":"1995","unstructured":"Choudhry VP, Kashyap R, Ahlawat S, et al. Vinblastine and danazol therapy in steroid resistent childhood chronic idiopathic thrombocytopenic purpura.Int J Hematol. 1995;61: 157\u2013162.","journal-title":"Int J Hematol."},{"issue":"suppl 2","key":"BF03165102_CR78","first-page":"29","volume":"78","author":"C Schiavotto","year":"1993","unstructured":"Schiavotto C, Castaman G, Rodeghiero F. Treatment of idiopathic thrombocytopenic purpura (ITP) in patients with refractoriness to or with contrainidcation for corticosteroids and\/or splenectomy with immunosuppressive therapy and danazol.Haematologica. 1993;78(suppl 2):29\u201334.","journal-title":"Haematologica"},{"key":"BF03165102_CR79","first-page":"840","volume":"32","author":"KM Richards","year":"1991","unstructured":"Richards KM, Ferraris VA. Mitral valve replacement in a patient with idiopathic thrombocytopenic purpura: preoperative treatment with danazol.J Cardiovasc Surg (Torino). 1991; 32:840\u2013842.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"BF03165102_CR80","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/pgmj.66.780.827","volume":"66","author":"DZ Edelman","year":"1990","unstructured":"Edelman DZ, Knobel B, Virag I, et al. Danazol in non-splenectomized patients with refractory thrombocytopenic purpura.Postgrad Med J. 1990;66:827\u2013830.","journal-title":"Postgrad Med J."},{"key":"BF03165102_CR81","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ajh.2830500306","volume":"50","author":"LL Horstman","year":"1995","unstructured":"Horstman LL, Jy W, Arce M, et al. Danazol distribution in plasma and cell membranes as related to altered cell properties: Implications for mechanism.Am J Hematol. 1995;50:179\u2013187.","journal-title":"Am J Hematol."},{"key":"BF03165102_CR82","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2165\/00003495-198019050-00001","volume":"19","author":"GO Potts","year":"1980","unstructured":"Potts GO, Schane HP, Edelson J. Pharmacology and pharmacokinetics of danazol.Drugs. 1980;19:321\u2013330.","journal-title":"Drugs."},{"key":"BF03165102_CR83","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1182\/blood.V81.11.2872.2872","volume":"81","author":"K Fujisawa","year":"1993","unstructured":"Fujisawa K, Tani P, Piro L, et al. The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura.Blood. 1993;81:2872\u20132877.","journal-title":"Blood"},{"key":"BF03165102_CR84","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0090-1229(87)90016-X","volume":"42","author":"R Mylvaganam","year":"1987","unstructured":"Mylvaganam R, Ahn YS, Harrington WJ, et al. Immune modulation by danazol in autoimmune thrombocytopenia.Clin Immunol Immunopath. 1987;42:281\u2013287.","journal-title":"Clin Immunol Immunopath"},{"key":"BF03165102_CR85","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1096\/fasebj.3.2.2914627","volume":"3","author":"YS Ahn","year":"1989","unstructured":"Ahn YS, Fernandez LF, Kim CI, et al. Danazol therapy renders red cells resistant to osmotic lysis.FASEB J. 1989; 3:157\u2013162.","journal-title":"FASEB J."},{"key":"BF03165102_CR86","first-page":"364A","volume":"39","author":"LL Horstman","year":"1991","unstructured":"Horstman LL, Jy W, Ahn YS. Danazol inhibits autoantibody binding to erythrocytes in vitro at physiologic concentrations.Clin Res. 1991;39:364A.","journal-title":"Clin Res"},{"key":"BF03165102_CR87","doi-asserted-by":"crossref","first-page":"809","DOI":"10.7326\/0003-4819-93-6-809","volume":"93","author":"SW Hosea","year":"1980","unstructured":"Hosea SW, Santaella ML, Brown EJ, et al. Long-term therapy of hereditary angioedema with danazol.Ann Int Med. 1980; 93:809\u2013812.","journal-title":"Ann Int Med."},{"key":"BF03165102_CR88","first-page":"242","volume":"312","author":"G Nesher","year":"1985","unstructured":"Nesher G, Dollberg L, Zimran A, et al. Hepatosplenic peliosis after danazol and glucocorticoids for ITP [letter].N Engl J Med. 1985;312:242.","journal-title":"N Engl J Med."},{"key":"BF03165102_CR89","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/jso.2930280209","volume":"28","author":"P Buamah","year":"1985","unstructured":"Buamah P. An apparent Danazol induced primary hepatocellular carcinoma \u0110 Case report.J Surg Oncol. 1985;28:114.","journal-title":"J Surg Oncol"},{"key":"BF03165102_CR90","doi-asserted-by":"crossref","first-page":"298","DOI":"10.7326\/0003-4819-102-3-298","volume":"102","author":"YS Ahn","year":"1985","unstructured":"Ahn YS, Harrington WJ, Mylvaganam R, et al. Danazol therapy for autoimmune hemolytic anemia.Ann Int Med. 1985;102:298\u2013301.","journal-title":"Ann Int Med"},{"key":"BF03165102_CR91","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1096-8652(199702)54:2<149::AID-AJH9>3.0.CO;2-X","volume":"54","author":"WJ Harrington","year":"1997","unstructured":"Harrington(Sr) WJ, Kolodny L, Horstman LL, et al. Danazol for paroxysmal nocturnal hemoglobinuria.Amer J Hemat. 1997;54:149\u2013154.","journal-title":"Amer J Hemat"}],"container-title":["International Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03165102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03165102\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03165102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T16:24:51Z","timestamp":1590164691000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03165102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":91,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["BF03165102"],"URL":"https:\/\/doi.org\/10.1007\/bf03165102","relation":{},"ISSN":["0925-5710","1865-3774"],"issn-type":[{"value":"0925-5710","type":"print"},{"value":"1865-3774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}