{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:44:51Z","timestamp":1757540691048,"version":"3.37.3"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1981,4,1]],"date-time":"1981-04-01T00:00:00Z","timestamp":354931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[1981,4]]},"DOI":"10.1007\/bf03189481","type":"journal-article","created":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T17:19:15Z","timestamp":1280683155000},"page":"141-148","source":"Crossref","is-referenced-by-count":3,"title":["Effect of diethyldithiocarbamate on the metabolic elimination of hexobarbital, phenazone, tolbutamide and four halogenated hydrocarbons"],"prefix":"10.1007","volume":"6","author":[{"given":"C. -P.","family":"Siegers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Biltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pentz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF03189481_CR1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00000441-196702000-00008","volume":"253","author":"F.W. Sunderman","year":"1967","unstructured":"Sunderman, F.W. (1967): Diethyldithiocarbamate therapy of thallotoxicoses. Amer. J. med. Sci.253, 107\u2013118.","journal-title":"Amer. J. med. Sci."},{"key":"BF03189481_CR2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0006-2952(66)90013-X","volume":"15","author":"T. Sakaguchi","year":"1966","unstructured":"Sakaguchi, T. Nishimura, H., Masuda, K., Tsuge, I., Onishi, K., Tatsumi, H. (1966): The relationship between chemical structure and protective effect of dithiocarbamate derivates against experimental hepatic injury induced by carbon tetrachloride administration in rats. Biochem. Pharmacol.15, 756\u2013758.","journal-title":"Biochem. Pharmacol."},{"key":"BF03189481_CR3","first-page":"425","volume":"27","author":"P. Lange","year":"1971","unstructured":"Lange, P., Jung, F. (1971): Die Verringerung der Lebertoxizit\u00e4t von Tetrachlorkohlenstoff durch Di\u00e4thyldithiocarbamat und 3-(o-Tolyl)-4-(nitro)-syndon. Acta biol. med. germ.27, 425\u2013434.","journal-title":"Acta biol. med. germ"},{"key":"BF03189481_CR4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00297053","volume":"33","author":"O. Strubelt","year":"1974","unstructured":"Strubelt, O., Siegers, C.-P., Schutt, A. (1974): The curative effects of cysteamine, cysteine and dithiocarb in experimental paracetamol poisoning. Arch. Toxicol.33, 55\u201364.","journal-title":"Arch. Toxicol."},{"key":"BF03189481_CR5","volume-title":"Vergleichende Untersuchungen zur antihepatotoxischen Wirkung von Di\u00e4thyldithiocarbamat (Dithiocarb) und anderer Thioverbindungen","author":"C.-P. Siegers","year":"1976","unstructured":"Siegers, C.-P. (1976): Vergleichende Untersuchungen zur antihepatotoxischen Wirkung von Di\u00e4thyldithiocarbamat (Dithiocarb) und anderer Thioverbindungen. Habilitationsschrift, L\u00fcbeck."},{"key":"BF03189481_CR6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00351772","volume":"41","author":"C.-P. Siegers","year":"1978","unstructured":"Siegers, C.-P., Strubelt, O., V\u00f6lpel, M. (1978): The antihepatotoxic activity of dithiocarb as compared with six other thio compounds in mice. Arch. Toxicol.41, 79\u201388.","journal-title":"Arch. Toxicol."},{"key":"BF03189481_CR7","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/0006-2952(75)90052-0","volume":"24","author":"A.L. Hunter","year":"1975","unstructured":"Hunter, A.L., Neal, R.A. (1975): Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur containing compounds. Biochem. Pharmacol.24, 2199\u20132205.","journal-title":"Biochem. Pharmacol."},{"key":"BF03189481_CR8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/B978-0-08-021523-5.50082-1","volume-title":"Microsomes and drug oxidations","author":"M. Marselos","year":"1977","unstructured":"Marselos, M., Alakuijala, P., Lang, M., T\u00f6rr\u00f6nen, R. (1977): Studies on the mechanism by which disulfiram and diethyldithiocarbamate effect drug metabolism. In: Microsomes and drug oxidations, Ulrich, V., Roots, I., Hildebrandt, A., Estabrook, R.W., Conney, A.H. (Eds.), Pergamon Press, Oxford, 589\u2013596."},{"key":"BF03189481_CR9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0041-008X(79)90041-3","volume":"48","author":"M.A. Zemaitis","year":"1979","unstructured":"Zemaitis, M.A., Greene, F.A. (1979): In vivo and in vitro effects of thiuram disulfides and dithiocarbamates on hepatic microsomal drug metabolism in the rat. Toxicol, appl. Pharmacol.48, 343\u2013350.","journal-title":"Toxicol, appl. Pharmacol."},{"key":"BF03189481_CR10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00293562","volume":"35","author":"H.M. Bolt","year":"1976","unstructured":"Bolt, H.M., Kappus, H., Buchter, A., Bolt, W. (1976): Disposition of 1,2 C14 vinylchloride in the rat. Arch. Toxicol.35, 153\u2013162.","journal-title":"Arch. Toxicol."},{"key":"BF03189481_CR11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0041-008X(78)90316-2","volume":"46","author":"C.-P. Siegers","year":"1978","unstructured":"Siegers, C.-P., Filser, J.G., Bolt, H.M. (1978): Effect of dithiocarb on metabolism and covalent binding of carbon tetrachloride. Toxicol, appl. Pharmacol.46, 709\u2013716.","journal-title":"Toxicol, appl. Pharmacol."},{"key":"BF03189481_CR12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00316492","volume":"42","author":"J.G. Filser","year":"1979","unstructured":"Filser, J.G., Bolt, H.M. (1979): Pharmacokinetics of halogenated ethylenes in rats. Arch. Toxicol.42, 123\u2013136.","journal-title":"Arch. Toxicol."},{"key":"BF03189481_CR13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00368231","volume":"39","author":"R. Pentz","year":"1978","unstructured":"Pentz, R., Sch\u00fctt, A. (1978): A rapid gaschromatographic method for the determination of drugs in clinical toxicology. Arch. Toxicol.39, 225\u2013233.","journal-title":"Arch. Toxicol."},{"key":"BF03189481_CR14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01480893","volume":"35","author":"H. Spingier","year":"1957","unstructured":"Spingier, H. (1957): Uber eine M\u00f6glichkeit zur colorimetrischen Bestimmung von N-(4-Methyl-Benzol-Sulfonyl)-N-Butyl-Harnstoff im Serum. Klin. Wschr.35, 533\u2013535.","journal-title":"Klin. Wschr."},{"key":"BF03189481_CR15","volume-title":"Angewandte Biopharmazie. Wiss.","author":"W.A. Ritschel","year":"1973","unstructured":"Ritschel, W.A. (1973): Angewandte Biopharmazie. Wiss. Verlagsgemeinschaft, Stuttgart."},{"key":"BF03189481_CR16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF00343274","volume":"39","author":"V. Ullrich","year":"1977","unstructured":"Ullrich, V., Krerhers, P. (1977): Multiple forms of cytochrome P-450 in the microsomal monooxygenase system. Arch. Toxicol.39, 41\u201350.","journal-title":"Arch. Toxicol."},{"key":"BF03189481_CR17","first-page":"1172","volume":"24","author":"H.S. Mason","year":"1965","unstructured":"Mason, H.S., North, J.C., Vanneste, M. (1965): Microsomal mixed-function oxidations. The metabolism of xenobiotics. Fed. Proc.24, 1172.","journal-title":"Fed. Proc."},{"key":"BF03189481_CR18","first-page":"393","volume":"14","author":"J.H. Str\u00f6mme","year":"1965","unstructured":"Str\u00f6mme, J.H. (1965): Metabolism of disulfiram and diethyldithiocarbamate in rats with demonstration of an in vivo ethanol-induced inhibition of the glucuronic acid conjugation of the thiol. Biochem.14, 393\u2013410.","journal-title":"Biochem."},{"key":"BF03189481_CR19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0026-895X(25)14002-9","volume":"10","author":"F. Matteis De","year":"1974","unstructured":"De Matteis, F. (1974): Covalent binding of sulfur to microsomes and loss of cytochrome P-450 during the oxidative desulfuration of several compounds. Molec. Pharmacol.10, 849\u2013854.","journal-title":"Molec. Pharmacol."},{"key":"BF03189481_CR20","first-page":"173","volume":"26","author":"A.M. Sauter","year":"1976","unstructured":"Sauter, A.M., Wiegrebe, W., v. Wartburg, J.P. (1976): Determination of disulfiram and its metabolites in human blood. Arzneimittel-Forsch.26, 173\u2013177.","journal-title":"Arzneimittel-Forsch."},{"key":"BF03189481_CR21","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0022-3565(25)31008-6","volume":"202","author":"J. Cobby","year":"1977","unstructured":"Cobby, J., Mayersohn, M., Selliak, S. (1977): The rapid reduction of disulfiram in blood and plasma. J. Pharmacol. exp. Ther.202, 724\u2013731.","journal-title":"J. Pharmacol. exp. Ther."},{"key":"BF03189481_CR22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00606562","volume":"9","author":"T.L. Svendson","year":"1976","unstructured":"Svendson, T.L., Kristensen, M.B., Hansen, I.M. Skovsted, L. (1976): The influence of disulfiram on the half-life and metabolic clearance rate of diphenylhydantoin and tolbutamide in man. Europ. J. clin. Pharmacol.9, 439\u2013441.","journal-title":"Europ. J. clin. Pharmacol."},{"key":"BF03189481_CR23","first-page":"323","volume":"16","author":"K.J. Freundt","year":"1978","unstructured":"Freundt, K.J. (1978): Variable inhibition of human hepatic drug metabolizing enzymes by disulfiram. Int. J. clin. Pharmacol.16, 323\u2013330.","journal-title":"Int. J. clin. Pharmacol."},{"key":"BF03189481_CR24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/cpt1978245583","volume":"24","author":"S.M. MacLeod","year":"1978","unstructured":"MacLeod, S.M., Sellers, E.M., Giles, H.G., Billings, B.J., Martin, P.R., Greenblatt, D.J., Marshman, J.A. (1978): Interaction of disulfiram with benzodiazepines. Clin. Pharmacol. Ther.24, 583\u2013589.","journal-title":"Clin. Pharmacol. Ther."}],"container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03189481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03189481\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03189481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T17:05:01Z","timestamp":1740330301000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03189481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["BF03189481"],"URL":"https:\/\/doi.org\/10.1007\/bf03189481","relation":{},"ISSN":["0378-7966","2107-0180"],"issn-type":[{"type":"print","value":"0378-7966"},{"type":"electronic","value":"2107-0180"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}