{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:56:02Z","timestamp":1757541362600},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[1987,10]]},"DOI":"10.1007\/bf03189917","type":"journal-article","created":{"date-parts":[[2010,8,2]],"date-time":"2010-08-02T15:38:20Z","timestamp":1280763500000},"page":"299-302","source":"Crossref","is-referenced-by-count":7,"title":["Chlorpromazine inhibition of melatonin metabolism by normal and induced rat liver microsomes"],"prefix":"10.1007","volume":"12","author":[{"given":"C.","family":"Beedham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF03189917_CR1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-079X.1985.tb00647.x","volume":"2","author":"R.J. Wurtman","year":"1985","unstructured":"Wurtman R.J., Lieberman H.R. (1985): Melatonin secretion as a mediator of circadian variations in sleep and sleepiness. J. Pineal Res., 2, 301\u2013303.","journal-title":"J. Pineal Res."},{"key":"BF03189917_CR2","first-page":"142","volume":"2","author":"G.M. Vaughan","year":"1984","unstructured":"Vaughan G.M. (1984): Melatonin in humans. Pineal Res. Rev., 2, 142\u2013201.","journal-title":"Pineal Res. Rev."},{"key":"BF03189917_CR3","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/S0021-9258(19)76431-X","volume":"236","author":"I.J. Kopin","year":"1961","unstructured":"Kopin I.J., Pare C.M.B., Axelrod J. Weissbach M. (1961): The fate of melatonin in animals. J. Biol. Chem., 236, 3072\u20133075.","journal-title":"J. Biol. Chem."},{"key":"BF03189917_CR4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/bms.1200120704","volume":"12","author":"I.M. Young","year":"1985","unstructured":"Young I.M., Leone R.M., Silman R.E. (1985): The mass spectrometric analysis of the urinary metabolites of melatonin and its deuterated analogues confirming their identity as N-acetylserotonin and 6-hydroxymelatonin. Biomed. Mass Spectrom., 12, 319\u2013337.","journal-title":"Biomed. Mass Spectrom."},{"key":"BF03189917_CR5","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1210\/jcem-60-6-1166","volume":"60","author":"J. Arendt","year":"1985","unstructured":"Arendt J., Bojkowski C, Franey C, Wright J., Marks V. (1985): Immunoassay of 6-hydroxymelatonin sulphate in human plasma and urine: Abolition of the 24-hour rhythm with atenolol. J. Clin. Endocrinol. Metab., 60, 1166\u20131173.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03189917_CR6","first-page":"105","volume":"23","author":"M. Tetsuo","year":"1981","unstructured":"Tetsuo M., Markey S.P., Colburn R.W., Kopin I.J. (1981): Measurement of 6-hydroxymelatonin in human urine and its diurnal variations. Life Sei., 23, 105\u2013109.","journal-title":"Life Sei."},{"key":"BF03189917_CR7","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1210\/endo-114-5-1825","volume":"114","author":"R.M. Leone","year":"1984","unstructured":"Leone R.M., Silman R.E. (1984): Melatonin can be differentially metabolised in the rat to produce N-acetylserotonin in addition to 6-hydroxymelatonin. Endocrinology, 114, 1825\u20131832.","journal-title":"Endocrinology"},{"key":"BF03189917_CR8","doi-asserted-by":"crossref","unstructured":"Smith J.A., Mee T.J.X., Barnes J.L. (1977): Elevated melatonin serum levels in psychiatric patients treated with chlorpromazine. J. Pharm. Pharmacol., 29, 30P.","DOI":"10.1111\/j.2042-7158.1977.tb11498.x"},{"key":"BF03189917_CR9","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1210\/endo-98-6-1418","volume":"98","author":"Y. Osaki","year":"1976","unstructured":"Osaki Y., Lynch H.J., Wurtman R.J. (1976): Melatonin in the rat pineal, plasma and urine, 24-hour rhythmicity and the effect of chlorpromazine. Endocrinology, 98, 1418\u20131424.","journal-title":"Endocrinology"},{"key":"BF03189917_CR10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M.M. Bradford","year":"1976","unstructured":"Bradford M.M. (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein dye binding. Anal. Biochem., 72, 248\u2013254.","journal-title":"Anal. Biochem."},{"key":"BF03189917_CR11","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-3188-7","volume-title":"Introduction to drug metabolism","author":"G.G. Gibson","year":"1986","unstructured":"Gibson G.G., Skett P. (1986): Introduction to drug metabolism, Chapman and Hall: London."},{"key":"BF03189917_CR12","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1210\/endo-108-3-1081","volume":"108","author":"U. Weinberg","year":"1981","unstructured":"Weinberg U., Gasparini F.J., Weitzman E.D. (1981): Development pattern of in vitro rat liver melatonin degrading activity. Endocrinology, 108, 1081\u20131082.","journal-title":"Endocrinology"},{"key":"BF03189917_CR13","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/endo-120-6-2453","volume":"120","author":"O. Vakkuri","year":"1987","unstructured":"Vakkuri O., Tervo J., Luttinen R., Ruotsalainen H., Rahkamaa E., Leppaluoto J. (1987): A cyclic isomer of 2-hydroxymelatonin: A novel metabolite of melatonin. Endocrinology, 120, 2453\u20132459.","journal-title":"Endocrinology"}],"container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03189917.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03189917\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03189917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T18:28:22Z","timestamp":1635877702000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03189917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["BF03189917"],"URL":"https:\/\/doi.org\/10.1007\/bf03189917","relation":{},"ISSN":["0378-7966","2107-0180"],"issn-type":[{"value":"0378-7966","type":"print"},{"value":"2107-0180","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}