{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T22:40:36Z","timestamp":1740350436105,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. J. Drug Metab. Pharmacokinet."],"published-print":{"date-parts":[[1990,4]]},"DOI":"10.1007\/bf03190196","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T04:31:37Z","timestamp":1281069097000},"page":"135-142","source":"Crossref","is-referenced-by-count":3,"title":["Non-invasive methods to study drug disposition: Positron Emission Tomography Detection and quantification of brain receptors in man"],"prefix":"10.1007","volume":"15","author":[{"given":"B.","family":"Sadzot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Franck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF03190196_CR1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1126\/science.2860723","volume":"228","author":"M.E. Phelps","year":"1985","unstructured":"Phelps M.E., Mazziotta J.C. (1985): Positron emission tomography: human brain function and biochemistry. Science, 228, 799\u2013809.","journal-title":"Science"},{"key":"BF03190196_CR2","first-page":"134","volume":"5","author":"J.C. Mazziotta","year":"1981","unstructured":"Mazziotta J.C., Phelps M.E., Plummer D., Kuhl D.E. (1981): Quantitation in positron emission tomography: 5. physical-anatomical effects. J. Comp. Assist Tomogr., 5, 134\u2013743.","journal-title":"J. Comp. Assist Tomogr."},{"key":"BF03190196_CR3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/0165-6147(86)90435-9","volume":"7","author":"J.J Frost","year":"1986","unstructured":"Frost J.J. (1986): Imaging neuronal biochemistry by emission computed tomography: focus on neuroreceptors. Trends Pharmacol. Sei., 7, 490\u2013496.","journal-title":"Trends Pharmacol. Sei."},{"key":"BF03190196_CR4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0006-8993(89)90094-2","volume":"491","author":"B. Sadzot","year":"1989","unstructured":"Sadzot B., Frost J.J., Wagner H.N., Jr. (1989): In vivo labeling of central benzodiazepine receptors with the partial inverse agonist [3H]-Ro 15-4513. Brain Res., 491, 128\u2013135.","journal-title":"Brain Res."},{"key":"BF03190196_CR5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0022-3565(25)21415-X","volume":"230","author":"P. Hartvig","year":"1984","unstructured":"Hartvig P., Bergstr\u00f6m K., Lindberg B., et al. (1984): Kinetics of11C-labeled opiates in the brain of rhesus monkeys. J. Pharmacol. Exp. Therap., 230, 250\u2013255.","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"BF03190196_CR6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2165\/00003088-198308050-00004","volume":"8","author":"L.E. Mather","year":"1983","unstructured":"Mather L.E. (1983): Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin. Pharmacokin, 8, 422\u2013446.","journal-title":"Clin. Pharmacokin"},{"key":"BF03190196_CR7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0020-708X(85)90089-4","volume":"36","author":"R.F. Dannais","year":"1985","unstructured":"Dannais R.F., Ravert H.T., Frost J.J., Wilson A.A., Burns H.D., Wagner H.N., Jr. (1985): Radiosynthesis of an opiate receptor binding radiotracer: [11C]carfentanil. Int J. Appl. Radiat Isot, 36, 303\u2013306.","journal-title":"Int J. Appl. Radiat Isot"},{"key":"BF03190196_CR8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00004728-198503000-00001","volume":"9","author":"J.J. Frost","year":"1985","unstructured":"Frost J.J., Wagner H.N., Jr., Dannais R.F., et al. (1985): Imaging opiate receptors in the human brain by positron emission tomography. J. Comput Ass. Tomogr, 9, 231\u2013236.","journal-title":"J. Comput Ass. Tomogr"},{"key":"BF03190196_CR9","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1016\/S0040-4039(01)83849-1","volume":"28","author":"J.R. Lever","year":"1987","unstructured":"Lever J.R., Dannals R.F., Wilson A.A., Ravert H.T., Wagner H.N., Jr. (1987): Synthesis of carbon-11 labeled diprenorphine: a radioligand for positron emission tomographic studies of opiate receptors. Tet. Lett, 28, 4015\u20134018.","journal-title":"Tet. Lett"},{"key":"BF03190196_CR10","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1073\/pnas.78.7.4141","volume":"78","author":"K-J. Chang","year":"1981","unstructured":"Chang K-J., Hazum E., Cuatrecasas P. (1981): Novel opiate binding sites selective for benzomorphan drugs. Proc. Natl. Acad. Sei. USA, 78, 4141\u20134145.","journal-title":"Proc. Natl. Acad. Sei. USA"},{"key":"BF03190196_CR11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/245447a0","volume":"245","author":"M.J. Kuhar","year":"1973","unstructured":"Kuhar M.J., Pert C.B., Snyder S.H. (1973): Regional distribution of opiate receptor binding in monkey and human brain. Nature, 245, 447\u2013451.","journal-title":"Nature"},{"key":"BF03190196_CR12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(82)91150-7","volume":"248","author":"A. Pfeiffer","year":"1982","unstructured":"Pfeiffer A., Pasi A., Mehraein P., Herz A. (1982): Opiate receptor binding sites in human brain. Brain Res, 248, 87\u201396.","journal-title":"Brain Res"},{"key":"BF03190196_CR13","doi-asserted-by":"crossref","unstructured":"Frost J J, Mayberg H.S, Sadzot B, et al. (1989): Comparison of11C-diprenorphine and11C-carfentanil binding to opiate receptors in man by positron emission tomography. J. Cereb. Blood Flow Metab, In press.","DOI":"10.1038\/jcbfm.1989.59"},{"key":"BF03190196_CR14","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/jcbfm.1986.96","volume":"6","author":"S.C. Huang","year":"1986","unstructured":"Huang S.C., Barrio J.R., Phelps M.E. (1986): Neuroreceptor assay with positron emission tomography: equilibrium versus dynamic approaches. J. Cereb. Blood Flow Metab, 6, 515\u2013521.","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"BF03190196_CR15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ana.410150302","volume":"15","author":"M.A. Mintun","year":"1984","unstructured":"Mintun M.A., Raichle M.E., Kilboum M.R., Wooten G.F., Welch M.J. (1984): A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol, 15, 217\u2013227.","journal-title":"Ann. Neurol"},{"key":"BF03190196_CR16","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/jcbfm.1989.119","volume":"9","author":"S-C. Huang","year":"1989","unstructured":"Huang S-C., Bahn M.M., Barrio J.R., et al. (1989): A double injection technique for the in vivo measurement of dopamine D2-receptor density in monkeys with 3-(2\u2032-[18F]fluoroethyl)spiperone and dynamic positron emission tomography. J. Cereb. Blood Flow Metab, 9, 850\u2013858.","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"BF03190196_CR17","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/jcbfm.1989.98","volume":"9","author":"L. Farde","year":"1989","unstructured":"Farde L., Eriksson L., Blomquist G., Halldin C. (1989): Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET \u2014 A comparison to the equilibrium analysis. J. Cereb. Blood Flow Metab, 9, 696\u2013708.","journal-title":"J. Cereb. Blood Flow Metab"},{"issue":"Suppll","key":"BF03190196_CR18","first-page":"192","volume":"9","author":"J.J. Frost","year":"1989","unstructured":"Frost J.J., Sadzot B., Mayberg H.S., et al. (1989): Estimation of receptor number and affinity for11C-diprenorphine binding to opiate receptors in man by PET. J. Cereb. Blood Flow Metab, 9 (Suppll), S192.","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"BF03190196_CR19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ana.410230304","volume":"23","author":"J.J. Frost","year":"1988","unstructured":"Frost J.J., Mayberg H.S., Fisher R.S., et al. (1988) Mu-opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsy. Ann. Neurol., 23, 231\u2013237.","journal-title":"Ann. Neurol."},{"key":"BF03190196_CR20","doi-asserted-by":"crossref","unstructured":"Savic I, Persson A, Roland P, Pauli S., Sedvall G, Widen L. (1988): In vivo demonstration of reduced benzodiazepine binding inhuman epileptic foci. Lancet, Oct 15, 863\u2013866.","DOI":"10.1016\/S0140-6736(88)92468-3"},{"key":"BF03190196_CR21","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1126\/science.2878495","volume":"234","author":"D.F. Wong","year":"1986","unstructured":"Wong D.F., Wagner H.N., Tune L.E., et al. (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science, 234, 1558\u20131563.","journal-title":"Science"},{"key":"BF03190196_CR22","first-page":"1207","volume":"29","author":"M.C. Lee","year":"1988","unstructured":"Lee M.C., Wagner H.N., Jr., Tanada S., Frost J.J., Bice A.N., Dannais R.F. (1988): Duration of occupancy of opiate receptors by naltrexone. J. Nucl. Med., 29, 1207\u20131211.","journal-title":"J. Nucl. Med."},{"key":"BF03190196_CR23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0006-3223(88)90048-0","volume":"23","author":"M. Smith","year":"1988","unstructured":"Smith M., Wolf A.P., Brodie J.D., et al. (1988): Serial [18F]N-methylspiperidol PET studies to measure changes in antipsychotic drug D2 receptor occupancy in schizophrenic patients. Biol Psychiatr., 23, 653\u2013663.","journal-title":"Biol Psychiatr."},{"key":"BF03190196_CR24","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.6334363","volume":"226","author":"D.F. Wong","year":"1984","unstructured":"Wong D.F., Wagner H.N., Jr, Dannais R.F., et al. (1984): Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science, 226, 1393\u20131396.","journal-title":"Science"},{"key":"BF03190196_CR25","first-page":"184","volume":"27","author":"A.N. Bice","year":"1986","unstructured":"Bice A.N., Wagner H.N., Jr., Frost J.J., et al. (1986): Simplified detection system for neuroreceptor studies in the human brain J. Nucl. Med., 27, 184\u2013191.","journal-title":"Nucl. Med."}],"container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03190196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03190196\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03190196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T22:07:55Z","timestamp":1740348475000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03190196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["BF03190196"],"URL":"https:\/\/doi.org\/10.1007\/bf03190196","relation":{},"ISSN":["0378-7966","2107-0180"],"issn-type":[{"type":"print","value":"0378-7966"},{"type":"electronic","value":"2107-0180"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}