{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T22:40:39Z","timestamp":1740350439159,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. J. Drug Metab. Pharmacokinet."],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1007\/bf03190453","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T07:30:41Z","timestamp":1281079841000},"page":"171-174","source":"Crossref","is-referenced-by-count":1,"title":["Effects of terfenadine and diphenhydramine on the CYP2D6 activity in healthy volunteers"],"prefix":"10.1007","volume":"27","author":[{"given":"Selim","family":"Kortunay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atila","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nursabah E.","family":"Basci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Oguz","family":"Kayaalp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF03190453_CR1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/0165-6147(92)90140-2","volume":"13","author":"S. Cholerton","year":"1992","unstructured":"Cholerton S., Daly A.K., Idle J.R. (1992): The role of individual human cytochromes P450 in drug metabolism and clinical response. Trends Pharmacol. Sci., 13, 434\u2013438.","journal-title":"Trends Pharmacol. Sci."},{"key":"BF03190453_CR2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0888-7543(05)80282-4","volume":"14","author":"M.H. Heim","year":"1992","unstructured":"Heim M.H., Meyer U.A. (1992): Evolution of highly polymorphic human cytochrome P450 gene cluster-CYP2D6. Genomics, 14, 49\u201358.","journal-title":"Genomics"},{"key":"BF03190453_CR3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/clpt.1994.48","volume":"55","author":"A. Bozkurt","year":"1994","unstructured":"Bozkurt A., Ba\u015f\u00e7i N.E., I\u015fimer A., Sayal A., Kayaalp S.O. (1994): Polymorphic debrisoquine metabolism in a Turkish population. Clin. Pharmacol. Ther., 55, 399\u2013401.","journal-title":"Clin. Pharmacol. Ther."},{"key":"BF03190453_CR4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/BF00637732","volume":"36","author":"K. Brosen","year":"1989","unstructured":"Brosen K. and Gram L.F. (1989): Clinical significance of sparteine\/debrisoquine oxidation polymorphism. Eur. J. Clin. Pharmacol., 36, 537\u2013547.","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"BF03190453_CR5","first-page":"536","volume":"26","author":"B.A. Hamelin","year":"1998","unstructured":"Hamelin B.A., Bouayad A., Drolet B., Gravel A., Turgeon J. (1998): In vitro characterisation of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug. Metab. Dispos., 26: 536\u2013539.","journal-title":"Drug. Metab. Dispos."},{"key":"BF03190453_CR6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0009-9236(95)90199-X","volume":"58","author":"S.U. Yasuda","year":"1995","unstructured":"Yasuda S.U., Wellstein A., Barbey J.T., Woosley R.L. (1995): Chlorpheniramine plasma concentration and histamine H1 receptor occupancy. Clin. Pharmacol. Ther., 58, 210\u201320.","journal-title":"Clin. Pharmacol. Ther."},{"key":"BF03190453_CR7","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1016\/0006-2952(88)90063-9","volume":"37","author":"R. Fonne-Pfister","year":"1988","unstructured":"Fonne-Pfister R., Meyer U.A. (1988): Xenobiotic and endobiotic inhibitors of cytochrome P-450 db 1 function, the target of the debrisoquine-sparteine type polymorphism. Biochem. Pharmacol., 37, 3829\u20133835.","journal-title":"Biochem. Pharmacol."},{"key":"BF03190453_CR8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0022-3565(25)24518-9","volume":"272","author":"T. Hiroi","year":"1995","unstructured":"Hiroi T., Ohishi N., Imaoka S., Yabusaki Y., Fukui H., Funae Y. (1995) Mepyramine, a histamine H1 receptor antagonist, inhibits the metabolic activity of rat and human P450 2D forms. J. Pharmacol. Exp. Ther., 272, 939\u2013944.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BF03190453_CR9","first-page":"875","volume":"26","author":"B.C. Jones","year":"1998","unstructured":"Jones B.C., Hyland R., Ackland M., Tyman C.A., Smith D.A. (1998): Interaction of terfenadine and its primary metabolites with CYP2D6. Drug Metab. Dispos., 26, 875\u201382.","journal-title":"Drug Metab. Dispos."},{"key":"BF03190453_CR10","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1067\/mcp.2000.106464","volume":"67","author":"B.A. Hamelin","year":"2000","unstructured":"Hamelin B.A., Bouayad A., M\u00e9thot A., Jobin J., Desgagn\u00e9s P., Piorier P., Allaire J., Dumesnil J. and Turgeon J. (2000): Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity. Clin. Pharmacol. Ther., 67, 466\u2013477.","journal-title":"Clin. Pharmacol. Ther."},{"key":"BF03190453_CR11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1034\/j.1600-0773.2001.d01-170.x","volume":"89","author":"S. Kortunay","year":"2001","unstructured":"Kortunay S., Bozkurt A., Basci N.E., Brosen K. and Kayaalp S.O. (2001): Dose-dependent inhibition of the CYP2D6 catalyzed oxidation of sparteine by mepyramine in healthy volunteers. Pharmacol. Toxicol., 89, 331\u2013334.","journal-title":"Pharmacol. Toxicol."},{"key":"BF03190453_CR12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0731-7085(93)80184-3","volume":"11","author":"A. Bozkurt","year":"1993","unstructured":"Bozkurt A., Ba\u015f\u00e7i N.E., I\u015fimer A., Kayaalp S.O. (1993): Determination of debrisoquine and 4-hydroxydebrisoquine in urine by high-performance liquid chromatography with fluorescence detection after solid-phase extraction. J. Pharmaceut. Biomed. Anal., 11, 745\u2013749.","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"BF03190453_CR13","first-page":"1185","volume":"32","author":"D.A. Garteiz","year":"1982","unstructured":"Garteiz D.A., Hook R.H., Walker B.J., Okerholm R.A. (1982): Pharmacokinetics and biotransformation studies of terfenadine in man. Arzneimittel-Forschung, 32, 1185\u20131190.","journal-title":"Arzneimittel-Forschung"},{"key":"BF03190453_CR14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/00003088-198510060-00002","volume":"10","author":"D.M. Paton","year":"1985","unstructured":"Paton D.M., Webster D.R. (1985): Clinical pharmacokinetics of H1-receptor antagonists (The antihistamines). Clin. Pharmacokinet., 10: 477\u201397.","journal-title":"Clin. Pharmacokinet."},{"key":"BF03190453_CR15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/clpt.1980.155","volume":"28","author":"R. Spector","year":"1980","unstructured":"Spector R., Choudhury A.K., Chiang C-K., Goldberg M.J., Ghoneim M.M. (1980): Diphenhydramine in Orientals and Caucasians. Clin. Pharmacol. Ther., 28, 229\u2013234.","journal-title":"Clin. Pharmacol. Ther."},{"key":"BF03190453_CR16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/jat\/11.5.186","volume":"11","author":"G.R. Jones","year":"1987","unstructured":"Jones G.R., and Pounder D.J. (1987): Site dependence of drug concentrations in postmortem blood: a case study. J. Anal. Toxicol., 11, 186\u2013190.","journal-title":"J. Anal. Toxicol."}],"container-title":["European Journal of Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03190453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03190453\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03190453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T22:09:25Z","timestamp":1740348565000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03190453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["BF03190453"],"URL":"https:\/\/doi.org\/10.1007\/bf03190453","relation":{},"ISSN":["0378-7966","2107-0180"],"issn-type":[{"type":"print","value":"0378-7966"},{"type":"electronic","value":"2107-0180"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}