{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:11Z","timestamp":1791252791931,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/bf03262282","type":"journal-article","created":{"date-parts":[[2012,12,23]],"date-time":"2012-12-23T18:47:40Z","timestamp":1356288460000},"page":"669-679","source":"Crossref","is-referenced-by-count":5,"title":["Adverse Drug Reactions in a Population of Hospitalized Very Elderly Patients"],"prefix":"10.1007","volume":"29","author":[{"given":"Balamurugan","family":"Tangiisuran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Graham Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakravarthi","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,23]]},"reference":[{"key":"2282_CR1","volume-title":"National service framework for older people","author":"Department of Health","year":"2001","unstructured":"Department of Health. National service framework for older people. London: The Stationary Office, 2001."},{"issue":"5","key":"2282_CR2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/01.mjt.0000183719.84390.4d","volume":"14","author":"E.S. ElDesoky","year":"2007","unstructured":"ElDesoky ES. Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther 2007 Sep\u2013Oct; 14 (5): 488\u201398.","journal-title":"Am J Ther"},{"issue":"1","key":"2282_CR3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/jama.1995.03530010043033","volume":"274","author":"D.W. Bates","year":"1995","unstructured":"Bates DW, Cullen DJ, Laird N, et al. Incidence of adverse drug events and potential adverse drug events: implications for prevention. ADE Prevention Study Group. JAMA 1995 Jul 5; 274 (1): 29\u201334.","journal-title":"JAMA"},{"issue":"4","key":"2282_CR4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1001\/jama.1997.03540280045032","volume":"277","author":"D.W. Bates","year":"1997","unstructured":"Bates DW, Spell N, Cullen DJ, et al. The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group. JAMA 1997 Jan 22\u201329; 277 (4): 307\u201311.","journal-title":"JAMA"},{"issue":"7456","key":"2282_CR5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/bmj.329.7456.15","volume":"329","author":"M. Pirmohamed","year":"2004","unstructured":"Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 2004 Jul 3; 329 (7456): 15\u20139.","journal-title":"BMJ"},{"issue":"2","key":"2282_CR6","doi-asserted-by":"crossref","first-page":"e4439","DOI":"10.1371\/journal.pone.0004439","volume":"4","author":"E.C. Davies","year":"2009","unstructured":"Davies EC, Green CF, Taylor S, et al. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One 2009; 4 (2): e4439.","journal-title":"PLoS One"},{"issue":"2","key":"2282_CR7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1023\/A:1015570104121","volume":"24","author":"H.J. Beijer","year":"2002","unstructured":"Beijer HJ, de Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 2002 Apr; 24 (2): 46\u201354.","journal-title":"Pharm World Sci"},{"issue":"5","key":"2282_CR8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00115514-200209000-00005","volume":"47","author":"N. Azad","year":"2002","unstructured":"Azad N, Tierney M, Victor G, et al. Adverse drug events in the elderly population admitted to a tertiary care hospital. J Healthc Manag 2002 Sep-Oct; 47 (5): 295\u2013305.","journal-title":"J Healthc Manag"},{"issue":"4","key":"2282_CR9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1445-5994.2001.00044.x","volume":"31","author":"M. Chan","year":"2001","unstructured":"Chan M, Nicklason F, Vial JH. Adverse drug events as a cause of hospital admission in the elderly. Intern Med J 2001 May\u2013Jun; 31 (4): 199\u2013205.","journal-title":"Intern Med J"},{"issue":"2","key":"2282_CR10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2796.1990.tb00199.x","volume":"228","author":"J. Hallas","year":"1990","unstructured":"Hallas J, Harvald B, Gram LF, et al. Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention. J Intern Med 1990 Aug; 228 (2): 83\u201390.","journal-title":"J Intern Med"},{"issue":"5","key":"2282_CR11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/ageing\/26.5.375","volume":"26","author":"G. Cunningham","year":"1997","unstructured":"Cunningham G, Dodd TR, Grant DJ, et al. Drug-related problems in elderly patients admitted to Tayside hospitals: methods for prevention and subsequent reassessment. Age Ageing 1997 Sep; 26 (5): 375\u201382.","journal-title":"Age Ageing"},{"issue":"11","key":"2282_CR12","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5694\/j.1326-5377.1996.tb122235.x","volume":"164","author":"J.G. Dartnell","year":"1996","unstructured":"Dartnell JG, Anderson RP, Chohan V, et al. Hospitalisation for adverse events related to drug therapy: incidence, avoidability and costs. Med J Australia 1996 Jun 3; 164 (11): 659\u201362.","journal-title":"Med J Australia"},{"issue":"3","key":"2282_CR13","first-page":"161","volume":"48","author":"B.J. Courtman","year":"1995","unstructured":"Courtman BJ, Stallings SB. Characterization of drug-related problems in elderly patients on admission to a medical ward. Can J Hosp Pharm 1995 Jun; 48 (3): 161\u20136.","journal-title":"Can J Hosp Pharm"},{"issue":"4","key":"2282_CR14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.amjopharm.2006.12.008","volume":"4","author":"R.L. Page 2nd","year":"2006","unstructured":"Page 2nd RL, Ruscin JM. The risk of adverse drug events and hospital-related morbidity and mortality among older adults with potentially inappropriate medication use. Am J Geriatr Pharmacother 2006 Dec; 4 (4): 297\u2013305.","journal-title":"Am J Geriatr Pharmacother"},{"issue":"1","key":"2282_CR15","doi-asserted-by":"crossref","first-page":"M59","DOI":"10.1093\/gerona\/53A.1.M59","volume":"53","author":"S.L. Gray","year":"1998","unstructured":"Gray SL, Sager M, Lestico MR, et al. Adverse drug events in hospitalized elderly. J Gerontol A Biol Sci Med Sci 1998 Jan; 53 (1): M59\u201363.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"2282_CR16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/ageing\/21.4.294","volume":"21","author":"C.M. Lindley","year":"1992","unstructured":"Lindley CM, Tully MP, Paramsothy V, et al. Inappropriate medication is a major cause of adverse drug reactions in elderly patients. Age Ageing 1992 Jul; 21 (4): 294\u2013300.","journal-title":"Age Ageing"},{"issue":"6","key":"2282_CR17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.amjmed.2003.10.031","volume":"116","author":"K.E. Schmader","year":"2004","unstructured":"Schmader KE, Hanlon JT, Pieper CF, et al. Effect of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med 2004 March 15; 116 (6): 394\u2013401.","journal-title":"Am J Med"},{"issue":"2","key":"2282_CR18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/09638288809164103","volume":"10","author":"C. Collin","year":"1988","unstructured":"Collin C, Wade DT, Davies S, et al. The Barthel ADL Index: a reliability study. Int Disabil Stud 1988; 10 (2): 61\u20133.","journal-title":"Int Disabil Stud"},{"issue":"4","key":"2282_CR19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ageing\/1.4.233","volume":"1","author":"H.M. Hodkinson","year":"1972","unstructured":"Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing 1972 Nov; 1 (4): 233\u20138.","journal-title":"Age Ageing"},{"issue":"5","key":"2282_CR20","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1532-5415.2008.01665.x","volume":"56","author":"S.M. Handler","year":"2008","unstructured":"Handler SM, Hanlon JT, Perera S, et al. Consensus list of signals to detect potential adverse drug reactions in nursing homes. J Am Geriatr Soc 2008 May; 56 (5): 808\u201315.","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"2282_CR21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/qhc.12.3.194","volume":"12","author":"J.D. Rozich","year":"2003","unstructured":"Rozich JD, Haraden CR, Resar RK. Adverse drug event trigger tool: a practical methodology for measuring medication related harm. Qual Saf Health Care 2003 Jun; 12 (3): 194\u2013200.","journal-title":"Qual Saf Health Care"},{"issue":"17","key":"2282_CR22","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1001\/archinternmed.2008.3","volume":"168","author":"A.J. Leendertse","year":"2008","unstructured":"Leendertse AJ, Egberts AC, Stoker LJ, et al. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med 2008 Sep 22; 168 (17): 1890\u20136.","journal-title":"Arch Intern Med"},{"key":"2282_CR23","unstructured":"Wiffen P GM, Edwards J, Moore A. Adverse drug reactions in hospital patients: a systematic review of the prospective and retrospective studies. Bandolier Extra Evidence-Based Health Care 2002 Jun: 1\u201315."},{"issue":"2","key":"2282_CR24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-2125.2006.02698.x","volume":"63","author":"R.L. Howard","year":"2007","unstructured":"Howard RL, Avery AJ, Slavenburg S, et al. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol 2007 Feb; 63 (2): 136\u201347.","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"2282_CR25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/157488607779315507","volume":"2","author":"E.C. Davies","year":"2007","unstructured":"Davies EC, Green CF, Mottram DR, et al. Adverse drug reactions in hospitals: a narrative review. Curr Drug Saf 2007 Jan; 2 (1): 79\u201387.","journal-title":"Curr Drug Saf"},{"issue":"9237","key":"2282_CR26","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(00)02799-9","volume":"356","author":"I.R. Edwards","year":"2000","unstructured":"Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000 Oct 7; 356 (9237): 1255\u20139.","journal-title":"Lancet"},{"key":"2282_CR27","first-page":"18","volume-title":"Textbook of adverse drug reactions","author":"M.D. Rawlins","year":"1991","unstructured":"Rawlins MD, Thompson JW. Mechanism of adverse drug reaction. In: Davies DM, editor. Textbook of adverse drug reactions. Oxford: Oxford University Press, 1991: 18\u201345."},{"issue":"16","key":"2282_CR28","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1056\/NEJMsa020703","volume":"348","author":"T.K. Gandhi","year":"2003","unstructured":"Gandhi TK, Weingart SN, Borus J, et al. Adverse drug events in ambulatory care. N Engl J Med 2003 Apr 17; 348 (16): 1556\u201364.","journal-title":"N Engl J Med"},{"issue":"4","key":"2282_CR29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/qshc.2004.010611","volume":"13","author":"T. Morimoto","year":"2004","unstructured":"Morimoto T, Gandhi TK, Seger AC, et al. Adverse drug events and medication errors: detection and classification methods. Qual Saf Health Care 2004 Aug; 13 (4): 306\u201314.","journal-title":"Qual Saf Health Care"},{"key":"2282_CR30","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/aje\/kwk052","volume":"165","author":"E.V. Vittinghoff","year":"2007","unstructured":"Vittinghoff EV, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 2007 Dec; 165: 710\u20138.","journal-title":"Am J Epidemiol"},{"issue":"6","key":"2282_CR31","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1067\/mem.2001.119456","volume":"38","author":"C.M. Hohl","year":"2001","unstructured":"Hohl CM, Dankoff J, Colacone A, et al. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Ann Emerg Med 2001 Dec; 38 (6): 666\u201371.","journal-title":"Ann Emerg Med"},{"issue":"8","key":"2282_CR32","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1532-5415.1997.tb02964.x","volume":"45","author":"J.T. Hanlon","year":"1997","unstructured":"Hanlon JT, Schmader KE, Koronkowski MJ, et al. Adverse drug events in high risk older outpatients. J Am Geriatr Soc 1997 Aug; 45 (8): 945\u20138.","journal-title":"J Am Geriatr Soc"},{"issue":"21","key":"2282_CR33","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1001\/archinte.159.21.2553","volume":"159","author":"D.W. Bates","year":"1999","unstructured":"Bates DW, Miller EB, Cullen DJ, et al. Patient risk factors for adverse drug events in hospitalized patients. Arch Intern Med 1999 Nov 22; 159 (21): 2553\u201360.","journal-title":"Arch Intern Med"},{"issue":"5","key":"2282_CR34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00228-002-0493-y","volume":"58","author":"G. Onder","year":"2002","unstructured":"Onder G, Gambassi G, Scales CJ, et al. Adverse drug reactions and cognitive function among hospitalized older adults. Eur J Clin Pharmacol 2002 Aug; 58 (5): 371\u20137.","journal-title":"Eur J Clin Pharmacol"},{"issue":"11","key":"2282_CR35","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1532-5415.1991.tb02875.x","volume":"39","author":"P. Carbonin","year":"1991","unstructured":"Carbonin P, Pahor M, Bernabei R, et al. Is age an independent risk factor of adverse drug reactions in hospitalized medical patients. J Am Geriatr Soc 1991 Nov; 39 (11): 1093\u20139.","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"2282_CR36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/ageing\/15.4.241","volume":"15","author":"S. Leach","year":"1986","unstructured":"Leach S, Roy SS. Adverse drug reactions: an investigation on an acute geriatric ward. Age Ageing 1986 Jul; 15 (4): 241\u20136.","journal-title":"Age Ageing"},{"issue":"4","key":"2282_CR37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/ageing\/afp050","volume":"38","author":"B. Tangiisuran","year":"2009","unstructured":"Tangiisuran B, Wright J, Van der Cammen T, et al. Adverse drug reactions in elderly: challenges in identification and improving preventative strategies. Age Ageing 2009; 38 (4): 358\u20139.","journal-title":"Age Ageing"},{"key":"2282_CR38","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.2105\/AJPH.55.8.1170","volume":"55","author":"L.G. Seidl","year":"1965","unstructured":"Seidl LG, Thornton GF, Cluff LE. Epidemiological studies of adverse drug reactions. Am J Public Health Nations Health 1965 Aug; 55: 1170\u20135.","journal-title":"Am J Public Health Nations Health"},{"issue":"17","key":"2282_CR39","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/ajhp\/60.17.1750","volume":"60","author":"P. Kanjanarat","year":"2003","unstructured":"Kanjanarat P, Winterstein AG, Johns TE, et al. Nature of preventable adverse drug events in hospitals: a literature review. Am J Health Syst Pharm 2003 Sep 1; 60 (17): 1750\u20139.","journal-title":"Am J Health Syst Pharm"},{"issue":"1","key":"2282_CR40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.amjopharm.2006.03.002","volume":"4","author":"J.K. Nguyen","year":"2006","unstructured":"Nguyen JK, Fouts MM, Kotabe SE, et al. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother 2006 Mar; 4 (1): 36\u201341.","journal-title":"Am J Geriatr Pharmacother"},{"issue":"9","key":"2282_CR41","first-page":"1060","volume":"35","author":"M. Spino","year":"1978","unstructured":"Spino M, Sellers EM, Kaplan HL. Effect of adverse drug reactions on the length of hospitalization. Am J Hosp Pharm 1978 Sep; 35 (9): 1060\u20134.","journal-title":"Am J Hosp Pharm"},{"issue":"9","key":"2282_CR42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2165\/00002018-200831090-00007","volume":"31","author":"Y. Zopf","year":"2008","unstructured":"Zopf Y, Rabe C, Neubert A, et al. Risk factors associated with adverse drug reactions following hospital admission: a prospective analysis of 907 patients in two German university hospitals. Drug Saf 2008; 31 (9): 789\u201398.","journal-title":"Drug Saf"},{"issue":"2","key":"2282_CR43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5414\/CPP46072","volume":"46","author":"P. Gallagher","year":"2008","unstructured":"Gallagher P, Ryan C, Byrne S, et al. STOPP (Screening Tool of Older Person\u2019s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther 2008 Feb; 46 (2): 72\u201383.","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"13","key":"2282_CR44","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1001\/archinternmed.2010.153","volume":"170","author":"G. Onder","year":"2010","unstructured":"Onder G, Petrovic M, Tangiisuran B, et al. Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Arch Intern Med 2010 Jul 12; 170 (13): 1142\u20138.","journal-title":"Arch Intern Med"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03262282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03262282\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03262282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T10:54:05Z","timestamp":1595156045000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03262282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["2282"],"URL":"https:\/\/doi.org\/10.1007\/bf03262282","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}