{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:54:40Z","timestamp":1770706480473,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[1995,2]]},"DOI":"10.1007\/bf03324292","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T04:56:22Z","timestamp":1372740982000},"page":"49-54","source":"Crossref","is-referenced-by-count":0,"title":["Cu\/Zn superoxide dismutase in patients with non-familial Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"7","author":[{"given":"M.","family":"Margaglione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Garofano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ruocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Grandone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Vecchione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Milan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Di Minno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"De Blasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Postiglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"BF03324292_CR1","volume-title":"Banbury report 15: Biological aspects of Alzheimer\u2019s disease","author":"R Katzmann","year":"1983","unstructured":"Katzmann R.: Banbury report 15: Biological aspects of Alzheimer\u2019s disease. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1983."},{"key":"BF03324292_CR2","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/archpsyc.1981.01780350019001","volume":"38","author":"LL Heston","year":"1981","unstructured":"Heston L.L., Mastri A.R., Anderson V.E., Whit J.: Dementia of Alzheimer\u2019s type. Arch. Gen. Psych. 38: 1085\u20131090, 1981.","journal-title":"Arch. Gen. Psych."},{"key":"BF03324292_CR3","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.2880399","volume":"235","author":"PH St. George-Hyslop","year":"1987","unstructured":"St. George-Hyslop P.H., Tanzi R.E., Polinsky R.J., Haines J., Nee L., Watkins P.C., Myers R., Feldman R., Pollen D., Drachmann D., Growdon J., Bruni A., Foncin J-F., Salmon D., Frommelt P., Amaducci L., Sorbi S., Piacentini S., Stuart G.D., Hobbs W.E., Conneally M.P., Gusella J.: The genetic defect causing familial Alzheimer\u2019s disease maps on chromosome 21. Science 235: 885\u2013890, 1987.","journal-title":"Science"},{"key":"BF03324292_CR4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0140-6736(89)91725-X","volume":"I","author":"AM Goate","year":"1989","unstructured":"Goate A.M., Haynes A.R., Owen M.J., Farral M., James L.A., Lai Y.A., Mullan M.J., Roques P., Rossor M.N., Williamson R., Hardy J.A.: Predisposing locus for Alzheimer\u2019s disease is on chromosome 21. Lancet I: 352\u2013355, 1989.","journal-title":"Lancet"},{"key":"BF03324292_CR5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1126\/science.3810169","volume":"235","author":"D Goldgaber","year":"1987","unstructured":"Goldgaber D., Leman M.I., McBride O.W., Saffiotti U., Gajdusek D.C.: Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer\u2019s disease. Science 235: 877\u2013880, 1987.","journal-title":"Science"},{"key":"BF03324292_CR6","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.2949367","volume":"235","author":"RE Tanzi","year":"1987","unstructured":"Tanzi R.E., Gusella J.F., Watkins P.C., Bruns G.A., St.George Hyslop P.H., van Keuren M.L., Patterson D.: Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235: 880\u2013884, 1987.","journal-title":"Science"},{"key":"BF03324292_CR7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/347194a0","volume":"347","author":"PH St. George-Hyslop","year":"1990","unstructured":"St. George-Hyslop P.H., Haines J.L., Farrer L.A., Polinsky R., van Broeckhoven C., Goate A., Crapper McLachlan D.R., Orr H., Bruni A.R., Sorbi S., Foncin J-F., Pollen D., Cantu J-M., Tupler R., Voskresenskaya N.I., Mayeux R., Frommelt P., Watksin P.C., Gusella J.F., Hardy J.A.: Genetic linkage studies suggest that Alzheimer\u2019s disease is not a single homogeneous disorder. Nature 347: 194\u2013197, 1990.","journal-title":"Nature"},{"key":"BF03324292_CR8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF03324196","volume":"5","author":"S Sorbi","year":"1993","unstructured":"Sorbi S.: Molecular genetics of Alzheimer\u2019s disease. Aging Clin. Exp. Res. 5: 417\u2013425, 1993.","journal-title":"Aging Clin. Exp. Res."},{"key":"BF03324292_CR9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1212\/WNL.35.7.957","volume":"35","author":"KE Wisniewski","year":"1987","unstructured":"Wisniewski K.E., Dalton A.J., Crapper McLachan D.R., Wen G.Y., Wisniewski H.M.: Alzheimer\u2019s disease in Down\u2019s syndrome: clinicopathological studies. Neurology 35: 957\u2013961, 1987.","journal-title":"Neurology"},{"key":"BF03324292_CR10","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0022-3476(86)81077-0","volume":"108","author":"AJ Kirkilionis","year":"1986","unstructured":"Kirkilionis A.J., Sergovich F.: Down\u2019s syndrome with apparently normal chromosomes: an update. J. Pediatr. 108: 793\u2013794, 1986.","journal-title":"J. Pediatr."},{"key":"BF03324292_CR11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000316930","volume":"37","author":"DR Cox","year":"1984","unstructured":"Cox D.R., Kawashima H., Vora S., Epstein C.J.: Regional mapping of SOD-1, PRGS and PFK-L on human chromosome 21. Cytogenet. Cell. Genet. 37: 441\u2013442, 1984.","journal-title":"Cytogenet. Cell. Genet."},{"key":"BF03324292_CR12","first-page":"563","volume":"29","author":"WW Feaster","year":"1987","unstructured":"Feaster W.W., Kwok L.W., Epstein C.J.: Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21. Am. J. Hum. Genet. 29: 563\u2013570, 1987.","journal-title":"Am. J. Hum. Genet."},{"key":"BF03324292_CR13","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.1073\/pnas.84.22.8044","volume":"84","author":"CJ Epstein","year":"1987","unstructured":"Epstein C.J., Avrahati K.B., Lovett M., Smith S., Elroy-Stein O., Rotman J., Bry C., Groner Y.: Transgenic mice with increased Cu-Zn superoxide dismutase activity: animal model or dosage effect in Down\u2019s syndrome. Proc. Natl. Acad. Sci. USA 84: 8044\u20138048, 1987.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03324292_CR14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000213215","volume":"36","author":"R Perrin","year":"1990","unstructured":"Perrin R., Briancon S., Jeandel C.: Blood activity of Cu\/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer\u2019s disease: a case control study. Gerontology 36: 306\u2013316, 1990.","journal-title":"Gerontology"},{"key":"BF03324292_CR15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0006-8993(89)91550-3","volume":"476","author":"FP Zemlan","year":"1989","unstructured":"Zemlan F.P., Thienhaus O.J., Bosmann H.B.: Superoxide dismutase activity in Alzheimer\u2019s disease: possible mechanisms for paired helical filament formation. Brain Res. 476: 160\u2013162, 1989.","journal-title":"Brain Res."},{"key":"BF03324292_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-328X(91)90123-F","volume":"9","author":"MJ Somerville","year":"1991","unstructured":"Somerville M.J., Percy M.E., Bergeron C., Yoong L.K., Grima E.A., Mc Lachlan D.R.: Localization and quantification of 68 kDa neurofilament and superoxide dismutase-1 mRNA in Alzheimer\u2019s brains. Mol. Brain Res. 9: 1\u20138, 1991.","journal-title":"Mol. Brain Res"},{"key":"BF03324292_CR17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0022-510X(85)90156-X","volume":"67","author":"SL Marklund","year":"1985","unstructured":"Marklund S.L., Adolfsson R., Gottfries C.G., Winblad B.: Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer\u2019s type. J. Neurol. Sci. 67: 319\u2013325, 1985.","journal-title":"J. Neurol. Sci."},{"key":"BF03324292_CR18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ajmg.1320350403","volume":"35","author":"ME Percy","year":"1990","unstructured":"Percy M.E., Dalton A.J., Markovic V.D., Mc Lachlan D.R, Hurmel S.T., Rusk A.C., Andrews D.F.: Red cells superoxide dismutase, glutathione peroxidase and catalase in Down disease patients with and without manifestations of Alzheimer disease. Am. J. Med. Genet. 35: 459\u2013467, 1990.","journal-title":"Am. J. Med. Genet."},{"key":"BF03324292_CR19","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/01.ATV.13.6.944","volume":"13","author":"E Stragliotto","year":"1993","unstructured":"Stragliotto E., Camera M., Postiglione A., Sirtori M., Di Minno G., Tremoli E.: Functionally abnormal monocytes in hypercholesterolemia. Arteriosclerosis and Thrombosis 13: 944\u2013950, 1993.","journal-title":"Arteriosclerosis and Thrombosis"},{"key":"BF03324292_CR20","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKahn","year":"1984","unstructured":"McKahn G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M.: Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s disease. Neurology 34: 939\u2013944, 1984.","journal-title":"Neurology"},{"issue":"97","key":"BF03324292_CR21","first-page":"77","volume":"21","author":"A Boyum","year":"1968","unstructured":"Boyum A.: Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21(Suppl. 97): 77\u201389, 1968.","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"BF03324292_CR22","first-page":"98","volume":"21","author":"F Cirillo","year":"1991","unstructured":"Cirillo F., Margaglione M., Vecchione G., Ames P.R.J., Coppola A., Grandone E., Cerbone A.M., Marelli C., Di Minno G.: In vitro inhibition by defibrotide of monocyte superoxide anion generation: a possibile role for the antithrombotic effect of a polydeoxy-ribonucleotide-derived drug. Haemostasis 21: 98\u2013105, 1991.","journal-title":"Haemostasis"},{"key":"BF03324292_CR23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1172\/JCI107236","volume":"52","author":"BM Babior","year":"1973","unstructured":"Babior B.M., Kipnes R.S., Curnutte J.T.: Biological defense mechanism: the production by leukocytes of superoxides, a potential bactericidal agent. J. Clin. Invest. 52: 741\u2013744, 1973.","journal-title":"J. Clin. Invest."},{"key":"BF03324292_CR24","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/nar\/3.9.2303","volume":"3","author":"N Blin","year":"1976","unstructured":"Blin N., Stafford D.W.: A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3: 2303\u20132306, 1976.","journal-title":"Nucleic Acids Res."},{"key":"BF03324292_CR25","volume-title":"Molecular cloning: a laboratory manual","author":"T Maniatis","year":"1989","unstructured":"Maniatis T., Fritsch E.F., Sambrook J.: Molecular cloning: a laboratory manual, ed 2. Cold Spring Harbor Laboratory, New York Cold Spring Harbor, 1989.","edition":"2"},{"key":"BF03324292_CR26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","volume":"98","author":"EM Southern","year":"1975","unstructured":"Southern E.M.: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98: 503\u2013510, 1975.","journal-title":"J. Mol. Biol."},{"key":"BF03324292_CR27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/j.1460-2075.1985.tb02320.x","volume":"4","author":"D Levanon","year":"1985","unstructured":"Levanon D., Lieman-Hurwitz J., Dafni N., Wigderson M., Sherman L., Bernstein Y., Laver-Rudich Z., Dancinger E., Stein O., Groner Y.: Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu\/Zn superoxide dismutase. EMBO J. 4: 77\u201384, 1985.","journal-title":"EMBO J."},{"key":"BF03324292_CR28","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1073\/pnas.83.11.3619","volume":"83","author":"E Dancinger","year":"1986","unstructured":"Dancinger E., Dafni N., Bernstein J., Laver-Rudich Z., Neer A., Groner Y.: Human Cu\/Zn superoxide dismutase gene family: molecular structure and characterization of four Cu\/Zn superoxide dismutase-related pseudogenes. Proc. Natl. Acad. Sci. USA 83: 3619\u20133623, 1986.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03324292_CR29","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1126\/science.3420406","volume":"241","author":"GD Schellenberg","year":"1988","unstructured":"Schellenberg G.D., Bird T.D., Wijsman E.M., Moore D.K., Boehnke M., Bryant E.M., Lampe T.H., Nochlin D., Sumi S.M.: Absence of linkage of chromosome 21q21 markers to familial Alzheimer\u2019s disease. Science 241: 1507\u20131510, 1988.","journal-title":"Science"},{"key":"BF03324292_CR30","first-page":"294","volume":"50","author":"JR Korenberg","year":"1992","unstructured":"Korenberg J.R., Bradley C., Disteche C.: Down\u2019s syndrome: molecular mapping of the congenital heart disease and duodenal stenosis. Am. J. Hum. Genet. 50: 294\u2013302, 1992.","journal-title":"Am. J. Hum. Genet."},{"key":"BF03324292_CR31","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.2950593","volume":"235","author":"JM Delabar","year":"1987","unstructured":"Delabar J.M., Goldgaber D., Lamour J., Nicole A., Hunt G.L., De Grouchy J., Brown P., Gajdusek D.C., Sinet P.M.: \u00df-Amyloid gene duplication in Alzheimer\u2019s Disease and karyotypically normal Down Syndrome. Science 235: 1390\u20131392, 1987.","journal-title":"Science"},{"issue":"1","key":"BF03324292_CR32","first-page":"222","volume":"37","author":"M Schweber","year":"1987","unstructured":"Schweber M., Tuson C., Shiloh R., Ben-Neriah Z.: Triplication of chromosome 21 material in Alzheimer\u2019s disease. Neurology 37 (Suppl. 1): 222, 1987.","journal-title":"Neurology"},{"key":"BF03324292_CR33","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511529702","volume-title":"The consequences of chromosome imbalance: principles, mechanisms, models","author":"CJ Epstein","year":"1986","unstructured":"Epstein C.J.: The consequences of chromosome imbalance: principles, mechanisms, models. Cambridge Univ. Press, New York, 1986."},{"key":"BF03324292_CR34","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0006-8993(91)90084-9","volume":"552","author":"I Ceballos-Picot","year":"1991","unstructured":"Ceballos-Picot I., Nicole A., Briand P.: Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice: animal model of gene dosage effects in Down\u2019s syndrome. Brain Res. 552: 198\u2013214, 1991.","journal-title":"Brain Res."},{"key":"BF03324292_CR35","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.210504","volume":"201","author":"I Fridovich","year":"1978","unstructured":"Fridovich I.: The biology of oxygen radicals. The superoxide radical is an agent of oxygen toxicity; superoxide dismutase provide an important defense. Science 201: 875\u2013880, 1978.","journal-title":"Science"},{"key":"BF03324292_CR36","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1016\/S0021-9258(19)43735-6","volume":"248","author":"RA Weisiger","year":"1973","unstructured":"Weisiger R.A., Fridovich I.: Mitochondrial superoxide dismutase. Site of synthesis and intramitochondrial localization. J. Biol. Chem. 248: 4793\u20134796, 1973.","journal-title":"J. Biol. Chem."},{"key":"BF03324292_CR37","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0014-4835(81)80105-4","volume":"33","author":"A Dovrat","year":"1981","unstructured":"Dovrat A., Gershon D.: Rat lens superoxide dismutase and glucose-6-phosphate dehydrogenase: studies on the catalytic activity and the fate of enzyme antigens a function of age. Exp. Eye Res. 33: 651\u2013655, 1981.","journal-title":"Exp. Eye Res."},{"key":"BF03324292_CR38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000213037","volume":"35","author":"C Jeandel","year":"1989","unstructured":"Jeandel C., Nicolas M.B., Dubois F., Nabet-Belleville F., Penin F., Cuny G.: Lipid peroxidation and free radical scavengers in Alzheimer\u2019s disease. Gerontology 35: 275\u2013282, 1989.","journal-title":"Gerontology"},{"key":"BF03324292_CR39","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0888-7543(91)90406-5","volume":"9","author":"MB Petersen","year":"1991","unstructured":"Petersen M.B., Slaugenhaupt S.A., Lewis J.G., Warren A.C., Chakrawarti A., Antonarakis S.E.: A genetic linkage map of 27 markers on human chromosome 21. Genomics 9: 407\u2013419, 1991.","journal-title":"Genomics"},{"key":"BF03324292_CR40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000133207","volume":"59","author":"AC Warren","year":"1992","unstructured":"Warren A.C., Antonarakis S.E., Chakravarti A.: Chromosome 21 genetic linkage data set based on CEPH pedigrees. Cytogenet. Cell Genet. 59: 86\u201387, 1992.","journal-title":"Cytogenet. Cell Genet."},{"key":"BF03324292_CR41","first-page":"551","volume":"50","author":"RE Tanzi","year":"1992","unstructured":"Tanzi R.E., Watkins P.C., Stewart G.D., Wexley N.S., Gusella J.F., Haines J.L.: A genetic linkage map of human chromosome 21: analysis of a combination as a function of sex and age. Am. J. Hum. Genet. 50: 551\u2013558, 1992.","journal-title":"Am. J. Hum. Genet."}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03324292.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03324292\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03324292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:27:14Z","timestamp":1645921634000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03324292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["BF03324292"],"URL":"https:\/\/doi.org\/10.1007\/bf03324292","relation":{},"ISSN":["1594-0667","1720-8319"],"issn-type":[{"value":"1594-0667","type":"print"},{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]}}}